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早期炎症性肠病IBD5基因的OCTN1/2变异与疾病易感性和生长指数的关系

世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 40-41页

作者： russell r.k. Drummond H.E. Nimmo E.r. 廖新华 Gastrointestinal Unit University of EdinburghWestern General HospitalCrewe RoadEdinburgh EH4 2XUUnited Kingdom Dr.

Background and aims:The OCTN1(SLC22A4 1672C→ T) and OCTN2(SLC22A5-207G→ C) variants within the IBD5 locus have been associated with susceptibility to adult onset Crohn’s disease(CD) ,but their contribution in children has not been ***:These OCTN1/2 variants and IBD5 marker single nucleotide polymorphisms(SNPs) (IGr2096a-1,IGr2198a-1,and IGr2230a-1) were examined in 299 Scottish children(200 with CD,74 with ulcerative colitis(UC) ,and 25 with indeterminate colitis(IC) ) ,together with 502 parents(for transmission disequilibrium testing) and 250 ***:All SNPs were in strong linkage disequilibrium(D’ >0.94) .TDT analysis showed association of the OCTN1 variant with inflammatory bowel disease(IBD) (p = 0.01) and CD(p = 0.04) .Allele frequencies of the OCTN1/2 variants were significantly higher in IBD/CD cases(p reased in IBD(24.3% v 16.1%,p = 0.02) and UC(28.2% v 16.1%,p = 0.02) compared with *** OCTN1/2 variants were not independent of the background IBD5 risk haplotype in conferring disease *** analysis in CD patients showed that carriage of the TC haplotype was associated with lower weight,height,and BMI centile(ratio(Or) = 3.52(95% confidence interval,1.51 to 8.22) ;height:84.1% v 68.4%(pr = 2.44(1.00 to 5.99) ;BMI:79.6% v 61.1%(p = 0.02) ,Or = 2.49(1.14 to 5.44) ) ,and lower weight centile at follow up(87.5% v 64.6%(p = 0.03) ,Or = 3.83(1.03 to 14.24) ) .Multifactorial binary logistic regression analysis confirmed association of the TC haplotype with lower weight centile at diagnosis(p = 0.02,Or = 3.41(1.20 to 9.66) ) .Conclusions:These data implicate variants within the IBD5 haplotype,as determinants of disease susceptibility and growth indices in early onset *** OCTN1/2 variants remain potential positional candidate genes,but require further analysis.

关键词：炎症性肠病 IBD5 OCTN1/2 疾病易感性生长指数克罗恩病溃疡性结肠炎遗传不稳定性携

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Tunnelling through weak and fragile rocks of Himalayas

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International Journal of Mining Science and Technology 2014年第6期24卷 783-790页

作者： Goel r.k. CSIr-Central Institute of Mining & Fuel research Regional CentreCBRI Campus Roorkee India

A considerable amount of tunnelling has been going on in India for various projects such as hydroelectric power, irrigation, roads and railways. Most of these projects are located in Himalayas, far away from the urban areas. Tunnelling through weak and jointed rock masses such as the one in the Himalayas is a challenging task for the planners, designers, engineers and geologists because of high overburden, thickly vegetated surface, weak, poor and fragile rocks and highly varying geology with the presence of numerous small and big shear zones, faults, etc. Due to these reasons, various tunnelling problems have been faced in the past and are still being encountered. Failures and the problems may be regarded as challenges and opportunities for generating new knowledge base and thereby increasing self-reliance in tunnelling. The experiences of Himalayan tunnelling through weak and fragile rocks covering varying and mixed geology, understanding on tunnelling in squeezing ground conditions and applicability of TBM in Himalayas are presented. It has also been highlighted that the probe holes planning, drilling and monitoring shall be followed seriously to reduce the geological surprises.

关键词： Varying geology Mixed geology Weak and fragile rocks Himalayan tunnelling Ground condition Squeezing

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Effect of Post Heat Treatment on Corrosion resistance of Phytic Acid Conversion Coated Magnesium

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Journal of Materials Science & Technology 2013年第2期29卷 180-186页

作者： r.k. Gupta k. Mensah-Darkwa D. kumar Engineering research Center for revolutionizing Metallic Biomaterials (ErC-rMB) Department of Mechanical Engineering North Carolina A&T State University 1601 East Market Street Greensboro NC 27411 USA

An environment friendly chemical conversion coating for magnesium was obtained by using a phytic acid solution. The effect of post-coating 1heat treatment on the microstructures and corrosion properties of phytic acid conversion coated magnesium was investigated. It was observed that the microstructure and corrosion resistive properties were improved for the heat treated samples. The corrosion current density for bare magnesium, phytic acid conversion coated magnesium, and post-coating heat treated magnesium was calculated to be 2.48 ×10^-5, 1.18×10^-6, and 9.27 × 10^7 A/cm^2, respectively. The lowest corrosion current density for the heat treated sample indicated its highest corrosion resistive effect for the magnesium. The maximum corrosion protective nature of the heat treated sample was further confirmed by the largest value of impedance in electrochemical impedance spectroscopy studies.

