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International Journal of Otolaryngology and Head & Neck.Surgery 2013年第5期2卷 207-210页

作者： Cory A. Vaughn k.itlin R. Jaqua ryan k. meacham Fransisco Vieira Department of Otolaryngology Head & Neck Surgery University of Tennessee Memphis USA MD Candidate University of Tennessee Health Science Center Memphis USA

Prostate cancer is the most common noncutaneous malignancy of American males and typically presents with genitourinary symptoms, however, head and neck.extension is a rare finding. We present a case of a 53-year-old male initially presenting with a large supraclavicular mass as the only complaint. After an initial non-diagnostic FNA biopsy, PSA levels, histology and immunohistochemical findings were consistent with metastatic prostatic adenocarcinoma. The patient was started on anti-hormonal treatment after diagnosis. Due to the increasing reports of such cases, we suggest PSA levels and appropriate immunohistochemical staining should be obtained on all unk.own neck.masses.

关键词： Neck Mass Prostate Adenocarcinoma Metastasis

The Impact of a Prior Norwood Procedure on Cardiac Transplantation in Failed Fontan Physiology

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Congenital Heart Disease 2024年第3期19卷 257-266页

作者： ryan G.McQueen Nik.i M.Singh Ronald k.Woods Medical College of Wisconsin Herma Heart Institute at Children’s WisconsinMilwaukeeUSA Division of Pediatric Cardiology Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA Division of Pediatric Cardiothoracic Surgery Medical College of WisconsinHerma Heart Institute at Children’s WisconsinMilwaukeeUSA

Objective:The objective of this study was to compare cardiac transplant operative and postoperative courses of patients with failed Fontan physiology who were initially palliated with a Norwood(FFN)to those without a prior Norwood(FF).Methods:A single-institution retrospective review of all patients with Fontan failure who under-went cardiac transplantation from 2003–2021 was completed-22 underwent prior Norwood(FFN)and 11 did not(FF).Descriptive and inferential statistics were calculated for operative course and patient ***:The operative course of the FFN cohort appeared to be more complex(not statistically significant,but clinically relevant)-this group exclusively experienced sternal re-entry events(3 of 22 patients)and concomitant neo-aor-tic reconstruction(6 patients),had a longer duration of surgery(median of 682 min vs.575.5 min),more time on circulatory arrest(median of 25.5 min vs.12.5 min),and more frequent use of open sternal management[50%of patients(11/22)vs.27.3%of patients(3/11)].Postoperatively,these patients underwent more mediastinal explora-tions[other than sternal closure;40.9%of patients(9/22)vs.18.2%of patients(2/11)],spent more time on mechanical ventilation(median of 5 days vs.2 days),had a longer length of stay(median of 30 days vs.19 days),and required more catheter-based re-interventions[22.7%of patients(5/22)vs.9.1%of patients(1/11)].Conclu-sion:Although underpowered,our results suggest that the operative course of FFN patients is more challenging,based mostly on neo-aortic arch *** turn,this lik.ly leads to a more complex postoperative *** are currently collaborating with other institutions to increase the cohort size and power of the study.

关键词： Fontan Fontan failure Norwood cardiac transplantation

Management of gestational diabetes mellitus via nutritional interventions:The relevance of gastric emptying

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World Journal of Diabetes 2024年第7期15卷 1394-1397页

作者： Wei-k.n Huang ryan J Jalleh Christopher k.Rayner Tong-Zhi Wu Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health The University of AdelaideAdelaide 5000Australia Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health The University of Adelaide and Department of Gastroenterology and HepatologyRoyal Adelaide HospitalAdelaide 5000Australia

Gestational diabetes mellitus(GDM)represents one of the most common medical complications of pregnancy and is important to the well-being of both mothers and offspring in the short and long *** intervention remains the mainstay for the management of *** efficacy of nutritional approaches(*** restriction and small frequent meals)to improving the maternal-neonatal outcomes of GDM was attested to by Chinese population data,discussed in two articles in recent issues of this ***,a specific focus on the relevance of postprandial glycaemic control was *** rather than fasting hyperglycaemia often represents the predominant manifestation of disordered glucose homeostasis in Chinese women with *** is now increasing appreciation that the rate of gastric emptying,which controls the delivery of nutrients for digestion and absorption in the small intestine,is a k.y determinant of postprandial glycaemia in both health,type 1 and 2 *** remains to be established whether gastric emptying is abnormally rapid in GDM,particularly among Chinese women,thus contributing to a predisposition to postprandial hyperglycaemia,and if so,how this influences the therapeutic response to nutritional *** is essential that we understand the role of gastric emptying in the regulation of postprandial glycaemia during pregnancy and the potential for its modulation by nutritional strategies in order to improve postprandial glycaemic control in GDM.

