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Microneedle-array patch with pH-sensitive formulation for glucoseresponsive insulin delivery

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Nano Research 2021年第8期14卷 2689-2696页

作者： Feng-Qin Luo Guojun Chen Wei Xu Daojia Zhou Jia-Xian Li Yong-Cong Huang run lin Zhen Gu Jin-Zhi Du Guangzhou First People’s Hospital and Institutes for Life SciencesSchool of MedicineSouth China University of TechnologyGuangzhou 510006China Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095-1413USA School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of TechnologyGuangzhou 510006China Department of Radiology the First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China National Engineering Research Center for Tissue Restoration and Reconstruction Key Laboratory of Biomedical Materials and Engineering of the Ministry of EducationKey Laboratory of Biomedical Engineering of Guangdong ProvinceInnovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510005China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China

Glucose-responsive insulin delivery systems show great promise to improve therapeutic outcomes and quality of life for people with diabetes.Herein,a new microneedle-array patch containing pH-sensitive insulin-loaded nanoparticles(NPs)(SNP(I))together with glucose oxidase(GOx)-and catalase(CAT)-loaded pH-insensitive NPs(iSNP(G+C))is constructed for transcutaneous glucose-responsive insulin delivery.SNP(I)are prepared via double emulsion from a pH-sensitive amphiphilic block copolymer,and undergo rapid dissociation to promote insulin release at a mild acidic environment induced by GOx in iSNP(G+C)under hyperglycemic conditions.CAT in iSNP(G+C)can further consume excess H_(2)O_(2) generated during GOx oxidation,and thus reduce the risk of inflammation toward the normal skin.The in vivo study on type 1 diabetic mice demonstrates that the platform can effectively regulate blood glucose levels within normal ranges for a prolonged period.

关键词： drug delivery diabetes glucose-responsive pH-sensitive microneedle

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可持续节水渠道衬砌设计与评价

海河水利 2024年第1期 40-42,46页

作者：林润霞满小军龙门县水利水电勘测设计室广东惠州516800 惠州市水土保持监督监测站广东惠州516003

以广东省惠州市龙门县渠道系统为例,对可持续节水渠道衬砌进行了设计与评价。通过调整设计横截面在选定的缩短距离(MRD)上进行数量和成本估算,择优选择普通水泥混凝土衬砌方式,实践证明该方式对渠道系统的长期运行是可行的。

关键词：混凝土衬砌渠道设计衬里评估可持续节水

橘红桔梗植物饮品对小鼠急性肺损伤和支气管哮喘的预防作用研究

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中国病理生理杂志 2024年第4期40卷 653-661页

作者：刘岩唐冬梅段蕊肖素军林润黄锦容赵明南方医科大学基础医学院病理生理学系广东省休克与微循环研究重点实验室广东广州510515 南华大学衡阳医学院附属南华医院心血管内科湖南衡阳421001

目的:观察橘红桔梗植物饮品(TPC)对脂多糖诱导的小鼠急性肺损伤(ALI)和卵清蛋白诱导的小鼠支气管哮喘的影响,并分析其作用机制。方法:(1)将48只雄性C57BL/6小鼠随机分成空白对照组、ALI组及低、中、高剂量(0.8、1.6和3.2 mL/d)TPC组,灌... 详细信息

