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A Magnetocatalytic Propelled Cobalt-Platinum@Graphene Navigator for Enhanced Tumor Penetration and Theranostics

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CCS Chemistry 2022年第7期4卷 2382-2395页

作者： Liang Zhang Qian Dong Hui Zhang Jieqiong Xu Shen Wang Lufeng Zhang Wentao Tang Zhaoqian Li Xin Xia Xinqi Cai Shengkai Li ruizi peng Zhengyu Deng Michael JDonovan Long Chen Zhuo Chen Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082 Faculty of Science and Technology University of MacaoTaipaMacao 999078 The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310022

Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy.In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment.However,one of the key challenges is to prepare nanomotors with an adequately small size,good biocompatibility,and precise positioning.Herein,we demonstrate a simple,ultrasmall,versatile,and real-time motion guidance strategy for magnetocatalytic CoPt@graphene navigators(MCGNs)that can enable highly efficient propulsion in the presence of H_(2)O_(2) or magnetic actuation.MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting,and the amount of drug in the tumor was three times than without navigation.By engaging movements powered through in situ energy conversion,MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery.

关键词： magnetocatalytic propelled nanomotors navigator tumor penetration photothermal therapy tumor theranostics

Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties

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Research 2019年第1期2019卷 859-867页

作者： Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu ruizi peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaChina Institute of Molecular Medicine(IMM) Renji HospitalShanghai Jiao Tong University School of Medicine and School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghaiChina Departments of Chemistry Physiology and Functional GenomicsMolecular Genetics and Microbiology and Pathology and Laboratory MedicineUF Health Cancer CenterCenter for Research at the Bio/Nano InterfaceUniversity of FloridaGainesvilleFLUSA

Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications.

关键词： attractive similarity preserve

New Insights from Chemical Biology:Molecular Basis of Transmission,Diagnosis,and Therapy of SARS-CoV-2

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CCS Chemistry 2021年第1期3卷 1501-1528页

作者： Zilong Zhao Yaling Wang Liping Qiu Ting Fu Yu Yang ruizi peng Mengyu Guo Lichun Mao Chunying Chen Yuliang Zhao Weihong Tan Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyHunan UniversityChangsha 410082 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190 The Cancer Hospital of the University of Chinese Academy of Sciences Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of SciencesZhejiang 310022 Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 University of Chinese Academy of Sciences Beijing 100049 GBA Research Innovation Institute for Nanotechnology Guangdong 510700

Coronavirus disease 2019(COVID-19)is caused by a novel strain of coronavirus,designated as severe acute respiratory syndrome coronavirus 2(SARSCoV-2).It has caused a global pandemic rapidly sweeping across all countries,bringing social and economic hardship to millions.Most countries have implemented early warning measures to detect,isolate,and treat patients infected with SARS-CoV-2.This minireview summarizes some of those steps,in particular,testing methods and drug development in the context of chemical biology,and discusses the molecular basis of COVID-19’s virulent transmissibility.

关键词： SARS-CoV-2 COVID-19 transmission diagnosis therapy

基于空洞转置卷积神经网络的人体骨骼关键点检测算法研究

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智能物联技术 2022年第1期54卷 8-13,42页

作者：彭睿孜施惠尹柳毅杭州电子科技大学浙江杭州310018

目前对人体姿态骨骼关键点检测存在两个研究难点,一是如何由2D姿态进行3D人体姿态估计,另一个是标准数据库和用户上传的视频动作在时间上不匹配。为此,本文提出基于空洞转置卷积的沙漏结构(Dilated and Transpose Convolutions Hourglas... 详细信息

目前对人体姿态骨骼关键点检测存在两个研究难点,一是如何由2D姿态进行3D人体姿态估计,另一个是标准数据库和用户上传的视频动作在时间上不匹配。为此,本文提出基于空洞转置卷积的沙漏结构(Dilated and Transpose Convolutions Hourglass,DTCH)神经网络;然后应用卡尔曼滤波算法进行数据降噪处理,最后利用动态时间规整(Dynamic Time Warping,DTW)算法提高患者运动时姿态匹配的准确性。在仿真实验中,该模型在Human3.6M数据集上的平均每关节位置误差(MPJPE)与相关研究的最佳结果相比减少了11%,可以精确高效地实现3D人体姿态估计。

关键词：空洞转置卷积神经网络骨骼关键点检测卡尔曼滤波 DTCH算法 DTW算法

Construction of bilayer PdSe2 on epitaxial graphene

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Nano Research 2018年第11期11卷 5858-5865页

