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New insight into the origin and evolution of the flora and fauna of Hainan Island, China

Science China Earth Sciences 2025年第1期68卷 52-61页

作者： Hua zhu Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants

The origin of the biota of Hainan Island, China, remains a fundamental scientific problem. Comparative studies on the biota, geological tectonics, and paleomagnetism proposed that during the Eocene, Hainan Island connected Vietnam and Guangxi, and then moved to the southeast to reach its present location. This review mainly discusses its biota origin from molecular phylogeny and palaeobotanical research. The formation and evolution of the biological groups of Hainan Island were identified via research on their genomes, phylogeny, and molecular biogeography. This research showed that the genera and species that appeared and diverged early in their evolution(i.e., before the Miocene) can be explained by the land connection between Hainan Island, Vietnam, and Guangxi during the Eocene-Oligocene. According to Southeast Asian tectonic theory, in the Middle Miocene(at about 15 million years ago), Hainan Island had moved to its present position. The population and genetic divergence of species with late divergence times(after 15 Ma) can be reasonably explained by the close proximity(or land connection) between Hainan Island and the Leizhou Peninsula, enabling genetic communication between Hainan Island and the Chinese mainland, but have exceptional cases. Conclusions have been obtained through palaeobotanical studies, showing that in the Eocene-Oligocene period, southwest China and Hainan Island had subtropical vegetation and flora. However, the fossil group in southeast China(in Maoming, near present-day Hainan Island) in the Late Eocene indicated a tropical rainforest vegetation and flora. This suggests that in the Paleogene, Hainan Island may have been located near or on the southwest border of Guangxi and northern Vietnam, rather than in its present location. The floristic division of the flora of Hainan Island basically presents a northeast-southwest inclined distribution pattern. This pattern can be explained by the counterclockwise rotation of Hainan Island during i

关键词： Molecular phylogeny Biogeography Paleobotany Origin of flora and fauna Hainan Island of China

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing rusen zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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Modification of Maxwell model for conductivity prediction of carbon nanotubes-filled polymer composites with tunneling effect

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 25-36页

作者： Jue zhu Longyuan LI Ningtao zhu Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and Pipeline Key Laboratory of Impact and Safety Engineering (Ningbo University) Ministry of Education School of Engineering Computing and Mathematics University of Plymouth Xi'an Zhanshi Testing & Engineering Co.Ltd.

Carbon nanotubes(CNTs) have garnered great attention in recent years due to their outstanding electrical, thermal, and mechanical properties. The incorporation of small amounts of CNTs in polymers can substantially improve the sensitivity of the polymer's electrical conductivity. This paper presents a modified Maxwell model to evaluate the electrical conductivity of CNTs-filled polymer composites by introducing a transition zone to account for the tunneling effect. In this modified Maxwell model, the CNTs-filled polymer composite is modeled as a three-phase composite, consisting of a matrix(polymer), inclusions(CNTs), and a transition zone(tunneling zone). The effective electrical conductivity(EEC) of the composite is calculated based on the volume fractions and electrical conductivities of the matrix, inclusions, and transition zone. The model's validity is confirmed through the use of available test data, which demonstrates its capability to accurately capture the nonlinear conductivity behavior observed in CNTs-polymer composites. This study offers valuable insights into the design of high-performance conductive polymer nanocomposites, and enhances the understanding of electrical conduction mechanisms in CNT-dispersed polymer composites.

关键词： Nanoclay

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腰椎间盘突出症神经根及神经节受累的磁共振神经成像研究

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临床放射学杂志 2022年第4期41卷 699-704页

作者：巴伟丽刘学焕朱如森包翠萍杨筠麻智慧刘筠天津医科大学研究生院 300070 天津市人民医院影像学部 300121 天津市人民医院脊柱外科 300121 南开大学人民医院转化医学研究院天津300121

目的初步探讨磁共振神经成像(MRN)技术评估腰椎间盘突出症神经根及神经节受累情况。方法搜集2021年2月至6月因腰骶神经根性疼痛就诊并诊断为腰椎间盘突出症患者49例。应用三维水激发双回波稳态(3D-DESS-WE)序列及三维可变翻转角快速... 详细信息

