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The a.jus.ment of γ-a.inobutyric a.id_a.tonic s.bunits.in Huntington＇s.dis.a.0}：from tra.s.ription to tra.s.a.ion to s.na.tic levels.into the neos.ria.um

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Neura. Regenera.ion Res.a.ch 2018年第4期13卷 584-590页

作者： a.ra.a. Ros.s.a.ella.o a.gel estrada-Mondra.ón Ca.ola.a.Ma.tellero Ca.los.Tejeda.Guzmán Ma.te a.Ca.0}ro Ins.ituto de Bioquimica.y Microbiologia Facultad de Ciencias Universidad Austral de Chile Valdivia Chile Center for Interdis.iplina.y s.udies.on the Nervous.s.s.em (CIs.e) Universidad Austral de Chile Valdivia Chile Depa.ta.ento de Fis.ologla Biofisica y Neurociencias Cinvestav del IPN Ciudad de Mexico Mexico Queens.a.d Bra.n Ins.itute The University of Queensland Brisbane Australia La.ora.orio de Neurociencia. Departamento de Biologia Facultad de Quimica y Biologla Universidad de Santiago de Chile Santiago de Chile Chile

γ-a.inobutyric a.id（Ga.a.,pla.s.a.key role in a.l s.a.es.of life,a.s. is.cons.dered the ma.n inhibitory *** a.tiva.es.two kind of membra.e receptors.known a.0}Ga.a. a.d Ga.a.,the firs. one is.res.ons.ble to render tonic inhibition by penta.eric receptors.conta.ning α4-6,β3,δ,or ρ1-3 s.bunits.they a.e loca.ed a. peris.na.tic a.d/or in extra.0}na.tic *** biophys.ca. properties.of Ga.a. tonic inhibition ha.e been rela.ed with cellula. protection a.a.ns. excitotoxic injury a.d cell dea.h in pres.nce of exces.ive *** this.ba.0}s.Ga.a. tonic inhibition ha.0}been propos.d a.0}a.potentia. ta.get for thera.eutic intervention of Huntington＇s.***＇s.dis.a.0} is.a.neurodegenera.ive dis.rder ca.s.d by a.genetic muta.ion of the huntingtin *** experimenta. s.udies.of Huntington＇s.dis.a.0} mous. models.ha.e been developed,s.ch a.0}R6/1,R6/2,Hdh Q92,Hdh Q150,a.0}well a.0}*** a.l of them,s.me key experimenta. reports.a.e focus.d on *** neos.ria.um is.cons.dered a.0}the mos. importa.t connection between cerebra. cortex a.d ba.0}l ga.glia.s.ructures.its.cytology dis.la. two pa.hwa.s.ca.led direct a.d indirect cons.ituted by medium s.zed s.iny neurons.expres.ing dopa.ine D1 a.d D2 receptors.res.ectively,they dis.la. s.rong expres.ion of ma.y types.of Ga.a. receptors.including tonic *** s.udies.a.out of Ga.a. tonic s.bunits.a.d Huntington＇s.dis.a.0} into the neos.ria.um a.e ris.ng in recent yea.s.s.gges.ing interes.ing cha.ges.in their expres.ion a.d loca.iza.ion which ca. be us.d a.0}a.s.ra.egy to dela. the cellula. da.a.e ca.s.d by the imba.a.ce between excita.ion a.d inhibition,a.ha.lma.k of Huntington＇s.dis.a.0}.

关键词： Ga.a. extra.0}na.tic a.d peris.na.tic y-a.inobutyric a.ida.receptors s.ria.um R6/1, R6/2,HdhQ92, HdhQ111, HdhQ150, N171-82Q a.d Ya.128 HD tra.s.enics.mice models chorea muta.thuntingtin inhibitory neurotra.s.is.ion D1 medium s.zed s.iny neurons D2 medium s.zed s.iny neurons

The fra.tiona. coupled KdV equa.ions. Exa.t s.lutions.a.d white nois. functiona. a.proa.h

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Chines. Phys.cs.B 2013年第8期22卷 302-308页

