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The Pharmacologic Intensification of the Water Dissociation Process, or Human Photosynthesis, and Its Effect over the Recovery Mechanisms in Tissues Affected by Bloodshed of Diverse Etiology

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International Journal of Clinical Medicine 2011年第3期2卷 332-338页

作者： Arturo solís Herrera María del Carmen arias Esparza J. Jesús Alvarado Esquivel Graciela Landín Miranda ruth isabel solís arias Paola Eugenia solís arias Martha Patricia solís arias 不详

The photoreceptor layer of the human retina has several characteristics that are unique. Their energy requirements are the highest in the organism;in proportion, rods and cones require 10-fold the energy consumed by the cerebral cortex, 6-fold more than the cardiac muscle, and 3-fold more than the renal cortex. Astonishingly, the photoreceptor layer has no blood vessels at all. so, where is the energy to this tissue coming from? In this article we’ll describe the hitherto unknown explanation.

关键词： Melanin Hydrogen Oxygen Water Energy Human Photosynthesis

The Unexpected Capability of Melanin to split the Water Molecule and the Alzheimer’s Disease

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A half century (1961-2011) of applying microsurgery to experimental liver research

Neuroscience & Medicine（神经系统科学与医药） 2011年第3期

作者： Maria del Carmen arias-Esparza ruth isabel solís arias Paola Eugenia solís arias Martha Patricia solís arias A. solís-Herrera

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World Journal of Hepatology 2012年第7期4卷 199-208页

作者： Maria-Angeles Aller Natalia arias isabel Prieto salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis arias Jaime arias surgery I Department School of Medicine Complutense University of Madrid 28040 Madrid Spain Neurosciences Lab Psychobiology Department School of Psychology University of Oviedo 33003 Oviedo Spain surgery Department La Paz Hospital School of Medicine Autonomous University of Madrid 28049 Madrid Spain General surgery Unit Sudeste Hospital Arganda del Rey 28500 Madrid Spain

The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies.

关键词： Microsurgery Portacaval shunts Cholestasis Hepatectomies Liver transplantation Portal hypertension

Characterization of solid Wastes from Aluminum Tertiary sector: The Current state of spanish Industry

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Journal of Minerals and Materials Characterization and Engineering 2015年第2期3卷 55-64页

作者： Roberto Galindo isabel Padilla Olga Rodríguez ruth sánchez-Hernández sol López-Andrés Aurora López-Delgado National Centre for Metallurgical Research CENIM-CSIC Madrid Spain Department of Crystallography and Mineralogy Faculty of Geology UCM Madrid Spain

Aluminum recycling is an important activity that allows returning this metal to the market saving energy and resources. This activity generates slag and dross, both hazardous materials, which are recovered by other industries (tertiary sector). In that process, new wastes are produced, but most of them are disposed in security storage facilities because of their hazardousness and scarce marketable value. In spain, the statistical data analysis on waste reveals that this sector is increasing every year. This study aims to characterize the wastes generated by the tertiary aluminum industries in spain. samples were collected in different aluminum recycling industries and characterized by chemical analyses, X-ray fluorescence, X-ray diffraction and particle size determination. Wastes rich in aluminum oxide and alkaline elements also comprise metallic aluminum and aluminum nitride. such components are the main responsible for the waste hazardousness since they generate toxic gases in the presence of water. Besides, their fine granulometry (x50 so contributes highly to the hazardousness.

关键词： Hazardous Aluminum Waste Characterization Recycling slag/Dross

Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell suspension Cultures of Parsley(Petroselinum crispum)

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国际实验植物学杂志(英文) 2023年第10期92卷 2807-2823页

作者： Laura isabel arias-Rodríguez Martha Alicia Rodríguez-Mendiola Carlos arias-Castro Federico Antonio Gutiérrez Miceli Diana Reséndez Pérez María Celina Luján Hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli Analytical Laboratory National Technological Institute of MexicoTuxtla Gutierrez CampusTuxtla GutierrezMexico Plant Biotechnology Laboratory Instrumental Analysis LaboratoryPlant Biochemistry LaboratoryNational Technological Institute of MexicoTlajomulco de ZunigaMexico Department of Cellular Biology and Genetics Faculty of Biological SciencesAutonomous University of Nuevo LeonSan Nicolas delos GarzaMexico

