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Mobile technology for health care in rural China

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International journal of Nursing Sciences 2014年第3期1卷 323-324页

作者： Zhao Ni Bei Wu Catherine Samples ryan j.shaw School of Nursing Duke UniversityDurhamNC 27710USA

With the proliferation of mobile technologies in China,the Chinese mobile medical applications market is growing *** may be particularly useful for Chinese rural populations who have limited access to quality medical care where mobile technologies can reach across geographic and socioeconomic boundaries and potentially increase access to care and improve health outcomes.

关键词： China Mobile health mHealth Rural

Revascularization and outcomes in Veterans with moderate to severe ischemia on myocardial perfusion imaging

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Military Medical Research 2017年第3期4卷 127-131页

作者： David E.Winchester Alexander j.Bolanos Anita Wokhlu Rebecca j.Beyth Leslee j.shaw Malcom Randall VAMC North Florida/South Georgia Veterans Health System Division of Cardiovascular Medicine University of Florida College of Medicine Malcom Randall VAMC Department of Medicine University of Florida College of Medicine Division of General Internal Medicine University of Florida College of Medicine Division of Cardiology Emory University School of Medicine

Background： The prevalence of ischemia on nuclear myocardial perfusion imaging （MPI） has been decreasing. Recent research has questioned the benefit of invasive revascularization for patients with moderate to severe ischemia. We hypothesized that patients with moderate to severe ischemia could routinely undergo successful revascularization. Methods： We analyzed data from 544 patients who underwent an MPI at a single academic Veterans Affairs Medical Center. Patients with moderate to severe ischemia, defined as a summed difference score （SDS） 8 or greater, were compared to the rest of the cohort. Results： Of the total cohort （n=544）, 39 patients had MPI studies with resultant moderate to severe ischemia. Patients with ischemia were more likely to develop coronary artery disease （74.4% versus 38.8%, P〈0.0001） and have successful revascularization （38.5% versus 4.0%, P〈0.0001） during the following year. Revascularization was attempted in 31 patients with moderate to severe ischemia, though only 15（47%） of these attempts were successful, Ischemia was predictive of myocardial infarction （5.1% versus 0.8%, P=0.01） within I year. Conclusion： Moderate to severe ischemia is an uncommon finding in a contemporary nuclear laboratory. Among patients with ischemia, revascularization is typically attempted but is frequently unsuccessful. Trial registration： This trial does not appear on a registry as it is neither randomized nor prospective.

关键词： Myocardial ischemia Nuclear myocardial perfusion imaqinq Veterans Revascularization

Accumulation sequence of Chinese loess and climatic records of Greenland ice core during the last 130 ka

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Chinese Science Bulletin 1995年第15期40卷 1272-1276页

作者：安芷生孙东怀张小曳周卫建 S.C.Porter j.shaw 张代州 Xi'an Laboratory of Loess and Quaternary Geology. Chinese Academy of Sciences. Xi'an 710061 China Quaternary Research Centre. University of Washington. Seattle. USA Geomagnetism Laboratory. University of Liverpool UK Department of Geophysics. Peking University. Beijing 100871 China

The present winter climate of continental China is associated with cold air *** cold air forming Siberian high pressure comes from the Northern Barents *** Kara Sea and Northern Atlantic Ocean (fig.1). in other words,... 详细信息

关键词： winter monsoon GRIP core and Chinese loess.

janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

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Translational Neurodegeneration 2023年第1期12卷 225-241页

作者： Peter j.Richardson Daniel P.Smith Alex de Giorgio Xenia Snetkov joshua Almond-Thynne Sara Cronin Richard j.Mead Christopher j.McDermott Pamela j.shaw BenevolentAI 4-8 Maple StreetLondon W1T 5HDUK BenevolentAI 15 MetroTech Centre8th FLBrooklynNY 11201USA Sheffield Institute for Translational Neuroscience Faculty of MedicineDentistry and HealthUniversity of SheffieldSheffieldUK NIHR Sheffield Biomedical Research Centre University of Sheffield and Sheffield Teaching Hospitals NHS Foundation TrustSheffieldUK