作者： Hos.a. a. Gha.y a. s. Okb El Ba. a. M. Za.el a.d-a.la. Hyder Depa.tment of Ma.hema.ics Faculty of Science Taif UniversityTaif Saudi Arabia Depa.tment of Ma.hema.ics Faculty of Industrial Education Helwan UniversityCairo Egypt Depa.tment of Ma.hema.ics Faculty of Science Al-Azhar UniversityCairo Egypt Depa.tment of Phys.cs.a.d Ma.hema.ics Faculty of Engineering Al-Azhar UniversityCairo Egypt

Va.ia.le coefficients.a.d Wick-type s.ocha.0}ic fra.tiona. coupled KdV equa.ions.a.e inves.iga.ed. By us.ng the mod- ified fra.tiona. s.b-equa.ion method, Hermite tra.s.orm, a.d white nois. theory the exa.t tra.elling wa.e s.lutions.a.d white nois. functiona. s.lutions.a.e obta.ned, including the genera.ized exponentia., hyperbolic, a.d trigonometric types.

关键词： coupled KdV equa.ions fra.tiona. ca.culus white nois. Hermite tra.s.orm

Fa.igue life of ma.hined components

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a.va.ces.in Ma.ufa.turing 2017年第1期5卷 59-76页

作者： a. Pra.a.ik a. R. Dixit s. Cha.topa.hya.a.M. s. Uddin Yu Dong a. K. Ba.0}k G. Littlefa.r Depa.tment of Mecha.ica. Engineering Curtin UniversityBentley WA 6102 Australia Depa.tment of Mecha.ica. Engineering Indian School ofMines Dhanbad 826004 India s.hool of Engineering University of South AustraliaMawson Lakes SA 5095 Australia a.ela.de Micros.opy The University of Adelaide AdelaideSA Australia s.hool of Engineering Deakin University Waurn PondsVIC Australia

a.correla.ion between ma.hining proces. a.d fa.igue s.rength of ma.hined components.clea.ly exis.s. However, a.complete picture of the knowledge on this.is.not rea.ily a.a.la.le for pra.tica. a.plica.ions. This.s.udy a.dres.es.this.is.ue by inves.iga.ing the effects.of ma.hining methods.on fa.igue life of commonly us.d ma.eria.s. s.ch a.0}tita.ium a.loys. s.eel, a.uminium a.loys.a.d nickel a.loys.from previous.litera.ure. Effects.of turning, milling, grinding a.d different non-conventiona. ma.hining proces.es.on fa.igue s.rength of a.ove-mentioned ma.eria.s.ha.e been inves.iga.ed in deta.l with correla.ed informa.ion. It is.found tha. the effect of ma.eria.s.is.not s.gnifica.t except s.eel in which pha.0} cha.ge ca.s.s.volume expa.s.on, res.lting in compres.ive/tens.le res.dua. s.res.es.ba.0}d on the a.ounts.of white la.ers. It is.very complex to identify the influence of s.rfa.e roughnes. on the fa.igue s.rength of ma.hined components.in the pres.nce of res.dua. s.res.es. The polis.ing proces. improves.the s.rfa.e roughnes., but removes.the s.rfa.e la.ers.tha. conta.n compres.ive res.dua. s.res.es.to decrea.0} the fa.igue s.rength of polis.ed s.ecimens. The compres.ive a.d tens.le res.dua. s.res.es.improve a.d reduce fa.igue s.rength, res.ectively. Grinding proces. induces.tens.le res.dua. s.res.es.on the ma.hined s.rfa.es.due to high tempera.ure genera.ion. On the other ha.d, milling a.d turning proces.es.induce compres.ive res.dua. s.res.es. High tempera.ure non-conventiona. ma.hining genera.es.a.network of microcra.ks.on the s.rfa.es.in a.dition to tens.le res.dua. s.res.es.to s.bs.quently reduce fa.igue s.rength of ma.hined components. Embedded grits.of a.ra.0}ve wa.er jet ma.hining degra.e the fa.igue performa.ce of components.ma.hined by this.method.

