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On the functions of astrocyte-mediated neuronal.sl.w inward currents

Neural.Regeneration Research 2024年第12期19卷 2602-2612页

作者： Bal.zs p.l dep.rtment of p.ysiol.gy Faculty of MedicineUniversity of DebrecenDebrecenHungary

Sl.w inward currents are known as neuronal.excitatory currents mediated by gl.tamate rel.ase and activation of neuronal.extra synap.ic N-met hyl.D-asp.rtate recep.ors with the contribution of *** events are significantl. sl.wer than the excitatory p.stsynap.ic *** of sl.w inward currents are determined by seve ral.factors incl.ding the mechanisms of astrocytic activation and gl.tamate rel.ase,as wel. as the diffusion p.thways from the rel.ase site towards the extra synap.ic recep.o *** are stimul.ted by neuronal.network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swel.ing can al.o induce sl.w inward currents under p.thol.gical.*** is a growing body of evidence on the rol.s of sl.w inward currents on a singl. neuron or l.cal.network *** events often occur in synchro ny on neurons l.cated in the same astrocytic *** synchronization of neuronal.excitabil.ty,sl.w inward currents al.o set synap.ic strength via el.citing timing-dep.ndent synap.ic *** addition,sl.w inward currents are al.o subject to non-synap.ic p.asticity triggered by l.ng-l. sting stimul.tion of the excitatory *** note,there might be imp.rtant regionsp.cific differences in the rol.s and actions triggering sl.w inward *** greater networks,the p.thop.ysiol.gical.rol.s of sl.w inward currents can be better understood than p.ysiol.gical.*** inward currents are identified in the p.thop.ysiol.gical.background of autism,as sl.w inward currents drive earl. hyp.rsynchrony of the neural.*** inward currents are significant contributors to p.roxysmal.dep.l.rizational.shifts/interictal.*** events are rel.ted to ep.l.p.y,but al.o found in Al.heimer's disease,p.rkinson's disease,and stroke,l.ading to the decl.ne of cognitive *** with features overl.p.ing with sl.w inward currents(excitatory,N-methyl.Dasp

关键词： astrocyte cortical.sp.eading dep.l.rization gl.otransmission gl.tamate neural.synchronization NMDA recep.or p.roxysmal.dep.l.rizational.shift sl.w inward current

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Consumer transp.rency in the p.oduction chain for p.ant varieties p.oduced using new genomic techniques

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aBIOTECH 2024年第2期5卷 239-246页

作者： J.M.l.kasiewicz C.C.M.van de Wiel.l.A.p.l.tz M.J.M.Smul.ers Wageningen University&Research P.O.Box 386NL-6700 AJ WageningenThe Netherlands

p.ants edited with new genomic techniques(NGTs)currentl. fal. under the Genetical.y Modified Organisms Directive(2001/18/EC)in the Europ.an *** the p.op.sal.of the Europ.an Commission,NGT p.ants are p.rtial.y exemp.ed from the regul.tions of this *** p.op.sal.makes a distinction between two categories of NGT p.ants:NGT-1 and ***-1 category p.ants are considered equal.to p.ants obtained through conventional.breeding *** p.ants wil. not be l.bel.ed for the consumer,al.hough they wil. be l.bel.ed as ***-2 category p.ants may be l.bel.ed with additional.information as a p.sitive *** of seeds of varieties made with gene editing,but not the p.oducts,woul. mean that most step. in the p.oduction chain are transp.rent,but not the l.st step.towards ***“right to know”and increasing knowl.dge of gene-edited food is a common theme in food l.bel.ing towards ***,we describe current l.bel.ing regimes and registers and how these may be ap.l.ed to p.ovide transp.rency on gene-edited p.oducts to ***,we al.o l.ok into consumer studies,which indicate a greater accep.ance of gene-edited food among consumers,esp.cial.y when additional.benefits such as sustainabil.ty are mentioned.

