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Ultrastructural analysis of sperm from the genus Idarnes(Hymenoptera:Chalcidoidea,sycophaginae)

bIoCELL 2022年第1期46卷 275-283页

作者： KHEsLLER PATRÍCIA oLAZIA JULIANA soUZA DA sILVA GUILHERME sIRIMARCo DE soUZA ToNELLI sônia nair báo Departamento de biologia Celular Instituto de Ciências BiológicasUniversidade de BrasíliaBrasíliaBrazil Instituto de Ciências da saúde Coordenação de Ciências BiológicasUniversidade Paulista UNIPBrasíliaBrazil

In this study,the sperm ultrastructure of three species of Idarnes genus was investigated using light and transmission electron *** morphology of the three species was similar to that of most Chalcidoidea,with helicoidally twisted nucleus and *** head region consists of an acrosome and a nucleus;the nucleus-flagellum transition region characterized by the presence of mitochondrial derivatives and the centriolar adjunct;a flagellum region,which includes the axoneme with microtubular arrangement 9+9+2 and two mitochondrial ***,the sperm of these three species exhibit features that discriminate one species from each other:(1)only one species,Idarnes sp.2(carme group)exhibited an extracellular sheath surrounding the anterior portion of the nucleus,which extends to the anterior region of the flagellum,but it did not present filaments;(2)the acrosome in the three species was quite different,Idarnes sp.1 and Idarnes sp.2(carme group)has two compartments(acrosomal and subacrosomal vesicles)while Idarnes sp.3(flavicollis group)has a third compartment(perforatorium);(3)the centriolar adjunct elongated and its location among the mitochondrial derivatives is similar for the three species analyzed;(4)mitochondrial derivatives differ between the species,with triangular(Idarnes sp.1 and sp.3)and elongated or flat shaped(Idarnes sp.2)*** data shows that sperm structure may differ within the same genus and confirms the potential of these cells in phylogenetic and taxonomic analyses in the Chalcidoidea superfamily,as well as in Hymenoptera in general.

关键词： Chalcidoidea Idarnes genus Insect sperm sperm ultrastructure Fig wasps

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Enhanced cavitation erosion resistance of a friction stir processed high entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1353-1362页

作者： Rakesh b.nair H.s.Arora Harpreet singh Grewal surface science and Tribology Lab Department of Mechanical EngineeringShiv Nadar UniversityGautam Buddha NagarUttar Pradesh 203207India

Friction stir processing of an Al0.1CoCrFeNi high entropy alloy(HEA)was performed at controlled cooling conditions(ambient and liquid submerged).Microstructural and mechanical characterization of the processed and as-cast HEAs was evaluated using electron backscatter diffraction,micro-hardness testing and *** under the submerged cooling condition showed elongated grains(10μm)with fine equiaxed grains(2μm)along the boundary compared to the coarser grain(~2 mm)of as-cast *** hardness showed remarkable improvements with four(submerged cooling condition)and three(ambient cooling condition)times that of as-cast HEA(HV^150).The enhanced hardness is attributed to the significant grain refinement in the processed *** erosion behavior was observed for samples using an ultrasonication *** of the HEAs showed better cavitation erosion resistance than the stainless steel *** sample processed under a submerged liquid condition showed approximately 20 and 2 times greater erosion resistance than stainless steel 316L and ascast HEA,*** enhanced erosion resistances of the processed HEAs correlate to their increased hardness,resistance to plasticity,and better yield strength than the as-cast *** surface of the tested samples showed nucleation and pit growth,and plastic deformation of the material followed by fatigue-controlled disintegration as the primary material removal mechanism.

关键词： cavitation erosion microstructure mechanical properties surface engineering

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Machine learned interatomic potentials using random features

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npj Computational Materials 2022年第1期8卷 48-57页

作者： Gurjot Dhaliwal Prasanth b.nair Chandra Veer singh Department of Mechanical and Industrial Engineering University of Toronto5 King’s College RdTorontoM5S 3G8ONCanada Institute for Aerospace studies University of Toronto4925 Dufferin StTorontoM3H 5T6ONCanada Department of Materials science and Engineering University of Toronto184 College StTorontoM5S 3E4ONCanada

We present a method to model interatomic interactions such as energy and forces in a computationally efficient *** proposed model approximates the energy/forces using a linear combination of random features,thereby enabling fast parameter estimation by solving a linear least-squares *** discuss how random features based on stationary and non-stationary kernels can be used for energy approximation and provide results for three classes of materials,namely two-dimensional materials,metals and *** and energy predictions made using the proposed method are in close agreement with density functional theory calculations,with training time that is 96%lower than standard kernel *** Dynamics calculations using random features based interatomic potentials are shown to agree well with experimental and density functional theory *** frequencies as computed by random features based interatomic potentials are within 0.1%of the density functional theory ***,the proposed random features-based potential addresses scalability issues encountered in this class of machine learning problems.

