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Diketopyrrolopyrrole-Au(I) as singlet oxygen generator for enhanced tumor photodynamic and photothermal therapy

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Science China Chemistry 2020年第1期63卷 55-64页

作者： Xiaoyu huang Rui Gu Jiewei Li Nan Yang Zijin Chen Weili si Peng Chen Wei huang Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemical and Biomedical Engineering Nanyang Technological UniversityNanyang 637459Singapore School of Chemistry and Materials Science Nanjing University of Information Science&TechnologyNanjing 210044China Shaanxi Institute of Flexible Electronics(siFE) Northwestern Polytechnical University(NPU)Xi'an 710072China

Diketopyrrolopyrrole(DPP)derivatived photosensitizers(PSs)with near infrared(NIR)absorption and good photophysical properties have drawn tremendous attention in cancer ***,current DPP derivatives present unsatisfactory quantum yield of singlet oxygen(1O2)due to the large energy gap between the excited singlet and triplet *** tackle this challenge,herein the DPP core is functionalized with triphenylphosphine-Au(I)group(Th DPP-Au),leading to a high1O2 quantum yield of *** calculation attributes the enhancement to spin-orbit coupling and population of the triplet excition upon *** hydrophilic Th DPP-Au nanoparticals(NPs)are prepared via nano-reprecipitation,which displays homogeneous size and excellent light absorption ability(ε=4.382×104 M-1cm-1).And the Th DPP-Au NPs exhibit low dark toxicity and high phototoxicity,which can effectively kill tumor cells via 1O2 induced mitochondrial apoptotic pathway upon ***,in vivo experiments demonstrate that Th DPP-Au NPs can selective accumulation in tumor and present excellent synergistic photodynamic/photothermal therapy guided by fluorescence and photothermal dual imaging.

关键词： diketopyrrolopyrrole-Au(I) singlet oxygen photodynamic therapy photothermal therapy

Film3立体化生态系统:Web3对影视产业的意义

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北京电影学院学报 2023年第2期 38-46页

作者：司若黄莺澳门科技大学人文艺术学院电影学院中国澳门清华大学新闻与传播学院

去中心化的Web3概念不仅已引发全球加密货币爱好者、科技巨头以及风险投资公司的兴趣,更是对全球影视产业产生着深远的影响力。本文从影视创作新变化、影视产业新形态两方面来论述Web3对影视产业的改变,指出Web3所带来的Film3状态,形成... 详细信息

去中心化的Web3概念不仅已引发全球加密货币爱好者、科技巨头以及风险投资公司的兴趣,更是对全球影视产业产生着深远的影响力。本文从影视创作新变化、影视产业新形态两方面来论述Web3对影视产业的改变,指出Web3所带来的Film3状态,形成了影视产业跨地域、跨媒介、跨物种、跨虚实的不断增厚的立体网络生态系统。

关键词： Web3 NFT 电影产业去中心化

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塑型、想象及构境:电影音乐情感影响力研究

当代电影 2024年第3期 136-143页

作者：司若黄莺清华大学新闻与传播学院澳门科技大学电影学院中国澳门

音乐在电影研究中曾长期被视为电影作品的辅助元素,但实际上,音乐是作为对人具有“超自然”式情感影响力的电影关键组成部分。本文先从历史角度追寻作为泛蒙太奇的影音流对人类思维与生活的塑造方式;其次,从哲学与脑科学角度分析人脑对... 详细信息

音乐在电影研究中曾长期被视为电影作品的辅助元素,但实际上,音乐是作为对人具有“超自然”式情感影响力的电影关键组成部分。本文先从历史角度追寻作为泛蒙太奇的影音流对人类思维与生活的塑造方式;其次,从哲学与脑科学角度分析人脑对电影音乐的回忆与再创作;最后,从格式塔理论角度阐述音乐通过电影给人带来的构境式情感影响力。

关键词：塑型构境电影音乐音乐情感影响力

A NEW QUADRILATERAL THIN PLATE ELEMENT BASED ON THE MEMBRANE-PLATE siMILARITY THEORY

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Applied Mathematics and Mechanics(English Edition) 2002年第3期23卷 259-270页

