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Inter-annual and seasonal variations in hydrological parameters and its implications on chlorophyll a distribution along the southwest coast of Bay of Bengal

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Acta Oceanologica Sinica 2015年第6期34卷 94-100页

作者： Shanthi r. Poornima D. raja k. Sarangi r.k. Saravanakumar A. Thangaradjou T. Centre of Advanced Study in Marine Biology Faculty of Marine Sciences Annamalai University Marine Geo and Planetary Sciences Group Space Application Centre (ISRO)

Seasonal and inter-annual variability of hydrological parameters and its impact on chlorophyll distribution was studied from January 2009 to December 2011 at four coastal stations along the southwest Bay of Bengal. Statistical analysis （principal component analysis （PCA）, two-way analysis of variance （ANOVA） and correlation analysis） showed the significant impact of hydrological parameters on chlorophyll distribution in the study area. The ranges of different parameters recorded were 23.8-33.8℃ （SST）, 4.00-36.00 （salinity）, 7.0-9.2 （pH）, 4.41-8.32 mg/L （dissolved oxygen）, 0.04-2.45 μmol/L （nitrite）, 0.33-16.10 μmol/L （nitrate）, 0.02-2.51 μmol/L （ammonia）, 0.04-3.32 μmol/L （inorganic phosphate）, 10.09-85.28 μmol/L （reactive silicate） and 0.04-13.8 μg/L （chlorophyll）. PCA analysis carried out for different seasons found variations in the relationship between physico-chemical parameters and chlorophyll in which nitrate and chlorophyll were positively loaded at PC1 （principal component 1） during spring inter-monsoon and at PC2 （principal component 2） during other seasons. Likewise correlation analysis also showed significant positive relationship between chlorophyll and nutrients especially with nitrate （~0.734）. Distribution of hydrobiological parameters between stations and distances was significantly varying as evidenced from the ANOVA results. The study found that the spatial and temporal distribution of chlorophyll was highly dependent on the availability of nutrients especially, nitrate in the southwest Bay of Bengal coastal waters.

关键词： chlorophyll nutrients PCA nitrate correlation analysis Bay of Bengal

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural regeneration research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p r5 mice).Human neurons expressing the longest TAU isoform(2N4r)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4r-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pr5 mice TAU tauopathy tubulin code

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Security Strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon ko Mar.k.r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of kr.k.w Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

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Human-Like robot Sensing Mediated by Body Heat

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Journal of Bionic Engineering 2014年第1期11卷 82-89页

作者： r. Andrew russell Department of Electrical and Computer Systems Engineering Monash University Clayton VIC 3800 Australia

This paper presents a novel robotic sensor system that can monitor volatile chemicals and airflow. The system is modelled on characteristics of the human body that are thought to have a significant influence on the human odour and airflow senses. In particular, the effect of buoyant airflow due to body heat acts to gather volatile chemicals over large areas of the human body and carry them to the nose. It is postulated that this effect increases the receptive area for human olfaction. In addition, the interaction between rising air heated by the body and external airflow produces a temperature distribution about head height that can be used to infer airflow direction and magnitude. A heated sensor system was constructed to investigate these effects and the resulting sensor was mounted on a mobile robot. The design of the sensor system is described. results are presented which demonstrate its ability to measure airflow direction and detect chemical signals over a wider receptive field compared with an unheated sensor.

关键词： sensing volatile chemicals sensing airflow human body heat biomimetic robots

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robot Pheromone Communication Using Vortex ring Transmission

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Journal of Bionic Engineering 2009年第2期6卷 153-160页

作者： r.Andrew russell Intelligent robotics research Centre Monash University

Unpredictable air movements have proved to be a problem in previous studies investigating robot communication by means of airborne pheromone chemicals. The project described in this paper investigates the use of air vortex rings as a means of carrying pheromone chemicals between transmitting and receiving robots. Sensitivity to chemicals including pheromones released by conspecifics is essential for many aspects of an insect's life. They assist in finding food, locating a mate, avoiding danger and help coordinate the activities of social insects. In the future, autonomous robots will be challenged by many situations similar to those that face insects and other simple creatures. Chemical communication may prove useful for these robots as well. This paper describes the equipment developed for generating and detecting vortex rings. results of experiments involving location and tracking of a sequence of pheromone vortex rings are also presented.

关键词： chemical communication vortex transmission crickets biomimetic robots

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Property enhancement of cast iron used for nuclear casks

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International Journal of Minerals,Metallurgy and Materials 2016年第1期23卷 40-48页

作者： r.k. Behera B.P. Mahto J.S. Dubey S.C. Mishra S. Sen Department of Metallurgical and Materials Engineering National Institute of Technology Rourkela Odisha 769008 India Bhaba Atomic research Centre (Post Irradiation Examination Division) Mumbai 400085 India

Ductile iron （DI） is a preferred material for use in various structural, automotive, and engineering fields because of its excellent combination of strength, toughness, and ductility. In the current investigation, we elucidate the relationship between the morphological and mechanical properties of DI intended for use in safety applications in the nuclear industry. DI specimens with various alloying elements were subjected to annealing and austempering heat treatment processes. A faster cooling rate appeared to increase the nodule count in austempered specimens, compensating for their nodularity value and subsequently decreasing their ductility and impact strength. The ductility and impact energy values of annealed specimens increased with increasing ferrite area fraction and nodularity, whereas an increase in the amounts of Ni and Cr resulted in an increase of hardness via solid solution strengthening. Austempered specimens were observed to be stronger than an- nealed specimens and failed in a somewhat brittle manner characterized by a river pattern, whereas the ductile failure mode was character- ized by the presence of dimples.

关键词： ductile iron nodularity mechanical properties failure modes nuclear industry

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural regeneration research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura reiche Andrew Chan robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HErV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mrNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural regeneration research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír.k.pecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

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