Amyotrophic lateral sclerosis(ALS)is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular *** with other multifactorial diseases,it is likely that drugs will need to target multiple disease processes and cell types to be *** review here the role of janus kinase(jAK)/Signal transducer and activator of transcription(STAT)signalling in ALS,confirm the association of this signalling with fundamental ALS disease processes using the BenevolentAI Knowledge Graph,and demonstrate that inhibitors of this pathway could reduce the ALS pathophysiology in neurons,glia,muscle fibres,and blood ***,we suggest that inhibition of the jAK enzymes by approved inhibitors known as jakinibs could reduce STAT3 activation and modify the progress of this *** of the jakinibs highlights baricitinib as a suitable candidate due to its ability to penetrate the central nervous system and exert beneficial effects on the immune ***,we recommend that this drug be tested in appropriately designed clinical trials for ALS.

关键词： janus kinase STAT3 Amyotrophic lateral sclerosis

RECENT PROGRESS IN STUDY OF THE QUATERNARY OF QAIDAM BASIN, QINGHAI

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Chinese Science Bulletin 1986年第4期31卷 252-256页

作者：王靖泰张勇 E.DERBYSHIRE j.shaw Lanzhou Institute of Glaciology and Cryopedology Academia Sinica First Hydrological Team of Geological Bureau of Qinghai Province Department of Geography University of Keel UK Department of Geology University Gollege Cardiff UK series of mountain systems and intermountane basins extend across the northern and western China. The largest of the basins are those of Tarim Junggar and Qaidam. A thick sedimentary sequence has been deposited in these basins during the Cenozoic. Accordingly the region has great potential for the study of the Quaternary stratigraphy. However information on the Quaternary sedimentology and chronostratigraphy of this huge region is sparse.

A series of mountain systems and intermountane basins extend across the northern and western China. The largest of the basins are those of Tarim, junggar and Qaidam. A thick sedimentary sequence has been deposited in these basins during the Cenozoic. Accordingly, the region has great potential for the study of the Quaternary stratigraphy. However, information on the Quaternary sedimentology and chronostratigraphy of this huge region is sparse.

关键词： sedimentary Quaternary stratigraphy Cenozoic thick PROGRESS folding borehole sparse abundant

辽西四合屯含化石层古地磁极性年龄的初步确定

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科学通报 2001年第8期46卷 680-684页

作者：潘永信朱日祥 j.shaw 周烑秀中国科学院地质与地球物理研究所北京100101 Geomagnetism Laboratory 国土资源部航空物探遥感中心北京100083

对辽西四合屯剖面合化石层及其下伏和上覆玄武岩进行了较为详细的岩石磁学和古地磁学研究，结果表明含化石的沉积岩层段和下伏玄武岩段具有正极性，上覆玄武岩则具有负极性．结合最新的同位素测年结果可知，含化石层段的古地磁极性年龄... 详细信息

对辽西四合屯剖面合化石层及其下伏和上覆玄武岩进行了较为详细的岩石磁学和古地磁学研究，结果表明含化石的沉积岩层段和下伏玄武岩段具有正极性，上覆玄武岩则具有负极性．结合最新的同位素测年结果可知，含化石层段的古地磁极性年龄为早白垩世Ｂａｒｒｅｍｉａｎ阶Ｍ３ｎ极性时．岩石磁学参数测量结果揭示出该湖相沉积岩中夹有数层火山凝灰质沉积物，这可能说明由火山活动等地球深部动力学过程引起的剧烈环境变化与古湖区生物的剧生剧灭有关．

关键词：磁性地层年龄下义县组早白垩世四合屯剖面辽宁

Enhancing pedestrian mobility in Smart Cities using Big Data

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journal of Management Analytics 2020年第2期7卷 173-188页

作者： Ebony Carter Patrick Adam Deon Tsakis Stephanie shaw Richard Watson Peter ryan Faculty of Business and Law Swinburne UniversityHawthornAustralia Swinburne University of Technology Defence Science&Technology Group MelbourneAustralia

