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教育学理研究的法则意识

当代教育与文化 2024年第4期16卷 8-19页

作者：项继发山西大学教育科学学院山西太原030006

学科基础理论规范本学科的知识分类和概念范畴,决定学科的精神气质和思想品味。基础理论关注认识以及认识方式的普遍性问题,朝向法则性的理论表达。教育学理除了关心人在现实教育生活中的遭遇,还关注人的道德和心灵世界。教育学理的创... 详细信息

学科基础理论规范本学科的知识分类和概念范畴,决定学科的精神气质和思想品味。基础理论关注认识以及认识方式的普遍性问题,朝向法则性的理论表达。教育学理除了关心人在现实教育生活中的遭遇,还关注人的道德和心灵世界。教育学理的创造性要直面创制关于教育世界的法则的企图。法则性的工作就是哲学工作,它面向教育学科诸多基础理论问题,自带知识的开端意识,呈现为彻底的、诞生性的理论表达,暗含将要成为典范的知识期望。研究者获得法则的理论化工作,无法仅仅通过对先前教育思想遗产的承接和发现来实现,而是需要面对自己所处的具体的、历史性的社会现实来“发明”理论。发明理论是研究者带着先验创造的想象力,将主体意识置于与思想对象对话的思维空间中,从而直接认识事物的本质。理论的创造性是建立在理智直观基础上的思维想象力。理智直观是理智依靠概念的展开形式直接把握事物本质的认识过程,它为思维想象创造了自由活动的空间。创造性作品的完成,就是理智自由发挥达成的结果。

关键词：教育学理学理研究法则发明创造性

Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

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Light(Science & Applications) 2020年第1期9卷 450-465页

作者： Yanfeng Dai xiang Yu Jianshuang Wei Fanxin Zeng Yiran Li Xiaoquan yang Qingming Luo Zhihong Zhang Britton Chance Center and MOE Key Laboratory for Biomedical Photonics School of Engineering SciencesWuhan National Laboratory for Optoelectronics–Huazhong University of Science and TechnologyWuhanHubei 430074China School of Biomedical Engineering Hainan UniversityHaikouHainan 570228China

Detection of sentinel lymph nodes(SLNs)is critical to guide the treatment of breast ***,distinguishing metastatic SLNs from normal and inflamed lymph nodes(LNs)during surgical resection remains a ***,we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle(5K-HA-HPPS)loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast *** small sized(~40 nm)self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal *** with normal popliteal LNs(N-LN),there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs(T-MLN)and inflamed LNs(Inf-LN),respectively,6 h after nanoparticle *** importantly,photoacoustic microscopy(PAM)of 5KHA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and *** were mainly distributed at the centre of T-MLN but at the periphery of N-LN and *** ratio of PA intensity(R)at the centre of the LNs compared with that at the periphery was 5.93±0.75 for T-MLNs of the 5K-HA-HPPS group,which was much higher than that for the Inf-LNs(R=0.2±0.07)and N-LNs(R=0.45±0.09).These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs,thus guiding the removal of SLNs during breast cancer surgery.

关键词： breast injection cancer

A 10 Gbps in-line network security processor based on configurable hetero-multi-cores

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第8期14卷 642-651页

作者： Yun NIU Li-ji WU yang LIU xiang-min ZHANG Hong-yi CHEN National Laboratory for Information Science and Technology Tsinghua University Institute of Microelectronics Tsinghua University

This paper deals with an in-line network security processor （NSP） design that implements the Intemet Protocol Security （IPSec） protocol processing for the 10 Gbps Ethernet. The 10 Gbps high speed data transfer, the IPSec processing in- cluding the crypto-operation, the database query, and IPSec header processing are integrated in the design. The in-line NSP is implemented using 65 nm CMOS technology and the layout area is 2.5 mm^3 mm with 360 million gates. A configurable crossbar data transfer skeleton implementing an iSLIP scheduling algorithm is proposed, which enables simultaneous data transfer between the heterogeneous multiple cores. There are, in addition, a high speed input/output data buffering mechanism and design of high performance hardware structures for modules, wherein the transfer efficiency and the resource utilization are maximized and the IPSec protocol processing achieves 10 Gbps line speed. A high speed and low power hardware look-up method is proposed, which effectively reduces the area and power dissipation. The post simulation results demonstrate that the design gives a peak throughput for the Authentication Header （AH） transport mode of 10.06 Gbps with the average test packet length of 512 bytes under the clock rate of 250 MHz, and power dissipation less than 1 W is obtained. An FPGA prototype is constructed to verify the function of the design. A test bench is being set up for performance and function verification.

