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Apomorphine effects on the hippocampus

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Neural Regeneration Research 2018年第12期13卷 2064-2066页

作者： Luis Enrique Arroyo-García Antonio Rodríguez-moreno Gonzalo Flores Laboratorio de Neuropsiquiatria Instituto de Fisiologia Benemerita Universidad Autenoma de Puebla Puebla Mexico Laboratorio de Neurociencia Celular y Plasticidad Universidad Pablo de Olavide Sevilla Spain

Apomorphine is a non-specific dopamine receptor agonist that has been used in the treatment of some diseases and mental disorders. Its use has particularly well documented in Parkinson＇s disease（PD）. The dopaminergic agonists like apomorphine are related to oxidative processes that could induce cell damage and the functional impairment of some structures in the brain. However, most information about apomorphine in literature is focused on the improvement of the motor problems characteristic of PD, but little is known about the effects on cognitive behaviors and brain structures indirectly related to motor function. The presence of dopaminergic receptors in the hippocampus has recently been discovered, in connection with cognitive behaviors like learning and memory, these receptors are needed in neuronal plasticity. There has been a growing interest to know if this structure could be compromised by the effect of apomorphine and elucidate if part of the cognitive impairment present in the PD is due to the effect of apomorphine. In this mini-review, we summarized how apomorphine has been used since its creation, we discuss the latest information about its effect on the hippocampus and also the future perspectives to fully understand the effects of this compound.

关键词： dopamine receptor apomorphine hippocampus learning and memory plasticity dendritic length oxidative stress Parkinson's disease

AN INTEGRATED DEsIGN PROCEss OF LOW-COsT HOUsING IN CHILE

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Journal of Green Building 2019年第3期14卷 81-93页

作者： Maureen Trebilcock-Kelly Gerardo saelzer-Fica Ariel Bobadilla-moreno Dept.Diseño y Teoría de la Arquitectura Universidad del Bío-Bío Centro de Investigación en Tecnologías de la Construcción CITEC UBB Universidad del Bío-Bío

This paper discusses the application of Integrated Design Process for the design of low-cost housing in *** aims to question common practice for the development of housing based on prescriptive regulations and non-interdisciplinary work,which has resulted in poor quality building *** first stage consisted in defining performance requirements for aspects such as energy demand,U value,air tightness and indoor air quality for a specific case of low-cost houses located in the city of *** integrated design process was carried out by an interdisciplinary team of professionals specialized in each of the performance aspects that were taken into *** construction and post-occupancy stages were characterized by verifying the performance requirements,which resulted in a low-cost house prototype that included strategies for energy efficiency and a healthy indoor environment.

关键词： Integrated Design Process low-cost housing performance requirements interdisciplinary work

specific primers design based on the superoxide dismutase b gene for Trypanosoma cruzi as a screening tool:Validation method using strains from Colombia classified according to their discrete typing unit

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 854-859页

作者： Francisco Olmo Javier Escobedo-Ortegón Patricia Palma Manuel sánchez-moreno Ana Mejía-Jaramillo Omar Triana Clotilde Marín Grupo de Parasitologia Molecular Departmento de Parasitologia Universidad de Granada Laboratorio de Zoonosis y ETV's C.I.R.Dr.Hideyo NoguchiUniversidad Autonoma de YucatanAve.Itzaes #490 x 5997000 MeridaYucatan(Mexico) Grupo Biologiay Control de Enfermedades Infecciosas BCEI-sIU Instituto de BiologiaUniversidad de Antioquia

Objective:To classify 21 new isolates of Trypanosoma cruai(***) according to the Discrete Typing Unit(DTU) which they belong to,as well as tune up a new pair of primers designed to detect the parasite in biological ***:strains were isolated,DNA extracted,and classified by using three Polymerase Chain Reactions(PCR).subsequently this DNA was used along with other isolates of various biological samples,for a new PCR using primers ***,the amplified fragments were ***:It was observed the predominance of DTU i in Colombia,as well as the specificity of our primers for detection of ***,while no band was obtained when other species were ***:This work reveals the genetic variability of 21 new isolates of *** in *** primers confirmed their specificity for detecting the presence of ***.

关键词： Trypanosoma cruzi Polymerase chain reaction Colombia superoxide dismutase gene b-based primers Discrete typing unit

Pancreatic neuroendocrine tumors:Are tumors smaller than 2 cm truly indolent?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1756-1762页

作者： sergio Hoyos Pablo Posada-moreno Natalia Guzman-Arango Romario Chanci-Drago Jaime Chavez Alvaro Andrés-Duarte santiago salazar-Ochoa Hepatobilary and Liver Transplant Unit Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de AntioquiaMedellin 050034AntioquiaColombia Department of General surgery Universidad Pontificia BolivarianaMedellín 050034AntioquiaColombia

BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are relatively rare but rank as the second most common pancreatic *** can be functional,causing early metabolic disturbances due to hormone secretion,or non-functional and diagnosed later based on tumor size-related *** diagnoses of PNETs under 2 cm in size have sparked debates about their management;some practitioners advocate for surgical removal and others suggest observation due to the tumors’lower potential for ***,it is unclear whether managing these small tumors expectantly is truly *** To evaluate poor prognostic factors in PNETs based on tumor size(>2 cm orsurgically treated *** This cohort study included 64 patients with PNETs who underwent surgical resection between 2006 and 2019 at a high-complexity reference hospital in Medellín,*** assess patient survival,quarterly follow-ups were conducted during the first year after surgery,followed by semi-annual con-sultations at the hospital's hepatobiliary surgery *** variables were described using absolute and relative frequencies,and quantitative variables were expressed using measures of central tendency and their corresponding measures of *** The presence of lymph node involvement,neural involvement,and lymphovascular invasion were all associated with an increased risk of mortality,with hazard ratios of 5.68(95%CI:1.26–25.61,P=0.024),6.44(95%CI:1.43–28.93,P=0.015),and 24.87(95%CI:2.98–207.19,P=0.003),*** involvement and lymphovascular invasion were present in tumors smaller than 2 cm in diameter and those larger than 2 cm in *** recurrence rates between the two tumor groups were furthermore similar:18.2%for tumors smaller than 2 cm and 21.4%for tumors larger than 2 *** survival was additionally comparable between the two tumor *** Tumor size does not dictate prognosis;lymph node and lymphovascular involvement a

关键词： Neuroendocrine tumor Pancreatic neoplasm Pancreas Pancreatic neuroendocrine neoplasm Pancreatic neuroendocrine tumors

Rat cardiomyocyte H9c2(2-1)-based sulforhodamine B assay as a promising in vitro method to assess the biological component of effluent toxicity

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Journal of Environmental sciences 2020年第10期32卷 163-170页

作者： Elsa T Rodrigues susana F Nascimento Maria Joao moreno Paulo J Oliveira Miguel A Pardal University of Coimbra Centre for Functional EcologyDepartment of Life SciencesCalcada Martim de FreitasCoimbra 3000-456Portugal University of Coimbra Coimbra Chemistry CenterDepartment of ChemistryCoimbra 3004-535Portugal Centre for Neuroscience and Cell Biology Uniuersity of CoimbraUC BiotechBiocant ParkCantanhede 3060-197Portugal

The treatment of wastewaters is crucial to maintain the ecological status of receiving waters,and thereby guarantee the protection of aquatic life and human *** quality evaluation is conventionally based on physicochemical parameters,but increasing attention has been paid to integrate physicochemical and biological ***,the regulatory use of fish in biological testing methods has been subject to various ethical and cost concerns,and in vitro cell-based assays have thus become an important topic of ***,the present study intends:(a) to evaluate the efficiency of two different sample pre-concentration techniques (lyophilisation and solid phase extraction) to assess the toxicity of municipal effluents on rat cardiomyoblast H9c2(2-1) cells,and (b) maximizing the use of the effluent sample collected,to estimate the environmental condition of the receiving *** gathered results demonstrate that the H9c2(2-1) sulforhodamine B-based assay is an appropriate in vitro method to assess biological effluent toxicity,and the best results were attained by lyophilising the sample as *** to its response,the H9c2(2-1) cell line might be a possible alternative in vitro model for fish lethal testing to assess the toxicity of municipal *** physicochemical status of the sample suggests a high potential for eutrophication,and iron exceeded the permissible level for wastewater discharge,possibly due to the addition of ferric chloride for wastewater *** general,the levels of carbamazepine and sulfamethoxazole are higher than those reported for other countries,and both surpassed the aquatic protective values for long-term exposure.

关键词： Municipal wastewater treatment plant effluent Lyophilisation solid phase extraction Cell-based assays H9c2(2-1)cell line sRB assay

A VsC-based Model for Power Flow Assessment of Multi-terminal VsC-HVDC Transmission systems

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Journal of Modern Power systems and Clean Energy 2021年第6期9卷 1363-1374页

作者： Ricardo Martínez-Parrales Claudio R.Fuerte-Esquivel Boris A.Alcaide-moreno Enrique Acha Faculty of Electrical Engineering Universidad Michoacana de San Nicolás de Hidalgo(UMSNH) National Center for Energy Control Secretary of Energy Department of Electrical Engineering Tampere University(TU)

This paper puts forward a new practical voltage source converter(VsC)based AC-DC converter model suitable for conducting power flow assessment of multi-terminal VsCbased high-voltage direct current(VsC-MTDC)*** model uses an advanced method to handle the operational limits and control modes of VsCs into the power flow *** new model is incorporated into a unified framework encompassing AC and DC power grids and is solved by using the Newton-Raphson method to enable quadratically convergent iterative *** use of complementarity constraints,together with the Fischer-Burmeister function,is proposed to enable the seamless incorporation of operational control modes of VsC and automatic enforcement of any converter’s operational limits that become violated during the iterative solution ***,a dedicated process for checking limits is no longer ***,all existing relationships between the VsC control laws and their operational limits are considered directly during the solution of the power flow *** applicability of the new model is demonstrated with numerical examples using various multi-terminal AC-DC transmission networks,one of which is a utility-sized power system.

