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Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression

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Journal of Biomedical Research 2024年第2期38卷 149-162,I0001-I0010页

作者： Lulu fan Hao Wang Shuai Ben Yifei Cheng Silu Chen Zhutao ding Lingyan Zhao Shuwei Li Meilin Wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving *** studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor ***,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular *** the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics *** then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target ***,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate *** current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.

关键词： super-enhancer prostate cancer genetic variants AhR BaP FAM227A

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N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation

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Asian Journal of Andrology 2024年第1期26卷 99-106页

作者： Wei ding Jun-Hong fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu Hai-Bo Zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei Department of Urology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China Department of Urology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Urology Shenzhen Immigration Inspection General Station HospitalShenzhen 518000China Department of Organ Transplantation The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China

Hyperlipidemia is a major risk factor for erectile dysfunction(ED).Oxidative stress and phenotypic modulation of corpus cavernosum smooth muscle cells(CcSMCs)are the key pathological factors of ED.N-acetylcysteine(NAC)can inhibit oxidative stress;however,whether NAc can alleviate pathological variations in the corpus cavernosum and promote erectile function recovery in hyperlipidemic rats remains unclear.A hyperlipidemia model was established using 27 eight-week-old male Sprague-Dawley(SD)rats fed a high-fat and high-cholesterol diet(hyperlipidemic rats,HR).In addition,9 male SD rats were fed a normal diet to serve as controls(NC).HR rats were divided into three groups:HR,HR+normal saline(NS),and HR+NAC(n=9 for each group;NS or NAc intraperitoneal injections were administered daily for 16 weeks).Subsequently,the lipid profiles,erectile function,oxidative stress,phenotypic modulation markers of ccsMCs,and tissue histology were *** experimental results revealed that erectile function was significantly impaired in the HR and HR+NS groups,but enhanced in the HR+NAC *** lipid levels,over-activated oxidative stress,and multi-organ lesions observed in the HR and HR+NS groups were improved in the HR+NAC ***,the HR group showed significant phenotypic modulation of CCSMCs,which was also inhibited by NAC *** report focuses on the therapeutic effect of NAc in restoring erectile function using a hyperlipidemic rat model by preventing CcSMC phenotypic modulationand attenuating oxidativestress.

关键词： erectile dysfunction hyperlipidemia N-acetylcysteine oxidative stress henotypic modulation

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Post-transcriptional regulation of grain weight and shape by the RBP-A-J-K complex in rice

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Journal of Integrative Plant Biology 2024年第1期66卷 66-85页

作者： ding Ren Hui Liu Xuejun Sun fan Zhang Ling Jiang Ying Wang Ning Jiang Peiwen Yan Jinhao Cui Jinshui Yang Zhikang Li Pingli Lu Xiaojin Luo State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology School of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China MOE Key Laboratory of Crop Physiology Ecology and Genetic Breeding College of AgronomyJiangxi Agricultural UniversityNanchang 330045China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China College of Agronomy Anhui Agricultural UniversityHefei 230036China

RNA-binding proteins(RBPs)are components of the post-transcriptional regulatory system,but their regulatory effects on complex traits remain *** an integrated strategy involving map-based cloning,functional characterizations,and transcriptomic and population genomic analyses,we revealed that RBP-K(LOC_Os08g23120),RBP-A(LOC_Os11g41890),and RBP-J(LOC_Os10g33230)encode proteins that form an RBP-A-J-K complex that negatively regulates rice yield-related *** of the RBP-A-J-K complex indicated RBP-K functions as a relatively non-specific RBP chaperone that enables RBP-A and RBP-J to function ***,RBP-J most likely affects GA pathways,resulting in considerable increases in grain and panicle lengths,but decreases in grain width and *** contrast,RBP-A negatively regulates the expression of genes most likely involved in auxin-regulated pathways controlling cell wall elongation and carbohydrate transport,with substantial effects on the rice grain filling process as well as grain length and ***,RBP-K is relatively ancient and highly conserved,whereas RBP-J and RBP-A are more ***,the RBP-A-J-K complex may represent a typical functional model for many RBPs and protein complexes that function at transcriptional and post-transcriptional levels in plants and animals for increased functional consistency,efficiency,and versatility,as well as increased evolutionary *** results clearly demonstrate the importance of RBP-mediated post-transcriptional regulation for the diversity of complex ***,rice grain yield and quality may be enhanced by introducing various complete or partial loss-of-function mutations to specific RBP genes using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9 technology and by exploiting desirable natural tri-genic allelic combinations at the loci encoding the components of the RBP-A-J-K complex through marker-assisted select