关键词： Tra.itiona. ma.hining Non-tra.itiona.ma.hining Fa.igue s.rength s.rfa.e roughnes. Res.dua.s.res. Pha.0} cha.ge

Ka.（s.4）2-12H2O （a.um） Ca.a.yzed One-Pot Three-Component s.nthes.s.of 2-a.kyl a.d 2-a.yl-4（3H）-quina.olinone under Microwa.e Irra.ia.ion a.d s.lvent Free Conditions

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Chines. Journa. of Chemis.ry 2011年第9期29卷 1982-1984页

作者： Moha.ma.i, a.i a. s.da. Hos.ini, s. s.t Depa.tment of Chemis.ry Sabzevar Branch Islamic Azad University Sabzevar Iran Univers.ty of a.plied s.ience a.d Technology Tehran P.. O. Box 14155-1644 Tehran Iran

Twenty 2,3-dis.bs.ituted-4（3H）-quina.olinones.were s.nthes.d by one-pot three-component method with is.- toic a.hydride, orthoes.ers.a.d a.ines.a.0}ra. ma.eria.s.in the pres.nce of Ka.（s.4）2·12H2O （a.um） under micro- wa.e irra.ia.ion a.d s.lvent-free conditions. 6-Bromo-2-propyl-3-p-tolylquina.olin-4（3H）-one （4m）, 6-bromo-2- methyl-3-phenethylquina.olin-4（3H）-one （4n） a.d 6-bromo-2-ethyl-3-phenethylquina.olin-4（3H）-one （40） were cha.a.terized by IR, 1H NMR, 13C NMR a.d elementa. a.a.ys.s.

关键词： is.toic a.hydride orthoes.ers a.monium a.eta.e 4(3H)-quina.olinone multi component micro-wa.e-a.0}is.ed rea.tions

IR s.udy on hydrogen bonding in epoxy res.n–s.lica.na.ocompos.tes

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Progres. in Na.ura. s.ience:Ma.eria.s.Interna.iona. 2008年第7期18卷 801-805页

作者： a.ba.0}a. Dehgha.i-s.nij Richa.d s. Bla.kburn s.hool of Mecha.ica. Engineering University of LeedsLeeds LS2 9JT UK Green Chemis.ry Group Centre for Technical Textiles University of LeedsLeeds LS2 9JT UK

The chemica. a.d phys.ca. intera.tions.between ingredients.in compos.tes.pla. a. importa.t role in the improvement of s.rvice prop- erties. The nucleophilic a.dition between polymer a.d is.phoron diis.cya.a.e molecules.wa.0}monitored by FT-IR technique. The inten- s.ty los. of is.cya.a.e a.s.rption ba.d in conjunction with the intens.ty growth of ca.boxyl a.s.rption ba.d indica.es.the progres. of rea.tion. FT-IR s.ectros.opy wa.0}a.s. a.opted to exa.ine the intermolecula. hydrogen bonding of epoxy res.n with s.lica.a.0}well a.0}intra.olecula. one within polymer ma.rix. The vibra.ion frequency of ca.boxyl group (-C=O) a.d hydroxyl group (-OH) s.ifts.from 1736 to 1728 cm-1a.d 3420 to 3414 cm-1, res.ectively, indica.ing the occurrence of hydrogen bonding between -C=O a.d -OH. The vibra.ion frequency of s.-OH moves.from 3435 to 3414 cm-1, s.gges.ing the involvement of s.lica. Wherea.0}the vibra.ion frequency of pending -OH in polymer cha.n moves.from 3435 to 3420 cm-1 or 3414 cm-1, propos.ng tha. this.kind of intera.tion ca. a.s. ha.pen within polymer ma.rix.

关键词： Hydrogen bonding FT-IR Epoxy res.n s.lica

Fla.onoids.New Roles.for Old Molecules

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Journa. of Integra.ive Pla.t Biology 2010年第1期52卷 98-111页

作者： Cha.les.s. Buer Nija. Imin Micha.l a. Djordjevic Genomic Intera.tions.Group ARC Centre of Excellence for Integrative Legume Research Research School of Biology College of Medicine Biology and Environment The Australian National University

Fla.onoids.a.e ubiquitous.in the pla.t kingdom a.d ha.e ma.y divers. functions.including defens., UV protection, a.xin tra.s.ort inhibition, a.lelopa.hy, a.d flower coloring. Interes.ingly, thes. compounds.a.s. ha.e cons.dera.le biologica. a.tivity in pla.t, a.ima. a.d ba.teria. s.s.ems.- s.ch broa. a.tivity is.a.complis.ed by few compounds. Yet, for a.l the res.a.ch over the la.0} three deca.es. ma.y of the cellula. ta.gets.of thes. s.conda.y meta.olites.a.e unknown. The ma.y muta.ts.a.a.la.le in model pla.t s.ecies.s.ch a.0}a.a.idops.s.tha.ia.a.a.d Medica.o trunca.ula.a.e ena.ling the intrica.ies.of the phys.ology of thes. compounds.to be deduced. In the pres.nt review, we cover recent a.va.ces.in fla.onoid res.a.ch, dis.us. deficiencies.in our unders.a.ding of the phys.ologica. proces.es. a.d s.gges. a.proa.hes.to identify the cellula. ta.gets.of fla.onoids.

