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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

Effectiveness of patient education focusing on circadian pain rhythms:A case report and review of literature

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World Journal of Clinical Cases 2021年第17期9卷 4441-4452页

作者： Yoichi tanaka Gosuke Sato ryota Imai Michihiro Osumi Hayato Shigetoh Ren Fujii Shu Morioka Graduate School of Health Sciences Kio UniversityKitakatsuragi-gun 635-0832NaraJapan Department of Rehabilitation Nara Prefecture General Rehabilitation CenterShiki Gun Tawaramoto Cho 636-0345NaraJapan Neuro Rehabilitation Research Center Kio UniversityKitakatsuragi-gun 635-0832NaraJapan Department of Rehabilitation Osaka Kawasaki Rehabilitation UniversityKaizuka Shi 597-0104OsakaJapan

BACKGROUND Neuropathic pain management should aim at improving quality of life and daily living activities of patients;therefore,emphasis should be placed on pain management including understanding the pain patterns during daily ***,lifestyle guidance should be based on a detailed understanding of pain;however,previous studies commonly evaluated pain intensity at a single point in *** report a case on patient education intervention based on the relationship between pain circadian rhythms and detailed physical activity during the *** SUMMARY A man in his 60s,who suffered a brachial plexus injury in a traffic accident,presented with neuropathic *** assessment of the importance of daily living activities to the patient,pain rhythmicity,and physical activity,was *** early assessments showed that the pain intensity was lower on days when more light-intensity physical activity(LIPA)was performed,than on days when less LIPA was ***,patient education focused on methods to decrease the pain intensity that tended to worsen in the afternoon,and encouraged behavioral changes by suggesting the patient to take walks,which could be used to maintain LIPA in the *** reassessment,the afternoon LIPA,which had been the focus of attention,had increased and a change was noted in the circadian rhythm of *** Patient education based on a composite assessment elicited positive results in relation to the pain circadian rhythm and physical activity.

关键词： Circadian rhythms Physical activity Neuropathic pain Pain management Patient education Case report

Assessment of the electrical penetration of cell membranes using four-frequency impedance cytometry

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Microsystems & Nanoengineering 2022年第3期8卷 117-128页

作者： Tao Tang Xun Liu Yapeng Yuan Tianlong Zhang ryota Krya Yang Yang Kengo Suzuki Yo tanaka Ming Li Yoichiroh Hosokawa Yaxiaer Yalikun Division of Materials Science Nara Institute of Science and Technology8916-5 Takayama-choIkomaNara 630-0192Japan Center for Biosystems Dynamics Research(BDR) RIKEN1-3 YamadaokaSuitaOsaka 565-0871Japan School of Engineering Macquarie UniversitySydney 2109 NSWAustalia Institute of Deep-Sea Science and Engineering Chinese Academy of SciencesSanyaHainan 572000P.R.China Euglena Co.Ltd Tokyo 108-0014Japan

The electrical penetration of the cell membrane is vital for determining the cell interior via impedance ***,we propose a method for determining the conductivity of the cell membrane through the tilting levels of impedance *** electrical penetration occurs,a high-frequency current freely passes through the cell membrane;thus,the intracellular distribution can directly act on the high-frequency impedance *** simulation shows that an uneven intracellular component distribution can affect the tilting levels of impedance pulses,and the tilting levels start increasing when the cell membrane is electrically *** evidence shows that higher detection frequencies(>7 MHz)lead to a wider distribution of the tilting levels of impedance pulses when measuring cell populations with four-frequency impedance *** finding allows us to determine that a detection frequency of 7 MHz is able to pass through the membrane of Euglena gracilis(***)***,we provide a possible application of four-frequency impedance cytometry in the biomass monitoring of single *** ***-frequency impedance(≥7 MHz)can be applied to monitor these biomass changes,and low-frequency impedance(<7 MHz)can be applied to track the corresponding biovolume ***,this work demonstrates an easy determination method for the electrical penetration of the cell membrane,and the proposed platform is applicable for the multiparameter assessment of the cell state during cultivation.

关键词： impedance electrical determining

Usefulness of ultrasonography to assess the response to steroidal therapy for the rare case of type 2b immunoglobulin G4-related sclerosing cholangitis without pancreatitis:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5821-5830页

作者： Yuto tanaka Kenya Kamimura ryota Nakamura Marina Ohkoshi-Yamada Yohei Koseki Takeshi Mizusawa Satoshi Ikarashi Kazunao Hayashi Hiroki Sato Akira Sakamaki Junji Yokoyama Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 9518510Japan

BACKGROUND A type 2b immunoglobulin G4(IgG4)-related sclerosing cholangitis(SC)without autoimmune pancreatitis is a rare condition with *** the variety of the imaging modalities have tested its usefulness in diagnosing the IgG4-SC,however,the usage of ultrasonography for the assessment of the response to steroidal therapy on the changes of bile duct wall thickness have not been reported in the ***,the information of our recent case and reported cases have been *** SUMMARY We report the case of an 82-year-old Japanese man diagnosed with isolated IgG4-related SC based on the increase of serum IgG4,narrowing of the bile duct,its wall thickness,no complication of autoimmune pancreatitis,and IgG4 positive inflammatory cell infiltration to the wall with the fibrotic *** cholangiogram revealed type 2b according to the *** treatment showed a favorable effect,with the smooth decrease in serum IgG4 and the improvement of the bile duct wall *** As isolated type 2b,IgG4-SC is rare,the images,histological findings,and clinical course of our case will be helpful for physicians to diagnose and treat the new cases appropriately.