作者： huang ruo-yu ZHENG Chang-liang ZHONG Wan-xie YAO Wei-an State Key Laboratory of Structural Analysis of Industrial Equipment Dalian University of TechnologyDalian 116023P R China

A new effective path has been proposed to formulate thin plate element by using the similarity theory between plane elasticity and plate *** of avoiding the difficulty of c(1)continuity,the construction of thin plate elements becomes *** similarity theory and its applications were discussed more deeply,and a new four nodes,sixteen D.O.F.(degree of freedom)thin plate element was presented on the base of the similarity *** results for typical problems show that this new element can pass the patch test and has a very good convergence and a high precision.

关键词： plate bending membrane-plate similarity convergence finite element

巴洛克化与克苏鲁化:论Web 3.0时代纪实性视听内容的发展路径

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现代传播（中国传媒大学学报） 2024年第3期46卷 79-88页

作者：司若黄莺清华大学新闻与传播学院澳门科技大学电影学院中国澳门

纪实性视听内容在Web 3.0、人工智能等新技术赋能下从边界到类型选择、创作方式上都出现了很大变化。德勒兹用巴洛克风格的褶子所阐述出的哲学理念,很好地解释了纪实性内容边界模糊的趋势。制作主体的灵活度提高、媒介形式的变化,体现... 详细信息

纪实性视听内容在Web 3.0、人工智能等新技术赋能下从边界到类型选择、创作方式上都出现了很大变化。德勒兹用巴洛克风格的褶子所阐述出的哲学理念,很好地解释了纪实性内容边界模糊的趋势。制作主体的灵活度提高、媒介形式的变化,体现了褶子的堆叠与延展。当代纪实性内容创作类型有着较强的跨界融合特点。虚构类叙事手法在纪实性内容中大量运用,媒体环境变化带来了资本方对小众化选题的高度重视,技术革新使得纪实性内容有了更好的互动性。NFT、人工智能等技术的新发展,使纪实性内容出现了创作颗粒度细化的新特点。此外,人的主体性由于技术过度发展而产生动摇,克苏鲁化成为纪实性内容当前与未来的发展新趋势。

关键词：纪实性视听内容 Web 3.0 人工智能巴洛克克苏鲁

Patrinia scabiosaefolia Inhibits Growth of 5-FU-Resistant Colorectal Carcinoma Cells via Induction of Apoptosis and Suppression of AKT Pathway

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Chinese Journal of Integrative Medicine 2019年第2期25卷 116-121页

作者： huang si-zhou LIU Wang-yu huang Yue SHEN A-ling LIU Li-ya PENG Jun College of Pharmacy Fujian University of Traditional Chinese Medicine Fujian Key Laboratory of Integrative Medicine on Geriatric Academy of Integrative MedicineFujian University of Traditional Chinese Medicine

Objective: To investigate the effects of ethanol extract of Patrinia scabiosaefolia(EEPS) on chemo-resistance of colorectal cancer cells(CRC) and explore the possible molecular mechanisms. Methods: 5-fluorouracil(5-FU)-resistant human colorectal carcinoma cell line(HCT-8/5-FU) and its parental cells HCT-8 were treated with EEPS(0, 0.25, 0.50, 1 or 2 mg/mL), or 5-FU(0, 100, 200, 400, 800 or 1600 μmol/L). The 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay was performed to evaluate the cell viability. Cell density was observed by phase-contrast microscope, cell counting and colony formation assay were used to determine the cell proliferation of HCT-8/5-FU cells treated with 0, 0.5, 1 or 2 mg/mL EEPS. Cell apoptosis was determined by Hoechst staining. Western-blot was performed to detect the phosphorylation of AKT as well as the protein expression level of B-cell CLL/lymphoma 2(Bcl-2) and Bcl-2-associated X protein(Bax). Results: Compared with HCT-8 cells, MTT assay results indicated that HCT-8/5-FU cells were resistant to 5-FU treatment(Psitive to EEPS treatment(P>0.05). Moreover, compared with untreated HCT-8/5-FU cells, 1 and 2 mg/mL of EEPS treatment significantly reduced cell density, cell number, inhibited cell survival(Psis in HCT-8/5-FU cells. Furthermore, 1 and 2 mg/mL of EEPS significantly decreased the phosphorylation level of p-AKT and Bcl-2 protein expression, and increased the expression of Bax protein(Psion: EEPS is a promising therapeutic agent that may overcome chemo-resistance in cancer cells, likely through suppression of the AKT pathway and promotion of cancer cell apoptosis.

