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Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

Acta Pharmaceutica Sinica B 2014年第2期4卷 141-145页

作者： ryuji uchida Seiko Ishikawa Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyo 108-8641Japan School of Pharmacy Kitasato UniversityTokyo 108-8641Japan

2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/***,2-HT dose-dependently inhibited tyrosinase activity(IC_(50),32.5 mmol/L)in the cell-free extract of B16 melanoma cells andα-melanocyte stimulating hormone(α-MSH)-stimulated melanin formation in intact B16 melanoma cells.

关键词： 2-Hydroxytyrosol Metarhizium sp. Tyrosinase inhibitor Melanine formation B16 melanoma cells

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Stereochemistries of monapinones produced by Talaromyces pinophilus FKI-3864

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Acta Pharmaceutica Sinica B 2013年第3期3卷 163-166页

作者： ryuji uchida Mio Kawaguchi Noriko Sato Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato University5-9-1 ShirokaneMinato-kuTokyo 108-864Japan

Monapinones A(1)to E(5),half parts of dinapinones,were produced by fermentation of Talaromyces pinophilus FKI-3864 in seawater-containing medium and have a common dihydronaphthopyranone skeleton with a different long alkyl *** relative stereochemistries of 3–5 were elucidated by various NMR experiments including analysis of 1 H NMR coupling constants,ROESY and the dihedral *** absolute stereochemistries of 3–5 at C-3 were determined by the circular dichroism spectra in comparison to the data of(R)-and(S)-semivioxanthins(6 and 7).Accordingly,total absolute stereochemistries of 3–5 were concluded to be 3S,13R,15R,17R,19R,3S,13R,15R,17R and 3S,13R,15R,respectively.

关键词： Monapinone Stereochemistry Triacylglycerol synthesis inhibitor Dinapinone Talaromyces pinophilus

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Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells

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Acta Pharmaceutica Sinica B 2012年第1期2卷 23-27页

作者： Takashi Fukuda ryuji uchida Hiroyo Inoue Satoshi Ohte Hiroyuki Yamazaki Daisuke Matsuda Takenobu Katagiri Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyoJapan Research Center for Genomic Medicine Saitama Medical UniversitySaitamaJapan

Fibrodysplasia ossificans progressiva(FOP)is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues.A constitutively activated mutation of a bone morphogenetic protein(BMP)receptor,ALK2,has been identified in patients with *** report here that four structurally related compounds,lucilactaene,hydroxylucilactaene,NG-391 and NG-393,produced by fungal strain Fusarium sp.B88,inhibit BMP signaling in *** phosphatase activity,a marker enzyme of osteoblastic differentiation,was decreased in C2C12 myoblasts stably expressing mutant ALK2 by treatment with those compounds with IC_(50) values of 5.7,6.8,6.9 and 6.1 mM,***,NG-391 and NG-393 inhibited BMP-specific luciferase reporter activity,which is directly regulated by transcription factor Smads,with IC50 values of 1.4 and 2.1 mM,*** findings suggest that these fungal metabolites may provide a new direction in the development of FOP therapeutics.

关键词： Lucilactaenes Fungal metabolites C2C12 myoblasts Fibrodysplasia ossificans progressiva

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Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019

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Infectious Microbes & Diseases 2020年第4期2卷 160-166页

作者： Yujiro Hirose Masaya Yamaguchi Norihiko Takemoto Tohru Miyoshi-Akiyama Tomoko Sumitomo Masanobu Nakata Tadayoshi Ikebe Tomoki Hanada Takahiro Yamaguchi ryuji Kawahara Rumi Okuno Hitoshi Otsuka Yuko Matsumoto Yuji Terashima Yu Kazawa Noriko Nakanishi Kaoru uchida Yumi Akiyama Kaori Iwabuchi Chikara Nakagawa Kazunari Yamamoto Victor Nizet Shigetada Kawabata Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuitaOsakaJapan Department of Pediatrics University of California at San Diego School of MedicineLa JollaCAUSA Department of Infectious Diseases Research InstituteNational Center for Global Health and MedicineTokyoJapan Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan Department of Bacteriology I National Institute of Infectious DiseasesTokyoJapan Division of Microbiology Osaka Institute of Public HealthOsaka CityOsakaJapan Department of Microbiology Tokyo Metropolitan Institute of Public HealthTokyoJapan Department of Public Health Sciences Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi CityYamaguchiJapan Microbiological Testing and Research Division Yokohama City Institute of Public HealthYokohamaKanagawaJapan Department of Microbiology Fukushima Prefectural Institute of Public HealthFukushima CityFukushimaJapan Department of Infectious Diseases Kobe Institute of HealthKobeHyogoJapan Department of Bacteriology Toyama Institute of HealthImizuToyamaJapan Infectious Disease Research Division Hyogo Prefectural Institute of Public Health ScienceKakogawaHyogoJapan Department of Health Science Iwate Prefectural Research Institute for Environmental Sciences and Public HealthMoriokaIwateJapan Division of Microbiology Kyoto City Institute of Health and Environmental SciencesKyoto CityKyotoJapan Niigata City Institute of Public Health and the Environment Niigata CityNiigataJapan Skaggs School of Pharmaceutical Sciences University of California at San DiegoLa JollaCAUSA.

Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains,designated clade *** Japan,the features of emm89 *** strains,such as clade classification,remains *** this study,we collected emm89 strains isolated from both streptococcal toxic shock syndrome(STSS)(89 STSS isolates)and noninvasive infections(72 non-STSS isolates)in Japan from 2011 to 2019,and conducted wholegenome sequencing and comparative analysis,which resulted in classification of a large majority into clade 3 regardless of disease *** addition,invasive disease-associated factors were found among emm89 strains,including mutations of control of virulence sensor,and absence of the hylP1 gene encoding *** findings provide new insights into genetic features of emm89 strains.

关键词： clade 3 emm89 streptococcal toxic shock syndrome Streptococcus pyogenes

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