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Biodegradable porous Zn-1Mg-3βTCP scaffold for bone defect repair:In vitro and in vivo evaluation

Journal of Materials Science & Technology 2023年第31期162卷 189-202页

作者： Runhua Yao Hui Wang Ruifeng Shan Lin Liu Yuyu Zhao Yonghua Sun Xiaohong Yao Di Huang ruiqiang hang Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Xinhua Chemical Defense Equipment Research Institute Co. LtdTaiyuan 030008China Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030060China

Zn-based materials are promising as bone repair materials,but their poor mechanical property and bioactivity as well as low degradation rate render the potential *** structural and material design can address the *** this study,porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds with 40%and 60%preset porosities were fabricated via heating-press sintering using NaCl particles as space holders,and their mechanical properties,in vitro degradation behavior,cytotoxicity and in vivo osteogenic activities were *** results showed that the actual porosities of the scaffolds were 22%and 50%.Mg exists in the form of Zn 2 Mg and Zn 11 Mg 2,whileβ-TCP evenly distributed in the *** compressive yield strength of scaffolds ranges from approximately 58.46 to 71.04 MPa,which is close to that of cancellous *** in vitro degradation tests showed that the corrosion rate of the scaffolds was in the range of about 2.73-4.28 mm y^(-1).Moreover,the scaffolds not only provided great space for osteoblasts adhesion and proliferation in vitro but also possessed favorable degradability and osteogenic activity in *** porous Zn-1 wt.%Mg-3 vol.%β-TCP scaffolds manifest reliable mechanical properties,desirable degradability,and osteogenic activity,which are promising as next-generation bone repair materials.

关键词： Biodegradation Zn-based composites Porous scaffolds Bone repair

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Corrosion behavior,antibacterial ability,and osteogenic activity of Zn-incorporated Ni-Ti-O nanopore layers on NiTi alloy

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Journal of Materials Science & Technology 2022年第2期97卷 69-78页

作者： Yonghua Sun Yuyu Zhao He Zhang Youjie Rong Runhua Yao Yi Zhang Xiaohong Yao ruiqiang hang Laboratory of Biomaterial Surfaces&Interfaces Institute of New Carbon MaterialsCollege of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Development of bone fixation devices with excellent corrosion resistance,antibacterial ability,and osteogenic activity is critical for promoting fracture *** this study,Zn-incorporated nanopore(NP)layers were prepared on the NiTi alloy through anodization and hydrothermal *** show that Zn can be evenly incorporated into the NP layers in the form of ZnTiO_(2).The Zn-incorporated samples exhibit good corrosion resistance and significantly reduce Ni^(2+)***,the samples can continuously release Zn^(2+),which is responsible for excellent long-term antibacterial ***,the synergetic effect of Zn^(2+) release and nanoporous structure of the NP layers endues the NiTi alloy excellent osteogenic activity,as verified by upregulated alkaline phosphatase activity,secretion of type I collagen,and extracellular matrix ***,Zn-incorporated Ni-Ti-O NP layers have great potential as biomedical coatings of NiTi-based implant materials.

关键词： Nickel-titanium alloy Anodization Corrosion behavior Antibacterial ability Osteogenic activity

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Self-assembled nanosheets on NiTi alloy facilitate endothelial cell function and manipulate macrophage immune response

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Journal of Materials Science & Technology 2021年第19期78卷 110-120页

