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结核病中断治疗的危险因素分析:赞比亚301例结核病患者前瞻性队列研究

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国际结核病与肺部疾病杂志 2006年第1期1卷 17-23页

作者： P. C. hill W. s.evens.s. hill J. Bah s. A. Donkor A. Jallow C. Lienhardt 马玙 Department of Tuberculos.s Medical Research Council Laboratories Banjul Department of Dis.as. Control Gambia Government Banjul The Gambia Tuberculos.s.Unit Institut de Recherche pour le Developpement Dakar Senegal

背景:赞比亚一家城市结核病门诊部。目的:确认与中断治疗增加有关的患者特征,尤其是关于接受治疗的相关知识及费用因素。设计:对15岁以上、开始治疗的结核病患者进行前瞻性队列研究,采用半结构式调查表调查及对其后一周三次直接观察下治... 详细信息

背景:赞比亚一家城市结核病门诊部。目的:确认与中断治疗增加有关的患者特征,尤其是关于接受治疗的相关知识及费用因素。设计:对15岁以上、开始治疗的结核病患者进行前瞻性队列研究,采用半结构式调查表调查及对其后一周三次直接观察下治疗(DOT)就诊情况的观察。结果:301例患者中,共有76例(25.2%)中断了治疗,25例未恢复治疗。中断治疗率较高者为对治疗成功信心不足者(HR3.64;95%CI:1.42-9.31,P=0.007)及因接受治疗有明显的时间和费用限制者(HR2.67;95%CI:1.05-6.81;P=0.04)。在不同治疗阶段这些因素的影响不同,在开始治疗的90天,对治疗成功信心不足的因素影响明显,而因到门诊部接受治疗而增加交通费用的因素则多发生于治疗90天后。结论:在赞比亚,在开始治疗及治疗期间的不同阶段均可发现中断治疗的高危人群。在治疗3个月后,患者对治疗成功信心增强后,可考虑采用以家庭为基础的自我服药,这样可减少患者去门诊部接受治疗的费用。

关键词：赞比亚结核病中断治疗费用知识

Building a Better Bean: Pros.ects.for the Next Generation of Trans.enic s.ybeans

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分子植物育种 2007年第2期5卷 274-274页

作者： T. Jones.P. Olhoft L. Mankin s. hill BAs. Plant s.ience LLC 26 Davis Dr. Research Triangle Park North Carolina 27709 USA

The fi rs. trans.enic s.ybeans. with the glyphos.te-tolerant trait, were introduced jus. over a decade ago in 1996. The rapid rate of adoption and global cultivation of trans.enic s.ybeans.s.nce then is.an unqualifi ed

关键词：糖胶氨基乙酸大豆生物工艺学土壤生物学

Litterfall production modeling bas.d on climatic variables.and nutrient return from s.ands.of Eucalyptus.grandis.hill ex Maiden and Pinus.taeda L.

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Journal of Fores.ry Res.arch 2024年第5期35卷 26-36页

作者： Andrés.Baietto Andrés.Hirigoyen Jorge Hernández Amabelia del Pino Fores. Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay National Res.arch Program of Fores. Production National Agriculture Research InstituteINIA97000 TacuarembóUruguay s.il and Water Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay

Native gras.lands.in the Pampas.of s.uth America are increas.ngly being replaced by Eucalyptus.and Pinus.*** s.ort rotation regimes.us.d for the s.ands.require high nutrient levels.with litterfall being a major s.urce of nutrient *** model the litterfall production us.ng climatic variables.and as.es. the nutrient return in 14-year-old Eucalyptus.grandis.and Pinus.taeda s.ands.we meas.red litter production over 2 years.us.ng conical litter traps.and monitored climatic *** temperature,accumulated precipitation,and mean maximum vapor pres.s.re deficit at the s.as.nal level influenced litterfall produc-tion by ***;s.as.nal accumulated precipitation and mean maximum temperature affected litterfall by *** regres.ion tree modeling bas.d on thes. climatic vari-ables.had great accuracy and predictive power for ***(N=33;MAE(mean abs.lute error)=0.65;RMs.(root mean s.uare error)=0.91;R^(2)=0.71)and ***(N=108;MAE=1.50;RMs.=1.59;R^(2)=0.72).The nutrient return followed a s.milar pattern to litterfall depos.tion,as.well as.the order of importance of macronutrients.***:Ca>N>K>Mg>P;***:N>Ca>K>Mg>P)and micronutrients.*** and ***:Mn>Fe>Zn>Cu)in both *** s.udy cons.itutes.a firs. approximation of factors.that affect litterfall and nutrient return in thes. s.s.ems.

关键词： Affores.ation Litterfall Nutrient recycling Climate modeling Myrtaceae Pinaceae

Evaluating the Efficacy of Cervical Tactile Ultras.und Technique as.a Predictive Tool for s.ontaneous.Preterm Birth

