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Improving ionic conductivity of von-Alpen-type NASICON ceramic electrolytes via magnesium doping

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Journal of Advanced Ceramics 2023年第5期12卷 1058-1066页

作者： Il-Seop Jang Wooseok go Bo-Ye Song Hayoung Park Yun Chan Kang Jinyoung Chun Emerging Materials R&D Division Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Energy Storage and Distribution Resources Division Lawrence Berkeley National LaboratoryBerkeley 94720USA

NASICON (sodium (Na) superionic conductor) compounds have attracted considerable attention as promising solid electrolyte materials for advanced Na-based batteries. In this study, we investigated the improvement in ionic conductivities of von-Alpen-type NASICON (vA-NASICON) ceramic electrolytes by introducing a magnesium ion (Mg^(2+)) as a heterogeneous element. The optimal Mg-doped vA-NASICON exhibited a high ionic conductivity of 3.64×10^(−3) S·cm^(−1), which was almost 80% higher than that of un-doped vA-NASICON. The changes in physicochemical properties of the vA-NASICONs through the Mg introduction were systematically analyzed, and their effects on the ionic conductivities of the vA-NASICON were studied in detail. When the optimal ratio of Mg^(2+) was used in a synthetic process, the relative density (96.6%) and grain boundary ionic conductivity (σgb) were maximized, which improved the total ionic conductivity (σt) of the vA-NASICON. However, when Mg^(2+) was introduced in excess, the ionic conductivity decreased because of the formation of an undesired sodium magnesium phosphate (NaxMgyPO_(4)) secondary phase. The results of this study are expected to be effectively applied in the development of advanced sodium-based solid electrolytes with high ionic conductivities.

关键词： NASICON solid electrolyte von-Alpen-type magnesium(Mg)doping ionic conductivity

Elucidating the evolution of long-period stacking ordered phase and its effect on deformation behavior in the as-cast Mg-6Gd-1Zn-0.6Zr alloy

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Journal of Magnesium and Alloys 2023年第8期11卷 2801-2810页

作者： Sangwon Lee Yejun Park Jongbin go Young Mok Kim Seok Su Sohn Jiehua Li Pyuck-Pa Choi Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Department of Materials Science and Engineering Kyoto UniversityKyoto606-8501Japan Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Institute of Casting Research Montanuniverstät LeobenLeobenA-8700Austria

Herein,the evolution of long-period stacking ordered(LPSO)phases in the as-cast Mg-6Gd-1Zn-0.6Zr(wt.%)alloy are investigated via transmission electron microscopy(TEM)and atom probe tomography(APT).The TEM results reveal that two types of LPSO phase(a bulky interdendritic phase and a plate-like matrix LPSO phase)are formed in the as-cast *** of the LPSO phases are confirmed to be of the 14H type,with a smaller proportion being of the 18R ***,the APT results reveal that the composition of the interdendritic LPSO phase is closer to that of the ideal 14H phase compared to the matrix LPSO phase,and both the interdendritic and matrix LPSO phases exhibit a Gd/Zn ratio of 2.5,thereby indicating a deficient Zn content compared to the ideal 14H phase(i.e.,1.3).In addition,the influence of the LPSO phases on the deformation behavior is investigated at different compressive plastic strains using electron backscatter diffraction(EBSD)analysis to reveal twinning and slip behavior during *** results indicate that the LPSO phase induces additional work hardening in the late stage of deformation via the suppression of{1011}compressive twinning and the activation of non-basal slip systems.

关键词： Magnesium alloy Long-period stacking ordered phase Transmission electron microscopy Atom probe tomography Work hardening behavior

Legends of the dashboard: an empirical evaluation of split and joint layout designs for geovisual analytics interfaces

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International Journal of Digital Earth 2023年第1期16卷 1395-1417页

作者： Izabela gołębiowska Tomasz Opach ArzuÇöltekin Jolanta Korycka-Skorupa Jan Ketil Rød Faculty of Geography and Regional Studies University of WarsawWarsawPoland Department of Geography Norwegian University of Science and TechnologyTrondheimNorway Institute for Interactive Technologies University of Applied Sciences and Arts Northwestern SwitzerlandWindischSwitzerland

Geodashboards are often designed with explanatory elements guiding *** elements(*** or annotations)need to be carefully designed to mitigate split attention or information integration *** this paper,we report expert interviews followed by a controlled experiment where we compare two interface designs with a focus on the split attention effect:(1)a multiple-legend layout with explanatory elements located next to each view,and(2)a single-legend layout with all explanatory elements gathered in one *** legend layouts did not affect the performance,but affected user satisfaction.75%of the participants preferred the multiple-legend layout,and rated it with a higher usability score,mainly attributing this preference to the proximity of legend elements to the view of *** tracking data strongly and clearly verifies that participants indeed make use of the proximity:With the single-legend,the majority of eye-movement transitions were between the single-legend and the closest view to the legend,whereas with multiple-legend participants have shorter and more frequent legend visits,as well as more transitions between legends and *** together,the design lesson we learned from this experiment can be summarized as‘split the legend elements,but make it close to the explained elements’.

