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Cancer vaccines:shared tumor antigens return to the spotlight

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signal Transduction and Targeted Therapy 2020年第1期5卷 324-325页

作者： Lijin Li s.Peter Goedegebuure william Gillanders Department of surgery Washington University School of MedicineSt LouisMOUSA The Alvin J.siteman Cancer Center at Barnes-Jewish Hospital and Washington University school of Medicine St LouisMOUSA

sahin et *** reported interim data from a phase 1 clinical trial(NCT02410733)treating melanoma patients with a RNAlipoplex vaccine(RNA-LPX),targeting melanoma TAA.1 The trial is a multicenter,non-randomized,open-label,dose-escalation trial designed to evaluate the safety and tolerability of BNT111 targeting four melanoma TAA(NY-EsO-1,MAGE-A3,tyrosinase,and TPTE).secondary endpoints include vaccine-induced immune responses and clinical response of patients with measurable disease.

关键词： vaccine melanoma clinical

The Psychosis of Power:A Lacanian Reading of Augusto Roa Bastos’s I the supreme

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Journal of Foreign Languages and Cultures 2021年第2期5卷 4-11,155页

作者： william Egginton John Hopkins University

In the mid-seventies,Paraguay was two decades into what would ultimately be the second longest dictatorship in its history,second only to the reign of its“founding father,”Doctor Jose Rodriguez Gaspar de *** regime of Alfredo stroessner justified its existence and articulated its continued role in Paraguayan politics on a genealogy of national identity that had its supposed roots in the Francia government,Francia’s political ideology and,in fact,in the historical person of Francia *** this essay I show how the great Paraguayan writer Augusto Roa Bastos’s 1974 novel,I,the supreme,takes aim at the“kernel of the real”in the stroessner regime’s political genealogy,using fiction to make evident its anamorphic manipulation of national and nationalist *** taking at its word the regime’s historical discourse,I,the supreme reveals the psychotic logic animating its version of political power.

关键词： Augusto Roa Bastos Paraguayan politics power and psychosis Lacan Zizek psychoanalysis authoritarianism

To linguists in the People’s Republic of China

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世界汉语教学 2001年第1期15卷 3-6页

作者： william Labov Director AtlasofNorthAmericanEnglish

In May of this year, I will be visiting China, along with my colleague from the University of Pennsylvania, Anthony Kroch. I am looking forward with keen anticipation to the opportunity to make contact with Chinese linguists. I hope to learn as much as possible about your researgh and the progress you have made in the study of the Chinese language as it is developing today.

关键词：语言学家中国学术研究思想活动

The politics of anti-corruption reforms and reversals in Uganda’s changing political terrain

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Economic and Political studies 2016年第1期4卷 62-84页

作者： william Muhumuza Department of Political science Makerere UniversityKampalaUganda

The article discusses the increasing levels of public sector corruption despite the NRM government’s pursuing of accountability reforms and anti-corruption policy *** asserts that having an impressive legal and institutional framework in place to enhance accountability and control corrupt tendencies may not be enough if political factors are *** the absence of exemplary political leadership and support to institutions that enforce compliance,fighting corruption will remain a far *** article further argues that in circumstances where the political terrain ascribes to patron-client and neo-patrimonial instruments to consolidate and retain power,curbing public sector corruption will be *** article insists that fighting public sector corruption largely depends on political commitment and less on the semblance of laws,institutions and technocrats.