目的:观察橘红桔梗植物饮品(TPC)对脂多糖诱导的小鼠急性肺损伤(ALI)和卵清蛋白诱导的小鼠支气管哮喘的影响,并分析其作用机制。方法:(1)将48只雄性C57BL/6小鼠随机分成空白对照组、ALI组及低、中、高剂量(0.8、1.6和3.2 mL/d)TPC组,灌胃给药,每日1次,持续1周及地塞米松阳性对照组。采用脂多糖气管内滴注建立小鼠ALI模型。采用HE染色法观察肺组织病理变化;流式细胞分析仪检测支气管肺泡灌洗液(BALF)中性粒细胞比例;ELISA检测BALF中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-6和IL-10含量;同时检测肺组织匀浆中的髓过氧化物酶(MPO)活性及肺组织中I-κBα和NF-κB的蛋白含量。(2)将48只雌性C57BL/6小鼠随机分成空白对照组、支气管哮喘组及低、中、高剂量(0.8、1.6和3.2 mL/d)TPC组,灌胃给药,每日1次,持续1周及地塞米松组。采用卵清蛋白腹腔注射致敏和鼻内刺激建立支气管哮喘小鼠模型。采用HE染色和甲苯胺蓝染色法观察肺组织病理变化;ELISA检测小鼠血清中IgE、IL-5和IL-13含量。结果:与空白对照组相比,ALI组小鼠肺组织病理学显示明显炎症细胞浸润;BALF中的中性粒细胞比例、MPO活性及TNF-α、IL-1β和IL-6含量显著升高(P<0.05),IL-10含量降低(P<0.05);Western blot结果显示肺组织中I-κBα蛋白含量降低,磷酸化NF-κB的蛋白含量升高(P<0.05)。与ALI组比较,高剂量TPC组和地塞米松组小鼠肺组织病理炎症明显减轻;BALF中的中性粒细胞比例、髓过氧化物酶活性及TNF-α、IL-1β和IL-6含量明显降低(P<0.05),IL-10含量升高(P<0.05);肺组织中I-κBα蛋白含量升高,磷酸化NF-κB的蛋白含量降低(P<0.05)。与空白对照组比较,支气管哮喘组小鼠肺组织病理有明显的炎症细胞及肥大细胞浸润;小鼠血清中的IgE和IL-13含量升高(P<0.05)。与支气管哮喘组相比,高剂量TPC组和地塞米松组小鼠肺组织病理炎症细胞及肥大细胞减少;小鼠血清中的IgE含量下降(P<0.05)。地塞米松组小鼠IL-13含量下降(P<0.05)。结论:TPC能在一定程度上预防脂多糖诱导的小鼠ALI,减轻支气管哮喘模型小鼠的过敏反应,其机制与抑制炎症反应、减少肥大细胞浸润和IgE生成有关。

关键词：橘红桔梗植物饮品急性肺损伤支气管哮喘炎症过敏反应

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Transient Stability Study of Power System with Large-Scale Wind Farm Integration

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Energy and Power Engineering 2017年第4期9卷 552-561页

作者： run lin Ruiye Liu Harbin Institute of Technology Research Institute of Power System Automation Harbin China

Large-scale wind power integration has become the current development trend of the power system. Large-scale wind power integration can change the original structure and characteristics of the system. Thus, it’s necessary to analyse the transient stability of power system which contains wind power, and to study the controlling strategy for improving the transient stability of power system. Based on EEAC, this paper studies the transient stability of the power system which contains wind power system theoretically, proposes the calculation method for accelerating area, decelerating area and margin, and illustrates the impact of wind power integration on the transient stability with power angle curve. Furthermore, this paper studies the modeling and simulation, and the experimental results prove the correctness of the theories.

关键词： Transient Stability DFIG EEAC Wind Farm Integration

基于圆弧样条参考路径的改进混合A^(*)泊车路径规划算法

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科学技术与工程 2024年第17期24卷 7376-7386页

作者：赵克刚曾润林梁志豪钟浩龙华南理工大学机械与汽车工程学院广州510641

在泊车空间狭窄的条件下,现有的基于混合A^(*)算法的泊车路径规划存在成功率低或规划速度慢等问题,为了解决这一问题,设计了一种改进混合A^(*)路径规划算法。通过将圆弧样条曲线作为参考路径,并以参考路径上的点作为混合A^(*)算法的目标... 详细信息

在泊车空间狭窄的条件下,现有的基于混合A^(*)算法的泊车路径规划存在成功率低或规划速度慢等问题,为了解决这一问题,设计了一种改进混合A^(*)路径规划算法。通过将圆弧样条曲线作为参考路径,并以参考路径上的点作为混合A^(*)算法的目标点,进而搜索出成功泊入车库的路径。根据不同车位宽度进行了基于MATLAB的批量仿真测试,结果表明:改进后的混合A^(*)算法能够显著提高车辆在特定区域泊入车库的成功率,同时具有一定的规划效率。最后基于Prescan、Carsim和Simulink进行了联合仿真实验,验证了所设计算法规划的路径满足实车实验的跟踪要求。

