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Management characteristics and prognosis after stroke in China:findings from a large nationwide stroke registry

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Stroke & Vascular Neurology 2021年第1期6卷 1-9页

作者： Haiqiang Qin Yiping Chen Gaifen Liu Iain Turnbull runhua zhang Zixiao Li Yilong Wang Liping Liu Xingquan Zhao Zhengming Chen Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Center of Stroke Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Medical Research Council Population Health Research Unit Nuffield Department of Population HealthUniversity of OxfordOxfordUK Clinical Trial Service Unit&Epidemiological Studies Unit Nuffield Department of Population HealthUniversity of OxfordOxfordUK

Background and purpose There is limited nationwide evidence about the standard management characteristics of stroke types and prognosis in *** study aimed to assess clinical characteristics,in-hospital and after-discharge management characteristics and prognosis for stroke types in *** A nationwide registry recruited 14244 imaging-confirmed first-ever incident strokes from 132 hospitals across 31 provinces of China during 2007-2008,recording presenting characteristics,diagnostic procedures and in-hospital *** hospital discharge,patients were followed up for 6 *** statistical methods were used to examine the patterns of management and *** Overall,68.7%,26.9%and 4.4%were ischaemic stroke(IS),intracerebral haemorrhage(ICH),and subarachnoid haemorrhage(SAH),*** 20%were managed in a dedicated stroke *** IS,1.3%received thrombolysis within 3 hours after symptom onset,whereas the proportions of receiving in-hospital antiplatelet therapy,neuroprotective agents and traditional Chinese medicines(TCM)were 88.4%,69.7%and 70.6%,*** ICH,63.3%and 36.3%received neuroprotective agents and TCM in hospital,*** discharge,70.7%and 38.0%of the patients with IS were given antiplatelet and statin therapies,respectively,decreasing to 64.8%and 23.9%,respectively,at 6 ***-hospital mortality was 3.2%,9.3%and 10.1%for IS,ICH and SAH,respectively,with a further 8.6%,18.2%and 22.0%,respectively,died by 6 ***,in-hospital recurrence rate was 2.6%,1.9%and 7.2%for IS,ICH and SAH,respectively,with a further 8.0%,5.1%and 7.5%,respectively,recurred by 6 *** In China,the mortality rate of stroke is lower than that reported from west populations,though most strokes are not managed in specialised stroke *** is widespread use of some unproven therapies but limited proven treatments,especially after discharge,leading to unnecessary recurrent risks.

关键词： protective prognosis mortality

Bessel vortices in spin-1 Bose-Einstein condensates with Zeeman splitting and spin-orbit coupling

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Chinese Physics B 2024年第10期33卷 159-165页

作者： Huan-Bo Luo Xin-Feng zhang runhua Li Yongyao Li Bin Liu Department of Physics South China University of TechnologyGuangzhou 510640China School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China

We investigate the ground states of spin-orbit coupled spin-1 Bose-Einstein condensates in the presence of Zeeman *** introducing the generalized momentum operator,the linear version of the system is solved exactly,yielding a set of Bessel ***,based on linear solution and using variational approximation,the solutions for the full nonlinear system and their ground state phase diagrams are derived,including the vortex states with quantum numbers m=0,1,as well as mixed *** this work,mixed states in spin-1 spin-orbit coupling(SOC)BEC are interpreted for the first time as weighted superpositions of three vortex ***,the results also indicate that under strong Zeeman splitting,the system cannot form localized *** variational solutions align well with numerical simulations,showing stable evolution and meeting the criteria for long-term observation in experiments.

关键词： spin-orbit coupling Bessel vortices variational method

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某集装箱船上层建筑振动控制方法

船舶工程 2019年第8期41卷 20-25页

作者：张润华中国船级社上海分社

对某集装箱船上层建筑出现的振动问题进行模态分析,找出引起其振动的主要激励源。在此基础上,提出几种增强上层建筑刚度的振动控制方案,并将其频率计算结果与激励频率相对比;同时,采用避开激励频率的方法给出上层建筑振动控制的优化方... 详细信息

对某集装箱船上层建筑出现的振动问题进行模态分析,找出引起其振动的主要激励源。在此基础上,提出几种增强上层建筑刚度的振动控制方案,并将其频率计算结果与激励频率相对比;同时,采用避开激励频率的方法给出上层建筑振动控制的优化方案。经实船振动测试,该优化方案的上层建筑振动响应有显著减少,验证了振动控制方法的有效性。

关键词：振动分析上层建筑固有频率实船振动测量

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转炉除尘循环水水处理工艺设计与运行效果

炼钢 1999年第1期15卷 21-24页

作者：张润华武汉钢铁集团公司

结合武钢某炼钢厂３座９０ｔ转炉除尘废水处理改造设计，通过现场调研、回访以及现场收集的大量实际运行资料，分析了“双文一塔”烟气除尘废水水质、水量特征。提出了转炉除尘循环水水处理最佳工艺流程，并对工艺设计特点、主要处理... 详细信息