关键词： Geodashboard layout design legend split attention user study eye tracking

Repeat laparoscopic anatomical liver resection in a hepatocellular carcinoma patient:a case report

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Hepatoma Research 2022年第1期8卷 248-253页

作者： Kazuharu Igarashi Kohei Mishima Takahiro Ozaki go Wakabayashi Department of Surgery Ageo Central General HospitalAgeoSaitama 362-8588Japan Department of General-Pediatric Hepatobiliary Pancreatic Surgery Kitasato University School of MedicineSagamiharaKanagawa 252-0374Japan

Anatomical resection(AR)has been reported to achieve better long-term outcomes than non-anatomical resection for the treatment of hepatocellular carcinoma(HCC).The surgical feasibility and oncological significance of laparoscopic AR(LAR),especially“subsegment resection”,“cone unit resection”,and repeat LAR for HCC,remain *** present a 67-year-old patient with alcoholic liver cirrhosis and HCC who underwent full LAR three times,focusing on the technical aspects of the Glissonean *** LAR for recurrent HCC could be a safe and feasible ***,HCC recurred in the neighboring segment twice,even though pathological vascular invasion and marginal remnants were not *** should investigate the oncological significance and advancements in subsegmentectomy and cone unit resection,in the future.

关键词： Repeat laparoscopic anatomical liver resection HCC Glissonean approach subsegmentectomy cone unit resection

Pear pomace water extract reduces adiposity in vivo and in vitro by activating the AMPK-dependent pathway

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Asian Pacific Journal of Tropical Biomedicine 2020年第5期10卷 208-215页

作者： Mi-Kyoung You Gwang-Woong go Hwa-Jin Kim Jin Rhyu Hyeon-A Kim Department of Nutrition and Health Sciences University of NebraskaLincolnNEUSA Department of Food and Nutrition Hanyang UniversitySeoulRepublic of Korea Department of Food and Nutrition Mokpo National UniversityJeollanam-doRepublic of Korea

Objective: To explore the inhibitory effect of water extract from pear pomace on abdominal fat accumulation and its underlying mechanism in high fat diet-fed animals. Methods: Three groups of male C57 BL/6 J mice were fed with a 60% kcal fat diet for 8 weeks. Pear pomace water extract(200 or 400 mg/kg body weight) was administered once daily via oral gavage. To confirm the possibility of the water extract of pear pomace acting as an activator of adenosine 5’-monophosphateactivated protein kinase(AMPK), differentiation of 3 T3-L1 preadipocytes was induced in the presence of the water extract of pear pomace with or without compound C. Body weight, food efficacy ratio, insulin resistance, and adipogenic protein expression were measured. Moreover, in the 3 T3-L1 cells, lipid content and lipogenesis-related proteins were measured using Oil Red O staining and Western blotting ***: Body weight gain and total abdominal fat weight were reduced in mice treated with pear pomace water extract. Pear pomace water extract reduced fasting blood glucose and insulin, thereby reducing the homeostatic model assessment of insulin resistance. It also resulted in dose-dependent decreases in triglyceride, total cholesterol, and low-density lipoproteincholesterol. The protein expression of p-AMPK increased, while the expression of AMPK-downstream proteins including PPAR-γ, C/EBPα, SREBP-1 c, ACC, and FAS decreased in the adipose tissue of mice treated with pear pomace water extract. Furthermore, the inhibition of AMPK by compound C blocked pear pomace water extract-induced reduction of lipid content and the expression of lipogenesis-related genes. Conclusions: Pear pomace water extract prevents fat accumulation both in vivo and in vitro by activating AMPK.

关键词： Pear pomace AMPK Compound C Obesity Insulin resistance

Agricultural adaptation to climate change in China

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Journal of Environmental Sciences 2001年第2期13卷 192-197页

作者： YOU Song\|cai(Tokyo Institute of Technology, Japan. E\|mail:you.songcai@nies.go.jp) Tokyo Institute of Technology 日本

This paper presents the study on agriculture adaptation to climate change by adopting the assumed land use change strategy to resist the water shortage and to build the capacity to adapt the expected climate change in the northern China. The cost\|benefit analysis result shows that assumed land use change from high water consuming rice cultivation to other crops is very effective. Over 7 billions m 3 of water can be saved. Potential conflicts between different social interest groups, different regions, demand and supply, and present and future interests have been analyzed for to form a policy to implement the adaptation strategy. Trade, usually taken as one of adaptation strategies, was suggested as a policy option for to support land use change, which not only meets the consumption demand, but also, in terms of resources, imports water resources.