关键词：自动泊车路径规划混合A*算法参考路径圆弧样条

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基于正交试验的多级节流孔板流动特性分析

船海工程 2024年第1期53卷 21-25页

作者：肖龙洲甘润林蔡标华俞健胡洋武哲武汉第二船舶设计研究所武汉430205 华中科技大学机械科学与工程学院武汉430074

为降低多级节流孔板空化与湍流噪声,采用正交试验法分析多级节流孔板的孔分布、板厚、板间距等参数以及通流孔形状对空化和湍流噪声的影响,分析最小压力、湍流动能等流场参数的变化规律。通过极差分析得到各参数对流场性能影响的主次关... 详细信息

为降低多级节流孔板空化与湍流噪声,采用正交试验法分析多级节流孔板的孔分布、板厚、板间距等参数以及通流孔形状对空化和湍流噪声的影响,分析最小压力、湍流动能等流场参数的变化规律。通过极差分析得到各参数对流场性能影响的主次关系,并筛选出空化与湍流噪声优化方案,结果表明,在满足通流能力的情况下,多级节流孔板孔的开孔形状对空化的影响较为显著;适当的增加孔板厚度与板间距,可以抑制空化的产生;同时增加多级节流孔板板间距和孔的分布间距,可以让流动更加平缓,减小湍流噪声。

关键词：多级节流孔板正交试验空化湍流噪声

Prostate sclerosing adenopathy:A clinicopathological and immunohistochemical study of twelve patients

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World Journal of Clinical Cases 2022年第18期10卷 6009-6020页

作者： run-lin Feng Yan-Ping Tao Zhi-Yong Tan Shi Fu Hai-Feng Wang Department of Pathology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of Emergency Kunming Third People's HospitalKunming 650000Yunnan ProvinceChina Department of Urology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina

BACKGROUND Although sclerosing adenopathy of the prostate is a very rare benign disease,an effective differential diagnosis is required.Here,we report the clinicopathological and immunohistochemical morphological features of 12 cases of sclerosing adenopathy of the prostate to improve understanding of the disease.AIM To investigate the clinicopathological features,diagnosis,and immunohistochemical phenotypes that distinguish prostate sclerosing adenopathy from other conditions.METHODS The clinical data,laboratory tests,pathological morphology,and immunohistochemical phenotypes of 12 cases of prostatic sclerosing adenopathy were retrospectively analyzed,and the relevant literature was reviewed.RESULTS All patients were elderly men(mean age,71.7 years;62–83 years).Eleven of them had hematuria,urinary frequency,urinary urgency,difficulty in urination,and serum total prostate-specific antigen values within the normal range.One patient had increased blood pressure.Enlarged prostates with single to multiple calcifying foci were observed.Moreover,prostate tissue hyperplastic changes were observed in all patients.Small follicular hyperplastic nodules without an obvious envelope,with a growth pattern mimicking the infiltration pattern of"prostate adenocarcinoma"were noted.Basal cells expressed AR,CKH,P63,and CK5/6,and myoepithelial markers,such as calponin,S100,and smooth muscle actin.No recurrence or exacerbation of the lesions was observed,except for one case of death due to bladder cancer.CONCLUSION Prostatic sclerosing adenopathy is highly misdiagnosed as prostate adenocarcinoma or other tumor-like lesions.Therefore,it should attract the attention of clinicopathologic researchers.