结合武钢某炼钢厂３座９０ｔ转炉除尘废水处理改造设计，通过现场调研、回访以及现场收集的大量实际运行资料，分析了“双文一塔”烟气除尘废水水质、水量特征。提出了转炉除尘循环水水处理最佳工艺流程，并对工艺设计特点、主要处理构筑物及其设计参数的选择确定、主要设备选型以及水质稳定措施等问题作了较系统的阐述。最后，以现场实际运行资料为依据，分析说明：该转炉除尘废水由原来直排改为闭路循环，显示出了其巨大的环境效益、经济效益和社会效益。

关键词：转炉除尘循环水运行效果废水处理工艺设计

气温对北京市居民缺血性卒中和出血性卒中死亡影响的时间序列研究

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中华流行病学杂志 2023年第11期44卷 1802-1807页

作者：张润华王晶李刚刘改芬首都医科大学附属北京天坛医院北京100070 北京市疾病预防控制中心北京100013

目的分析日均气温对北京市居民缺血性卒中和出血性卒中死亡的影响。方法使用北京市2014年1月1日至2019年12月31日卒中死亡监测数据和气象数据,应用分布滞后非线性模型,校正时间长期趋势、星期效应、空气污染物和相对湿度,评价日均气温... 详细信息

目的分析日均气温对北京市居民缺血性卒中和出血性卒中死亡的影响。方法使用北京市2014年1月1日至2019年12月31日卒中死亡监测数据和气象数据,应用分布滞后非线性模型,校正时间长期趋势、星期效应、空气污染物和相对湿度,评价日均气温对缺血性卒中和出血性卒中死亡的累积效应。对性别和年龄进行分层分析以评价其效应修饰作用。结果2014-2019年北京市因卒中死亡人数共99222例,其中缺血性卒中69327例,出血性卒中24954例,其他未明确分类卒中4941例。分布滞后非线性模型分析显示,气温对卒中死亡风险影响呈非线性,且存在滞后性。对于缺血性卒中死亡,与卒中死亡风险最小所对应的温度(MMT,10.0℃)相比,极低温(-6.2℃)存在滞后效应,在滞后0~21 d时达到最大效应(RR=1.26,95%CI:1.04~1.51);极高温的效应自滞后0~3 d出现,到滞后0~14 d时累积RR值为2.13(95%CI:1.72~2.62)。对于出血性卒中死亡,极低温对卒中死亡风险较持续,以MMT(28.0℃)为参照,极低温在滞后0~21 d达到最大效应(RR=2.14,95%CI:1.23~3.70),而极高温作用较为短暂,只在滞后0~3 d的效应有统计学意义(RR=1.14,95%CI:1.01~1.28)。分层分析结果显示,极低温和较低温对女性的出血性卒中死亡效应高于男性,差异有统计学意义。而极高温可增加不同性别和年龄组人群缺血性卒中死亡风险。结论低温对缺血性卒中死亡风险具有滞后性,而对出血性卒中死亡风险较持续,高温对缺血性卒中死亡风险较持续,而对出血性卒中影响较短暂。性别和年龄可能会修饰气温对卒中死亡风险影响的效应大小。

关键词：气温卒中死亡率

Effects of Shuanghuanglian oral liquids on patients with COVID-19:a randomized,open-label,parallel-controlled,multicenter clinical trial

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Frontiers of Medicine 2021年第5期15卷 704-717页

作者： Li Ni Zheng Wen Xiaowen Hu Wei Tang Haisheng Wang Ling Zhou Lujin Wu Hong Wang Chang Xu Xizhen Xu Zhichao Xiao Zongzhe Li Chene Li Yujian Liu Jialin Duan Chen Chen Dan Li runhua zhang Jinliang Li Yongxiang Yi Wei Huang Yanyan Chen Jianping Zhao Jianping Zuo Jianping Weng Hualiang Jiang Dao Wen Wang Division of Cardiology Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China The First Affiliated Hospital of University of Science and Technology of China Hefei 230026China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Harbin Pharmaceutical Group Co. Ltd.Harbin 150070China The Sixth Hospital of Harbin Harbin 150036China The Second Hospital of Nanjing and the Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210003China Department of Cardiology Chinese People’s Liberation Army Central War Command General HospitalWuhan 430010China Department of Information Management Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Division of Respiratory Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

We conducted a randomized,open-label,parallel-controlled,multicenter trial on the use of Shuanghuanglian(SHL),a traditional Chinese patent medicine,in treating cases of COVID-19.A total of 176 patients received SHL by three doses(56 in low dose,61 in middle dose,and 59 in high dose)in addition to standard *** control group was composed of 59 patients who received standard therapy *** with SHL was not associated with a difference from standard care in the time to disease *** with 14-day SHL treatment had significantly higher rate in negative conversion of SARS-CoV-2 in nucleic acid swab tests than the patients from the control group(93.4%vs.73.9%,P=0.006).Analysis of chest computed tomography images showed that treatment with high-dose SHL significantly promoted absorption of inflammatory focus of pneumonia,which was evaluated by density reduction of inflammatory focus from baseline,at day 7(mean difference(95%CI),−46.39(−86.83 to−5.94)HU;P=0.025)and day 14(mean difference(95%CI),−74.21(−133.35 to−15.08)HU;P=0.014).No serious adverse events occurred in the SHL *** study illustrated that SHL in combination with standard care was safe and partially effective for the treatment of COVID-19.