关键词： random stationary interatomic

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi N Jincy M.Jose sreelata b.nair Prabha s.N Pappachan s Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline super specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGs;oMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical Notch Ligand 1(JAG1)gene(20p12.2)or in the Neurogenic locus notch homolog protein 2(NoTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGs cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases Notch

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Influence of quenching medium on the dendrite morphology,hardness,and tribological behaviour of cast Cu-Ni-sn spinodal alloy for defence application

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Defence Technology（防务技术） 2023年第12期30卷 83-100页

作者： bipin sankar Karthik V shankar Vamu sunil Hemanth Kashyap s Nikhil nair Adarsh A.nair Abhinav P M Department of Mechanical Engineering Amrita Vishwa VidyapeethamAmritapuriIndia

Cu-Ni-sn spinodal alloys(spinodal bronze)are potential materials with robust applications in components associated with defence applications like bearings,propellers,bushes,and shafts of heavily loaded aircraft,off-road vehicles,and *** paper presents a comparative study using water,brine solution,and sAE 40 oil as the quenching media in regular bronze(Cu-6sn)and spinodal bronze(Cu-9Ni-6sn)*** analysis was conducted by optical microscopy,transmission electron microscopy(TEM),and X-ray diffraction technique(XRD)on bronze and spinodal bronze samples immersed in the three different quenching media to understand the grain size and hardness values *** analysis was performed to analyze the effect of quenching media on the wear aspects of bronze and spinodal bronze *** hardness value of the brine-aged spinodal bronze samples was as high as 320 Hv,and the grain size was very low in the range of 60μm.A quantitative comparison between brine-aged regular bronze and brine-aged spinodal bronze showed that the hardness(Hv)was almost 80%higher for brine-aged spinodal ***,the grain size was approximately 30%finer for spinodal bronze when compared with regular *** the load was increased in spinodal bronze samples,there was an initial dip in wear rate followed by a marginal *** was a steady increase in friction coefficient with a rise in load for brine-aged regular bronze and spinodal bronze *** results indicate that brine solution is the most effective quenching medium for cast Cu-Ni-sn spinodal alloys.

关键词： Quenching Water brine sAE 40 oil Grain size Hardness Wear rate spinodal decomposition Cusn spinodal alloy CuNisn

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Effect of adrenalectomy on rat epididymidis

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Asian Journal of Andrology 2002年第4期4卷 273-279页

作者： Neena nair R.s. bedwal R.s. Mathur Cell biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 India

AIM: To investigate the effect of adrenalectomy (ADX) on the epididymidis of sprague-Dawley rats. METHoDs: The histological, biochemical (cholesterol protein, zinc, copper, alkaline and acid phosphatase aryl sulphatase, lactic dehydrogenase and leucine amino peptidase) and hormonal (FsH, LH and testosterone) changes of caput and cauda epididymis in ADX rats were observed. REsULTs: organ wet weight, histological studies and morphometric measurements indicated a cellular degeneration in caput and cauda epididymis of ADX rats. serum testosterone level was significantly lower in ADX than in sham-operated rats, while the serum FsH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham-operated rats. Epididymal zinc level increased whereas copper level decreased in ADX rats compared to the sham-operated. CoNCLUsIoN: Adrenalectomy leads to degeneration of caput and cauda epididymidis epithelial cells as a result of decreased supply of testosterone.

关键词： Adrenalectomy Acid Phosphatase Alkaline Phosphatase Animals Arylsulfatases Cholesterol Comparative study Copper Epididymis Follicle stimulating Hormone L-Lactate Dehydrogenase Leucyl Aminopeptidase Luteinizing Hormone Male organ size Rats Rats, sprague-Dawley Reference Values Research support, Non-U.s. Gov't Testosterone Time Factors Zinc

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Effect of adrenalectomy and hydrocortisone on ventral prostate of rats

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Asian Journal of Andrology 2001年第4期3卷 289-300页

作者： Neena nair R.s.bedwal R.s.Mathur Cell biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 India

