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Comparative analysis of C-type lectin domain proteins in the ghost moth, Thitarodes xiaojinensis (Lepidoptera: Hepialidae)

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Insect Science 2019年第3期26卷 453-465页

作者： Qian Meng Ji-Hong Zhang Huan Zhang Gui-Ling Zhou ruo-yao ni Yan-ni Zhao Qi-Lian Qin Zhen Zou State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology Chinese Academy of Sciences Beijing China College of Life Sciences Hebei University Baoding Hebei China University of Chinese Academy of Sciences Beijing China

Insects have a large family of C-type lectins involved in cell adhesion, pathogen recognition and activation of immune responses. In this study, 32 transcripts encoding C-type lectin domain proteins (CTLDPs) were identified from the Thitarodes xiaojinensis transcriptome. According to their domain structures, six CTLDPs with one carbohydraterecognition domain (CRD) were classified into the CTL-S subfamily. The other 23 CTLDPs with two CRDs were grouped into the immulectin (IML) subfamily. The remaining three with extra regulatory domains were sorted into the CTL-X subfamily. Phylogenetic analysis showed that CTL-S and CTL-X members from different insects could form orthologous groups. In contrast, no T. xiaojinensis IML orthologues were found in other insects. Remarkable lineage-specific expansion in this subfamily was observed reflecting that these CTLDPs, as important receptors, have evolved diversified members in response to a variety of microbes. Prediction of binding ligands revealed that T. xiaojinensis, a coldadapted species, conserved the ability of CRDs to combine with Ca^2+ to keep its receptors from freezing. Comparative analysis of induction of CTLDP genes after different immune challenges indicated that IMLs might play critical roles in immune defenses. This study examined T. xiaojinensis CTLDPs and provides a basis for further studies of their characteristics.

关键词： binding ligand carbohydrate-recognition domain C-type lectin domain protein expression profiling phylogenetic feature Thitarodes xiaojinensis

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Effective regulation mechanisms of Fe-ni(oxy)hydroxide:ni-rich heteroatomic bonding(ni–O–Fe–O–ni)is essential

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Nano Research 2023年第10期16卷 12026-12034页

作者： ruo-yao Fan Hui-Ying Zhao Zi-Yi Zhao Wen-Hui Hu Xin Liu Jian-Feng Yu Han Hu Yong-Ming Chai Bin Dong State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China Stanford PULSE Institute SLAC National Accelerator LaboratoryMenlo ParkCA 95025USA

Although Fe-ni combination performs well in transition metal-based oxygen evolution reaction(OER)electrocatalysts,there are lack of clear and general regulations mechanism to fully play the synergistic catalytic ***,we made the utmost of the interaction of Fe–ni heteroatomic pair to obtain a highly active Fe-ni(oxy)hydroxide catalytic layer on iron foam(IF)and nickel foam(NF)by in-situ electrochemical deposition and rapid surface reconstruction,which only required 327 and 351 mV overpotential to provide a large current of 1,000 mA·cm^(−2),*** results confirm that the moderate ni-rich heteroatomic bonding(ni–O–Fe–O–ni)formed by adjusting the ni/Fe ratio on the catalyst surface is important to offer predominant OER *** is a key component that enhances OER activity of ni(O)OH,but Fe-rich structural surface formed by Fe–O–ni–O–Fe bonding is not ***,the remarkable oxygen evolution performance of the prepared ni2Fe(O)OH/IF and Feni2(O)OH/NF can be chalked up to the optimized electronic structure of Fe–ni heteroatomic bonding,the efficient gas spillover,the fast electron transport,and nanosheet clusters *** summary,our work suggests a comprehensive regulation mechanism for the construction of efficient Fe-ni(oxy)hydroxide catalytic layer on inexpensive,stable,and self-supporting metallic material surface.