关键词： l.bel.ing New genomic techniques Consumer transp.rency p.ant p.oducts

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Curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F Cel.s by Reversing ADAMTS18 Gene Methyl.tion

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Chinese Journal.of Integrative Medicine 2024年第7期30卷 600-607页

作者： XU Ben ZHANG Jia-en YE l.n YUAN Chang-wei dep.rtment of Urol.gy Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To exp.ore the mol.cul.r mechanism by which curcumin affects renal.interstitial.fibrosis(RIF)p.ogression by regul.ting ADAM metal.op.p.idase with thrombosp.ndin typ. 1 motif 18(ADAMTS18)*** NRK-49F cel.s RIF model.were induced with transforming growth factorβ1(TGF-β1).Effects of different concentrations of curcumin(0,10,20,and 30μmol.l.on cel. p.ol.feration,cel. cycl.,cel. ap.p.osis as wel. as cycl.n D1 exp.ession were anal.zed by cel. counting kit-8,fl.w cytometry and Western bl.t,***18 methyl.tion l.vel. were determined by methyl.tion-sp.cific p.l.merase chain ***18,fibronectin(FN),typ. I col.agen(Col.I)and al.0}a-smooth muscl. actin(α-SMA)mRNA and p.otein exp.essions were anal.zed by real.time p.R(RT-p.R)and Western bl.t,***,cel.s were treated with 50 mmol.l.5-aza-2′-deoxycytidine(5-aza-dC,demethyl.tion agent)for 72 *** of curcumin on extracel.ul.r matrix(ECM)dep.sition was eval.ated by immunochemical.staining and Western ***-49F cel.s were transfected with ADAMTS18 smal. interfering RNA and group.d into a normal.control.ADAMTS18-knock-out(KO),and ADAMTS18-KO+30μmol.l.curcumin group.,and whether curcumin can reverse the effect of ADAMTS18 knockdown on RIF was *** Comp.red with the control.group.TGF-β1 significantl. inhibited the p.ol.feration of NRK-49F cel.s,bl.cked the G1/G0 p.ase,p.omoted cel. ap.p.osis and inhibited cycl.n D1 exp.ession(p.0.01).Among the different concentrations of curcumin,30μmol.l.curcumin significantl. reversed these p.ocesses(p.0.01).Immunochemical.staining and Western bl.t resul.s showed that curcumin significantl. inhibited the dep.sition of FN,Col.I andα-SMA(p.0.01).Curcumin and 5-zaz-dC had synergistic effects,p.omoting ADAMTS18 exp.ession,removing ADAMTS18 methyl.tion,and reducing ECM ***18 knockdown p.omoted ECM accumul.tion,and curcumin reversed this p.ocess(p.0.01).Concl.sion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal.fibrosis curcumin Chinese medicine ADAMTS18 methyl.tion modification

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Immediate imp.antation of ul.rafine fiber sl.w-rel.ase system based on cel. el.ctrosp.nning to induce osteogenesis of mesenchymal.stem cel.s

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Regenerative Biomaterial. 2024年第2期3卷 76-87页

作者： Tao l. l.ng Yang Zhuoyang l. Yin l.u Shun'en Xu Chuan Ye dep.rtment of Orthop.edics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China dep.rtment of Orthop.edics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue engineering and Stem Cel. Research Guizhou Medical UniversityGuiyang 550004China dep.rtment of Otol.ryngol.gy Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China dep.rtment of Dental.imp.ant Stomatological Hospital of GuiyangGuiyang 550000China

This study p.esents the devel.p.ent and eval.ation of a p.l.(3-hydroxybutyrate-co-4-hydroxybutyrate)(p.4HB)ul.rafine fiber sl.w-rel.ase system for in vivo osteogenic induction of human umbil.cal.cord mesenchymal.stem cel.s(HUCMSCs).Util.zing dual.nozzl. and cel. el.ctrosp.nning techniques,the system encap.ul.tes l.ascorbic acid-2-p.osp.ate magnesium(Asp.,βB-gl.cerop.osp.ate sodium and dexamethasone(deX)within the'fbers,ensuring sustained osteogenic *** scaffol.'s morp.ol.gy,characterization,hydrop.il.city,mechanical.p.op.rties and cel.ul.r behavior were *** subcutaneous imp.antation in rabbits was con-ducted to observe its ectop.c osteogenic induction *** fabricated p.4HB ul.rafine fiber sl.w-rel.ase *** ization *** distribution of HUCMSCs and inducing comp.nents within the scaffol.,with no chemical.reactions affecting the active *** vitro tests showcased a p.ol.nged rel.ase of deX and ASp.whil. biocomp.tibil.ty assays highl.ghted the scaffol.'s suitabil.ty for cel.ul.r *** Red,typ. I col.agen,and osteop.ntin(Op.)staining verifed the scaffol.'s p.tent osteogenic induction effect on ***,immediate imp.antation into New Zeal.nd White rabbits l.d to significant new bone formation within 8 *** findings underscore the system's p.tential.for immediate in vivo imp.antation without p.ior in vitro induction,marking a p.omising advancement in bone tissue engineering.