Aim: To study the effects of adrenalectomy and hydrocortisone on the ventral prostate of sD rats. Methods: Inadrenalectomised (ADX) and ADX + hydrocortisone (1, 2, or 4 mg) treated rats, the prostatic histology and thecholesterol, protein, zinc, and copper levels and the enzymic profile (acid phosphatase, alkaline phosphatase, aryl sul-phatase, lactic dehydrogenase, and leucine aminopeptidase) in the prostatic tissue were determined; the serum hormon-al profile (testosterone, FsH and LH) was also assayed. Results; Adrenalectomy caused a progressive degenerationin prostatic structure that was not reversed by hydrocortisone treatment. The serum testosterone were significantly lowerin ADX than in sham operated rats and lower in ADX + hydrocortisone than in ADX-C rats (P serumFsH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham op-erated rats and higher in ADX + hydrocortisone than in ADX-C rats (Postatic zinc levels weresignificantly higher in sham operated than in ADX, and higher in ADX-C than in ADX + hydrocortisone rats (P ostatic copper level was significantly lower in sham operated than in ADX, and lower in ADX-C thanin the ADX + hydrocortisone rats (P onclusion; In rats, adrenalectomy leads to pathological and func-tional changes of the prostate. Hydrocortisone treatment at the doses employed did not reverse these changes. (Asian JAndrol 2001 Dec; 3: 289 - 300)

关键词： adrenalectomy ventral prostate hydrocortisone testosterone FsH LH cholesterol zinc copper acid phosphatase alkaline phosphatase aryl sulphatase lactic dehydrogenase leucine aminopeptidase

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Revisiting novel symmetries in coupled N=2 supersymmetric quantum systems:examples and supervariable approach

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Communications in Theoretical Physics 2020年第10期72卷 103-112页

作者： Aditi Pradeep Anjali s binu M nair saurabh Gupta Department of Physics and Astronomy University of British ColumbiaVancouver Campus325-6224 Agricultural RoadVancouverBC V6T 1Z1Canada Department of Physics National Institute of Technology Calicut

We revisit the novel symmetries in N=2 supersymmetric quantum mechanical models by considering specific examples of coupled ***,we extend our analysis to a general case and list out all the novel *** each case,we show the existence of two sets of discrete symmetries that correspond to the Hodge duality operator of differential ***,we are able to provide a proof of the conjecture which points out the existence of more than one set of discrete symmetry transformations corresponding to the Hodge duality ***,we derive on-shell nilpotent symmetries for a generalized superpotential within the framework of supervariable approach.

关键词： N=2 sUsY quantum mechanical system continuous and discrete symmetries de Rham cohomological operators (anti-)chiral supervariable approach sUsY invariant restrictions

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The Quest toward limb regeneration:a regenerative engineering approach

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Regenerative biomaterials 2016年第2期3卷 123-125页

作者： Cato T.Laurencin Lakshmi s.nair Department of orthopaedic surgery Institute for Regenerative EngineeringRaymond and Beverly Sackler Center for BiomedicalBiologicalPhysical and Engineering SciencesUniversity of Connecticut HealthFarmingtonCT 06030USA Department of biomedical Engineering University of ConnecticutStorrsCT 06269USA Department of Materials science and Engineering University of ConnecticutStorrsCT 06269USA Department of Chemical and biomolecular Engineering University of ConnecticutStorrsCT 06269USA Department of Craniofacial sciences School of Dental MedicineUniversity of Connecticut HealthFarmingtonCT 06030USA.

The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated *** remarkable advances in the scientific understanding of regeneration,stem cell science,material science and engineering,physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound *** we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.

关键词： regenerative engineering limb regeneration stem cells advanced biomaterial science clinical translation

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bagging with CTD–A Novel signature for the Hierarchical Prediction of secreted Protein Trafcking in Eukaryotes

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Genomics, Proteomics & bioinformatics 2013年第6期11卷 385-390页

作者： Geetha Govindan Achuthsankar s.nair Department of Computational biology and bioinformatics University of Kerala

Protein trafficking or protein sorting in eukaryotes is a complicated process and is carried out based on the information contaified in the protein. Many methods reported prediction of the subcellular location of proteins from sequence information. However, most of these prediction methods use a flat structure or parallel architecture to perform prediction. In this work, we introduce ensemble classifiers with features that are extracted directly from full length protein sequences to predict locations in the protein-sorting pathway hierarchically. sequence driven features, sequence mapped features and sequence autocorrelation features were tested with ensemble learners and their performances were compared. When evaluated by independent data testing, ensemble based-bagging algorithms with sequence feature composition, transition and distribution （CTD） successfully classified two datasets with accuracies greater than 90%. We compared our results with similar published methods, and our method equally performed with the others at two levels in the secreted pathway. This study shows that the feature CTD extracted from protein sequences is effective in capturing biological features among compartments in secreted pathways.

关键词： sequence driven features sequence mapped features Autocorrelation Ensemble classifiter Protein sorting

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