关键词： 10 Gbps Ethernet Network security processor (NSP) Internet Protocol Security (IPSec) Crossbar

New Discovery and Zircon Hf Isotopic Composition of the Early Yanshannian Monzogranite in the Yingyangguan Group of Eastern Guangxi, China

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Acta Geologica Sinica(English Edition) 2018年第4期92卷 1653-1655页

作者： LI xiang TU Bing WANG Lingzhan TIAN yang XIE Guogang ZHANG Jianyu Wuhan Center of Geological Survey China Geological Survey Research Center of Granitic Diagenesis and Mineralization China Geological Survey School of Earth Sciences China University of Geosciences

Objective The Yingyangguan Group is widely exposed in the southwestern segment of boundary belt between yangtze and Cathaysian blocks and is mainly composed of a suit of lower-grade metamorphic marine volcanoclastic- sedimentary rocks （Zhou Hanwen et al., 2002）. Its forming age and petrogenesis are critical for better understanding the orogenic process and relationship of the yangtze and Cathaysian blocks since the Neoproterozoic. However, few zircon U-Pb ages of samples from the Yingyangguan Group have been reported, which are much debated, such as the metamorphic spilite （819±11 Ma）, keratophyre （415.1±2.1 Ma） and ignimbrite （821.3±3.9 Ma）（Tian yang et al., 2015 and references in）. In this study, we focus on the new discovered Early Yanshannian monzogranite and its mafic enclaves from the Yingyangguan Group, and conducted zircon U-Pb dating and in-situ Hf isotopic analyses to constrain their petrogenesis.

关键词： Hf ICP MS Pb New Discovery and Zircon Hf Isotopic Composition of the Early Yanshannian Monzogranite in the Yingyangguan Group of Eastern Guangxi China

多输入多输出雷达搜索模式下5G毫米波射频算法

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吉林大学学报（工学版） 2024年第3期54卷 836-841页

作者：黄志祥彭照楠侯学师陈谦安徽大学电子信息工程学院合肥230601

为提升毫米波在射频传输中的传输安全,提出了多输入多输出(MIMO)雷达搜索模式下5G毫米波射频算法。根据5G毫米波的传输特性,获取了MIMO雷达搜索模式的雷达截获因子,建立了毫米波射频隐身模型并获取目标函数,计算了雷达搜索模式的射频截... 详细信息

为提升毫米波在射频传输中的传输安全,提出了多输入多输出(MIMO)雷达搜索模式下5G毫米波射频算法。根据5G毫米波的传输特性,获取了MIMO雷达搜索模式的雷达截获因子,建立了毫米波射频隐身模型并获取目标函数,计算了雷达搜索模式的射频截获概率。基于毫米波信道稀疏性结果结合贝叶斯算法获取了毫米波射频通道的最佳估计值,从而计算出射频通道最佳值,利用估计后的信号传输隐身后的射频实现射频传输。实验结果表明,本文方法在毫米波射频传输时间为140 s时,信纳比ρ高达0.83。证明使用该方法开展毫米波射频传输时,毫米波传输质量高,不易发生相位幅值的变形,可实现5G毫米波射频的高质量传输。

关键词：多输入多输出雷达搜索模式 5G毫米波射频算法射频隐身贝叶斯算法

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OsELF3 Is Involved in Circadian Clock Regulation for Promoting Flowering under Long-Day Conditions in Rice

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Molecular Plant 2013年第1期6卷 202-215页

作者： Ying yang Qiang Peng Guo-Xing Chen xiang-Hua Li Chang-Yin Wu National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan430070 China

Heading date is a critical trait that determines cropping seasons and regional adaptability in rice （Oryza sativa）. Research efforts during the last decade have identified some important photoperiod pathway genes that are conserved between Arabidopsis and rice. In this study, we identified a novel gene, Oryza sativa ELF3 （OsELF3）, which is a putative homolog of the ELF3 gene in Arabidopsis thaliana. OsELF3 was required for the control of heading date under long-day conditions. Its Tos17-tagging mutants exhibited a delayed heading date phenotype only under long-day, but not short-day, conditions. OsELF3 was highly expressed in leaf blades, and the OsELF3 protein was localized in the nucleolus. An obvious diurnal rhythm of OsELF3 transcript level was observed, with a trough in the early day and a peak in the late night in wild-type plants. However, this expression pattern was disrupted in oself3 mutants. Further inves- tigations showed that the expression of OsGI and Ghd7 was up-regulated in the oself3 mutant, indicating that OsELF3 acts as a negative regulator upstream of OsGI and Ghd7 in the flowering-time control under long-day conditions. The rhythmic expression of circadian clock-related genes, including some OsPRR members, was obviously affected in oself3 mutants. Our results indicated that OsELF3 acts as a floral activator in the long-day photoperiodic pathway via its cross- talk with the circadian clock in rice.

关键词： heading date photoperiod pathway circadian clock rice.