关键词： Complementarity constraint current limit high-voltage direct current(HVDC) voltage source converter(VsC) multi-terminal VsC-HVDC(VsC-MTDC)system power flow

Feeding behavior, life history, and virus transmission ability of Bemisia tabaci Mediterranean species (Hemiptera: Aleyrodidae) under elevated CO2

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Insect science 2020年第3期27卷 558-570页

作者： Ainara Penalver-Cruz Elisa Garzo Ines Prieto-Ruiz Miguel Diaz-Carro Ana Winters Aranzazu moreno Alberto Fereres Departamento de Proteccion vegetal Instituto de Ciencias Agrarias(ICA-CSIC)MadridSpain Laboratorio de Control Biologico Instituto de Ciencias BiologicasUniversidad de TalcaTalcaChile Institute of Biological Environmental and Rural SciencesAberystwyth UniversityAberystwythCeredigionUK

The continuous rise of CO2 concentrations in the atmosphere is reducing plant nutritional quality for herbivores and indirectly affects their *** whitefly(Bemisia tabaci,Gennadius)is a major worldwide pest of agricultural crops causing significant yield *** study investigated the plant‐mediated indirect effects of elevated CO2 on the feeding behavior and life history of *** Mediterranean *** were grown under elevated and ambient CO2 concentrations for 3 weeks after which plants were either used to monitor the feeding behavior of whiteflies using the Electrical Penetration Graph technique or to examine fecundity and fertility of *** leaf carbon,nitrogen,phenols and protein contents were also analyzed for each *** tabaci feeding on plants exposed to elevated CO2 showed a longer phloem ingestion and greater fertility compared to those exposed to ambient CO2 suggesting that *** is capable of compensating for the plant nutritional ***,this study looked at the transmission of the virus Tomato yellow leaf curl virus(Begomovirus)by *** exposing source and receptor tomato plants to ambient or elevated CO2 levels before or after virus transmission *** indicate that *** transmitted the virus at the same rate independent of the CO2 levels and plant ***,we conclude that *** Mediterranean species prevails over the difficulties that changes in CO2 concentrations may cause and it is predicted that under future climate change conditions,*** would continue to be considered a serious threat for agriculture worldwide.

关键词： carbon dioxide eggplant EPG fitness tomato whiteflies

Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications

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World Journal of Gastroenterology 2014年第44期20卷 16518-16528页

作者： Alejandra de moreno de Le Blanc Jean Guy Le Blanc Centro de Referencia para Lactobacilos San Miguel de Tucuman

Although it is now known that the human body is colonized by a wide variety of microbial populations in different parts(such as the mouth, pharynx and respiratory system, the skin, the gastro- and urogenital tracts), many effects of the complex interactions between the human host and microbial symbionts are still not completely understood. The dysbiosis of the gastrointestinal tract microbiota is considered to be one of the most important contributing factors in the development of many gastrointestinal diseases such as inflammatory bowel disease, irritable bowel syndrome and colorectal cancer, as well as systemic diseases like obesity, diabetes, atherosclerosis and non-alcoholic fatty liver disease. Fecal microbial transplantations appear to be promising therapies for dysbiosis-associated diseases; however, probiotic microorganisms have been growing in popularity due to increasing numbers of studies proving that certain strains present health promoting properties, among them the beneficial balance of the intestinal microbiota. Inflammatory bowel diseases andobesity are the pathologies in which there are more studies showing this beneficial association using animal models and even in human clinical *** this review,the association of the human gut microbiota and human health will be discussed along with the benefits that probiotics can confer on this symbiotic activity and on the prevention or treatment of associated diseases.

关键词： Probiotics Dysbiosis Gut microbiota symbiosis Treatment

Fuzzy Logic Programming in Action with <i>FLOPER</i>

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Journal of software Engineering and Applications 2014年第4期7卷 273-298页

作者： Ginés moreno Carlos Vázquez Department of Computing systems University of Castilla-La Mancha Albacete Spain

During the last years, we have developed the FLOPER platform for providing a practical support to the so-called Multi-Adjoint Logic Programming approach (MALP in brief), which represents an extremely flexible framework into the Fuzzy Logic Programming arena. Nowadays, FLOPER is useful for compiling (to standard Prolog code), executing and debugging (by drawing execution trees) MALP programs, and it is ready for being extended in the near future with powerful transformation and optimization techniques designed in our research group during the recent past. Our last update consists in the integration of a graphical interface for a comfortable interaction with the system which allows, among other capabilities, the use of projects for packing scripts and auxiliary definitions of fuzzy sets/connectives, together with fuzzy programs and their associated lattices modeling truth-degrees beyond the simpler crisp case ﹛true;false﹜.

关键词： Fuzzy Logic Programming Language Design and Implementation New Programming Concepts and Paradigms software Tools Cost Measures