关键词： Fe-ni(oxy)hydroxide oxygen evolution reaction(OER) heteroatomic bonding ni-rich structure regulation mechanisms

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Bulging Distortion of Austenitic Stainless Steel Sheet on the Partially Penetrated Side of Non-Penetration Lap Laser Welding Joint

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 286-295页

作者： Chengwu yao Enze Liu Jiaming ni Binying nie Shanghai Key Laboratory of Materials Laser Processing and Modification School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Aerospace Precision Machinery Institute Shanghai 201600China Chemical and Biological Engineering College Yichun UniversityYichun 336000China

Non-penetration laser welding of lap joints in austenitic stainless steel sheets is commonly preferred in fields where the surface quality is of utmost ***,the application of non-penetration welded austenitic stainless steel parts is limited owing to the micro bulging distortion that occurs on the back surface of the partial penetration *** this paper,non-penetration lap laser welding experiments,were conducted on galvanized and SUS304 austenitic stainless steel plates using a fiber laser,to investigate the mechanism of bulging distortion.A comparative experiment of DC01 galvanized steel-Q235 carbon steel lap laser welding was carried out,and the deflection and distortion profile of partially penetrated side of the sheets were measured using a noncontact laser *** addition,the cold-rolled SUS304 was subjected to heat holding at different temperatures and water quenching after bending to characterize its microstructure under tensile and compressive *** results show that,during the heating stage of the thermal cycle of laser lap welding,the partial penetration side of the SUS304 steel sheet generates compressive stress,which extrudes the material in the heat-affected zone to the outside of the back of the SUS304 steel sheet,thereby forming a *** findings of these experiments can be of great value for controlling the distortion of the partial penetrated side of austenitic stainless steel sheet during laser non-penetration lap welding.

关键词： Non-penetration lap laser welding Bulging distortion Austenitic stainless steel Compressive stress Tension stress

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Expression and characterization of a new valosin-containing protein from silkworm

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Insect Science 2012年第5期19卷 549-558页

作者： Ping Chen ruo-Ran Wang Zhen Peng Qiong Liu Jia-Zuan ni Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun College of Life Sciences Shenzhen University Shenzhen Guangdong Province Graduate University of the Chinese Academy of Sciences Chinese Academy of Sciences Changchun China

Valosin-containing protein （VCP） is a type-II adenosine triphosphatase （ATPase） wih extensive biological function in organisms. Silkworm is the second in- sect model for genetic studies and a bioreactor for proteinaceous drugs and biomaterials. In this paper, a new VCP-like gene was amplified from the fat body of silkworm follow- ing genome prediction and spliced expressed sequence tag sequences, using both reverse transcription polymerase chain reaction （RT-PCR） and 3＇-RACE （rapid amplification of complementary DNA ends） methods. Bioinformatical analysis showed that the translated amino acid sequence contained a highly conserved domain of VCPs similar to that of many insects. This domain consists of the conserved structure motifs of the ATP binding site and the catalytical center, which is closely related to the insect VCPs in a phylogenetic tree. The silkworm VCP-like gene was successfully inserted into the plasmid and transformed into Escherichia coli cells to express VCP-like protein with ATPase activity. The expression of silkworm VCP-like protein was also confirmed by Western blotting and mass spectromet- ric analyses. Distribution of the VCP-like gene in various tissues of the silkworm was also studied by real-time PCR. Results showed that the messenger RNA （mRNA） of VCP-like protein is widely expressed in fat body, reproductive organs （testis or ovary）, silk gland, head, Malpighian tubule, epidermis and midgut. Among them, fat body has the highest mRNA expression level of the VCP-like gene, while the midgut has the lowest expression level. This study provides groundwork for further study on the structure and function of the new VCP-like protein.

关键词： ATPase activity Bombyx mori gene cloning protein expression real-timPCR valosin-containing protein

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Comparison of different versions of the quick sequential organ failure assessment for predicting in-hospital mortality of sepsis patients:A retrospective observational study

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World Journal of Emergency Medicine 2022年第2期13卷 114-119页

作者： Hai Hu Jing-yuan Jiang ni yao Emergency Office of West China Hospital Sichuan UniversityChengdu 610041China China International Emergency Medical Team Chengdu 610041China Emergency Department West China HospitalSichuan UniversityChengdu 610041China West China School of Nursing Sichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