Gorham-Stout syndrome in China's Mainland:a case series of 67 patients and review of the literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 729-735页

作者： Po HU xiang-gui YUAN Xin-yang HU Fa-rong SHEN Jian-an WANG Cardiovascular Key Lab of Zhejiang Province Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Department of Cardiology Zhejiang Hospital Department of Internal Medicine Hangzhou Binjiang Hospital the Second Affiliated Hospital (Binjiang Branch) School of Medicine Zhejiang University

Objective:Gorham-Stout syndrome (GSS) is a rare disorder of uncertain etiology and unpredictable prognosis. This study aims to present a comprehensive understanding of this rare entity. Methods:A literature search in PubMed and three Chinese databases was performed to screen histologically proven GSS cases among Chinese residents in the mainland. We analyzed the patients' clinical characteristics, the value of different treatment modalities and their influence on the clinical outcome. Results:Sixty-seven cases were finally enrolled. There were 43 men (64.2%) and 24 women (35.8%). The mean age at diagnosis was 28 years (1.5-71 years). The most common clinical symptoms included pain (n=40, 59.7%), functional impairment (n=13, 19.4%), and swelling (n=12, 17.9%). The radiographic presentation of 37 cases (55.2%) was disappearance of a portion of the bone. The others presented as radiolucent foci in the intramedullary or subcortical regions. A total of 42 cases provided data on therapy, these included surgery (n=27, 40.3%), radiation therapy (n=6, 9.0%), surgery combined with radiation therapy (n=2, 3.0%), and medicine therapy (n=7, 10.4%). For 30 of these 42 cases, follow-up data were available:21 cases had the disorder locally controlled and 9 had a symptom progression. Fortunately, the disease is not fatal in the majority of cases. Conclusions:GSS has no specific symptoms and it should be taken into consideration when an unclear massive osteolysis occurs. The efficacies of different treatment modalities are still unpredictable and further research is required to assess the values of different treatments.

关键词： Gorham-Stout syndrome (GSS) Massive osteolysis Chinese

Comparison of phenolic profiles and antioxidant activities in skins and pulps of eleven grape cultivars(Vitis vinifera L.)

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Journal of Integrative Agriculture 2019年第5期18卷 1148-1158页

作者： LI Fu-xiang LI Fu-hua yang Ya-xuan YIN Ran MING Jian College of Food Science Southwest University Research Center of Food Storage & Logistics Southwest University Ernest Mario School of Pharmacy Rutgers University

Eleven grape cultivars were analysed to explore the variety differences of fresh grape phenolic profiles. The results showed that free phenolics were predominant in grape skins and pulps, and showed the higher antioxidant activities than bound. In 11 cultivars, Muscat Kyoho extracts had the highest total phenolic content in skins(10.525 mg GAE g^(–1) FW) and pulps(1.134 mg GAE g^(–1) FW), and exhibited the highest DPPH radical scavening capacity(EC_(50)=11.7 μg mL^(–1)) and oxygen radical absorbance capacity(ORAC) value(190.57 μmol TE g^(–1) FW) of free phenolic in skin. In addition, the most abundant phenolics in grape skins were found to be flavonoids such as kaempferol in Kyoho skin(541.2 μg g^(–1) FW), rutin, catechin and epicatechin in Muscat Kyoho skin(262.3, 86.3 and 70.0 μg g^(–1) FW, respectively). Furthermore, the principal component analysis showed a strong difference of phenolic profiles with the cultivars, existing forms and distributions. Pearson correlation coefficient analysis showed a significant linear correlation between total phenolic content and antioxidant activity(P<0.05). Therefore, both skins and pulps were rich sources of bioactive phenolic compounds, and Muscat Kyoho was the ideal source among all samples.

关键词： grape phenolics varietal diversity antioxidant activity principal component analysis

Review:Actin-based dynamics during spermatogenesis and its significance

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 498-506页

作者： XIAO xiang yang Wan-xi The Sperm Laboratory Institute of Cell Biology and Genetics School of Life Sciences Zhejiang University Hangzhou 310058 China

Actin can be found in all kinds of eukaryotic cells, maintaining their shapes and motilities, while its dynamics in sperm cells is understood less than their nonmuscle somatic cell counterparts. Spermatogenesis is a complicated process, resulting in the production of mature sperm from primordial germ cell. Significant structural and biochemical changes take place in the seminif-erous epithelium of the adult testis during spermatogenesis. It was proved that all mammalian sperm contain actin, and that F-actin may play an important role during spermatogenesis, especially in nuclear shaping. Recently a new model for sperm head elonga-tion based on the acrosome-acroplaxome-manchette complex has been proposed. In Drosophila, F-actin assembly is supposed to be very crucial during individualization. In this mini-review, we provide an overview of the structure, function, and regulation characteristics of actin cytoskeleton, and a summary of the current status of research of actin-based structure and movement is also provided, with emphasis on the role of actins in sperm head shaping during spermiogenesis and the cell junction dynamics in the testis. Research of the Sertoli ectoplasmic specialization is in the spotlight, which is a testis-specific actin-based junction very important for the movement of germ cells across the epithelium. Study of the molecular architecture and the regulating mechanism of the Sertoli ectoplasmic specialization has become an intriguing field. All this may lead to a new strategy for male infertility and, at the same time, a novel idea may result in devising much safer contraception with high efficiency. It is hoped that the advances listed in this review would give developmental and morphological researchers a favorable investigating outline and could help to enlarge the view of new strategies and models for actin dynamics during spermatogenesis.

关键词： Testis Actin Spermatogenesis Nuclear shaping Sertoli cell