N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation
作者机构：Department of UrologyThe First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China Department of UrologyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Department of UrologyNanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of UrologyShenzhen Immigration Inspection General Station HospitalShenzhen 518000China Department of Organ TransplantationThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000China Department of EndocrinologyThe First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2024年第26卷第1期
页 面：99-106页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：This work is supported by a grant from the National Natural Science Foundation of China(No.82060809) the Natural Science Foundation of Guangdong Province(No.2017A030313453 and No.2018A030313638) Guangzhou Basic and Applied Basic Research Foundation(No.202102020417)
主 题：erectile dysfunction hyperlipidemia N-acetylcysteine oxidative stress henotypic modulation
摘 要：Hyperlipidemia is a major risk factor for erectile dysfunction(ED).Oxidative stress and phenotypic modulation of corpus cavernosum smooth muscle cells(CcSMCs)are the key pathological factors of ED.N-acetylcysteine(NAC)can inhibit oxidative stress;however,whether NAc can alleviate pathological variations in the corpus cavernosum and promote erectile function recovery in hyperlipidemic rats remains unclear.A hyperlipidemia model was established using 27 eight-week-old male Sprague-Dawley(SD)rats fed a high-fat and high-cholesterol diet(hyperlipidemic rats,HR).In addition,9 male SD rats were fed a normal diet to serve as controls(NC).HR rats were divided into three groups:HR,HR+normal saline(NS),and HR+NAC(n=9 for each group;NS or NAc intraperitoneal injections were administered daily for 16 weeks).Subsequently,the lipid profiles,erectile function,oxidative stress,phenotypic modulation markers of ccsMCs,and tissue histology were *** experimental results revealed that erectile function was significantly impaired in the HR and HR+NS groups,but enhanced in the HR+NAC *** lipid levels,over-activated oxidative stress,and multi-organ lesions observed in the HR and HR+NS groups were improved in the HR+NAC ***,the HR group showed significant phenotypic modulation of CCSMCs,which was also inhibited by NAC *** report focuses on the therapeutic effect of NAc in restoring erectile function using a hyperlipidemic rat model by preventing CcSMC phenotypic modulationand attenuating oxidativestress.
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