Smart City is an emerging concept in global urban development.A Smart City applies ICT technologies to provide greater efficiencies for its urban areas and civilian *** of the key requirements for a Smart City is to exploit data from its ICT infrastructure(such as Internet of Things connected sensors)to improve city services and features such as accessibility and *** address this requirement,the City of Melbourne(COM)Smart City office maintains several hundred data sets relating to urban activity and *** datasets address parking,mobility,land use,3D data,statistics,environment,and major city developments such as rail *** promising dataset relates to pedestrian *** are obtained from sensors and updated on the COM website(City of Melbourne Open Data Platform:https://***/.)at regular *** data include the number of pedestrians passing 53 specific locations in the central business district and also their times and directions of *** a 24 h period,over 650,000 pedestrians were counted passing all *** rates of several thousand pedestrians per minute are regularly recorded during city rush hours at hotspots making the data amenable to Big Data analysis *** are obtained in graphical format as heatmaps and charts of city pedestrian traffic using both Microsoft Excel^(■)for static analysis and PowerBI^(■)for more advanced interactive visualisation and *** findings can identify pedestrian hotspots and inform future locations of traffic lights and street configurations to make the city more pedestrian ***,the experience gained can be used to examine other data sets such as bicycle traffic that can be analysed to inform city infrastructure *** work is suggested that could link these pedestrian flow data with social media data from smartphones and potentially wearable devices such as fitness monitors to correlate pedestrian s

关键词： Internet of Things Smart Cities Big Data analytics

Inter-signal interaction and uncertain information in anuran multimodal signals

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Current Zoology 2011年第2期57卷 153-161页

作者： ryan C. TAYLOR Barrett A. KLEIN Michael j. ryan Department of Biological Sciences Salisbury University Salisbury MD 21801 USA Section of Integrative Biology University of Texas at Austin Austin TX 78712 USA Smithsonian Tropical Research Institute P.O. Box 0843-03092 Balboa Ancon Republic of Panama

Disentangling the influence of multiple signal components on receivers and elucidating general processes influencing complex signal evolution are difficult tasks. In this study we test mate preferences of female squirrel treefrogs Hyla squirella and female tungara frogs Physalaemus pustulosus for similar combinations of acoustic and visual components of their multimodal courtship signals. In a two-choice playback experiment with squirrel treefrogs, the visual stimulus of a male model significantly increased the attractivness of a relatively unattractive slow call rate. A previous study demonstrated that faster call rates are more attractive to female squirrel treefrogs, and all else being equal, models of male frogs with large body stripes are more attractive. In a similar experiment with female tungara frogs, the visual stimulus of a robotic frog failed to increase the attractiveness of a relatively unattractive call. Females also showed no preference for the distinct stripe on the robot that males commonly bear on their throat. Thus, features of conspicuous signal components such as body stripes are not universally important and signal function is likely to differ even among species with similar ecologies and communication systems. Finally, we discuss the putative information content of anuran signals and suggest that the categorization of redundant versus multiple messages may not be sufficient as a general explanation for the evolution of multimodal signaling. Instead of relying on untested assumptions concerning the information content of signals, we discuss the value of initially collecting comparative empirical data sets related to receiver responses.

关键词： Inter-signal interaction Multimodal signaling Signal detection Signal weighting Squirrel treefrog Hyla squirella Tfingara frog Physalaemus pustulosus Vocal sac

Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan

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Neural Regeneration Research 2018年第8期13卷 1309-1312页

作者： ryan j.Piers Department of Psychological and Brain Sciences Boston University

Apolipoprotein E4（ApoE4） is a prominent genetic risk factor for Alzheimer＇s disease. The purpose of this review is to explore differences in structural brain volume detected by magnetic resonance imaging between cognitively intact ApoE4 carriers and non-carriers across the lifespan（i.e., older adults, middle-aged adults, young adults, children and adolescents, and neonates）. Consistent findings are found throughout various developmental stages. This area of research may elucidate the mechanisms by which ApoE4 influences risk of developing Alzheimer＇s disease. It could also inform potential treatment strategies and interventions for carriers of the ApoE4 allele.

关键词： MRI healthy aging genetic risk factor biomarker Alzheimer's disease