关键词： Gastric emptying Postprandial glycaemia Diet Nutritional interventions Gestational diabetes mellitus

D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-sk.ll photodynamic therapy of gliomas

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Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan ryan T.k.k.ok.Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo k.y Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong k.y Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work.we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-sk.ll PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

Effect of TiB_(2)Addition on Microstructure and Mechanical Properties of AA8009 Alloy Fabricated by Laser Additive Manufacturing

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 67-77页

作者： Xinxing Xiong Sijie Yu Pei Wang Junfang Qi Haichao Li Xulei Wang Michael ryan Debajyoti Bhaduri Rossitza Setchi Additive Manufacturing Institute Shenzhen UniversityShenzhen518060China Henan k.y Laboratory of High Performance Carbon Fiber Reinforced Composites Institute of Carbon Matrix CompositesHenan Academy of SciencesZhengzhou450046China School of Materials Science and Engineering Shanghai University of Engineering ScienceShanghai201620China School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou450046China High-Value Manufacturing Research Group School of EngineeringCardiff UniversityCardiffCF243AAUK

The research involves the addition of 5 vol.%TiB_(2)particles into AA8009 alloy powder to synthesize TiB_(2)/AA8009 composite parts produced via laser powder bed fusion(LPBF).The addition of the TiB_(2)particles causes the TiB_(2)/AA8009 composites with and without annealing have lower compressive strength than AA8009 alloy due to the change of the strengthening *** results further indicated that solid solution strengthening was the main strengthening mechanism of the LPBF AA8009 alloy at room temperature whereas Orowan strengthening became the primary strengthening factor after annealing at 673 *** contrast,Orowan strengthening always remained the main strengthening mechanism for the TiB_(2)/AA8009 composite,irrespective of the annealing *** addition,after annealing of the LPBF parts at 673 k.the compressive yield strength(CYS)of the unblended AA8009 alloy specimens had a~2.5 times greater reduction(from 705±16 to 459±30 MPa)compared to that of the composite TiB_(2)/AA8009 samples(from 466±23 to 368±3 MPa).Therefore,TiB_(2)particles can suppress the drop in yield strength of LPBF AA8009 alloy below 673 k.providing a theoretical and experimental basis for the applications of both LPBF AA8009 and TiB_(2)/AA8009 alloys at low and medium temperatures.

关键词： Laser powder bed fusion AA8009 alloy Microstructure Mechanical properties

The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy

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Science China(Life Sciences) 2024年第8期67卷 1549-1562页

作者： Peidong Zhang Peiwei Li Muya Tang ryan CGimple Liang Huang Jing Yue Qiuhong Shen Yiwei Du Qian Zhang Zhengnan Yang Haihuai He k.ilin Yang Linjie Zhao Shengtao Zhou Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOEState Key Laboratory of BiotherapyWest China Second HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Physician Scientist Training Program Department of MedicineWashington University School of MedicineSt.Louis 63110USA Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Department of Radiation Oncology Taussig Cancer CenterCleveland ClinicCleveland 44106USA

Mechanics shape cell and tissue plasticity and maintain their *** cancers,mechanical signals regulate cancer hallmark. via mechanotransduction pathways,such as proliferation,metastasis and metabolic ***,comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains ***,we systematically portrayed the alterations of mechanotransduction pathway genes across 31 cancer types using The Cancer Genome Atlas(TCGA)*** the cancer types could be categorized into 6 subtypes based upon the transcriptional pattern of mechanics pathway *** subtype has its own unique molecular expression pattern,mutation landscapes,immune infiltrates,and patient clinical *** further found that the responses of two subtypes of cancers,one with the optimal outcome and the other with the worst prognosis,to a classical mechanotherapeutic agent(Fasudil,RhoA/ROCk.inhibitor)were totally different,indicating that our cancer stratification system based upon mechanotransduction pathway genes could inform clinical responses of patients to mechanotherapeutic ***,our study provides a novel pan-cancer landscape of the mechanotransduction pathways and underscores its potential clinical significance in the prediction of clinical prognosis and therapeutic responses to mechanotherapy among cancer patients.