关键词： Anti-corruption institutions neo-patrimonial politics patronage public sector corruption Uganda

Proteomics Technologies and Challenges

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Genomics, Proteomics & Bioinformatics 2007年第2期5卷 77-85页

作者： william C.s. Cho Department of Clinical Oncology Queen Elizabeth Hospital

Proteomics is the study of proteins and their interactions in a cell. With the completion of the Human Genome Project, the emphasis is shifting to the protein compliment of the human organism. Because proteome reflects more accurately on the dynamic state of a cell, tissue, or organism, much is expected from proteomics to yield better disease markers for diagnosis and therapy monitoring. The advent of proteomics technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of diseases. High-throughput proteomics technologies combining with advanced bioinformatics are extensively used to identify molecular signatures of diseases based on protein pathways and signaling cascades. Mass spectrometry plays a vital role in proteomics and has become an indispensable tool for molecular and cellular biology. While the potential is great, many challenges and issues remain to be solved, such as mining low abundant proteins and integration of proteomics with genomics and metabolomics data. Nevertheless, proteomics is the foundation for constructing and extracting useful knowledge to biomedical research. In this review, a snapshot of contemporary issues in proteomics technologies is discussed.

关键词： proteomics mass spectrometry, protein chip

Convergence of COVID-19 and recurrent stroke:In-hospital mortality risks explored

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World Journal of Virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree V Dhotre Ajay M Gavkare sachin s Mumbre Pradnya s Dhotre Department of Microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COVID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient *** findings reveal significantly higher mortality rates in COVID-19-positive patients compared to non-COVID-19 patients,particularly among middle-aged individuals,males,and ethnic *** editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk *** results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COVID-19 pandemic.

关键词： Recurrent stroke COVID-19 In-hospital mortality Nationwide analysis stroke admissions Infectious diseases Chronic health conditions Hypercoagulability

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

It’s not just science: challenges for public health intervention in Ebola epidemics in the Democratic Republic of Congo

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science China(Life sciences) 2020年第7期63卷 1079-1081页

作者： Pengyan Wang william J.Liu school of Laboratory Medicine and Life sciences Wenzhou Medical UniversityWenzhou 325035China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

The Democratic Republic of Congo (DRC) is suffering from the world’s second largest and most prolonged Ebola virus disease (EVD) epidemic on record (Figure 1). The current prevalence of EVD in the DRC makes this the 10th (and largest) EVD epidemic in the DRC since the first discovery of the Zaire Ebola virus in 1976 (Ilunga Kalenga, 2019).Globally, it is the second worst outbreak in the history of Ebola epidemics.

关键词： It’s not just science challenges for public health intervention in Ebola epidemics in the Democratic Republic of Congo

Male Homosexuality and Foxes in Ji Yun's Zhiguai Collection Tales of the Thatched Cottage

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Fudan Journal of the Humanities and social sciences 2020年第3期13卷 357-374页

作者： Thomas william Whyke Department of Foreign Languages Ningbo University818 Fenghua RoadJiangbei DistrictNingboZhejiangChina

Tales reflecting homosexual relationships between foxes and humans had appeared as early as the Ming *** both the increase in prevalence in society and fictional representation of homosexuality during the Ming and Qing Dynasties,the stories of male-male sex between foxes and humans became increasingly popular,demonstrating the popular attitudes toward homosexuality among the Qing *** this paper,I analyze late imperial Chinese homosexuality as portrayed in Ji Yun's zhiguai collection uTales of the Thatched Cottage?,(Yuewei Caotang Biji).Zhiguai,or strange tales in English,is a genre of writing featuring ghosts,magical animalhuman shapeshiftings,dreams that intervene in reality,and other supernatural characters and *** tales are set against a background of strict Confucian orthodoxy and Buddhist beliefs in sexual activity(whether heterosexual or homosexual)as a manifestation of human greed,in a society where everything had its place,in which the boundaries of sexuality were rigidly controlled.I examine what foxes reveal about homosexuality in these tales as they cross the boundary between moral and immoral,healthy and destructive.1 argue that the fox’s homosexual punishment of humanity has two motives:(1)disciplining sexual lasciviousness and(2)karmic retribution for misdeeds in a former *** these instances,the fox’s ensuing erotic deviancy serves as the vehicle for cautionary tales that demonstrate homosexuality to be a taboo as it punishes greedy desires(sexual or otherwise).

关键词： Zhiguai tales Ji Yun Yuewei Caotang Biji Foxes Male homosexuality