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Immunogenic potential and protective efficacy of formalin inactivated circulating Indian strain of West nile virus

Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 946-951页

作者： Pritom Chowdhury siraj Ahmed Khan Rashmee Topno Prafulla Dutta R.n.s.yadav Jagadish Mahanta Regional Medical Research Centre ICMR(NE Region)DibrugarhAssamIndia Centre for studies in Biotechnology Dibrugarh UniversityDibrugarh-786004AssamIndia

Objective:To assess the best suitable condition for virus *** to study the immunogenic potential and protective efficacy of a circulating West nile virus(WnV) strain in ***:Bulk preparation of circulating WnV:WnIRGC07(GeneBank ID:HQ246154).was undertaken in a bioreaclor using *** Inactivation was done in three different conditions:22 ℃.4 ℃ and room *** virus preparations were evaluated for antigenicity by ELIsA and toxicity by cell proliferation *** efficacy was done in-viro on swiss albino mice against standard Indian WnV and Japanese encephalitis virus(JKV)*** and cell mediated immune response was evaluated in mice sera by ELIsA and neutralization ***:Inactivation at 22 ℃ was found to be more suitable in terms of less toxicity and high *** same was selected to study the immune response and efficacy in *** induced neutralizing antibody titre of 1:625 and high EgG *** vivo experiment showed 100% protective efficacy against WnV and 20.8% cross protective efficacy against *** assessment of cellular immunity through immunized mice revealed augmentation of high levels of pro-inflammatory cytokines and moderate levels of anti—cytokines indicating a mixed balance of Th1 and Th2 ***:Findings suggest that formalin inactivated Indian WnV strain has a good immunogenic *** is the first study on assessment of immunogenic potential of a lineage 5 strain of *** study reveals that it would be a promising and effective candidate for vaccine studies which warrants further evaluation.

关键词： West nile virus Assam Immunization Efficacy neutralizing antibody Cytokine

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Astrophysical s-factor and reaction rate for 15n(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili n.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan new York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh national University 050040 AlmatyKazakhstan

We study radiative p^(15)n capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)n(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)n channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)n(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CnO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)n(p,γ)^(13)O,^(13)n(p,γ)^(14)O,^(14)n(p,γ)^(15)O,and ^(15)n(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)n system thermonuclear reaction rate potential cluster model CnO-cycle

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Dynamic and electrical responses of a curved sandwich beam with glass reinforced laminate layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 155-178页

作者： n.sHAHVEIsI s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic responses and generated voltage in a curved sandwich beam with glass reinforced laminate(GRL)layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact(LVI)are *** current study aims to carry out a dynamic analysis on the sandwich beam when the impactor hits the top face sheet with an initial *** the layer analysis,the high-order shear deformation theory(HsDT)and Frostig's second model for the displacement fields of the core layer are *** classical non-adhesive elastic contact theory and Hunter's principle are used to calculate the dynamic responses in terms of *** order to validate the analytical method,the outcomes of the current investigation are compared with those gained by the experimental tests carried out by other researchers for a rectangular composite plate subject to the *** element(FE)simulations are conducted by means of the ABAQUs *** effects of the parameters such as foam modulus,layer material,fiber angle,impactor mass,and its velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved sandwich beam glass reinforced laminate(GRL) pliable core low-velocity impact(LVI) classical non-adhesive elastic contact theory

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印度的甘蔗栽培机械

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粮油加工(电子版) 1985年第12期 35-37页

作者： R.n.s yadav ,蕴山

甘蔗是印度的重要作物之一。印度甘蔗种植面积约有320万公顷。在印度,甘蔗生产成本约占糖生产成本的70%。甘蔗栽培所需工序较多,如整地、播种、灌溉、中耕除草、培土、植保、收获、运输、宿根管理等。大多数工序需要繁重的劳力,因此,迫... 详细信息

甘蔗是印度的重要作物之一。印度甘蔗种植面积约有320万公顷。在印度,甘蔗生产成本约占糖生产成本的70%。甘蔗栽培所需工序较多,如整地、播种、灌溉、中耕除草、培土、植保、收获、运输、宿根管理等。大多数工序需要繁重的劳力,因此,迫切需要机械化。现将印度新研制的几种甘蔗栽培机械介绍如下。

关键词：甘蔗刀砍切印度南亚

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Towards defining soil quality of Mediterranean calcareous agricultural soils:Reference values and potential core indicator set

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International soil and Water Conservation Research 2024年第1期12卷 145-155页

作者： Germán A.Durán Daniel sacristán Edelweis Farrús Jaume Vadell Institut de Recerca i FormacióAgrària i Pesquera de les Illes Balears C/Eusebi Estada14507009PalmaSpain Plant Biology Department University of Valencia46100BurjassotValenciaSpain soil and Environmental Quality Department Centro de Investigaciones sobre Desertificación-CIDE(CSIC-Universitat de València-Generalitat Valenciana)Carretera Moncada-Náquera km 4.546113MoncadaValenciaSpain Universitat de les Illes Balears Cra.De Valldemossakm 7507122PalmaSpain

To avoid soil degradation,adapt to climate change and comply with the sustainable Development goals 2030(Un General Assembly),establishing the quality/fertility of the agricultural soils of the Mediterranean region and evaluate how these evolve with time is *** enables adequate management practices to be *** Mediterranean calcareous region has received little attention in this sense,in spite its soil ***,24 different representative calcareous agricultural soils of the Mediterranean region,including the main management strategies of agricultural soils(rainfed and irrigated),were sampled from the island of Mallorca;and their physical,chemical and biological properties *** values obtained for most of the soil characteristics allowed to establish an initial approach to the reference values for the type of calcareous agricultural soils considered,and to clearly distinguish the effect of rainfed or irrigation management practices on soils properties and *** enzyme activities were not stimulated by the irrigation conditions assayed or they were only in dry conditions,suggesting optimum enzyme activities could be obtained when alternating dry and humid soil *** organic carbon,calcium carbonate and active lime revealed of significant importance in the collection of ***,the results obtained clearly indicate the heterogeneity of the region and its implications on the different soil ***,this study could serve as a starting point to adequately establish the quality(fertility)for Mediterranean calcareous agricultural soils and their reference values by conducting further research in this region and including more type of soils.