关键词： agriculture adaptation climate change land use change

Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences

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World Journal of Gastroenterology 2010年第25期16卷 3091-3102页

作者： Carmen Berasain Saioa gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila Division of Hepatologyand Gene Therapy CIMA University of Navarra Pamplona31008 Spain

Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies.

关键词： Cell signalling Hepatocarcinogenesis PremRNA splicing Splicing factors Targeted anticancer therapy

Gene expression of CCL8 and CXCL10 in peripheral blood leukocytes during early pregnancy in cows

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Journal of Animal Science and Biotechnology 2018年第4期9卷 813-823页

作者： Ryosuke Sakumoto Kosuke Iga Ken-go Hayashi Shiori Fujii Hiroko Kanahara Misa Hosoe Tadashi Furusawa Division of Animal Breeding and Reproduction Research Institute of Livestock and Grassland Science National Agriculture and Food Research Organization (NARO) Division of Livestock and Forage Research Tohoku Agricultural Research CenterNARO Division of Animal Sciences Institute of Agrobiological SciencesNARO

Background: The aim of the present study was to evaluate CCL8 and CXCL10 expression and its regulatory mechanism in peripheral blood leukocytes(PBLs) at the time of maternal recognition in cows. Blood samples were collected on 14, 15, 16, 17 and 18 d after artificial insemination(AI). Based on the day of return of estrus, cows were divided into three groups, pregnant(n = 5), early embryonic mortality(EEM; n = 5) and late embryonic mortality(LEM; n = 5). The gene expression levels in PBLs were assessed with quantitative real-time reverse transcription ***: The expression of CCL8 and CXCL10 mRNA in PBLs gradually increased from 14 to 18 d of pregnant cows and significant differences were observed on 18 d(P < 0.05), whereas no significant changes were observed both in EEM and LEM cows. Interferon-stimulated protein 15 k Da(ISG15), myxovirus-resistance gene(MX) 1 and MX2 mRNA expression in PBLs increased from 14 to 18 d which was significant on 18 d of pregnant cows as well as in LEM cows(P < 0.05), but no changes were observed in EEM cows. To determine whether the expression of CCL8 and CXCL10 in PBLs was regulated by pregnancy-related substances or not, expression level was assessed after exposure to interferon-τ(IFNT) and CCL16. Monocytes, granulocytes and lymphocytes were obtained using density-gradient centrifugation and flow cytometry. The addition of IFNT(100 ng/mL) and CCL16(100 ng/mL) to cultured PBLs increased the expression of CCL8 and CXCL10 mRNA(P < 0.05). The expression of ISG15, MX1 and MX2 mRNA in PBLs was also stimulated by IFNT and CCL16(P < 0.05).Conclusions: The expression of CCL8 and CXCL10 genes increased in PBLs during early pregnancy. Since IFNT stimulated CCL8 and CXCL10 expression in cultured PBLs, the increase of CCL8 and CXCL10 might be pregnancy-dependent *** expression of both CCL8 and CXCL10 in PBLs was stimulated by CCL16 as wel as IFNT, suggesting a chemokine interaction that at least includes CCL8, CXCL10 and CCL16, and m

关键词： CCL8 Cow CXCL10 Leukocytes Pregnancy

"Commissural drop"wiring technique facilitates catheter crossing of severely stenotic aortic valve

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Chinese Medical Journal 2021年第2期134卷 245-246页

作者： Yu Du Paul Sorajja Miho Fukui go Hashimoto Aisha Ahmed Mario Gössl Valve Science Center Minneapolis Heart Institute FoundationAbbott Northwestern HospitalMN 55407USA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

To the Editor:An 82-year-old man with symptomatic severe calcific aortic valve stenosis(peak velocity:5.19 m/s;mean gradient:78.0 mmHg;aortic valve area:0.48 cm2)underwent transfemoral transcatheter aortic valve *** the procedure,a 0.035-inch straight-tip glide wire(Terumo,Somerset,NJ,USA)supported by a 6 Fr Judkins Right 4(JR4)coronary catheter(Medtronic,Minneapolis,MN,USA)were used to cross the severely stenotic aortic ***,the JR4 catheter could not pass the aortic valve because the wire crossed the aortic valve in the left/right coronary commissure creating an unfavorable angle and limited pushability for the *** of switching to a differently shaped catheter(eg,an Amplatz left 1 catheter),we advanced the glide wire and therefore the more supportive portion of the wire further through the aortic ***,both wire and JR4 catheter dropped into the non/left coronary commissure,allowing the JR4 catheter to cross the valve ***,a 34 mm self-expanding Evolut R valve(Medtronic)was implanted,and the patient was discharged uneventfully(Figure 1A-E and Supplementary Video 1,http://***/CM9/A353["Commissural drop"wiring technique.]).

关键词： catheter valve Figure