关键词： Immunoglobulin G4-related sclerosing cholangitis Type 2b Corticosteroid Autoimmune pancreatitis Ultrasonography Imaging Case report

The Fefferman-Stein-Type Inequality for the Kakeya Maximal Operator Ⅱ

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Acta Mathematica Sinica,English Series 2002年第3期18卷 447-454页

作者： Hitoshi tanaka Department of Mathematics Gakushuin University 1-5-1 Mejiro Toshima-ku Tokyo 171-8588 Japan

Let K, 0 ±1, be the Kakeya maximal operator defined as the supremum of averages over tubes of the eccentricity . The (so-called) Fefferman-Stein-type inequality: $|| {K_\delta f} ||_{L^d({{\rm R}^d,w})} \le C_d ({1 \over \delta})^{(d - 2)/2d}(\log ({1 \over \delta } ))^{\alpha_d} || f ||_{L^d ({\rm R}^d,K_{\delta}w})}$is shown, where Cd and d are constants depending only on the dimension d and w is a weight. The result contains the exponent (d-2)/2d which is smaller than the exponent (d-2)(d-1)/d(2d-3) obtained in [7].

关键词： Maximal functions Weighted inequalties

One-Dimensional Modeling of Multiple Scattering in the Upper Inner Core: Depth Extent of a Scattering Region in the Eastern Hemisphere

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Journal of Earth Science 2013年第5期24卷 706-715页

作者： Satoru tanaka Institute for Research on Earth Evolution Japan Agency for Marine-Earth Science and Technology

Attenuation of PKP（DF） in the Eastern Hemisphere is examined in terms of multiple scattering to simultaneously explain a puzzling relationship, a relatively fast velocity anomaly corre- sponding to strong attenuation. Reflectivity synthetics with one-dimensional random velocity fluctua- tions are compared with observations of PKP（DF）/PKP（Cdiff） amplitude ratios and differential travel times of PKP（Cdiff）-PKP（DF） for the equatorial paths. A Gaussian distribution of P-wave velocity fluctuations with the standard deviations of 5%, 6%, and 7% in the uppermost 200 km of the inner core is superimposed on the velocity structure that is slightly faster than the typical structure in the Eastern Hemisphere, which is likely to explain both the travel time and amplitude data as far as only the one-dimensional structure is considered. Further examinations of the statistic characteristic of scat- terer distribution in two and three-dimensions are required to obtain a realistic conclusion.

关键词： seismology the inner core attenuation scattering.

Tingley's Problem on Symmetric Absolute Normalized Norms on R^2

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Acta Mathematica Sinica,English Series 2014年第8期30卷 1324-1340页

作者： ryotaro tanaka Department of Mathematical Science Graduate School of Science and TechnologyNiigata University

In this paper,we study Tingley＇s problem on symmetric absolute normalized norms on R^*** construct new methods for Tingley＇s problem on two-dimensional spaces by using isosceles orthogonality,which does not make use of the notion of natural ***,using our methods,several sufficient conditions for Tingley＇s problem on symmetric absolute normalized norms on R2 are *** applications,we present various new examples including the two-dimensional Lorentz sequence space d^（2）（ω,q） and its dual d^（2）（ω,q）＊by simple arguments.

关键词： Tingley's problem isometric extension problem isosceles orthogonality symmetric absolute normalized norm

Application of 3D Scanned Big Data of Large-scale Cultural Heritage Objects Based on Noise-robust Transparent Visualization

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系统仿真学报 2023年第8期35卷 1635-1650页

作者： tanaka Satoshi College of Information Science and Engineering Ritsumeikan UniversityShiga 525-8577Japan

Three-dimensional(3D) scanning technology has undergone remarkable developments in recent *** acquired by 3D scanning have the form of 3D point *** 3D scanned point clouds have data sizes that can be considered big *** also contain measurement noise inherent in measurement *** properties of 3D scanned point clouds make many traditional CG/visualization techniques *** paper reviewed our recent achievements in developing varieties of high-quality visualizations suitable for the visual analysis of 3D scanned point *** demonstrated the effectiveness of the method by applying the visualizations to various cultural heritage *** main visualization targets used in this paper are the floats in the Gion Festival in Kyoto(the float parade is on the UNESCO Intangible Cultural Heritage List) and Borobudur Temple in Indonesia(a UNESCO World Heritage Site).

关键词： 3D scanning point cloud transparent visualization noise transparentization cultural heritage object

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The Research Existing Condition and Application of Solid Waste Disposal in Japan

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四川大学学报（工程科学版） 2009年第S1期41卷 62-69页

作者： tanaka Reiji KITATSUJI Masafumi Faculty of Eng. Tohoku Inst.e of Technol. Miyagi Univ.

Japan lacked resources is a large import country and also a large consuming *** it is turned society structure system of consumption goods stocked in domestic,which leads to 450 millions ton waste ***,because of continuing development of intermediate handling and recycled utilization technology,finally disposed waste materials approximately 30 millions *** quantity of concrete product is consumed 300 millions ton per year unprecedented,beau case of large scope,it is expected valid and large absorption industry of recycled material. The purpose of this paper is to do a report on applied present status and future assignment of recycled material and building structure in Japan.

关键词： inorganic waste recycled aggregate circumstance security precast concrete product reinforced concrete structure