BACKGROUND:The quick sequential organ failure assessment(qSOFA)is recommended to identify sepsis and predict sepsis ***,some studies have recently shown its poor performance in sepsis mortality *** enhance its effectiveness,researchers have developed various revised versions of the qSOFA by adding other parameters,such as the lactate-enhanced qSOFA(LqSOFA),the procalcitonin-enhanced qSOFA(PqSOFA),and the modified qSOFA(MqSOFA).This study aimed to compare the performance of these versions of the qSOFA in predicting sepsis mortality in the emergency department(ED).METHODS:This retrospective study analyzed data obtained from an electronic register system of adult patients with sepsis between January 1 and December 31,*** operating characteristic(ROC)curve analyses were performed to determine the area under the curve(AUC),with sensitivity,specificity,and positive and negative predictive values calculated for the various ***:Among the 936 enrolled cases,there were 835 survivors and 101 *** AUCs of the LqSOFA,MqSOFA,PqSOFA,and qSOFA were 0.740,0.731,0.712,and 0.705,*** sensitivity of the LqSOFA,MqSOFA,PqSOFA,and qSOFA were 64.36%,51.40%,71.29%,and 39.60%,*** specificity of the four scores were 70.78%,80.96%,61.68%,and 91.62%,*** LqSOFA and MqSOFA were superior to the qSOFA in predicting in-hospital ***:Among patients with sepsis in the ED,the performance of the PqSOFA was similar to that of the qSOFA and the values of the LqSOFA and MqSOFA in predicting in-hospital mortality were greater compared to *** the added parameter of the MqSOFA was more convenient compared to the LqSOFA,the MqSOFA could be used as a candidate for the revised qSOFA to increase the performance of the early prediction of sepsis mortality.

关键词： Quick sequential organ failure assessment In-hospital mortality Sepsis Lactate-enhanced qSOFA Modified qSOFA

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World Journal of Emergency Medicine 2022年第6期13卷 425-432页

作者： Hai Hu ni yao Xiao-qin Lai Emergency Management Office of West China Hospital Sichuan UniversityChengdu 610041China China International Emergency Medical Team Chengdu 610041China Sichuan University’s Emergency Medical Rescue Base Chengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China Day Surgery Center West China HospitalSichuan UniversityChengdu 610041China West China School of Nursing Sichuan UniversityChengdu 610041China

BACKGROUND:There is limited evidence for emergency physicians and emergency trauma surgeons regarding the determinants of early and rapid assessment of older adult in-hospital mortality due to *** study explored factors related to the early and rapid assessment of the mortality among older adult earthquake trauma patients(OAETPs)and created a screening ***:Data on 7,308 OAETPs from the West China Earthquake Patients Database were analyzed *** 35 variables that can be obtained rapidly on arrival at the hospital were *** absolute shrinkage and selection operator(LASSO)regression analysis was ***,the nomogram for assessing the mortality of OAETPs was ***:We identified 10 independent mortality-related factors that contributed to the in-hospital mortality of *** 10 factors included age(odds ratio[OR]=1.061,95%confidence interval[CI]:1.031-1.090),dementia(OR=5.146,95%CI:1.169-17.856),coronary heart disease(CHD;OR=23.441,95%CI:4.799-83.927),malignant tumor(OR=8.497,95%CI:3.583-17.967),deep vein thrombosis(DVT;OR=7.110,95%CI:1.369-27.168),chronic kidney disease(CKD;OR=11.783,95%CI:5.419-24.407),pulse rate(PR;OR=1.036,95%CI:1.022-1.048),mean artery pressure(MAP;OR=0.960,95%CI:0.945-0.975),Glasgow Coma Scale(GCS;OR=0.864,95%CI:0.760-0.972),and Triage Revised Trauma Score(T-RTS,OR=0.485,95%CI:0.351-0.696).CONCLUSION:The 10 mortality-related factors could be quickly obtained on hospital arrival and should be the focal point of future earthquake response strategies regarding hospitalized older adults with trauma.A nomogram was constructed based on the factors for screening OAETPs with a higher risk of in-hospital mortality.