关键词： GL11 grain weight and shape post-transcriptional regulation RNA-binding proteins

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难以消逝的“先锋”记忆——从文学史的视角读《通古斯记忆》

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当代作家评论 2024年第3期 41-44页

作者：丁帆南京大学

2023年岁末,“王啸峰小说集《通古斯记忆》~①研讨会”在南京召开。与文学史上发生的大概率事件相比,这次研讨会是一个小概率事件,因为过去能够把这样的小说文本进行细读的人甚少。说实话,过去我还从未读过王啸峰的小说,会议前几天的匆... 详细信息

2023年岁末,“王啸峰小说集《通古斯记忆》~①研讨会”在南京召开。与文学史上发生的大概率事件相比,这次研讨会是一个小概率事件,因为过去能够把这样的小说文本进行细读的人甚少。说实话,过去我还从未读过王啸峰的小说,会议前几天的匆匆阅读,让我对这本小说集里的许多篇什产生了浓厚兴趣。不是因为小说故事情节吸引了我,而是它的创作方法和形式,激发了我对40年来文学史的联想。

关键词：小概率事件小说文本通古斯小说集记忆啸峰先锋创作方法

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铝/钢异种金属焊接接头腐蚀行为及其影响因素综述

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焊接学报 2024年第7期45卷 116-128页

作者：徐灏曹睿樊丁兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室兰州730050

铝/钢异种金属焊接接头结合了两种材料优异的性能,在各行各业具有较为广泛的应用.由于铝、钢两种金属之间理化性能的巨大差异以及极小的固溶度,导致铝/钢接头容易出现脆性金属间化合物、气孔等缺陷,严重影响着接头的力学性能.然而,随着... 详细信息

铝/钢异种金属焊接接头结合了两种材料优异的性能,在各行各业具有较为广泛的应用.由于铝、钢两种金属之间理化性能的巨大差异以及极小的固溶度,导致铝/钢接头容易出现脆性金属间化合物、气孔等缺陷,严重影响着接头的力学性能.然而,随着铝/钢接头越来越广的应用范围和复杂多样的应用环境,接头的耐腐蚀性能也得到了更多的关注.对近些年铝/钢异种金属焊接接头的耐腐蚀方面研究工作做了系统的汇总,旨在从接头腐蚀机理出发,提升接头的耐腐蚀性.综述了接头腐蚀形式规律,并从焊接工艺、腐蚀环境、微观组织和金属间化合物等影响因素的角度出发,详细地讨论了腐蚀行为与各因素之间的关系及影响机理.同时,指出了接头腐蚀机理,从各影响因素方面提出了改善接头耐腐蚀性能的措施,减小铝/钢接头实际服役过程中腐蚀所带来的影响.