作者： Ya Zhao Yonghua Sun Weiwei Lan Zhong Wang Yi Zhang Di Huang Xiaohong Yao ruiqiang hang Laboratory of Biomaterial Surfaces Interfaces Institute of New Carbon MaterialsTaiyuan University of TechnologyTaiyuan030024China Research Center for Nano-Biomaterials fy Regenerative Medicine College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Stenting has been widely adopted for the treatment of cardiovascular diseases,but the complications such as in-stent restenosis and late stent thrombosis cannot be completely avoided,which are closely related to endothelial dysfunction and inflammatory *** the present work,oxide nanosheets were grown on the surface of nearly equiatomic Ni Ti alloy by alkaline corrosion(AC),aiming at yielding favorable endothelial functionality and immune *** results show nanosheets mainly composed of TiO_(2),Ni(OH)_(2),and K_(2)TiO_(3)can be grown on the alloy in KOH solution of 2.5–15 M at room *** AC-treated samples significantly promote endothelial cell(EC)functionality such as proliferation,migration,NO production,VEGF secretion,and *** addition,the sample grown in KOH of 15 M can switch macrophages to an anti-inflammatory M2 phenotype and up-regulate the gene expression of VEGF to facilitate EC *** results demonstrate that the nanosheets can directly and indirectly up-regulate EC functionality,possibly leading to rapid re-endothelialization of the stents thus addressing the stent-related complications.

关键词： Stents Macrophages Endothelial cells Nickel-titanium alloy Nanosheets

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Antibacterial hydroxyapatite coatings on titanium dental implants

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Frontiers of Materials Science 2023年第1期17卷 69-85页

作者： Ziming Liao Jingxuan Li Yimeng Su Fenyan Miao Xiumei Zhang Yu Gu Jingjing Du ruiqiang hang Yan Wei Weiyi Chen Di Huang Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Analytical&TestingCenter Hainan UniversityHaikou570028China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China

Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good ***,their ability to bind to neighboring bone is limited due to the lack of biological *** the same time,they show poor antibacterial ability which can easily cause bacterial infection and chronic inflammation,eventually resulting in implant *** preparation of composite hydroxyapatite coatings with antibacterial ability can effectively figure out these *** this review,the research status and development trends of antibacterial hydroxyapatite coatings constructed on titanium and its alloys are analyzed and *** review may provide valuable reference for the preparation and application of high-performance and multi-functional dental implant coatings in the future.

关键词： composite dental implant hydroxyapatite titanium antibacterial

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生物可降解Zn-Nb复合材料的制备及性能研究

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太原理工大学学报 2022年第4期53卷 588-599页

作者：韩书扬姚润华杭瑞强姚晓红太原理工大学材料科学与工程学院医用金属材料山西省重点实验室太原030024

以Zn粉和Nb粉为原料,通过真空热压烧结工艺制备了Zn-xNb(x=0,0.5,1,3,5,10)复合材料,对其表面形貌和物相进行表征,并探究了Nb的添加对材料力学性能、腐蚀降解行为以及细胞相容性的影响。结果表明:Nb颗粒呈层片状分布于Zn基体中;随着Nb... 详细信息

以Zn粉和Nb粉为原料,通过真空热压烧结工艺制备了Zn-xNb(x=0,0.5,1,3,5,10)复合材料,对其表面形貌和物相进行表征,并探究了Nb的添加对材料力学性能、腐蚀降解行为以及细胞相容性的影响。结果表明:Nb颗粒呈层片状分布于Zn基体中;随着Nb含量的增加,复合材料的压缩屈服强度先增加后降低,其中Zn-0.5Nb性能最佳;Nb含量的增加促进了复合材料的降解;相比于纯Zn,可能是由于Nb的添加减少了Zn^(2+)的释放,因此Nb含量越高的试样表现出越好的细胞相容性。

关键词：热压烧结生物可降解材料锌-铌复合材料腐蚀降解行为细胞相容性

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Bio-properties of Zr-based BMGMC as potential hard tissue implants

Bio-properties of Zr-based BMGMC as potential hard tissue im...