关键词： Magnesium Phytic acid Corrosion Impedance spectroscopy Scanning electron microscopy

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Geochemistry of groundwater, Markandeya river Basin, Belgaum district, karnataka State, India

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Chinese Journal Of Geochemistry 2011年第1期30卷 51-74页

作者： ravikumar P. Somashekar r.k. Department of Environmental Science Bangalore University Bangalore-560 056India

The Markandeya river Basin stretches geographically from 15o56′ to 16o08′ N latitude and 74o37′ to 74o58′ E longitude, positioned in the midst of Belgaum district, in the northern part of karnataka. The groundwater quality of 54 pre-monsoon samples in the Markandeya river Basin was evaluated for its suitability for drinking and irrigation purposes by estimating pH, EC, TDS, hardness and alkalinity besides major cations (Na+, k+, Ca2+, Mg2+) and anions (HCO3–, Cl–, SO42–, PO43-, F-, NO3–), boron, SAr, % Na, rSC, rSBC, chlorinity index, SSP, non-carbonate hardness, Potential Salinity, Permeability Index, kelley’s ratio, Magnesium hazard and Index of Base Exchange. Negative Index of Base Exchange indicates the chloro-alkaline disequilibrium in the study area and the majority of water samples fall in the rock dominance field based on Gibbs’ ratio. Permeability indices of classes I and II suggest suitability of groundwater for irrigation. Based on Cl, SO4, HCO3 concentrations, water samples can be classified as normal chloride (96.3%) and normal sulfate (94.4%) and normal bicarbonate (44.4%) water types.

关键词：水地球化学流域贝尔纳塔地下水水质碳酸盐硬度印度碳酸氢钠

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Spectroscopic investigations and luminescence spectra of Sm3+ doped soda lime silicate glasses

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Journal of rare Earths 2009年第5期27卷 773-780页

作者： Y.k. Sharma S.S.L. Surana r.k. Singh Department of Physics Govt. Post Graduate College Rudrapur 263153 (U S Nagar) India Department of Physics J. N. V. University Jodhpur-342001 India Department of Physics Govt. Post Graduate College Rudrapur 263153 (U S Nagar) India

Sm3+ doped soda lime silicate glasses co-doped with As2O3 were prepared and characterised by measuring their absorption spectra in UV-VIS/NIr regions and luminescence spectra in the visible region. Judd-Ofelt intensity parameters, Ωλ, were evaluated from the measured intensities of the various absorption bands. Ωλ parameters of these glasses were compared with the Ωλ parameters of other reported Sm3+ glasses to study the bonding environment surrounding the Sm3+ in the present glasses. Presence of [AsO4]3– tetrahedra in the second coordination sphere around the central Sm3+ ion made these glasses less covalent as compared to other oxide glasses but the ratio Ω4/Ω6 of the 1.83 indicated them to be fairly stable. With the help of Ωλ parameters and luminescence data for various emission lines, radiative properties for different emission lines were calculated. The values of radiative properties indicated that 4G5/2→6H7/2 and 4G5/2→6H9/2 transitions responsible for orange luminescence might be used in the development of materials for LED's and other optical devices in the visible region.

关键词： rare earth glasses Judd-Ofelt theory absorption spectroscopy luminescence

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A study of local amplification effect of soil layers on ground motion in the kathmandu Valley using microtremor analysis

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Earthquake Engineering and Engineering Vibration 2012年第2期11卷 257-268页

作者： Paudyal Y.r. Yatabe r. Bhandary N.P. Dahal r.k. Geo-disaster research Laboratory Graduate School of Science and EngineeringEhime UniversityEhimeMatsuyamaJapan

Past researchers have anticipated the occurrence of a great earthquake in the central Himalayas in the near *** may cause serious damage in the kathmandu Valley,which sits on an ancient lake bed zone,with lacustrine sediments of more than 500 m *** this study,the predominant frequency of ground motion is evaluated using the Horizontal-to-Vertical (H/V) spectral ratio technique and recordings of ambient *** results of the H/V ratio show two peaks in about 20 percent of the locations,which are distributed mainly in and around the center and northern part of the kathmandu *** predominant frequencies vary from 0.5 Hz to 8.9 Hz in the study area,whereas the second resonance fiequency varies from 4 Hz to 6 Hz in the center and northern part of the *** indicates that the center and northern part of the valley have a wide range of resonance frequency due to two levels of impedance contrast- one may be from the surface layer and the other may be from the layer *** two levels of resonance indicate the importance of considering the effects of surface and lower layers during the planning and designing of infrastructures in the kathmandu Valley.

关键词： microtremor predominant frequency resonance kathmandu Valley

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Transmission Electron Microscopy Study of the Infrared Brazed High-strength Titanium Alloy

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Journal of Materials Science & Technology 2010年第4期26卷 311-316页

作者： Z.Y. Wu r.k. Shiue C.S. Chang Department of Materials Science and Engineering National Taiwan University Taipei 106 Taiwan China Engineered Materials Solutions 39 Perry Avenue MS 4-1 Attleboro MA 02703-2410 USA

The transmission electron microscopy was employed to investigate the microstructure of infrared brazed highstrength Ti alloy using the Ti-15Cu-15Ni filler metal. Coarse primary Ti2Ni and transformed β-Ti are observed in the 300 s brazed specimen. Blocky Ti2Ni and eutectoid Ti2Cu intermetallics are disappeared from the joint with increasing the brazing time to 1800 s. Both acicular α-Ti and retained β-Ti dominate the entire brazed joint.

关键词： Infrared Brazing Ti Ti-Cu-Ni filler Microstructure

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Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

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Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTrUMEr,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTrUMEr model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTrUMEr in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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