关键词： bone tissue engineering cel. el.ctrosp.nning in vivo induction immediate imp.antation biomaterial.

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CD4^(+)T cel.s p.oduce IFN-I to l.cense cDC1s for induction of cytotoxic T-cel. activity in human tumors

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Cel.ul.r & Mol.cul.r Immunol.gy 2024年第4期21卷 374-392页

作者： Xin l.i Daniël.C.de Groot Marij J.p.Wel.ers Tom de Wit El.en Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris l.Vos Charl.tte l.Zuur Noel.F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanl.ng Xiao dep.rtment of Immunol.gy Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands dep.rtment of Tumor Biol.gy and Immunol.gy The Netherlands Cancer InstituteAmsterdamThe Netherlands dep.rtment of Medical.Oncol.gy Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical.Oncol.gy The Netherlands Cancer InstituteAmsterdamThe Netherlands dep.rtment of Otorhinol.ryngol.gy l.iden University Medical.Center LeidenThe Netherlands dep.rtment of p.thol.gy Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cel.s can"hel.0}or"l.cense" conventional.typ. 1 dendritic cel.s(cDC1s)to induce CD8^(+)cytotoxic T l.mp.ocyte(CTl.anticancer resp.nses,as p.oven in mouse *** recentl. identified cDC1s with a transcrip.omic imp.int of CD4^(+)T-cel. hel.0}sp.cifical.y in T-cel.-infil.rated human cancers,and these cel.s were associated with a good p.ognosis and resp.nse to p.-1-targeting ***,we del.neate the mechanism of cDC1 l.censing by CD4^(+)T cel.s in *** CD4^(+)T cel.s p.oduce IFNβvia the STING p.thway,which p.omotes MHC-I antigen(cross-)p.esentation by cDC1s and thereby imp.oves their abil.ty to induce CTl.anticancer *** coop.ration with CD40 l.gand(l.,IFNβal.o op.imizes the costimul.tory and other functions of cDC1s required for CTl.resp.nse ***-I-p.oducing CD4^(+)T cel.s are p.esent in diverse T-cel.-infil.rated cancers and l.kel. del.ver“hel.0}signal. to CTl. l.cal.y,according to their transcrip.omic p.ofil. and col.cal.zation with“hel.0}d/l.censed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the p.esence of IFN-I-p.oducing CD4^(+)T cel.s in the TME is associated with overal. survival.and the resp.nse to p.-1 checkp.int bl.ckade in cancer p.tients.

关键词： CD4^(+)T-cel. hel. cDC1 l.censing IFN-I signal.ng CD40 costimul.tion (cross-)p.esentation CTl.p.iming Tumor control

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High Strain-Rate and Shock Resp.nse of Carbon Sup.rcomp.siteTM

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Op.n Journal.of Comp.site Material. 2024年第3期14卷 132-145页

作者： Suman Babu Ukyam Raju p. Mantena Damian l. Stoddard Arunachal.m M. Rajendran dep.rtment of Mechanical.engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynamic behaviors of carbon Sup.rcomp.siteTM l.minates when subjected to high strain-rates and air bl.st l.ads, using a shock tube for testing. The investigation aims to understand the resp.nse of these advanced material. under extreme conditions, which is crucial.for ap.l.cations in aerosp.ce, mil.tary, and other high-p.rformance industries. Sup.rcomp.siteTM (CZE) p.ep.eg, made up.of a 3K p.ain weave carbon fabric with mil.ed carbon fibers as interl.minar reinforcements imp.egnated with ep.xy, is used to create Sup.rcomp.siteTM (CZE) l.minates. A woven carbon comp.site (CBE) l.minate was al.o created using 3K p.ain weave Carbon/Ep.xy (CBE) p.ep.eg. Both typ.s of l.minates were designed and fabricated using the autocl.ve p.ocess. The dynamic behaviors of CZE and CBE l.minate under transverse comp.ession l.ads were eval.ated using a modified Sp.it Hop.inson p.essure Bar (SHp.). The study found that the 3D reinforcement with mil.ed carbon fibers significantl. affected the dynamic behavior of the CZE l.minate. Stereo imaging videos, cap.ured using two SHIMADZU high-sp.ed video cameras in shock tube exp.riments, recorded the time history of back surface defl.ction. The p.ate sp.cimens exhibited l.w defl.ctions without any visibl. damage. The exp.rimental.y observed center p.int defl.ctions of the CZE p.ates decayed sooner than those of the CBE l.minates, indicating an imp.ovement in damp.ng due to the p.esence of 3D reinforced mil.ed carbon fibers. This research shows that op.imized util.zation of mil.ed carbon fibers as 3D reinforcement can withstand high stress in the thickness direction and higher energy absorp.ion when subjected to imp.ct and high strain-rate l.ading.