关键词： pan-cancer cancer mechanics multi-omics immunology

Factors predictive of an academic otolaryngologist’s scholarly impact

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World Journal of Otorhinolaryngology-Head and Neck.Surgery 2021年第4期7卷 275-279页

作者： Courtney B.Shires Theodore D.k.ug ryan k.meacham Merry E.Sebelik West Cancer Center GermantownTNUSA Tanner Clinic LaytonUTUSA Department of Otolaryngology Emory UniversityAtlantaGAUSA

Objectives:Describe the h index as a bibliometric that can be utilized to objectively evaluate scholarly *** which otolaryngology subspecialties are the most *** if NIH funding to one’s choice of medical school,residency,or fellowship has any impact on one’s scholarly *** other factors predictive of an academic otolaryngologist’s *** design:Analysis of bibliometric data of academic ***:Active grants from the National Institutes of Health(NIH)to otolaryngology departments were ascertained via the NIH Research Portfolio Online Reporting Tools Expenditures and Reports *** listings from these departments were gleaned from departmental websites.H index was calculated using the Scopus ***:Forty-seven otolaryngology programs were actively receiving NIH *** were 838 faculty members from those departments who had a mean h index of ***(h index 12.50)and head and neck.h index 11.96)were significantly(Pk.are the most scholarly subspecialists within *** funding to an individual’s medical school,residency,or fellowship of origin is not correlative with one’s scholarly impact,but current institutional affiliation and choice of subspecialty are.

关键词： Bibliometric Impact h-index Citation

Nexus between polymer support and metal oxide nanoparticles in hybrid nanosorbent materials （HNMs） for sorption/desorption of target ligands

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 929-938页

作者： ryan C. SMITH Jinze LI Surapol PADUNGTHON Arup k. SENGUPTA Environmental Engineering Program Department of Civil and Environmental Engineering Lehigh University Bethlehem PA 18015 USA

Metal oxide nanoparticles lik. hydrated ferric oxide （HFO） or hydrated zirconium oxide （HZrO） are excellent sorbents for environmentally significant ligands lik. phosphate, arsenic, or fluoride, present at trace concentrations. Since the sorption capacity is surface dependent for HFO and HZrO, nanoscale sizes offer significant enhancement in performance. However, due to their miniscule sizes, low attrition resistance, and poor durability they are unable to be used in typical plug-flow column setups. Meanwhile ion exchange resins, which have no specific affinity toward anionic ligands, are durable and chemically stable. By impregnating metal oxide nanoparticles inside a polymer support, with or without functional groups, a hybrid nanosorbent material （HNM） can be prepared. A HNM is durable, mechanically strong, and chemically stable. The functional groups of the polymeric support will affect the overall removal effi- ciency of the ligands exerted by the Donnan Membrane Effect. For example, the removal of arsenic by HFO or the removal of fluoride by HZrO is enhanced by using anion exchange resins. The HNM can be precisely tuned to remove one type of contaminant over another type. Also, the physical morphology of the support material, spherical bead versus ion exchange fiber, has a significant effect on k.netics of sorption and desorption. HNMs also possess dual sorption sites and are capable of removing multiple contaminants, namely, arsenate and perchlorate, concurrently.

关键词： ion exchange sorpfion arsenic perchlorat~,fluoride

Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

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Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Sk.rstad Norevik.Alek.i M.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen k.milla Jacobsen Rodrigo Miguel-dos-Santos Liv ryan Belma Sk.nder Jose Bianco N.Moreira Asgeir k.bro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway k.vli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway k.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Back.round:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-lik. stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week.for 6 week.).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 week. at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(pk.nes were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytok.nes High-intensity interval training Inflammation Neurons Plasma transfusion

Capitalizing on Superconvergence for More Accurate Multi‑Resolution Discontinuous Galerk.n Methods

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Communications on Applied Mathematics and Computation 2022年第2期4卷 417-436页

作者： Jennifer k.ryan Applied Mathematics and Statistics Colorado School of MinesGoldenCO 80401USA

This article focuses on exploiting superconvergence to obtain more accurate multi-resolution analysis. Specifcally, we concentrate on enhancing the quality of passing of information between scales by implementing the Smoothness-Increasing Accuracy-Conserving (SIAC) fltering combined with multi-wavelets. This allows for a more accurate approximation when passing information between meshes of diferent resolutions. Although this article presents the details of the SIAC flter using the standard discontinuous Galerk.n method, these techniques are easily extendable to other types of data.

关键词： Multi-resolution analysis Multi-wavelets Discontinuous Galerk.n Smoothness-Increasing Accuracy-Conserving(SIAC) Post-processing Superconvergence Accuracy enhancement