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中国材料大会2012

作者： Xiaobo Huang Naiming Lin ruiqiang hang Bin Tang Junwei Qiao Institute of Surface Engineering Taiyuan University of technology School of Material Science and Engineering Taiyuan University of technology

ISBN: (纸本)9783037856079

In this study, an in situ formed bulk metallic glass matrix composite （BMGMC）（Zr58.5Ti14.3Ni4.9Cu6.1Nb5.2Be11.0） was synthesized. Bulk metallic glass （BMG）（Zr52.5Cu17.9Ni14.6Al10.0Ti5.0） was also included in this work and a Ti-6Al-4V alloy was used as a reference material. Due to the glassy matrix that postpones the growth of corrosion pits, the BMGMC displays high positive corrosion potentials and low corrosion current densities. The BMGMC exhibited a higher improved corrosion resistance than the Ti alloys. Furthermore, the biocompatibility of this BMGMC was assessed by studying the cellular behavior of bone-forming mouse M3T3-E1 pre-osteoblast cells. The matrix did not significantly affect cell adhesion, proliferation and ALP activity. The general biosafety of Zr-based BMGMC for M3T3-E1 cells was revealed as normal cell responses. Zr-based BMGMC shows great potential for applications in the hard tissue implants.

关键词： Zr-based BMGMC Biocompatibility Anticorrosion

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类金刚石涂层的厚度对生物医用NiTi合金力学性能和腐蚀行为的影响(英文)

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稀有金属材料与工程 2012年第9期41卷 1505-1510页

作者：杭瑞强马胜利 Paul K.Chu 西安交通大学金属材料强度国家重点实验室陕西西安710049 香港城市大学中国香港九龙

采用电弧增强磁控溅射技术在生物医用NiTi合金表面沉积253~1880nm厚的类金刚石涂层。用轮廓仪、划擦仪、摩擦磨损仪和电化学工作站等检测涂层的力学性能和腐蚀行为。结果发现,厚度在700~1000nm之间的涂层具有较低的残余应力、较高的膜... 详细信息

采用电弧增强磁控溅射技术在生物医用NiTi合金表面沉积253~1880nm厚的类金刚石涂层。用轮廓仪、划擦仪、摩擦磨损仪和电化学工作站等检测涂层的力学性能和腐蚀行为。结果发现,厚度在700~1000nm之间的涂层具有较低的残余应力、较高的膜基结合力、长的磨损寿命和良好的耐腐蚀性。因此,更适合于作为生物医用NiTi合金的保护性涂层,同时也对NiTi合金表面类金刚石涂层的厚度对其力学性能和腐蚀行为的影响机制进行探讨。

关键词：类金刚石镍钛合金力学性能腐蚀行为

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Mitigating growth-stress tradeoffs via elevated TOR signaling in rice

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Molecular Plant 2024年第2期17卷 240-257页

作者： Wei Li Jiaqi Liu Zeqi Li ruiqiang Ye Wenzhen Chen Yuqing Huang Yue Yuan Yi Zhang Huayi Hu Peng Zheng Zhongming Fang Zeng Tao Shiyong Song Ronghui Pan Jian Zhang Jumim Tu Jen Sheen Hao Du State Key Laboratory of Rice Biology College of Agriculture and BiotechnologyZhejiang UniversityYu-Hang-Tang Road No.866Hangzhou 310058China ZJU-hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Hainan Institute of Zhejiang University Sanya 572025China National Key Laboratory of Plant Molecular Genetics CASCenter for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Agricultural SciencesGuizhouUniversityGuiyang 550025China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Department of Molecular Biology and Center for Computational and Integrative Biology Massachusetts General Hospitaland Department of GeneticsHarvard Medical SchoolBostonMA02114USA

