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World Journal of Gastroenterology 2014年第28期20卷 9541-9548页

作者： Xiao-Dong He Qiao Wu Wei Liu Tao Hong Jing-Jing Li ruo-yu miao Hai-Tao Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM: To evaluate the risk factors for ampullary adenoma and ampullary cancer.

关键词： Metabolic syndromes Ampullary adenoma Ampullary cancer Risk factors

Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

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Zoological Research 2024年第4期45卷 924-936页

作者： ruo-Wen Guo Wen-Jing Xie Biao yu Chao Song Xin-miao Ji Xin-yu Wang Mei Zhang Xin Zhang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD *** diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic *** this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD *** indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in *** the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory *** examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse *** findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

关键词： lzheimer’s disease Rotating magnetic field Amyloid-β Cognitive function Alzheimer’s disease animal models

Advanced electrospinning nanomaterials:From spinning fabrication techniques to electrochemical applications

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Nano Research 2024年第8期17卷 7077-7116页

作者： Jie Zhang miao yu Shuhui Tao College of Materials Science and Engineering Sichuan UniversityChengdu 610065China School of Mechanical Engineering Sichuan UniversityChengdu 610065China National University of Singapore(Chongqing)Research Institute Chongqing 401123China

Fuel cells,rechargeable metal–air batteries,metal-ion batteries,and supercapacitors have been regarded as prospective energy sources technologies to replace the fossil ***,electrochemical sensors also have been successfully developed as promising platforms for detecting pollutants,drug analysis,and healthcare *** is a scalable and suitable technique to design and fabricate diverse nanofibers and their nanocomposites for key components in electrochemical ***,a comprehensive review of electrospinning,from the technological innovations to the novel electrospun composite nanofibers,is *** importantly,the recent advances on the diverse components of electrochemical devices are highlighted,followed with the detailed discussion about the corresponding enhancement mechanism based on the electrospun ***,the currently faced challenges on the fabrication of electrospun nanomaterials are raised and a brief perspective for the future development of electrospun nanomaterials-based electrochemical applications is prospected.

关键词： electrospinning carbon nanofibers metal-organic frameworks electrode materials electrochemical applications

Heat Transfer Characteristics of a Microchannel Heat Sink with Highly-Dense Micro-Jet Arrays

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Journal of Thermal Science 2024年第3期33卷 1148-1160页

作者： ZHANG yu CHEN Xiaoyan miao Lin CHEN Liang HOU yu State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China Beijing Aerospace Technology Institute Beijing100083China

This paper proposed a new structure of highly-dense micro-jet arrays for hybrid jet-impingement/microchannel heat sinks(~120 jet per cm^(2) with jet width of 0.35 mm).Parametric study is performed to investigate the influence of structure and flow parameters on the convective heat transfer of water jet cooling in confined *** simulation results show that the optimal jet width,jet spacing and impingement distance are around 0.2 mm,0.2 mm and 0.3 mm,respectively,which can achieve a low thermal resistance as well as a relatively low pressure *** analysis of the heat transfer pathways shows that the micro-fin jet structures can extend the impinging heat transfer area and conduct a considerable proportion of heat,which can reach up to 38.9%with the Reynolds number ranging from 797.1 to *** heat transfer characteristics in the heat sink will shift from impingement dominated heat transfer to the channel-convection dominated heat transfer as the jet impingement distance increases.A correlation is proposed to predict the average Nusselt number on the stagnation area for the heat sink with different structure parameters,and the deviations of predictions from the numerical results are less than 10%.

关键词： hybrid heat sink impingement microchannel thermal management high heat flux

Capture Efficiency Analysis in the Circular Restricted Three-body Problem

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Research in Astronomy and Astrophysics 2024年第5期24卷 198-210页

作者： yu-Xuan miao Xi-yun Hou Department of Astronomy and Space Science Nanjing UniversityNanjing 210023China Institute of Space Environment and Astrodynamics Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two ***, a non-uniform distribution of test particles around the secondary's orbit is obtained by fully accounting the secondary's gravitational influence. Second, the capture efficiency is computed based on the non-uniform distribution. Several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency(p) and the mass ratio(μ) is established, which is given by p ≈ 0.27 × μ^(0.53), within the range of 3.0035 ×10^(-6)≤ μ ≤ 3.0034 × 10^(-5). Taking the Sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. Our studies find that the secondary's orbit eccentricity has a negative influence on the capture efficiency.

关键词： methods numerical-celestial mechanics-planets and satellites dynamical evolution and stability

Supplier Development under Supply Risk and Reputational Risk

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 360-388页

作者： Zhaowei miao yu Wang Rongjing Zhu Lili Shangguan School of Management Xiamen UniversityXiamen361005China School of Economics and Management Tsinghua UniversityBeijing100084China

This paper considers the supplier investment decision-making problem in a supply chain consisting of an original equipment manufacturer(OEM),a global supplier,and a local *** reduce dependence on global suppliers and improve supply stability,we develop a differential game model to investigate the optimal investment decisions of the OEM towards the local supplier under different risk scenarios and the impact of different risks on the optimal *** results show that investment efficiency and risks have a significant impact on OEM investment ***,when the OEM has higher investment efficiency,investing in the local supplier is profitable for the OEM;conversely,when the investment efficiency of the OEM is lower,it does not *** addition,an increase in the supply risk of the global supplier will lower the entry threshold for OEM investment,but an increase in the supply risk of the local supplier and the reputational risk of both will increase this threshold,meaning that only the OEM with significantly higher investment efficiency can profit.