In recent years,there has been a growing interest in exploring alternative treatments for bone *** tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone *** our study,we specifically investigated the extract of Petroselinum crispum,a plant known for its abundance of osteogenic flavonoids such as apigenin,quercetin,and *** objective was to compare the total flavonoid content(TFC)and their accumulation in different *** obtained hydrolyzed aqueous extracts from the leaves of parsley plants(grown for 12 weeks in the field),weekly embryogenic cultures,and suspension cell *** TFC,measured in mg quercetin equivalent per gram of dry weight(QE mg/g dw),was found to be 53.81±0.97 for 52 g dw of leaves(1 kg plant fw),31.10±1.52 for 420 g dw of embryogenic cultures,and 11.80±0.76 for 210 g dw of cell ***,only the leaves and embryogenic cultures showed significant accumulation of osteogenic flavonoids,with apigenin levels of 1.8±0.3 and 0.32±0.02 mg/g dw,and kaempferol levels of 1.0±0.18 and 0.2±0.01 mg/g dw,*** findings indicate that embryogenic cultures have the potential to produce up to 40%more apigenin in 12 weeks compared to 1 kg of parsley plant,thanks to their superior biomass reproductive *** results present a promising biotechnological approach for generating extracts enriched with bioactive compounds,which can be further utilized in in vitro osteogenic testing.

关键词： Parsley(Petroselinum crispum)cultures osteogenic flavonoids bone regeneration aqueous extracts

Embrionary way to create a fatty liver in portal hypertension

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World Journal of Gastrointestinal Pathophysiology 2017年第2期8卷 39-50页

作者： Maria-Angeles Aller Natalia arias isabel Peral sara García-Higarza Jorge-Luis arias Jaime arias Department of surgery School of MedicineComplutense University of Madrid UCL Division of Medicine Institute for Liver and Digestive Health Laboratory of Neuros-cience Department of PsychologyUniversity of Oviedo

Portal hypertension in the rat by triple partial portal vein ligation produces an array of splanchnic and systemic disorders, including hepatic steatosis. In the current review these alterations are considered components of a systemic inflammatory response that would develop through three overlapping phenotypes: The neurogenic, the immune and the endocrine. These three inflammatory phenotypes could resemble the functions expressed during embryonic development of mammals. In turn, the inflammatory phenotypes would be represented in the embryo by two functional axes, that is, a coelomic-amniotic axis and a trophoblastic yolk-sac or vitelline axis. In this sense, the inflammatory response developed after triple partial portal vein ligation in the rat would integrate both functional embryonic axes on the liver interstitial space of Disse. If so, this fact would favor the successive development of steatosis, steatohepatitis and fibrosis. Firstly, these recapitulated embryonic functions would produce the evolution of liver steatosis. In this way, this fat liver could represent a yolk-sac-like in portal hypertensive rats. After that, the systemic recapitulation of these embryonic functions in experimental prehepatic portal hypertension would consequently induce a gastrulationlike response in which a hepatic wound healing reaction or fibrosis occur. In conclusion, studying the mechanisms involved in embryonic development could provide key results for a better understanding of the nonalcoholic fatty liver disease etiopathogeny.

关键词： Inflammation Non-alcoholic fatty liver disease Hepatic steatosis Extraembryonic functions Fibrosis Portal hypertension

The Unexpected Bioenergetic Function of Neuromelanin. Implications in the Biology of Learning and Memory

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Natural science 2017年第11期9卷 386-398页

作者： Arturo solis Herrera ruth I. solis arias Human Photosynthesis<sup>® sup> Research Center Aguascalientes Mexico

Progressive Recent Memory loss is the main complaint in Alzheimer’s disease patients. There is not a simple or congruous explanation yet due to highly complex mechanisms by which the Central Nervous system store and organize experiences every day, developed along 4 billion years of evolution;thereby learning and memory are poorly understood biological processes. The finding of the unsuspected intrinsic property of melanin to transforms light into chemical energy through water dissociation, as chlorophyll in plants;opens a new and wider horizon in the form in which the CNs generate and distribute chemical energy transporting it through molecular hydrogen produced by substantia nigra of mesencephalon and other pigmented structures. The mechanisms by which human modifies their behavior through learning and memory remain a mystery despite several decades of research. However, the?unexpected role of melanin molecule bioenergetics of first order, very above the chlorophyll and glucose, indicates?that the study of the fascinating processes involved in learning and memory several levels, needs to be started with the study of the generation and distribution of energy neuro-melanin-releasing to all the brain. In this article, we explain succinctly, the way hydrogen molecular (H2)-gas-, from the dissociation of water by the neuro melanin, moves from its source and permeates easily through the different structures of the Central Nervous system, as well as be the smaller atom, does not combine with water, moving through it in accordance with the laws of the simple diffusion. Molecular hydrogen is the main carrier of energy that nature uses in the entire universe, so that, once the neuro melanin separates it from the water, this displaces transporting its precious cargo of energy and its remarkable antioxidant capacity capable of reduce oxygen and form water.