关键词： AKT pathway colorectal cancer 5-fluorouracil resistance Patrinia scabiosaefolia Chinese medicine

Comment on 'Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis'

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World Journal of Gastroenterology 2017年第32期23卷 6007-6008页

作者： Huan-Huan Sun si-lin huang Yang Bai Department of Gastroenterology Nanfang Hospital Southern Medical University

This is a comment on a meta-analysis of published studies comparing cold vs hot polypectomy. We believe that the conclusion of this meta-analysis that "cold polypectomy is a time-saving procedure for removing small po... 详细信息

关键词： Cold polypectomy Hot polypectomy Colon adenoma meta-analysis

single-centre study comparing standard apical dissection with a modified technique to facilitate vesico-urethral anastomosis during laparoscopic radical prostatectomy

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Asian Journal of Andrology 2011年第3期13卷 494-498,515页

作者： Xin Gao Xiao-Yong Pu Jie si-Tu Wen-Tao huang Department of Urology the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

A modified apical dissection of the prostate to improve the efficiency of vesico-urethral anastomosis （VUA） in laparoscopic radical prostatectomy （LRP） was reported. A total of 42 patients were randomly selected and enrolled in this study. A standard LRP was performed in 21 patients （group 1）, whereas a novel, modified apical dissection of the prostate in LRP was performed in another 21 patients （group 2）. Surgical data, total operative time, VUA time, extravasation rate, catheterisation time, occurrence of anastomotic strictures, and the early and late continence rates were analysed statistically. No differences in clinical or pathological characteristics were determined between the two groups. The total operative time, VUA time, blood loss and catheterisation time were lower in group 2, which received the novel, modified technique compared with group 1, which received the standard technique to dissect the apex of the prostate （P〈0.01 for each variable）. Regarding the extravasation rate and the occurrence of anastomotic strictures, no significant differences were found between the two groups （P〉0.0.05 for each）. After catheter removal, a statistically significant difference in the continence rates was present at 3 and 30 days post operation in the two groups （P〈0.01, respectively）. At 90 days post operation, the difference, although still present, was no longer statistically significant （P〉0.05）. The novel, modified apical dissection of the prostate facilitates the VUA and significantly improves the efficacy of the procedure and early restoration of continence.

关键词： continence laparoscopic technique radical prostatectomy vesico-urethral anastomosis

Digital image processing of saturation for two-phase flow in planar porous media model

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Water Science and Engineering 2012年第2期5卷 202-209页

作者： Zhi DOU Zhi-fang ZHOU si WANG Yong huang School of Earth Sciences and Engineering Hohai UniversityNanjing 210098R R.China

In this paper, the accuracy of estimating stained non-wetting phase saturation using digital image processing is examined, and a novel post-processing approach for calculating threshold is presented. In order to remove the effect of the background noise of images and to enhance the high-frequency component of the original image, image smoothing and image sharpening methods are introduced. Depending on the correct threshold, the image binarization processing is particularly useful for estimating stained non-wetting phase saturation. Calculated saturation data are compared with the measured saturation data during the two-phase flow experiment in an artificial steel planar porous media model. The results show that the calculated saturation data agree with the measured ones. With the help of an artificial steel planar porous media model, digital image processing is an accurate and simple method for obtaining the stained non-wetting phase saturation.

关键词： digital image processing " saturation " two-phase flow " planar porous media model