目的初步探讨磁共振神经成像(MRN)技术评估腰椎间盘突出症神经根及神经节受累情况。方法搜集2021年2月至6月因腰骶神经根性疼痛就诊并诊断为腰椎间盘突出症患者49例。应用三维水激发双回波稳态(3D-DESS-WE)序列及三维可变翻转角快速自旋回波(3D-SPACE)序列评价神经根及神经节显示清晰度并测量神经根、椎体、肌肉的信号强度及计算神经根/椎体、神经根/肌肉的对比噪声比(CNR)。在神经节显示更清晰的序列上测量神经根受压水平双侧神经节各方位最大径线并计算神经节体积。应用配对检验比较同水平双侧神经节测量指标及两种3D序列对神经显示情况。结果 3D-DESS-WE序列神经根及神经节主观评分均高于3D-SPACE序列。3D-DESS-WE序列CNR_(神经根/椎体)(0.70±0.08)高于3D-SPACE序列(0.63±0.11),而CNR_(神经根/肌肉)(0.18±0.09)低于3D-SPACE序列(0.70±0.09),差异均具有统计学意义(P<0.01)。神经根受压侧神经节前后径(6.62±1.22)mm、上下径(11.93±1.64)mm及体积(262.79±84.12)mm^(3)较健侧[(5.95±1.17)mm;(11.09±1.94)mm;(217.25±91.75)mm^(3)]明显增大,差异有统计学意义(P<0.01)。而受压侧神经节左右径与对侧差异无统计学意义(P=0.09)。结论 3D-DESS-WE序列对神经根及神经节的显示优于3D-SPACE序列。3D-DESS-WE序列可清晰显示腰椎间盘突出受压侧神经节肿大情况,且患侧脊神经节前后径及上下径较健侧肿大更明显,这可为临床制定针对性治疗策略提供客观影像学证据。

关键词：三维水激发双回波稳态序列可变反转角三维快速自旋回波序列腰骶神经根脊神经节腰椎间盘突出症

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Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO Jin-Hui YANG Guang zhu State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

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Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang Wang Yasu Chen Jie Li Chen zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

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仿生药物人工虎骨及钙剂在退行性腰椎滑脱椎间植骨融合治疗中的应用

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中国组织工程研究 2018年第36期22卷 5741-5745页

作者：胡炜阚顺利曹泽岗江泽华张学利朱如森天津市人民医院脊柱外科天津市300121

背景:人工虎骨是一种虎骨的仿生药物,具有与天然虎骨一致的成分及药理药效,能够祛风止痛和强筋骨,有效缓解骨质疏松所导致的腰酸背痛现象。目的:探究人工虎骨对退行性腰椎滑脱术后疼痛、功能障碍及植骨融合的作用效果。方法:采用随机数... 详细信息

背景:人工虎骨是一种虎骨的仿生药物,具有与天然虎骨一致的成分及药理药效,能够祛风止痛和强筋骨,有效缓解骨质疏松所导致的腰酸背痛现象。目的:探究人工虎骨对退行性腰椎滑脱术后疼痛、功能障碍及植骨融合的作用效果。方法:采用随机数字法将60例退行性腰椎滑脱症接受椎间植骨融合治疗的患者分为治疗组和对照组,每组各30例。治疗组给予人工虎骨粉及钙尔奇D,对照组只给予钙尔奇D。治疗前及治疗后7d及1,6,12个月分别采用目测类比评分法、Oswestry功能障碍指数(Oswestrydisabilityindex,ODI)评估,治疗后12个月观察椎间植骨融合率。结果与结论:(1)两组患者均顺利完成手术并接受不同药物干预;(2)治疗前两组目测类比、ODI评分差异无统计学意义;治疗后第6,12个月,治疗组目测类比评分和ODI评分显著优于对照组(P 0.05);(4)人工虎骨用于接受椎间融合的退行性腰椎滑脱患者能够缓解疼痛、改善功能障碍,但不能明显增加椎间植骨融合率。

关键词：腰椎滑脱人工虎骨疼痛椎间植骨融合退行性病变健骨组织构建

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Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li Wei-Hong zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

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成人骨髓源性神经干细胞肿瘤相关基因表达的分析

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中华神经医学杂志 2016年第9期15卷 865-870页

作者：朱汝森徐如祥姜晓丹蔡颖谦邹雨汐广东医科大学附属医院神经外科湛江524001 北京陆军总医院附属八一脑科医院北京100700 国家临床重点专科教育部工程技术研究中心广东省脑功能修复与再生重点实验室南方医科大学珠江医院神经外科广州510282