关键词： Clinicopathology Immunohistochemistry Prostate disease Sclerosing adenopathy

Discordance analysis for apolipoprotein and lipid measures for predicting myocardial infarction in statin-treated patients with coronary artery disease:a cohort study

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Journal of Geriatric Cardiology 2023年第12期20卷 845-854页

作者： Tian-Yu LI Pei ZHU Ying SONG Xiao-Fang TANG Zhan GAO run-lin GAO Jin-Qing YUAN National Clinical Research Center for Cardiovascular Diseases National Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The optimal apolipoprotein or lipid measures for identifying statin-treated patients with coronary artery disease(CAD)at residual cardiovascular risk remain controversial.This study aimed to compare the predictive powers of apolipoprotein B(apoB),non-high-density lipoprotein cholesterol(non-HDL-C),low-density lipoprotein cholesterol(LDL-C),apoB/apolipoprotein A-1(apoA-1)and non-HDL-C/HDL-C for myocardial infarction(MI)in CAD patients treated with statins in the setting of secondary prevention.METHODS The study included 9191 statin-treated CAD patients with a five-year median follow-up.All measures were anal-yzed as continuous variables and concordance/discordance groups by medians.The hazard ratio(HR)with 95%CI was estimated by Cox proportional hazards regression.Patients were classified by the clinical presentation of CAD for further analysis.RESULTS The high-apoB-low-LDL-C and the high-non-HDL-C-low-LDL-C categories yielded HR of 1.40(95%CI:1.04–1.88)and 1.51(95%CI:1.07–2.13)for MI,respectively,whereas discordant high LDL-C with low apoB or non-HDL-C was not associa-ted with the risk of MI.No association of MI with discordant apoB versus non-HDL-C,apoB/apoA-1 versus apoB,non-HDL-C/HDL-C versus non-HDL-C,or apoB/apoA-1 versus non-HDL-C/HDL-C was observed.Similar patterns were found in patients with acute coronary syndrome.In contrast,no association was observed between any concordance/discordance category and the risk of MI in patients with chronic coronary syndrome.CONCLUSIONS ApoB and non-HDL-C better predict MI in statin-treated CAD patients than LDL-C,especially in patients with acute coronary syndrome.ApoB/apoA-1 and non-HDL-C/HDL-C show no superiority to apoB and non-HDL-C for predict-ing MI.

关键词： patients coronary infarction

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单丛茶多糖的表征及其体外降糖降脂活性研究

食品安全质量检测学报 2024年第7期15卷 283-288页

作者：彭紫君林润李泓杭吴小勇广东药科大学食品科学学院中山528453

目的探究单丛茶多糖的理化性质及其体外降糖降脂活性。方法以制得的单丛茶多糖为原料,采用苯酚-硫酸法、咔唑-硫酸法检测其糖占比情况,采用DEAE-52色谱柱分析其多糖组成情况,通过紫外光谱、傅里叶变换红外光谱、热重-差热分析对其进行... 详细信息

目的探究单丛茶多糖的理化性质及其体外降糖降脂活性。方法以制得的单丛茶多糖为原料,采用苯酚-硫酸法、咔唑-硫酸法检测其糖占比情况,采用DEAE-52色谱柱分析其多糖组成情况,通过紫外光谱、傅里叶变换红外光谱、热重-差热分析对其进行初步表征,通过扫描电镜观测其表面形貌,再通过测定其对α-葡萄糖苷酶,胰脂肪酶抑制率及体外胆酸盐结合能力,评价其体外降糖、降脂活性。结果该茶多糖的中性糖占比为(33.51±0.29)%,酸性糖占比为(47.39±0.47)%,DEAE-52色谱分离在洗脱剂NaCl溶液浓度0.9 mmol/L时出现一个主要峰,说明该茶多糖是一种酸性多糖。该多糖是以α构型的糖苷键连接的吡喃型糖环,且其中无核酸类和蛋白类杂质。热重-差热分析表明该多糖热稳定性较好。扫描电镜观测显示其为不规则片状结构,表面光滑且结构紧密。其与牛磺胆酸盐、甘氨胆酸盐和胆酸盐的结合率分别是(24.08±0.30)%、(8.30±0.70)%和(7.66±0.60)%,分别相当于阳性对照考来烯胺结合率的85.71%、31.58%和25.86%。其对α-葡萄糖苷酶和胰脂肪酶的抑制作用,最高分别达到了81.76%、61.16%,显示出较好的抑制效果。结论本研究获得的单丛茶多糖是一种酸性多糖,具有较好的体外降糖、降脂活性,在功能性食品及医疗保健领域具有良好应用前景。

关键词：单丛茶多糖胆酸盐结合能力降脂降糖