Rice production accounts for approximately half of the freshwater resources utilized in agriculture,result-ing in greenhouse gas emissions such as methane(CH4)from flooded paddy *** address this chal-lenge,environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice ***,the implementation of water-saving treatments(WsTs)in paddy-field rice has been associated with a substantial yield loss of up to 50%as well as a reduction in nitrogen use efficiency(NUE).In this study,we discovered that the target of rapamycin(TOR)signaling pathway is compromised in rice under *** profiling-coupled transcriptome sequencing(polysome-seq)analysis unveiled a substantial reduction in global translation in response to WST associated with the downregulation of TOR ***,biochemical,and genetic analyses revealed new insights into the impact of the positive TOR-S6K-RPS6 and negative TOR-MAF1 modules on translation repression under ***,ammonium exhibited a greater ability to alleviate growth constraints under WsT by enhancing TOR signaling,which simultaneously promoted uptake and utilization of ammonium and nitrogen *** further demonstrated that TOR modulates the ammonium transporter AMT1;1 as well as the amino acid permease APP1 and dipeptide transporter NPF7.3 at the translational level through the 5'untranslated ***,these findings reveal that enhancing TOR signaling could mitigate rice yield penalty due to WST by regulating the processes involved in protein synthesis and *** study will contribute to the breeding of new rice varieties with increased water and fertilizer utilization efficiency.

关键词： target of rapamycin TOR water-saving rice low-carbon agriculture drought nitrogen use efficiency NUE

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电力波分复用网络中基于软管模型的生存性设计

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电力系统自动化 2015年第21期39卷 99-106页

作者：戴睿王磊邢宁哲李明张瑞强陈少磊国网四川省电力公司信息通信公司四川省成都市610041 国网山东省电力公司信息通信公司山东省济南市250001 国网冀北电力有限公司北京市100053 国网安徽省电力公司信息通信公司安徽省合肥市230061

生存性设计是规划电力通信波分复用(WDM)网络时必须考虑的问题。传统的方法根据各节点对的峰值速率来制定保护规划方案,也并未考虑光纤链路之间共享物理资源的情况,既不准确又浪费资源。为解决上述问题,提出了一种新的计算共享风险链路... 详细信息

生存性设计是规划电力通信波分复用(WDM)网络时必须考虑的问题。传统的方法根据各节点对的峰值速率来制定保护规划方案,也并未考虑光纤链路之间共享物理资源的情况,既不准确又浪费资源。为解决上述问题,提出了一种新的计算共享风险链路组的失效概率模型,并以此为基础,提出了基于软管不确定业务量模型和共享风险链路组的分级保护算法——HSP算法,并通过计算机仿真对该算法的性能进行了评估。结果表明,HSP显著提高了找到保护路径的可能性,从而降低了受损业务无法恢复的概率。失效概率模型和HSP算法还应用到了某省级电力波分复用核心网络的成效评估和规划设计中,作为评估该省电力骨干光传输网络建设成本和可靠性的依据。

关键词：波分复用共享风险链路组软管不确定业务量模型分级保护可靠性电力通信

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辛伐他汀通过介导衰老巨噬细胞免疫促进成骨和成血管的研究

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太原理工大学学报 2022年第4期53卷 600-611页

作者：屈广平赵宇宇姚晓红杭瑞强太原理工大学材料科学与工程学院医用金属材料山西省重点实验室太原030024

研究辛伐他汀浓度对衰老巨噬细胞生物学行为及其介导的免疫微环境对成骨和成血管功能的影响,并探索在钛表面装载辛伐他汀介导衰老巨噬细胞功能的可行性。结果表明:当药物浓度为0.1μmol/L时,可促进巨噬细胞的增殖并使其极化为促组织愈合... 详细信息

研究辛伐他汀浓度对衰老巨噬细胞生物学行为及其介导的免疫微环境对成骨和成血管功能的影响,并探索在钛表面装载辛伐他汀介导衰老巨噬细胞功能的可行性。结果表明:当药物浓度为0.1μmol/L时,可促进巨噬细胞的增殖并使其极化为促组织愈合的M2表型,有利于巨噬细胞营造促进成骨和成血管的免疫微环境。在钛表面构建的壳聚糖/明胶涂层可装载并缓释辛伐他汀,促进巨噬细胞的活力和增殖。

关键词：辛伐他汀巨噬细胞钛免疫微环境成骨功能成血管功能

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