关键词：铝/钢焊接接头腐蚀行为微观组织金属间化合物

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The Epidemiological Characteristics of Mpox Cases-China,2023

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China CDC weekly 2024年第26期6卷 619-623页

作者： Ruiqi Ren Chao Li Wenqing Bai Yali Wang Dan Li fan ding Niu Yan Qi Wang Nijuan Xiang Lianmei Jin Lei Zhou Wenling Wang fan Lyu Peilong Li Dapeng Zhang Yan Li Quanyi Wang Qun Li Guoqing Shi National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Beijing Municipal Center for Disease Prevention and Control BeijingChina

Summary What is already known about this topic?Since May 2022,a global outbreak of mpox has emerged in more than 100 non-endemic *** of December 2023,over 90,000 cases had been *** outbreak has predominantly affected men who have sex with men(MSM),with sexual contact identified as the principal mode of *** is added by this report?Since June 2023,China has faced an occurrence of mpox,predominantly affecting the MSM *** 90%of those affected reported engaging in homosexual behavior within 21 days prior to symptom onset,a trend that aligns with the global outbreak *** prompt identification of cases,diligent tracing of close contacts,and the implementation of appropriate management strategies have successfully mitigated the spread of mpox virus in *** are the implications for public health practice?We propose that mpox is transmitted locally within *** from our experiences in controlling the virus spread,it is crucial to investigate and formulate effective surveillance and educational ***,we must encourage high-risk populations to promptly seek medical care upon the onset of symptoms.

关键词： prompt Drawing spread

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Wafer-level substrate-free YIG single crystal film for a broadband tunable terahertz isolator

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Photonics Research 2024年第3期12卷 505-513页

作者： XILAI ZHANG DAN ZHAO ding ZHANG QIANG XUE FEI fan YULONG LIAO QINGHUI YANG QIYE WEN School of Electronic Science and Engineering State Key Laboratory of Electronic Thin Film and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu 610054China Tianjin Key Laboratory of Optoelectronic Sensor and Sensing Network Technology Institute of Modern OpticsNankai UniversityTianjin 300350China Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen 518110China

Yttrium iron garnet(YIG)is a promising material for various terahertz applications due to its special optical *** present,a high-quality YIG wafer is the desire of terahertz communities and it is still challenging to prepare substrate-free YIG single crystal *** this work,we prepared wafer-level substrate-free La:YIG single crystal films,for the first time,to our *** optical and magneto-optical properties of La:YIG films were characterized by terahertz time domain spectroscopy(THz-TDS).Results show that the as-prepared La:YIG film has an insertion loss of less than 3 dB and a low absorption coefficient of less than10 cm-1below 1.6 *** from the thickness of the substrate-free YIG films and low insertion loss,their terahertz properties could be further manipulated by simply using a wafer-stacking *** four La:YIG films were stacked,there was an insertion loss of less than 10 dB in the range of 0.1-1.2 *** Faraday rotation angle of the four-layer-stacked La:YIG films reached 19°,and the isolation could reach17 *** further increasing the stacking number to eight pieces,a remarkable Faraday rotation angle of45°was achieved with an isolation of 23 dB,which is important for practical application in the THz *** material may provide a milestone opportunity to make various non-reciprocal devices,such as isolators and phase shifters.

关键词： YIG film insertion

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通胀指数债券研究述评及对中国的启示

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新疆大学学报（哲学社会科学版） 2024年第1期52卷 90-98页

作者：刘若斯丁浩中南林业科技大学经济学院湖南长沙410004 广东外语外贸大学商学院广东广州510420

在疫情冲击叠加俄乌冲突、全球通胀高企的背景下,通胀指数债券因其保护投资者收益不受或少受通胀侵蚀的功能而价值凸显,有可能成为我国进一步深化改革的制度探索和改善民生的可选举措。鉴于其他国家或地区在该领域的实践和研究较为丰富... 详细信息

在疫情冲击叠加俄乌冲突、全球通胀高企的背景下,通胀指数债券因其保护投资者收益不受或少受通胀侵蚀的功能而价值凸显,有可能成为我国进一步深化改革的制度探索和改善民生的可选举措。鉴于其他国家或地区在该领域的实践和研究较为丰富,在探究实践根源与研究缘起后,对通胀指数债券的功能从投资者、发行人和货币当局三个视角进行了系统梳理并指出其风险。考虑到通胀指数债券的收益率为通胀预期提供了重要但是并不完美的信息,从流动性风险溢价和通胀风险溢价两个重要方面对已有研究进行了细致论述。最后对通胀指数债券领域未来的研究进行展望,并提出对中国的启示。