关键词： soil fertility Mediterranean agricultural soils Calcareous soils soil enzymes soil management

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Early Phases of star Formation: Testing Chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： n.C.Martinez s.Paron COnICET-Universidad de Buenos Aires.Instituto de Astronomía y Física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

star-forming processes strongly influence the IsM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the HCn/HnC ratio as a thermometer,and the use of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDCs),highmass protostellar objects(HMPOs),hot molecular cores(HMCs) and ultracompact H II *** found that the use of the HCn/HnC ratio as a universal thermometer in the IsM should be taken with care because the HCn optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the HCn spectrum,checking that no line,neither the main nor the hyperfine ones,presents absorption *** point out that the analysis of the emission of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H could be useful to trace and distinguish regions among IRDCs,HMPOs and *** molecular line widths of these four species increase from the IRDC to the HMC stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation IsM:molecules IsM:clouds

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Dispersion effect of nano-structure pyrolytic carbon on mechanical,electrical,and microstructural characteristics of cement mortar composite

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International Journal of smart and nano Materials 2024年第3期15卷 534-578页

作者： n.K.Karthikeyan s.Elavenil school of Civil Engineering Vellore Institute of TechnologyChennaiIndia

In material science,converting waste into nanomaterials by green technologies highlights the interest in producing sus-tainable carbon nanomaterial(sCn).This study first-ever uti-lized tyre-char as a nano-structure Pyrolytic Carbon(nsPC)to develop electrically conductive *** other car-bon nanomaterials,the efficiency of nsPC particle as an sCn in developing electrically conductive composites was investi-gated in terms of dispersion,mechanical,water absorption,electrical resistivity,and *** results of sedi-mentation and zeta potential(-19 mV)showed the excellent dispersion of nsPC particle in water with the combined effect of superplasticizer and *** compressive(40.37%)and flexural strength(10.76%)than that of plain cement mortar composite(CMC)is achieved with 2 wt.%and 1.5 wt.%of nsPC particle,*** water absorption rate and volume of permeable voids were reduced,exhibiting less *** percolation zone of AC and DC resis-tivity of nsPC composite ranges between 1 and 2 wt.%,and the established percolation threshold is at 2 wt.%.XRD analysis showed C-s-H formation consistently increased with curing age,and HR-sEM with EDAX analysis exhibits the dense micro-structure and well-distributed nsPC particle at the *** experimental outcomes significantly enhanced the relia-bility and provided a framework for tailoring nsPC particle as sCn for developing electrically conductive composite.

关键词： sustainable nanomaterial dispersion mechanical properties electrical resistivity microstructure analysis

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new insights into nitric oxide biosynthesis underpin lateral root development

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Molecular Plant 2024年第5期17卷 691-693页

作者： Kapuganti Jagadis Gupta nidhi yadav Aprajita Kumari Gary J.Loake national Institute for Plant Genome Research Aruna Asaf Ali MargNew Delhi 110070India Institute of Molecular Plant sciences School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK Centre for Engineering Biology School of Biological SciencesUniversity of EdinburghEH93BF EdinburghUK

In recent years,nitric oxide(nO)has emerged as a key redox signaling molecule in plants functioning in the regulation of key developmental programs and the orchestration of responses to a plethora of environmental cues(Kolbert et al.,2019).The predominant route for the transfer of nO bioactivity is through s-nitrosylation,the addition of an nO moiety to a protein cysteine thiol to form an s-nitrosothiol(Yun et al.,2011).specificity for this process is established by the structural constraints imposed by tertiary protein structure in gating access to given cysteine redox switches and associated proteins that can either facilitate the addition or removal of the nO moiety at these residues(Umbreen et al.,2018).

关键词： moiety addition redox

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi n Jincy M.Jose sreelata B.nair Prabha s.n Pappachan s Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline super specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGs;OMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical notch Ligand 1(JAG1)gene(20p12.2)or in the neurogenic locus notch homolog protein 2(nOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGs cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases notch

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Conformally symmetric wormhole solutions supported by non-commutative geometry in f(Q,T)gravity

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Communications in Theoretical Physics 2024年第2期76卷 111-124页

作者： Chaitra Chooda Chalavadi V Venkatesha n s Kavya s V Divya Rashmi Department of P.G.studies and Research in Mathematics Kuvempu UniversityShankaraghattaShivamogga 577451KarnatakaIndia Department of Mathematics Vidyavardhaka College of EngineeringMysuru—570002India

This paper investigates wormhole solutions within the framework of extended symmetric teleparallel gravity,incorporating non-commutative geometry,and conformal *** achieve this,we examine the linear wormhole model with anisotropic fluid under Gaussian and Lorentzian *** primary objective is to derive wormhole solutions while considering the influence of the shape function on model parameters under Gaussian and Lorentzian *** resulting shape function satisfies all the necessary conditions for a traversable ***,we analyze the characteristics of the energy conditions and provide a detailed graphical discussion of the matter contents via energy ***,we explore the effect of anisotropy under Gaussian and Lorentzian ***,we present our conclusions based on the obtained results.

关键词： traversable wormhole f(Q T)gravity energy conditions non-commutative geometry conformal motion

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