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In search of a pan-coronavirus vaccine:next-generation vaccine design and immune mechanisms

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Cellular & Molecular Immunology 2024年第2期21卷 103-118页

作者： s.Cankat M.u.Demael L.swadling Division of Infection and Immunity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent *** this review,we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all members of the coronavirus *** will detail the unmet clinical need associated with the continued transmission of sARs-CoV-2,MERs-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,HKu1 and 229E)in humans and the potential for future zoonotic *** will highlight how first-generation sARs-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral immunity to coronaviruses and have informed next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of immunity that may offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive immunity Cross-protection universal

A Robust Method of Bipolar Mental Illness Detection from Facial Micro Expressions using Machine Learning Methods

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Intelligent Automation & soft Computing 2024年第1期39卷 57-71页

作者： Ghulam Gilanie sana cheema Akkasha Latif Anumsaher Muhammad Ahsan Hafeez ullah Diya Oommen Department of Artificial Intelligence Faculty of ComputingThe Islamia University of BahawalpurBahawalpur63100Pakistan Biophotonics Imaging Techniques Laboratory Institute of PhysicsThe Islamia University of BahawalpurBahawalpur63100Pakistan West High school Salt Lake CityUT84103USA

Bipolar disorder is a serious mental condition that may be caused by any kind of stress or emotional upset experienced by the *** affects a large percentage of people globally,who fluctuate between depression and mania,or vice versa.A pleasant or unpleasant mood is more than a reflection of a state of ***,it is a difficult task to analyze through physical examination due to a large patient-psychiatrist ratio,so automated procedures are the best options to diagnose and verify the severity of *** this research work,facial microexpressions have been used for bipolar detection using the proposed Convolutional Neural Network(CNN)-based *** Action Coding system(FACs)is used to extract micro-expressions called Action units(Aus)connected with sad,happy,and angry *** have been conducted on a dataset collected from Bahawal Victoria Hospital,Bahawalpur,Pakistan,using the Patient Health Questionnaire-15(PHQ-15)to infer a patient’s mental *** experimental results showed a validation accuracy of 98.99%for the proposed CNN modelwhile classification through extracted featuresusing supportVectorMachines(sVM),K-NearestNeighbour(KNN),and Decision Tree(DT)obtained 99.9%,98.7%,and 98.9%accuracy,***,the outcomes demonstrated the stated method’s superiority over the current best practices.

关键词： Bipolar mental illness detection facial micro-expressions facial landmarked images

stability analysis and soliton solutions of the(1+1)-dimensional nonlinear chiral schrodinger equation in nuclear physics

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Communications in Theoretical Physics 2024年第9期76卷 1-15页

作者： Fazal Badshah Kalim u Tariq Ahmet Bekir s M Raza Kazmi Emad Az-Zo'bi school of Electrical and Information Engineering Hubei University of Automotive TechnologyShiyan 442002China Department of Mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey Department of Mathematics and statistics Faculty of ScienceMutah UniversityAlKarak 61710Jordan

The nonlinear schrodinger equation equation is one of the most important physical models used in optical fiber theory to explain the transmission of an optical *** field of chiral soliton propagation in nuclear physics is very interesting because of its numerous applications in communications and ultra-fast signal routing ***(1+1)-dimensional chiral dynamical structure that describes the soliton behaviour in data transmission is dealt with in this work using a variety of in-depth analytical *** work has applications in particle physics,ionised science,nuclear physics,optics,and other applied mathematical *** are able to develop a variety of solutions to demonstrate the behaviour of solitary wave structures,periodic soliton solutions,chiral soliton solutions,and bell-shaped soliton solutions with the use of applied ***,in order to verify the scientific calculations,the stability analysis for the observed solutions of the governing model is taken into *** addition,the3-dimensional,contour,and 2-dimensional visuals are supplied for a better understanding of the behaviour of the *** employed strategies are dependable,uncomplicated,and effective;yet have not been utilised with the governing model in the literature that is now *** resulting outcomes have impressive applications across a large number of study areas and computational physics phenomena representing real-world *** methods applied in this model are not utilized on the given models in previous literature so we can say that these describe the novelty of the work.

关键词： solitons the nonlinear schrodinger equation stability analysis chiral solitons exact solutions

Paradoxical systemic toxicity by inhaled paraquat poisoning: A case report

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Journal of Acute Disease 2024年第1期13卷 40-42,I0001-I0005页

作者： Tulika Garg Jaspreet Kaur Yuvraj singh cheema Department of General Medicine Government Medical College and HospitalChandigarhIndia

Rationale:Multi-organ failure is a symptom of paraquat poisoning,resulting in high mortality and morbidity *** paraquat is widely available,poisoning through inhalation is ***’s Concern:A 37-year-old male reported to the emergency department with complaints of vomiting after an alleged history of inhalation of paraquat while at ***:Paraquat ***:supportive management along with multiple sessions of ***:Renal complications caused by paraquat were improved after multiple sessions of ***,the patient developed respiratory complications and later due to persistent hypoxemia and non-responsive to supportive therapy,he succumbed to his ***:Acute kidney injury is a complication of paraquat ***,kidney involvement with the inhalational mode is *** is caused by reduction and oxidation cycles,as well as the formation of reactive oxygen species,necessitating hemodialysis as the *** a clear history,a specific clinical trait,or a diagnostic test,diagnosis can be *** case thus highlights the inhaled paraquat poisoning,presenting with acute kidney injury with late respiratory impairment as a consequence.