关键词： Supplier investment supplier development supply risk reputational risk dual sourcing

International standard of Traditional Chinese Medicine techniques: the operating specification for Traditional Chinese Medicine enema(2022)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1035-1043页

作者： yu miao PEI Xiaohua Department of General surgery Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Department of Chest and Breast Surgery Beijing University of Chinese Medicine Xiamen Hospital

Chinese Medicine Enema is one of the external therapies in Traditional Chinese Medicine(TCM), which has been widely used clinically. The "International Standard of Traditional Chinese Medicine Techniques: The Operating Specifications for Chinese Medicine Enema is drawn up by the Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University and Beijing University of Chinese Medicine Xiamen Hospital in collaboration with domestic TCM universities and hospitals. The specification includes definition, operating process, points for attention and contraindications. It is targeted to provide reference for TCM providers at home and abroad with TCM background in clinical decision-making.

关键词： Chinese Medicine Enema international standard operating specifications traditional Chinese medical technology

Current status and trends in small nucleic acid drug development:Leading the future

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3802-3817页

作者： yuxi miao Chen Fu Zhaojin yu Lifeng yu yu Tang Minjie Wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation China Medical UniversityShenyang 110122China Liaoning Medical Diagnosis and Treatment Center Shenyang 110000China Department of Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042China

Small nucleic acid drugs,composed of nucleotides,represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based *** agents function by selectively targeting specific genes or their corresponding messenger RNAs(mRNAs),further modulating gene expression and regulating translation-related *** examples within this category include antisense oligonucleotides(ASO),small interfering RNAs(siRNAs),micro-RNAs(miRNAs),and *** emergence of small nucleic acid drugs as a focal point in contemporary biopharmaceutical research is attributed to their remarkable specificity,facile design,abbreviated development cycles,expansive target spectrum,and prolonged *** challenges such as poor stability,immunogenicity,and permeability issues have been addressed through the integration of chemical modifications and the development of drug delivery *** review provides an overview of the current status and prospective trends in small nucleic acid drug *** with a historical context,we introduce the primary classifications and mechanisms of small nucleic acid ***,we delve into the advantages of the *** and Drug Administration(FDA)approved drugs and mainly discuss the challenges encountered during their *** from researching chemical modification and delivery system that efficiently deliver and enrich small nucleic acid drugs to target tissues,promoting endosomal escape is a critical scientific question and important research direction in siRNA drug *** directions in this field will prioritize addressing these challenges to facilitate the clinical transformation of small nucleic acid drugs.

关键词： Small nucleic acid drugs Oligonucleotide drugs siRNA ASO miRNA Aptamer RNAi Drug development

Polymer-on-HOF:a new strategy for fabricating“armour-plated”HOFs to sequester radioactive anions

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Science China Chemistry 2024年第9期67卷 2958-2967页

作者： Hai-ruo Li Shitao Wu Xuezhuo Jing Zhengyi Di Kun Liu Lu Wang Cheng-Peng Li Zhong Liu miao Du College of Chemistry Tianjin Key Laboratory of Structure and Performance for Functional MoleculesTianjin Normal UniversityTianjin 300387China Shanghai Key Laboratory of High-Resolution Electron Microscopy School of Physical Science and TechnologyShanghaiTech UniversityShanghai 201210China Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Provincial Key Laboratory of Resources and Chemistry of Salt LakesQinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China College of Material and Chemical Engineering Institute of New Energy Science and TechnologySchool of Future Hydrogen Energy TechnologyZhengzhou University of Light IndustryZhengzhou 450001China

The development of hydrogen-bonded organic frameworks(HOFs)faces significant constraints,primarily attributed to their fragile architectures and limited functionalization *** overcome these limitations,this work presents a new polymeron-HOF strategy by covalently tethering armor-like polymers onto the surface of *** application of this approach not only bolsters the stability of HOFs,but also facilitates the customization of their functional expansion in radionuclide *** optimized HOF-polymer materials display extraordinary ability in radionuclide sequestration,achieving uptake of I^(-)(0.699 g g^(-1)),IO_(3)^(-)(0.285 g g^(-1))and ReO_(4)^(-)(1.616 g g^(-1),setting a world record),fast adsorption kinetics(~100% removal within 45 s),and exceptional regeneration capability(>30 cycles)under continuous flow *** outstanding performances benefit from the internal porous channels and surface imidazolium polymer coatings of HOFs,as proved by density functional theory calculation and molecular dynamics *** work paves the way for the rational design of HOF-based hybrid materials tailored to versatile applications.

关键词： hydrogen-bonded organic frameworks(HOFs) post-synthetic modification radionuclide sequestration

Tongue swelling as a manifestation of tongue metastasis from pulmonary sarcomatoid carcinoma: A case report

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World Journal of Clinical Oncology 2021年第4期12卷 282-289页

作者： Meng-Ni Guo Anum Jalil Jie-Ying Liu ruo-yu miao Tien Anh Tran Jian Guan Department of Internal Medicine AdventHealth OrlandoOrlandoFL 32804United States Department of Pathology AdventHealth OrlandoOrlandoFL 32804United States

BACKGROUND Sarcomatoid carcinoma is a rare subtype of non-small-cell lung cancer,commonly associated with locally advanced disease,early metastasis,and poor *** metastasis from lung cancer is a rare condition that may occur in advanced stage of the *** SUMMARY The patient was a 70-year-old female with a history of resected pulmonary sarcomatoid carcinoma(PSC)who presented with subacute tongue swelling,imparting the clinical impression of a lingual ***,histologic examination of the partial glossectomy revealed a high-grade,poorly differentiated spindle and epithelioid carcinoma consistent with metastatic *** Although uncommon,clinicians should be cognizant of the possibility of a metastatic process to the tongue mimicking a benign or inflammatory process.A high index of suspicion for metastatic disease should be maintained when tongue swelling is observed in patients with a known history of PSC.

关键词： Sarcomatoid carcinoma Lung cancer Tongue Metastasis Tongue swelling Case report