作者： En Li Dongfei Wang peng Fan ruizi Zhang Yu-Yang Zhang Geng Li Jinhai Mao Yeliang Wang Xiao Lin Shixuan Du Hong-Jun Gao Institute of Physics & University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 1 O0190 Chino

Two-dimensional (2D) materials have received significant attention due to their unique physical properties and potential applications in electronics and optoelectronics. Recent studies have demonstrated that exfoliated PdSe2, a layered transition metal dichalcogenide (TMD), exhibits ambipolar field-effect transistor (FET) behavior with notable performance and good air stability, and thus serves as an emerging candidate for 2D electronics. Here, we report the growth of bilayer PdSe2 on a graphene-SiC(0001) substrate by molecular beam epitaxy (MBE). A bandgap of 1.15 ± 0.07 eV was revealed by scanning tunneling spectroscopy (STS). Moreover, a bandgap shift of 0.2 eV was observed in PdSe2 layers grown on monolayer graphene as compared to those grown on bilayer graphene. The realization of nanoscale electronic junctions with atomically sharp boundaries in 2D PdSe2 implies the possibility of tuning its electronic or optoelectronic properties. In addition, on top of the PdSe2 bilayers, PdSe2 nanoribbons and stacks of nanoribbons with a fixed orientation have been fabricated. The bottom-up fabrication of low-dimensional PdSe2 structures is expected to enable substantial exploration of its potential applications.

关键词： two-dimensional materials transition-metal dichalcogenides PdSe 2 scanning tunneling microscopy/spectroscopy semiconducting bandgap nanoribbon

清华简《郑武夫人规孺子》《郑文公问太伯》中郑国权贵女性涉政问题探析

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中州学刊 2023年第4期 131-134页

作者：彭邦本韩昊坤四川大学历史文化学院成都610065

《郑武夫人规孺子》中武姜涉政现象集中在:告以先君事迹、教诲郑孺子并要求他让政于大夫三年。武姜涉政,以对新君一系列的要求为主要内容,起到促进新君与旧臣相洽的效果。武姜履行礼制规范并取得成效,展现了礼制和稳定政治之间互相促进... 详细信息

《郑武夫人规孺子》中武姜涉政现象集中在:告以先君事迹、教诲郑孺子并要求他让政于大夫三年。武姜涉政,以对新君一系列的要求为主要内容,起到促进新君与旧臣相洽的效果。武姜履行礼制规范并取得成效,展现了礼制和稳定政治之间互相促进的可能性。《郑文公问太伯》中,太伯劝诫郑文公毋淫逸荒怠,暗示其狎近荆宠将给政事造成困难。两篇文献丰富了春秋时期权贵女性涉政现象,展现了权贵女性在平衡君卿关系、积极配合新君施政方面所起到的重要作用。

关键词：郑武夫人荆宠涉政现象家内职责

蜂窝式VPO低温脱硝催化剂浸渍法成型实验研究

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安徽工业大学学报（自然科学版） 2021年第3期38卷 275-281页

作者：田迎春彭永丽殷翼云郑睿子蒋进贾勇马鞍山学院建筑工程学院安徽马鞍山243100 安徽工业大学能源与环境学院安徽马鞍山243002

采用超声辅助溶液浸渍法制备蜂窝式钒磷氧(VPO)低温脱硝催化剂,考察活性组分水浴加热时间、载体浸渍时间、浸渍温度、超声时间和超声功率等成型工艺因素对其催化转化NOx性能的影响,优化催化剂成型工艺条件;同时,对制备的蜂窝式VPO催化... 详细信息

采用超声辅助溶液浸渍法制备蜂窝式钒磷氧(VPO)低温脱硝催化剂,考察活性组分水浴加热时间、载体浸渍时间、浸渍温度、超声时间和超声功率等成型工艺因素对其催化转化NOx性能的影响,优化催化剂成型工艺条件;同时,对制备的蜂窝式VPO催化剂的机械强度和抗硫抗水性能进行研究。结果表明:蜂窝式成型催化剂最佳活性对应的制备条件为蜂窝载体在活性组分溶液(水浴6 h,80℃)中浸渍4 h(60℃),辅以超声1.0 min(250 W);此条件下制备的催化剂在反应温度180℃时的脱硝率为95%,240℃时的脱硝率接近100%,其机械强度符合国家标准,且具有良好的抗硫抗水性能。

关键词：氮氧化物低温脱硝钒磷氧催化剂成型