关键词： Trauma Mortality Earthquakes Elderly patients

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Nonreciprocal metasurface with space-time phase modulation

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Light(Science & Applications) 2019年第1期8卷 30-38页

作者： Xuexue Guo Yimin Ding yao Duan Xingjie ni Department of Electrical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

Creating materials with time-variant properties is critical for breaking reciprocity that imposes fundamental limitations on wave ***,it is challenging to realize efficient and ultrafast temporal modulation in a photonic ***,leveraging both spatial and temporal phase manipulation offered by an ultrathin nonlinear metasurface,we experimentally demonstrated nonreciprocal light reflection at wavelengths around 860 *** metasurface,with travelling-wave modulation upon nonlinear Kerr building blocks,creates spatial phase gradient and multi-terahertz temporal phase wobbling,which leads to unidirectional photonic transitions in both the momentum and energy *** observed completely asymmetric reflections in forward and backward light propagations over a large bandwidth around 5.77 THz within a sub-wavelength interaction length of 150 *** approach highlights a potential means for creating miniaturized and integratable nonreciprocal optical components.

关键词： reciprocal phase nonlinear

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Resolution of DL-Pantolactone with Ethyldiamine Bridged Dimer Permethyβ-Cyclodextrin as GC Stationary Phase

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Chinese Chemical Letters 2001年第5期12卷 447-448页

作者： Dan ni TAO Xue Yan SHI Jun Ling GU ruo Nong FU College of Chemical Engineering and Materials Science Beijing Institute of TechnologyBeijing 100081 Department of Application Chemistry Chinese Agriculture UniversityBeijing 100094

Ethyldiamine bridged dimer permethy-β-CD and other cyclodextrins were used as GC stationary phase to resolute DL-pantolactone. It is found that this CD dimer has a good selectivity for DL-pantolactone.

关键词： Cyclodextrin dimer gas chromatography stationary phase.

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Geochemical speciation and spatial distributions of phosphorus in surface sediments from the basin of the Marcus-Wake seamounts in the western Pacific Ocean

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Acta Oceanologica Sinica 2022年第4期41卷 80-90页

作者： Chao Yuan Fansheng Meng Xuying yao Jianyu ni Key Laboratory of Submarine Geosciences Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China

The concentrations of five forms of phosphorus(P)including exchangeable or loosely adsorbed P(Ex-P),Febound P(Fe-P),authigenic P(Auth-P),detrital P(Det-P),and organic P(Org-P)from the basin among the Marcus-Wake seamounts(19.4°–24°N,156.5°–161.5°E)in the western Pacific Ocean were quantified using a sequential extraction method(SEDEX)to investigate the distribution and sources of different P *** of total P(TP)varied from 14.0μmol/g to 44.1μmol/g,with an average of(32.4±7.7)μmol/*** phosphorus,which was the major chemical form of sedimentary P,ranged from 12.6μmol/g to 40.6μmol/g,while the concentration of Org-P varied between 1.38μmol/g and 5.18μmol/g,accounting for 83.4%–93.4%and 6.6%–16.6%of the TP,*** relative proportions of the five P species followed the order of Det-P>Auth-P>Org-P>Fe-P>*** average,Det-P was the major P sink resulted from the atmospheric input and accounted for approximately 58.9%±12.4%of the ***-P and Org-P comprised 22.8%±11.4%and11.5%±3.0%of the TP,respectively,while Fe-P accounted for 5.1%±2.6%.Lastly,Ex-P comprised 1.6%±0.3%of the ***-P exhibited a negative correlation with Fe-P and Auth-P,while Fe-P showed a positive correlation with *** indicated that the formation of Fe-P and Auth-P was at the expense of the regeneration or remineralization of Org-P during early *** concentrations of Det-P and Auth-P as well as a low ratio of total organic C to reactive P(TOC/Rea-P)suggested that the aeolian input may play a significant role in sedimentary P budget in the study ***,well-oxygenated bottom water and low sedimentation rate could be responsible for the low TOC/Org-P ratio in the sediment.

关键词： phosphorus speciation SEDEX sediments western Pacific Ocean

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