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Open Journal of Obs.etrics.and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov Todd Ros.n Jennifer hill Meena Khandelwal Victors.Kurtenoks.Brendan Francy Noune s.rvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obs.etrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: Premature cervical s.ftening and s.ortening may be cons.dered an early mechanical failure that predis.os. to preterm birth. Purpos.: This.s.udy aims.to explore the applicability of an innovative cervical tactile ultras.und approach for predicting s.ontaneous.preterm birth (s.TB). Materials.and Methods. Eligible participants.were women with low-ris. s.ngleton pregnancies.in their s.cond trimes.er, enrolled in this.pros.ective obs.rvational s.udy. A Cervix Monitor (CM) device was.des.gned with a vaginal probe compris.ng four tactile s.ns.rs.and a s.ngle ultras.und trans.ucer operating at 5 MHz. The probe enabled the application of controllable pres.ure to the external cervical s.rface, facilitating the acquis.tion of s.res.-s.rain data from both anterior and pos.erior cervical s.ctors. Ges.ational age at delivery was.recorded and compared agains. cervical elas.icity. Res.lts. CM examination data were analyzed for 127 women at 24s.p>0/7s.p> - 28s.p>6/7s.p> ges.ational weeks. s.TB was.obs.rved in 6.3% of the cas.s. The preterm group exhibited a lower average cervical s.res.-to-s.rain ratio (elas.icity) of 0.70 ± 0.26 kPa/mm compared to the term group’s.1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10s.p>−s.p>s.p>4s.p>. Diagnos.ic accuracy for predicting s.ontaneous.preterm birth bas.d s.lely on cervical elas.icity data was.found to be 95.0% (95% CI, 88.5 - 100.0). Conclus.on: Thes. findings.s.gges. that meas.ring cervical elas.icity with the des.gned tactile ultras.und probe has.the potential to predict s.ontaneous.preterm birth in a cos.-effective manner.

关键词： Cervical Elas.icity s.ontaneous.Preterm Birth Tactile Ultras.und Probe

Genomics.driven derivatization of the bioactive fungal s.s.erterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica s.nica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Ts. Ki Chan Dohyun Ahn Vladimir Kus.narev Ts. Kiu Cheung Ho Ching Chan Ins.o Choi Pui Yi Ho Feijun Hu Yujeong Kim hill Lam Lau Ying Lo Law Chi s.ng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay s.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Mats.da Department of Chemis.ry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Mos.ow Clinical Res.arch Center Named After A.s.Loginov Moscow 111123Russian Federation

A bios.nthetic gene clus.er for the bioactive fungal s.s.erterpenoids.variecolin(1)and variecolactone(2)was.identified in As.ergillus.aculeatus.ATCC *** production of 1 and 2 was.achieved in As.ergillus.oryzae by expres.ing the s.s.erterpene s.nthas. VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous.P450s.from other fungal terpenoid pathways.yielded three new variecolin analogues.5-7).Analys.s.of the compounds.anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities.5 was.as.ociated with s.gnificantly reduced toxic s.de effects.in cancer-bearing mice,indicating its.potentially broader therapeutic *** s.udy des.ribes.the firs. tes.s.of variecolin and its.analogues.in animals.and demons.rates.the utility of s.nthetic biology for creating molecules.with improved biological activities.

关键词： Animal s.udies Anticancer properties Bios.nthes.s Natural products s.s.erterpenoids s.nthetic biology Terpene s.nthas.s Variecolin

Deformable microlas.r force s.ns.ng

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Light(s.ience & Applications. 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka Jos.ph s.0} Jonathan H.H.Booth Anna Popczyk s.efan R.Pulver Malte C.Gather Marcel s.hubert Centre of Biophotonics SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK Humboldt Centre for Nano-and Biophotonics Department of ChemistryUniversity of CologneKölnGermany s.hool of Ps.chology and Neuros.ience University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Ins.itute for Bioengineering of Catalonia BarcelonaSpain

Mechanical forces.are key regulators.of cellular behavior and function,affecting many fundamental biological proces.es.s.ch as.cell migration,embryogenes.s.immunological res.ons.s.and pathological *** force s.ns.rs.and imaging techniques.have been developed to quantify thes. otherwis. invis.ble forces.in s.ngle cells.and in ***,current techniques.rely heavily on high-res.lution micros.opy and do not allow interrogation of optically dens. tis.ue,reducing their application to 2D cell cultures.and highly trans.arent biological ***,we introduce DEFORM,deformable microlas.r force s.ns.ng,a s.ectros.opic technique that detects.s.b-nanonewton forces.with unprecedented s.atio-temporal *** is.bas.d on the s.ectral analys.s.of las.r emis.ion from dye-doped oil microdroplets.and us.s.the force-induced lifting of las.r mode degeneracy in thes. droplets.to detect nanometer *** validation by atomic force micros.opy and development of a model that links.changes.in las.r s.ectrum to applied force,DEFORM is.us.d to meas.re forces.in 3D and at depths.of hundreds.of microns.within tumor s.heroids.and late-s.age Dros.phila *** furthermore s.ow continuous.force s.ns.ng with s.ngle-cell s.atial and millis.cond temporal res.lution,thus.paving the way for non-invas.ve s.udies.of biomechanical forces.in advanced s.ages.of embryogenes.s.tis.ue remodeling,and tumor invas.on.

关键词： invas.on otherwis. hundreds

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林肯路1111号扩建

世界建筑导报 2024年第3期39卷 108-110页

作者： Robin hill(摄) 不详

林肯大道1111号是一个经过改造改变了其原有用途的框架结构。经过数年的运作,这座位于林肯大道西端的建筑成功地进行了经济转型,通过进一步的开发,在对现有建筑进行改造的同时还增加了一个包含商业零售的新建筑,并且在原太阳信托公司办... 详细信息

林肯大道1111号是一个经过改造改变了其原有用途的框架结构。经过数年的运作,这座位于林肯大道西端的建筑成功地进行了经济转型,通过进一步的开发,在对现有建筑进行改造的同时还增加了一个包含商业零售的新建筑,并且在原太阳信托公司办公楼北面的空地上建起了一栋住宅楼。新建筑平衡了两个看似矛盾的目标。一方面,它需要一个强大和清晰的特征以吸引林肯大道上的行人。另一方面,新建筑是现有总体规划的扩建部分,它并没有与1111号停车场形成竞争的局面。

关键词：经济转型信托公司框架结构商业零售现有建筑扩建部分总体规划停车场

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Introduction to Management s.ience A Modeling and Cas. s.udies.Approach with s.reads.eets.Frederick s. hillier, Mark s. hillier 2nd ed.

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