目的检测成人骨髓源性神经干细胞（Md-NSCs）中肿瘤相关基因的表达情况，评价其致瘤性。方法将体外培养并鉴定过的Md-NSCs作为实验组．以新鲜正常成人骨髓细胞去红细胞作为对照组。用人肿瘤基因芯片检测2组细胞440个肿瘤相关基因的表达... 详细信息

目的检测成人骨髓源性神经干细胞（Md-NSCs）中肿瘤相关基因的表达情况，评价其致瘤性。方法将体外培养并鉴定过的Md-NSCs作为实验组．以新鲜正常成人骨髓细胞去红细胞作为对照组。用人肿瘤基因芯片检测2组细胞440个肿瘤相关基因的表达：实时定量***检测2组细胞癌基因MYC、基质金属蛋白酶2（MMP2）、Notch同源物2motch2）、斯钙素I（STC1）、整合素α3（ITGA3）、信号转导与转录激活因子5b（STAT5b）、Ras同源物基因家族成员C（RhoC）、无翅型小鼠乳腺肿瘤病毒（MMTV）整合位点家族成员1（Wnt1）的表达。结果基因芯片检测结果显示，与对照组比较，实验组Md-NSCs中有66个肿瘤相关基因呈高度表达。实时定量RT-PCR检测结果显示，与对照组比较，实验组Md-NSCs中癌基因MYC、MMP2、Notch2、STCl、ITGA3、STAT5b、RhoC、Wnt1均呈高度表达，与基因芯片检测的结果相符。各高度表达基因及其表达倍数分别为：MYC（4．35×10^0）、MMP2（2．84×10^0）、Notch2（2．87×10^0）、STCl（3．41×10^2）、ITGA3（2．22×10^2）、STA1T5b（6．99×10^0）、RhoC（4．92×10^0）、Wnt1（3．64×10^0）。结论大量的肿瘤相关基因在Md-NSCs呈高度表达，其中部分基因的激活已被证实可以促进肿瘤的发生。

关键词：成人骨髓源性神经干细胞肿瘤相关基因基因芯片致瘤性

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Ⅸ型胶原蛋白A2基因多态性与环境因素在腰椎间盘退变疾病中的作用

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中华实验外科杂志 2017年第7期34卷 1232-1235页

作者：张学利宋海峰朱如森袁建军江泽华天津市人民医院脊柱脊髓病诊疗中心 300121

目的分析Ⅸ型胶原蛋白A2（C019A2）基因的单核苷酸多态性（SNP），用调查表对椎间盘退变性疾病（DDD）可能的危险因素（劳动强度、吸烟史、同类疾病家族史等），探讨COL9A2基因与环境因素对中国汉族人DDD发病的相关件，并评价其与椎间... 详细信息

目的分析Ⅸ型胶原蛋白A2（C019A2）基因的单核苷酸多态性（SNP），用调查表对椎间盘退变性疾病（DDD）可能的危险因素（劳动强度、吸烟史、同类疾病家族史等），探讨COL9A2基因与环境因素对中国汉族人DDD发病的相关件，并评价其与椎间盘退变严重程度的相关性。方法200例中国汉族DDD患者与80例对照组。所有研究对象均行惯椎磁共振成像（MRI）检查，提取全部研究对象的外周血DNA，采用病例一对照研究方法，对COL9A2基因在326位的氨基酸位置处的两个突变位点SNPI（rs7533552）和SNP2（rs2077871）进行基因检测。结合腰椎间盘退变危险因素的调查表，观察家族史、吸烟、劳动强度和与腰椎间盘退变的相关性。结果吸烟、劳动强度、DDD的家族史，与DDD相关。病例组中，rs2077871（SNP2）的TT和CT基因型频率显著高于对照组。其中TT在病例组的携带率（15／200，15．0），显著高于对照组（1／80，1．3％），两组比较差异有统计学意义[比值比（OR）=0．982，P=0．001]。进一步对候选基因不同的椎间盘退变程度进行关联分析中，rs2077871（SNP2）的TT基因型频率与椎间盘退变程度明最相关。结论DDD与环境因素（如劳动强度、吸烟等）以及阳性家族史均明显相关；以COL9A2基因为候选基因，发现其rs2077871的基因多态性与椎间盘退变性疾病明显相关；程度严重的椎间盘退变与候选基因多态性明显相关，高于程度较低的退变。

关键词：椎间盘退变单核甘酸环境因素关联分析

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