关键词：通胀指数债券通胀预期平准通胀率流动性风险溢价通胀风险溢价

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Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2819-2834页

作者： Jikai Deng Shimin Yang Yingjian Li Xue Tan Jiejie Liu Yanying Yu Qiang ding Chengpeng fan Hongyun Wang Xianyin Chen Qianyun Liu Xiao Guo Feiyu Gong Li Zhou Yu Chen State Key Laboratory of Virology RNA InstituteCollege of Life Sciences and Frontier Science Center for Immunology and MetabolismWuhan UniversityWuhanChina School of Medicine Tsinghua UniversityBeijingChina School of Basic Medical Sciences Wuhan UniversityWuhanChina Animal Bio-Safety Level Ⅲ Laboratory/Institute for Vaccine Research Wuhan University School of MedicineWuhanChina

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune ***,the K-D-K-E catalytic motif of 2′-O-MTase is highly conserved across numerous viruses,including flaviviruses,vaccinia viruses,coronaviruses,and extends even to ***,we observed a stronger 2′-O-MTase activity in SARS-CoV-2 compared to SARS-CoV,despite the presence of a consistently active catalytic *** further identified critical residues(Leu-36,Asn-138 and Ile-153)which served as determinants of discrepancy in 2′-O-MTase activity between SARS-CoV-2 and *** residues significantly enhanced the RNA binding affinity of 2′-O-MTase and boosted its versatility toward RNA *** interest,a triple substitution(Leu^(36)→Ile^(36),Asn^(138)→His^(138),Ile^(153)→Leu^(153),from SARS-CoV-2 to SARS-CoV)within nsp16 resulted in a proportional reduction in viral 2′-O-methylation and impaired viral ***,it led to a significant upregulation of type I interferon(IFN-I)and proinflammatory cytokines both in vitro and vivo,relying on the cooperative sensing of melanoma differentiation-associated protein 5(MDA5)and laboratory of genetics and physiology 2(LGP2).In conclusion,our findings demonstrated that alterations in residues other than K-D-K-E of 2′-O-MTase may affect viral replication and subsequently influence *** changes in nsp16 residues is crucial as it may aid in identifying and assessing future alteration in viral pathogenicity resulting from natural mutations occurring in nsp16.

关键词： pathogenesis impaired alterations

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A telomere-to-telomere genome assembly of Hongyingzi,a sorghum cultivar used for Chinese Baijiu production

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The Crop Journal 2024年第2期12卷 635-640页

作者： Yanqing ding Yilin Wang Jianxia Xu Feng Jiang Wenzhen Li Qiaoling Zhang Longping Yang Zhenyu Zhao Bin Cheng Ning Cao Xu Gao Xin Zhang Guihua Zou fan Yang Liyi Zhang Guizhou Institute of Upland Crops Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Kweichow Moutai Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Kweichow Moutai Distillery(Group)Hongyingzi Agricultural Technology Development Co. Ltd.Maotai TownRenhuai 564501GuizhouChina Wuhan GrandOmics Biosciences Co. Ltd.Grandomics BiosciencesWuhan 430000HubeiChina Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesZhejiang

Sorghum(Sorghum bicolor(L.)Moench)is a world cereal crop used in China for producing Baijiu,a distilled *** report a telomere-to-telomere genome assembly of the Baijiu cultivar Hongyingzi,HYZ-T2T,using ultralong *** 10 chromosome pairs contained 33,462 genes,of which 93%were functionally *** 20 telomeres and 10 centromeric regions on the HYZ-T2T chromosomes were predicted and two consecutive large inversions on chromosome 2 were characterized.A 65-gene reconstruction of the metabolic pathway of tannins,the flavor substances in Baijiu,was performed and may advance the breeding of sorghum cultivars for Baijiu production.

关键词： Sorghum Telomere-to-telomere assembly Hongyingzi(HYZ) Chinese Baijiu-making cultivar

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