关键词： Hydrogen Energy Memory Eukaryotic Cell Neurons Cerebral Cortex substantia Nigra

Portal hypertension-related inflammatory phenotypes: From a vitelline and amniotic point of view

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Advances in Bioscience and Biotechnology 2012年第7期3卷 881-899页

作者： Maria-Angeles Aller Natalia arias isabel Prieto Luis santamaria Maria-Paz de Miguel Jorge-Luis arias Jaime arias Cell Engineering Laboratory La Paz Hospital Autonoma University of Madrid Madrid Spain Cellular Biology and Morphological sciences Department School of Medicine Autonoma University of Madrid Madrid Spain Department of surgery I School of Medicine Complutense University of Madrid Madrid Spain Department of surgery La Paz Hospital Autonoma University of Madrid Madrid Spain Neurosciences Laboratory Department of Psychobiology School of Psychology University of Oviedo Oviedo Spain

Prehepatic portal hypertension induces a splanchnic low-grade inflammatory response that could switch to high-grade inflammation with the development of severe and life-threatening complications when associated with chronic liver disease. The extraembryonic origin of the portal system maybe determines the regression to an extraembryonic phenotype, i.e., vitellogenic and amniotic, during the evolution of both types of portal hypertension. Thus, prehepatic portal hypertension, or compensated hypertension by portal vein ligation in the rat, is associated with molecular mechanisms related to vitellogenesis, where hepatic steatosis and splanchnic angiogenesis stand out. In turn, extrahepatic cholestasis in the rat induces intrahepatic portal hypertension, or decompensated hypertension, with ascites and hepatorenal syndrome. The splanchnic interstitium, the mesenteric lymphatic system, and the peritoneal mesothelium seem to create an inflammatory pathway that could have a key pathophysiological relevance in the production of ascites. The hypothetical comparison between the ascitic and the amniotic fluid also allows for translational investigation. The induced regression of the splanchnic system to extraembryonic functions by portal hypertension highlights the great relevance of the extraem-bryonic structures even during postnatal life.

关键词： Portal Hypertension Ascites Vitellogenic Amniotic Extrahepatic Cholestasis Partial Portal Vein Ligation

Gut Lymphangiopathy: Adding Fuel to the Fire in Chronic Liver Disease

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Advances in Bioscience and Biotechnology 2019年第10期10卷 305-319页

作者： Luis Tresierra Maria-Angeles Aller isabel Prieto Luis santamaria Jaime arias Department of surgery Sant Joan Despi Moises Broggi Hospital Barcelona Spain Department of surgery School of Medicine Complutense University of Madrid Madrid Spain Department of General and Digestive surgery La Paz Hospital Autonoma University of Madrid Madrid Spain Department of Anatomy Histology and Neuroscience School of Medicine Autonoma University of Madrid Madrid Spain.

The splanchnic inflammation inchronic liver disease increases intestinal angiogenesis. In the current study our aim was demonstrating that the small bowel lymphangiogenesis is associated with angiogenesis in chronic cholestasis in the rat. A stereological study of the lymphatic microcirculation in the small intestine was performed in cholestatic rats. Portal enteropathy in cholestasis increases lymphatic microvessels in the mucosa and submucosa layers. Thus, the lymphatic microvessel volume fraction was superior (p sa (0.16 ± 0.01) and submucosa (0.16 ± 0.01), in regard to the muscle layer 0.015 ± 0.01. The lymphatic microvessel length density was higher in the mucosa (76.89 ± 2.86 mm-2;p -2;p ship to the muscle layer (5.04 ± 2.92 mm-2). These alterations predominate in the duodenum (volume fraction: 0.10 ± 0.01 and length density: 33.55 ± 5.98 mm-2) and ileum (volume fraction: 0.16 ± 0.01 and length density: 38.62 ± 6.07 mm-2). This study demonstrates the predominance of an increased lymphangiogenic response in both end sides of the small bowel associated with chronic liver disease. since the porto-systemic venous collateral circulation in the chronic liver insufficiency is developed in the ends of the gastrointestinal tract, the excessive duodeno-ileal lymphangiogenesis could suggest the development of amesenteric-systemic lymphatic bypass in the chronic portal hypertension.

关键词： Chronic Liver Disease Lymphangiogenesis Microsurgery Collateral LymphaticCirculation