关键词： COVID-19 SARS-CoV-2 Shuanghuanglian oral liquid clinical trial

草酰胺对菇渣混合基质理化性状和番茄幼苗生长的影响

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中国农学通报 2011年第22期27卷 271-275页

作者：张润花段增强中国科学院南京土壤研究所/土壤与农业可持续发展国家重点实验室南京210008

为提高工厂化育苗生产效率,降低生产成本,方便管理者取得简单易用的肥料,试验以菇渣有机复合基质为育苗基质,以缓效氮肥草酰胺为肥源,番茄为试验材料,采用穴盘育苗法研究了草酰胺在培育番茄壮苗中的施肥效果。结果表明,与施速效肥尿素基... 详细信息

为提高工厂化育苗生产效率,降低生产成本,方便管理者取得简单易用的肥料,试验以菇渣有机复合基质为育苗基质,以缓效氮肥草酰胺为肥源,番茄为试验材料,采用穴盘育苗法研究了草酰胺在培育番茄壮苗中的施肥效果。结果表明,与施速效肥尿素基质EC值相比,在整个育苗过程中,施缓效肥草酰胺的育苗基质EC值变化平缓,呈现缓慢上升而后缓慢下降的趋势;草酰胺施肥处理能够促进番茄幼苗对N、P、K营养元素的均衡吸收,利于鲜重、干重的快速积累,幼苗生长较快,株高、茎粗和叶绿素含量显著高于尿素处理,幼苗生长健壮。表明草酰胺是培育壮苗的优良氮肥肥源,能够促进番茄壮苗形成,操作简单适于工厂化育苗使用。

关键词：草酰胺菇渣基质肥料番茄

外源亚精胺对盐胁迫下黄瓜幼苗体内抗氧化酶活性的影响

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生态学杂志 2006年第11期25卷 1333-1337页

作者：张润花郭世荣樊怀福李娟南京农业大学园艺学院南京210095

以不同耐盐性黄瓜品种“长春密刺”和“津春2号”为材料,采用营养液栽培,研究了外源亚精胺(Spd)对NaCl胁迫下黄瓜幼苗叶片与根系中超氧阴离子(O2-.)产生速率、超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)活性的影响。结果表... 详细信息

以不同耐盐性黄瓜品种“长春密刺”和“津春2号”为材料,采用营养液栽培,研究了外源亚精胺(Spd)对NaCl胁迫下黄瓜幼苗叶片与根系中超氧阴离子(O2-.)产生速率、超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)活性的影响。结果表明,外源Spd对未经盐胁迫处理(对照)黄瓜幼苗体内O2-.产生速率、SOD、CAT和POD活性均无显著性影响;盐胁迫处理提高了O2-.产生速率,SOD、POD和CAT活性都有不同程度的升高;外源Spd处理进一步提高了盐胁迫下SOD、POD和CAT活性,减缓了O2-.产生速率。与耐盐型“长春密刺”品种相比,盐胁迫对盐敏感型“津春2号”影响较大,外源Spd对盐敏感型黄瓜品种盐胁迫伤害的缓解作用较大。表明盐胁迫下外源Spd可缓解盐胁迫对膜的伤害,从而提高黄瓜幼苗的耐盐性。

关键词：亚精胺盐胁迫黄瓜抗氧化酶

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盐胁迫对黄瓜根系活力、叶绿素含量的影响

长江蔬菜 2006年第2期 47-49页

作者：张润花郭世荣李娟南京农业大学园艺学院

采用营养液水培添加2.925g/LNaCl,研究了盐胁迫处理对黄瓜幼苗根系活力和叶片叶绿素含量的影响。结果表明:随着盐胁迫处理时间的延长,黄瓜幼苗根系活力呈现先升高后降低的变化趋势,叶绿素含量呈现下降的趋势;耐盐型品种长春密刺与盐敏... 详细信息

采用营养液水培添加2.925g/LNaCl,研究了盐胁迫处理对黄瓜幼苗根系活力和叶片叶绿素含量的影响。结果表明:随着盐胁迫处理时间的延长,黄瓜幼苗根系活力呈现先升高后降低的变化趋势,叶绿素含量呈现下降的趋势;耐盐型品种长春密刺与盐敏感型品种津春2号相比,受盐胁迫的影响小。

关键词：盐胁迫黄瓜根系活力叶绿素含量