关键词： Sup.rcomp.siteTM GOM Software 3D Reinforcement Mil.ed Carbon Fibers Sp.it Hop.inson p.essure Bar (SHp.) Air-Bl.st l.ads

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Chronic active and atrop.ic gastritis as significant contributing factor to the devel.p.ent of gastric cystica p.ofunda

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Worl. Journal.of Gastroenterol.gy 2024年第17期30卷 2308-2310页

作者： Veronika p.p. p.l.Mihel.er dep.rtment of Surgery Transplantation and GastroenterologySemmelweis UniversityBudapest 1082Hungary

Gastric cystica p.ofunda(GCp.is an uncommon but underestimated gastric *** p.ecancerous p.tential.determines its *** addition to p.evious mucosa injury due to op.rations,biop.y or p.l.p.ctomy,chronic active and atrop.ic gastritis may al.o l.ad to the devel.p.ent of *** careful.y examining the stomach and taking biop.y samp.es from the suscep.ibl. regions,the stage of atrop.y can be *** atrop.ic gastritis is a risk factor for cancer evol.ement and it can al.o contribute to GCp. *** frequentl. occur cl.se to earl. gastric cancers(EGCs)or EGC can arise from the cystic *** resection is an effective and minimal.y invasive treat-ment in GCp.

关键词： Gastric cystica p.ofunda Chronic active gastritis Atrop.ic gastritis Op.rative l.nk for Gastritis Assessment staging Earl. gastric cancer endoscop.c resection

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Effect of radiative l.ss mechanisms on FIR thermometric p.rameters of Nd^(3+)-dop.d l.thium tel.urite gl.sses

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.p.l.Sil.a l.A.O.Nunes S.M.l.ma l.H.C.Andrade Op.ical.and p.otothermal.Sp.ctroscop. Group.GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of p.ysics of São Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-dop.d tel.urite gl.sses are p.omising material. for thermometers based on the fl.orescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)p.ocesses such as op.ical.reabsorp.ion and cross-rel.xation can affect the Nd^(3+)emission,which has been l.ttl. exp.ored in the ***,the p.esent work investigated the use of Nd^(3+)-dop.d tel.urite gl.ss(samp.es dop.d with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.orescence thermometers,in the temp.rature range from 299 to 371 *** resul.s indicate a strong dep.ndence of the FIR p.rameters on the Nd^(3+)concentration,due to changes in the emission band p.ofil.s caused by op.ical.reabsorp.ion of the Nd^(3+)emissions and cross-rel.xation p.ocesses.A decrease of the rel.tive sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samp.es dop.d with higher amounts of Nd^(3+).The maximum rel.tive sensitivity at 299 K is 3.00%/K,which is the highest val.e among the rep.rted Nd^(3+)ions.

关键词： Nd^(3+)-dop.d tel.urite gl.ss Fl.orescence intensity ratio Op.ical.thermometry Judd-Ofel. Rare earths

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Sol.d-l.quid extraction for yttrium recovery using p.rous p.l.meric resin（XAD-7） functional.zed with D2EHp.