关键词： Paraquat poisoning Pesticide Acute kidney injury Respiratory insufficiency Hemodialysis

Bubble coalescence in interacting system of DNA molecules

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International Journal of Biomathematics 2024年第4期17卷 195-216页

作者： u.A.Rozikov V.I.Romanouskiy Institute of Mathematics 9 Universitet Street100174 Tashkent uzbekistan AKFA university National Park StreetBarkamol MFY Mirzo-Ulugbek District111221 Tashkent uzbekistan National university of uzbekistan 4Universitet Street 100174 TashkentUzbekistan

We consider two models of interacting DNA molecules:First is(four parametric)bubble coalescence model in interacting DNAs(shortly:BCI-DNA).second is(three parametric)bubble coalescence model in a condensed DNA molecules(shortly BCC-DNA).To study bubble coalescence thermodynamics of BCI-DNA and BCC-DNA models we use methods of statistical ***,we define Hamiltonian of each model and give their translation-invariant Gibbs measures(TIGMs).For the first model,we find parameters such that corresponding Hamiltonian has up to three TIGMs(three phases of system)biologically meaning existence of three states:“No bubble coalescence”,“Dominated soft zone”,“Bubble coalescence”.For the second model,we show that for any(admissible)parameters,this model has unique *** is a state where“No bubble coalescence”phasedominates.

关键词： DNA bubble configuration Cayley tree Gibbs measure Potts model

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： u.s.Mahabaleshwar G.P.Vanitha L.M.Pérez Emad H.Aly I.Pop Department of studies in Mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of Mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection

Variational data encoding and correlations in quantum-enhanced machine learning

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Chinese Physics B 2024年第9期33卷 298-306页

作者： Ming-Hao Wang Hua L¨u school of Physics Hubei UniversityWuhan 430062China school of science Hubei University of TechnologyWuhan 430068China

Leveraging the extraordinary phenomena of quantum superposition and quantum correlation,quantum computing offers unprecedented potential for addressing challenges beyond the reach of classical *** paper tackles two pivotal challenges in the realm of quantum computing:firstly,the development of an effective encoding protocol for translating classical data into quantum states,a critical step for any quantum *** encoding strategies can significantly influence quantum computer ***,we address the need to counteract the inevitable noise that can hinder quantum *** primary contribution is the introduction of a novel variational data encoding method,grounded in quantum regression algorithm *** adapting the learning concept from machine learning,we render data encoding a learnable *** allowed us to study the role of quantum correlation in data *** numerical simulations of various regression tasks,we demonstrate the efficacy of our variational data encoding,particularly post-learning from instructional ***,we delve into the role of quantum correlation in enhancing task performance,especially in noisy *** findings underscore the critical role of quantum correlation in not only bolstering performance but also in mitigating noise interference,thus advancing the frontier of quantum computing.

关键词： quantum machine learning variational data encoding quantum correlation

Fuzzy and IRLNC-based routing approach to improve data storage and system reliability in IoT

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Intelligent and Converged Networks 2024年第1期5卷 68-80页

作者： u.Indumathi A.R.Arunachalam the Department of Computer science and Engineering Dr.M.G.R.Educational and Research InstituteChennai 600095India

Internet of Things(IoT)based sensor network is largely utilized in various field for transmitting huge amount of data due to their ease and cheaper *** performing this entire process,there is a high possibility for data corruption in the mid of *** the other hand,the network performance is also affected due to various *** address these issues,an efficient algorithm that jointly offers improved data storage and reliable routing is ***,after the deployment of sensor nodes,the election of the storage node is achieved based on a fuzzy expert *** Random Linear Network Coding(IRLNC)is used to create an encoded *** encoded packet from the source and neighboring nodes is transmitted to the storage ***,to transmit the encoded packet from the storage node to the destination shortest path is found using the Destination sequenced Distance Vector(DsDV)*** analysis of the proposed work is carried out by evaluating some of the statistical *** residual energy,packet delivery ratio,compression ratio and storage time achieved for the proposed work are 8.8%,0.92%,0.82%,and 69 *** on this analysis,it is revealed that better data storage system and system reliability is attained using this proposed work.

关键词： Internet of Things(IoT) data storage management fuzzy system improved random linear network coding energy utilization system reliability

symmetries,optimal system,exact and soliton solutions of(3+1)-dimensional Gardner-KP equation

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Journal of Ocean Engineering and science 2024年第2期9卷 178-190页

作者： Amjad Hussain Ashreen Anjum M.Junaid-u-Rehman Ilyas Khan Mariam A.sameh Amnah s.Al-Johani Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-MajmaahP.O Box 66Majmaah 11952Saudi Arabia Electrical Engineering Department Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo 11845Egypt Mathematics Department Faculty of ScienceUniversity of TabukTabukSaudi Arabia

In this research article,the(3+1)-dimensional nonlinear Gardner-Kadomtsov-Petviashvili(Gardner-KP)equation which depicts the nonlinear modulation of periodic waves,is analyzed through the Lie group-theoretic *** the Lie invariance condition,we find the symmetry *** pro-posed model yields eight-dimensional Lie ***,an optimal system of sub-algebras is com-puted,and similarity reductions are *** considered nonlinear partial differential equation is re-duced into ordinary differential equations(ODEs)by utilizing the similarity transformation method(sTM),which has the benefit of yielding a large number of accurate traveling wave *** ODEs are further solved to get closed-form solutions of the Gardner-KP equation in some cases,while in other cases,we use the new auxiliary equation method to get its soliton *** evolution profiles of the obtained solutions are examined graphically under the appropriate selection of arbitrary parameters.

关键词： Gardner-KP equation Lie symmetry analysis Optimal system New auxiliary equation method solitary wave solutions