检索结果-南通市图书馆

Nat Cell Biol:研究发现乳腺癌的新型细胞起源

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2017年第8期17卷 I0002-I0002页

作者： Leander Blaas, Agneta B. Andersson, Marco Gerling, Alexandra Musch, Dorothee Bornhorst rune toftg #x000E5 rd Fabio Pucci, Hendrik A. Messal, E. Josue Ruiz Axel Behrens Iyadh Douagi Bradley Spencer-Dene, Richard Stone Gordon Stamp Richard Mitter Leena Bhaw Abdul K. Sesay Jos Jonkers Ilaria Malanchi Axel Behrens Center for Innovative Medicine (CIMED) Department of Biosciences and Nutrition Karolinska Institutet Novum 141 83 Huddinge Sweden Adult Stem Cell Laboratory The Francis Crick Institute 1 Midland Road London NW1 1AT UK Department of Medicine Center for Hematology and Regenerative Medicine Karolinska Institutet Novum 141 83 Huddinge Sweden Experimental Histopathology The Francis Crick Institute 1 Midland Road London NW1 1AT UK Bioinformatics and Biostatistics The Francis Crick Institute 1 Midland Road London NW1 1AT UK Advanced Sequencing Facility The Francis Crick Institute Mill Hill Laboratory The Ridgeway London NW7 1AA UK Division of Molecular Pathology and Cancer The Netherlands Cancer Institute 1066 CX Amsterdam The Netherlands Tumour-Stroma Interactions in Cancer Laboratory The Francis Crick Institute 1 Midland Road London NW1 1AT UK Faculty of Life Sciences & Medicine King&#x02019 s College London Guy&#x02019 s Campus London SE1 1UL UK

乳腺癌是女性常见的癌症类型之一，长期以来科学家们知道并不是所有的乳腺癌都是相似的，腔体肿瘤主要包含一些和乳腺管内层细胞非常相似的细胞类型，而其它肿瘤所包含的细胞则同乳腺上皮组织外层的细胞相似，研究者认为，这种多样性起... 详细信息

乳腺癌是女性常见的癌症类型之一，长期以来科学家们知道并不是所有的乳腺癌都是相似的，腔体肿瘤主要包含一些和乳腺管内层细胞非常相似的细胞类型，而其它肿瘤所包含的细胞则同乳腺上皮组织外层的细胞相似，研究者认为，这种多样性起源于不同干细胞或祖细胞的突变，

关键词：细胞起源乳腺癌 Cell Nat 细胞类型上皮组织种多样性相似

Semen analysis with regard to and functional aspects sperm number, sperm morphology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第1期12卷 26-32页

作者： rune Eliasson Bjornstigen 13 SE 165 71 HASSELBY Sweden

The new World Health Organization （WHO） Manual for Semen Analysis contains several improvements. One is that the 20 million spermatozoa per mL paradigm has been ousted in favour of proper calculations of lower reference limits for semen from men, whose partners had a time-to-pregnancy of 12 months or less. The recommendation to grade the progressive motility as described in the third and fourth editions of the WHO manual was not evidence-based, and WHO was therefore motivated to abandon it. However, the new recommendation is not evidence-based either, and it is difficult to understand the rational for the new assessment. It may have been a compromise to avoid returning to the rather robust system recommended in the first edition （1980）. The unconditional recommendation of the ＇Tygerberg strict criteria＇ is not evidence-based, and seems to be the result of an unfortunate bias in the composition of the Committee in favour of individuals known to support the ＇strict criteria＇ method. This recommendation will have negative effects on the develop- ment ofandrology as a scientific field. Given the importance of the WHO manual, it is unfortunate that the recommenda- tions for such important variables, as motility and morphology, lack evidence-based support.

关键词： evaluation report semen analysis spermatozoa sperm morphology sperm motility

DIGITAL INCLUSION FOR PERSONS WITH DISABILITIES IN CHINA UNDER COVID-19:HOW FAR HAS CHINA COME?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Law in China-Selected Publications from Chinese Universities 2021年第1期16卷 35-57页

作者： HE Biao rune Halvorsen Faculty of Social Sciences Oslo Metropolitan UniversityOsloNorway Department of Social Work Child Welfare and Social PolicyOslo Metropolitan UniversityOslo 0130Norway Norwegian University of Science and Technology TrondheimNorwayDepartment of Social WorkChild Welfare and Social PolicyCEDIC-Center for the Study of Digitalization of Public Services and CitizenshipOslo Metropolitan UniversityOslo 0130Norway

This article reviews social regulatory and redistributive policies in China that aim at fostering digital inclusion of persons with *** examine the emerging Chinese policies and how China has responded to the impacts of the coronavirus disease(COVID-19)on digital inclusion in terms of redistribution,market regulation,involvement of persons with disabilities and disabled people’s organizations(DPOs),and awareness-raising *** policy review demonstrates that the Chinese policy framework contains a few redistributive initiatives,for example,cash transfer programs,and free distribution of information and communications technology(ICT).These have the potential to increase the uptake of ICT among persons with *** Chinese policy framework also includes provisions to ensure consultation with individual persons with disabilities and DPOs in the deliberation and implementation of ICT accessibility *** China has initiated awareness-raising campaigns among market actors about the importance of digital inclusion,so far,the Chinese government has adopted little legal regulation of the market to foster accessibility to *** article thus argues that some of the limitations may be due to the way state–market relations have developed since the economy opened up in *** from the growing benefits of several cash transfer programs,we have not seen major changes or adjustments to the current policy framework during the efforts to mitigate the impact of COVID-19 on digital inclusion.