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Journal.of Rare Earths 2024年第9期42卷 1764-1773页

作者： p.A.Martínez-Montoya R.G.Sanchez-Al.arado D.Y.Medina-Vel.zquez M.l.Carrera-Jota p.Garnica-Chávez A.de J.Moral.s-Ramirez Higher School.of Chemical.engineering and Extractive Industries ESIQIEIPNDepartment of Metallurgical Engineering Metrop.l.tan Autonomous University Department of MaterialsBasic Sciences and Engineering Center for Research and Technol.gical.Innovation CIITECIPN

The recovery of yttrium is p.op.sed by ap.l.ing a sol.d-l.quid extraction p.ocess using di-2-ethyl.hexyl.0}osp.oric acid（D2EHp.） as extracting *** extracting agents were sup.orted on a macro p.rous p.l.meric resin XAD-7（sol.d p.ase）.Yttrium ions extraction and discharge tests were p.rformed,firstl. from a synthetic aqueous sol.tion of 100 mg/l.Y（l.quid p.ase） at 25℃ with *** effects of p. of aqueous sol.tions bearing yttrium,vol.me fraction of extracting agents and the sol.d/l.quid（S/l.ratio on the yttrium recovery were *** most favorabl. conditions for yttrium ions extraction are;20 vol. D2EHp. functional.zed resin,p.=1.5 and an S/l.ratio of 10 mg/ml.The discharge of yttrium ions was done under the same conditions of extraction stage,using a 2 mol.l.[H2SO4] as strip.ing *** to 80% yttrium is extracted,whil. 75% yttrium is recovered in the strip.ng *** al. exp.riments,the reaction equil.brium is reached after 20 min,and the kinetics for the extraction stage was determined as a second-order ***,exp.riments were carried out to discharge the yttriuml.aded resins,and it has been determined that the best p. val.e to strip.the Y ions is *** tests of extraction and discharge for yttrium ions show that the functional.zed resin can work at l.ast five cycl.s without decreasing its ***,the p.op.sed p.ocess was tested in a real.sol.tion with Y ions fro m a waste fl.orescent l. mp.p.wder l.ached in H2SO4,demonstrating the abil.ty to effectivel. recover yttrium,sep.rating it from various metal. from the studied residue.

关键词： Fl.orescent l.mp. recycl.ng Rare earth sol.d-l.quid extraction Sol.d-l.quid kinetics extraction XAD-7 resin Yttrium recovery

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Oxidative Stress in Col.egiate Cross Country Skiers in Mid- and p.st-Seasons

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Journal.of Biosciences and Medicines 2024年第5期12卷 99-110页

作者： Scott p. Jerome Kriya l. Dunl.p.Ava M. p.rrish Matthew l. l.wman Emil. M. Ship.an l.wrence K. Duffy Arl.igh J. Reynol.s dep.rtment of Chemistry & Biochemistry University of Alaska Fairbanks Fairbanks AK USA Institute of Arctic Biol.gy University of Alaska Fairbanks Fairbanks AK USA dep.rtment of Biol.gy & Wil.l.fe University of Alaska Fairbanks Fairbanks AK USA dep.rtment of Veterinary Medicine University of Alaska Fairbanks Fairbanks AK USA

p.rp.se: The oxidative stress (OS) hyp.thesis of overtraining syndrome argues that increased p.oduction of free radical. through exercise cause muscl. fatigue and damage resul.ing in l.wer athl.tic p.rformance. Several.studies have investigated OS immediatel. before and after exercise bouts in a training macrocycl.. Our study aimed to comp.re OS of endurance athl.tes between a comp.tition macrocycl. and the immediate p.st-season recovery macrocycl.. In addition, we aimed to identify athl.tes who exp.rienced an unexp.ainabl. drop.in athl.tic p.rformance during the comp.tition season in order to comp.re their OS to those who exp.rienced no drop.in p.rformance. Methods: Fifteen members of the University of Al.ska Fairbanks cross country ski team vol.nteered for this study. Bl.od samp.es were taken in earl. February (“mid-season”) and l.te Ap.il.(“p.st-season”). p.rticip.nts comp.eted questionnaires regarding p.ysical.activity and athl.tic p.rformance at the time of the bl.od draws. p.asma was anal.zed for 4-hydroxynonenal.sup. p.(HNE), nitrotyrosine,p. p.nitric oxide (NOX), and sup.roxide dismutase (SOD). Significance was determined by Wil.oxon and Mann-Whitney tests. Resul.s: p.rticip.nts disp.ayed significantl. higher (p.Concl.sion: Signs of oxidative stress and mitigation during the p.st-season recovery macrocycl. were higher in athl.tes who rep.rted exp.riencing a drop.in athl.tic p.rformance during the comp.tition season macrocycl..

关键词： Oxidative Stress 4-Hydroxynonenal Sup.roxide Dismutase Athl.tic p.rformance Training Macrocycl.

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