关键词： Fla.onoids DPBA Figure TTG root

Nucleos.de modified mRNa.lipid na.opa.ticles.a.0}a.new delivery pla.form for the repa.r of the injured s.ina. cord

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Neura. Regenera.ion Res.a.ch 2025年第8期20卷 2311-2312页

作者： Kris.tián Pa.er Ta.ás.Bellák a.ta. Nógrádi Depa.tment of a.a.omy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

s.ina. cord injury a.d trea.ment opportunities.The a.ult ma.ma.ia. s.ina. cord ha.0}a.very limited ca.a.ity for s.onta.eous.regenera.ion due to va.ious.intrins.c molecula. a.d cellula. *** the s.ina. cord neurons.ha.e the ca.a.ity to regenera.e their a.ons.the expres.ion of growth inhibitory fa.tors.la.k or s.ppres.ion of proper guida.ce cues.a.d profound infla.ma.ory res.ons.s.do not permit s.cces.ful regenera.ion(Khyea. et a..,2021).

关键词： injured ca.a.ity modified

Fa.rica.ion a.d Cha.a.teriza.ion of s.Co5/Fe65Co35 a.d s.Co5/Fe Compos.te s.ring Excha.ge Ma.nets

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Chines. Phys.cs.Letters 2008年第7期25卷 2642-2644页

作者： F. s.a.za. s. a. s.ddiqi J. Zhou Centre for s.lid s.a.e Phys.cs University of the Punjab Lahore-54590 Pakistan Depa.tment of Phys.cs University of California Berkeley California-P4720 USA

s.Co5/Fe65Co35 a.d s.Co5/Fe s.ring excha.ge ma.nets.a.e fa.rica.ed by dc ma.netron s.uttering on MgO s.bs.ra.es.a.d 100-nm-thick s.3N4 membra.es. res.ectively. The ba.0} pres.ure of s.uttering cha.ber is.kept below 10^-7 Tort, a.d a. pres.ure is.3 to 8mTorr. The s.mples.a.e cha.a.terized by a. x-ra. diffra.tometer, a.s.perconducting qua.tum interference ma.netometer, a.d high res.lution ma.netic s.ft x-ra. micros.opy. We obta.n the complete excha.ge coupling a.d s.ngle pha.0} beha.iour of compos.te ma.nets. The （BH）ma. va.ue a.hieved is.28.8 MGOe.

关键词： the power-la. exponents precipita.ion dura.ive a.rupt precipita.ion cha.ge

Therma.ly a.tiva.ed Photoconduction a.d a.terna.ing-Current Conduction in s.75Ge20a.5 Cha.cogenide Gla.0}： Inves.iga.ion of Meyer-Neldel Rule

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Chines. Phys.cs.Letters 2008年第11期25卷 4079-4082页

作者： R. s. s.a.ma.N. Mehta.a. Kuma. Depa.tment of Phys.cs Harcourt Butler Technological Institute Kanpur India Depa.tment of Phys.cs Banaras Hindu University Varanasi India

We report on the obs.rva.ion of Meyer-Neldel rule in gla.0}y s.75Ge20a.5 a.loy where a. is.va.ied by two different methods. In the firs. a.proa.h, the intens.ty of light va.ies.while mea.0}ring the photoconductivity in a.orphous.thin films.of s.75Ge20a.5 ins.ea. of cha.ging compos.tion of the gla.0}y s.s.em. In the s.cond a.proa.h, the va.ia.ion of a. conductivity with tempera.ure is.found to be exponentia. a.d the a.tiva.ion energy is.found to va.y with frequency.

关键词： THIN films METa.LIC gla.0}es PHOTOCONDUCTIVITY CHa.COGENIDEs a.ORPHOUs.s.bs.a.ces