关键词： disability policy digital inclusion accessibility social regulation China information and communication technology(ICT)

New solvent blends for post-combustion CO2 capture

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2019年第4期4卷 439-452页

作者： Hanna K.Knuutila rune Rennemo Arlinda F.Ciftja Norwegian University of Science and Technology Department of Chemical Engineering

In the current work five different solvent blends are experimentally studied and the reboiler duties are calculated using the so-called short-cut *** amines,2-(diethylamino)ethanol(DEEA),3-(Diethylamino)-1,2-propanediol(DEA-12PD),2-[2-(Diethylamino)ethoxy]ethanol(DEA-EO),1-(2-Hydroxyethyl)piperidine(12HE-PP)are blended with 3-(Methylamino)propylamine(MAPA)and ethanolamine(MEA).The first results from simple solvent screening are given and the cyclic capacities are calculated based data at 40℃ and 80℃.Then,five solvent systems are chosen for vapor–liquid equilibrium *** vapor–liquid equilibrium data are then used to estimate cyclic capacities at more realistic temperatures,between 40℃ and 120℃ and by using a short-cut method proposed in the literature the reboiler duties of the characterized solvents are ***,the potential of the studied systems is *** of the characterized blends showed reboiler duties around 2.5 MJ kgCO2^-1.

关键词： CO2 capture Chemical absorption Vapor-liquid equilibria

Non-homologous functions of the AlkB homologs

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2015年第6期7卷 494-504页

作者： rune Ougland Torbjørn Rognes Arne Klungland Elisabeth Larsen Clinic for Diagnostics and Intervention and Institute of Medical Microbiology Oslo University HospitalRikshospitalet0027 OsloNorway Department of Anesthesiology Division of Emergencies and Critical CareOslo University HospitalThe Norwegian Radium Hospital0310 OsloNorway Department of Informatics University of Oslo0316 OsloNorway Faculty of Medicine Institute of Basic Medical SciencesUniversity of Oslo0317 OsloNorway

TheDNArepair enzyme AlkB was identified in *** more than three decades *** then,nine mammalian homologs,all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases,have been identified(designated ALKBH1–8 and FTO).While *** AlkB serves as a DNA repair enzyme,only two mammalian homologs have been confirmed to repair DNA in *** other mammalian homologs have remarkably diverse substrate specificities and biological *** recognized by the different AlkB homologs comprise erroneous methyl-and etheno adducts in DNA,unique wobble uridine modifications in certain tRNAs,methylated adenines in mRNA,and methylated lysines on *** phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity,severe sensitivity to inflammation,infertility,growth retardation,and multiple *** we review the present knowledge of the mammalian AlkB homologs and their implications for human disease and development.

关键词： AlkB homologs ALKBH epigenetics histone demethylation DNA repair RNA repair tRNA modiﬁcation

A century of National Forest Inventory in Norway–informing past,present,and future decisions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2020年第4期7卷 602-620页

作者： Johannes Breidenbach Aksel Granhus Gro Hylen rune Eriksen Rasmus Astrup National Forest Inventory Norwegian Institute of Bioeconomy ResearchÅsNorway

Past:In the early twentieth century,forestry was one of the most important sectors in Norway and an agitateddiscussion about the perceived decline of forest resources due to over-exploitation was *** base thediscussion on facts,the young state of Norway established Landsskogtakseringen–the world’s first National ForestInventory(NFI).Field work started in 1919 and was carried out by *** were recorded on 10m wide stripswith 1–5 km *** quality and land cover categories were recorded along each *** for the firstcounty were published in 1920,and by 1930 most forests below the coniferous tree line were *** 2ndto 5th inventories followed in the years 1937–*** of 1954,temporary sample plot clusters on a 3 km×3 kmgrid were used as sampling ***:The current NFI grid was implemented in the 6th NFI from 1986 to 1993,when permanent plots ona 3 km×3 km grid were established below the coniferous tree *** of the 7th inventory in 1994,the NFIis continuous,and 1/5 of the plots are measured *** trees with a diameter≥5 cm are recorded oncircular,250 m2 *** NFI grid was expanded in 2005 to cover alpine regions with 3 km×9 km and 9km×9 km *** 2012,the NFI grid within forest reserves was doubled along the cardinal *** temporary plots are used periodically to facilitate county-level *** of today,more than 120variables are recorded in the NFI including bilberry cover,drainage status,deadwood,and forest *** are monitored and trees outside forests are ***:Considerable research efforts towards the integration of remote sensing technologies enable thepublication of the Norwegian Forest Resource Map since 2015,which is also used for small area estimation atthe municipality *** the analysis side,capacity and software for long term growth and yield prognosisare being ***,we foresee the inclusion of further variables for monitoring ec

关键词： Forest forest annually

First attempt to produce experimental Campylobacter concisus infection in mice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第45期14卷 6954-6959页

作者： rune Aabenhus Unne Stenram Leif Percival Andersen Henrik Permin sa Ljungh Department of Clinical Microbiology National University Hospital (Rigshospitalet) Department of Pathology University of Lund Department of Infectious Control and Prevention National University Hospital (Rigshospitalet) Department of Internal Medicine Bispebjerg Hospital Department of Medical Microbiology Dermatology and Infection Lund University

AIM： TO infect mice with atypical Campylobacter concisus （C. concisus） for the first time. METHODS： Three separate experiments were conducted in order to screen the ability of five clinical C. concisus isolates of intestinal origin and the ATCC 33237 type strain of oral origin to colonize and produce infection in immunocompetent BALB/cA mice. The majority of the BALB/cA mice were treated with cyclophosphamide prior to C. concisus inoculation to suppress immune functions. Inoculation of C. conc/sus was performed by the gastric route. RESULTS： C. concisus was isolated from the liver, ileum and jejunum of cyclophosphamide-treated mice in the first experiment. No C. concisus strains were isolated in the two subsequent experiments. Mice infected with C. concisus showed a significant loss of body weight from day two through to day five of infection but this decreased at the end of the first week. Histopathological examination did not consistently find signs of inflammation in the gut, but occasionally microabscesses were found in the liver of infected animals. CONCLUSION： Transient colonization with C. concisus was observed in mice with loss of body weight. Future studies should concentrate on the first few days after inoculation and in other strains of mice.

关键词： Animal model BALB/cA mice Campylobacter concisus Colonization Infection

Observation or resection of pancreatic intraductal papillary mucinous neoplasm:An ongoing tug of war

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2019年第12期11卷 1092-1100页

作者： Jan rune Aunan Nigel B.Jamieson Kjetil Sφreide Department of Gastrointestinal Surgery HPB UnitStavanger University HospitalStavanger 4068Norway Wolfson Wohl Cancer Research Centre Institute of Cancer SciencesUniversity of GlasgowGlasgow G611BDUnited Kingdom West of Scotland Pancreatic Unit Glasgow Royal InfirmaryGlasgow G40SFUnited Kingdom Gastrointestinal Translational Research Unit Laboratory for Molecular MedicineStavanger University HospitalStavanger 4068Norway Department of Clinical Medicine University of BergenBergen 5003Norway

An increasing number of patients are being referred to pancreatic centres around the world due to often incidentally discovered cystic neoplasms of the *** evaluation and management of pancreatic cystic neoplasms is a controversial topic and with existing guidelines based on a lack of strong evidence there is discordance between centres and guidelines with regard to when to offer surgery and when to favour *** frequency,duration and modality of surveillance is also controversial as this is resource-consuming and must be balanced against the perceived benefits and risks *** there is consensus that the risk of malignancy should be balanced against the lifeexpectancy and comorbidities,the indications for surgery and surveillance strategies vary among the ***,the tug of war between surveillance or resection *** we discuss the recommendations from guidelines with further accumulating data and emerging reports on intraductal papillary mucinous neoplasm in the literature.

关键词： Neoplasia Pancreatic cancer Pancreatic cyst Diagnosis Resection Surveillance Mutation Biomarker

Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第6期12卷 1103-1116页

作者： Marcello Meneghetti Jaspreet Kaur Kunyang Sui Jakob F.Sørensen rune W.Berg Christos Markos DTU Electro Department of Electrical and Photonics EngineeringTechnical University of DenmarkDK-2800 KgsLyngbyDenmark Department of Neuroscience University of CopenhagenBlegdamsvej 3BDK-2200 Kbh NCopenhagenDenmark NORBLIS ApS Virumgade 35DDK-2830 VirumDenmark

Controlling neuronal activity using implantable neural interfaces constitutes an important tool to understand and develop novel strategies against brain *** neurostimulation is a promising alternative to optogenetics for controlling the neuronal circuitry with high spatial ***,bi-directional interfaces capable of simultaneously delivering infrared light and recording electrical signals from the brain with minimal inflammation have not yet been ***,we have developed a soft fibre-based device using high-performance polymers which are>100-fold softer than conventional silica glass used in standard optical *** developed implant is capable of stimulating the brain activity in localized cortical domains by delivering laser pulses in the 2μm spectral region while recording electrophysiological *** and local field potentials were recorded in vivo from the motor cortex and hippocampus in acute and chronic settings,*** analysis of the brain tissue indicated insignificant inflammatory response to the infrared pulses while the signal-to-noise ratio of recordings still remained *** neural interface constitutes a step forward in expanding infrared neurostimulation as a versatile approach for fundamental research and clinically translatable therapies.

关键词： neural stimulation recording