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Polylactic acid micro/nanoplastic-induced hepatotoxicity: Investigating food and air sources via multi-omics

Environmental Science and Ecotechnology 2024年第5期21卷 294-308页

作者： Hua Zha Shengyi Han ruiqi tang Dan Cao Kevin Chang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Statistics The University of AucklandAucklandNew Zealand

Micro/nanoplastics(MNPs)are detected in human liver,and pose significant risks to human *** exposure to MNPs derived from non-biodegradable plastics can induce toxicity in mouse ***,nasal exposure to non-biodegradable plastics can cause airway dysbiosis in ***,the hepatotoxicity induced by foodborne and airborne biodegradable MNPs remains poorly *** we show the hepatotoxic effects of biodegradable polylactic acid(PLA)MNPs through multi-omics analysis of various biological samples from mice,including gut,fecal,nasal,lung,liver,and blood *** results show that both foodborne and airborne PLA MNPs compromise liver function,disrupt serum antioxidant activity,and cause liver ***,foodborne MNPs lead to gut microbial dysbiosis,metabolic alterations in the gut and serum,and liver transcriptomic *** MNPs affect nasal and lung microbiota,alter lung and serum metabolites,and disrupt liver *** gut Lachnospiraceae_NK4A136_group is a potential biomarker for foodborne PLA MNP exposure,while nasal unclassified_Muribaculaceae and lung Klebsiella are potential biomarkers for airborne PLA MNP *** relevant results suggest that foodborne PLA MNPs could affect the“gut microbiota-gutliver”axis and induce hepatoxicity,while airborne PLA MNPs could disrupt the“airway microbiota-lungliver”axis and cause *** findings have implications for diagnosing PLA MNPs-induced hepatotoxicity and managing biodegradable materials in the *** current study could be a starting point for biodegradable MNPs-induced *** research is needed to verify and inhibit the pathways that are crucial to MNPs-induced hepatotoxicity.

关键词： Micro/nanoplastics Hepatotoxicity Microbiota dysbiosis Metabolic disruption Transcriptomic dysregulation

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基于伪标签依赖增强与噪声干扰消减的小样本图像分类

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计算机科学 2024年第8期51卷 152-159页

作者：唐芮琪肖婷迟子秋王喆华东理工大学信息科学与工程学院上海200237

深度学习在图像分类领域的成功很大程度上依赖于大规模数据,然而在许多应用场景中,收集足够的数据用于模型的训练是比较困难的。因此,旨在利用有限的数据获得高性能模型的小样本学习成为热点研究方向。在小样本图像分类领域,使用无标签... 详细信息

深度学习在图像分类领域的成功很大程度上依赖于大规模数据,然而在许多应用场景中,收集足够的数据用于模型的训练是比较困难的。因此,旨在利用有限的数据获得高性能模型的小样本学习成为热点研究方向。在小样本图像分类领域,使用无标签数据来扩充训练数据集是一种常用的方法,但该方法面临两个亟待解决的难题:如何获取无标签数据的伪标签以及如何减轻噪声标签累积的负面影响?首先,为获得高质量的伪标签,需要解决由源域和目标域的分布偏移导致的噪声标签问题,因而提出基于希尔伯特-施密特独立准则(Hilbert-Schmidt Independent Criterion,HSIC)的依赖增强方法,通过最大化图像特征表示与标签之间的相关性,从而提高伪标签的预测可靠度。其次,为克服标签预测误差随着时间推移不断累积的问题,提出噪声标签干扰消减(Noise Label Interference Reduction,NLIR)方法,确保具有正确标签的样本的梯度始终主导着训练动态,从而将模型引向最优解。所提方法在小样本图像分类基准数据集mini-ImageNet和tiered-ImageNet上进行了评估,实验结果表明,该方法能够很好地利用无标签数据提升分类精度,具有良好的分类性能。

关键词：深度学习图像分类小样本学习伪标签噪声标签希尔伯特-施密特独立准则

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蓝相液晶对聚集诱导发光分子荧光性能的影响

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液晶与显示 2024年第3期39卷 299-311页

作者：陈影段然许子言唐瑞琪童颖萍赵东宇北京航空航天大学化学学院北京100191

为了拓宽蓝相液晶的应用范围,构建多功能化蓝相体系平台,本文将具有聚集诱导发光(AIE)特性的液晶TPE-PPE引入蓝相液晶体系,围绕复合体系的荧光性能展开研究。一方面,系统研究并归纳了手性添加剂含量对蓝相液晶相转变行为和光子带隙位移... 详细信息

为了拓宽蓝相液晶的应用范围,构建多功能化蓝相体系平台,本文将具有聚集诱导发光(AIE)特性的液晶TPE-PPE引入蓝相液晶体系,围绕复合体系的荧光性能展开研究。一方面,系统研究并归纳了手性添加剂含量对蓝相液晶相转变行为和光子带隙位移情况的影响;另一方面,探究了蓝相液晶对AIE分子荧光性能的影响,提出了相关荧光增强效应的假说。实验结果表明,不同手性添加剂体系的蓝相Ⅱ的温域范围基本一致,且反射带隙随着温度的降低发生蓝移;而蓝相Ⅰ的温域与手性密切相关,体系中仅存在蓝相Ⅰ时,其反射带隙随温度的降低而红移。蓝相液晶体系对AIE分子有一定的荧光增强效应,并且在整个蓝相温域内,蓝相Ⅰ的反射带隙红移,体系的荧光强度明显增强。由此得出结论,TPE-PPE分子在一定程度上参与了蓝相液晶体系的自组装。由于TPE-PPE分子在双螺旋柱结构中的受限运动,导致其荧光强度增强。随着蓝相Ⅱ的消失和蓝相Ⅰ光子带隙的红移,更多TPE-PPE分子参与到双螺旋柱的自组装中,体系的荧光发射增强。

关键词：聚集诱导发光聚合物稳定蓝相液晶光子晶体

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重组抗黑猩猩腺病毒68型单克隆抗体制备及应用研究

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国际生物制品学杂志 2024年第2期47卷 72-78页

作者：赵萍吴月何佩赵瑾唐瑞琪武汉博沃生物科技有限公司检验开发部武汉430075

目的制备1株抗黑猩猩腺病毒68型(chimpanzee adenovirus type 68,AdC68)六邻体(hexon,hex)蛋白重组单克隆抗体(单抗)。方法表达并纯化AdC68-hex蛋白,免疫BALB/c小鼠,取其脾细胞与骨髓瘤细胞融合,经间接ELISA及细胞免疫染色法筛选得到1... 详细信息

目的制备1株抗黑猩猩腺病毒68型(chimpanzee adenovirus type 68,AdC68)六邻体(hexon,hex)蛋白重组单克隆抗体(单抗)。方法表达并纯化AdC68-hex蛋白,免疫BALB/c小鼠,取其脾细胞与骨髓瘤细胞融合,经间接ELISA及细胞免疫染色法筛选得到1株分泌抗AdC68-hex蛋白单抗的杂交瘤细胞。抽提杂交瘤细胞RNA进行测序,获得单抗重链与轻链可变区序列,分别与小鼠重链与轻链恒定区序列拼接得到小鼠全长IgG1κ抗体重链与轻链,并构建至真核细胞高效表达质粒。将重链与轻链质粒共同转染至哺乳动物细胞表达并纯化得到抗AdC68-hex重组单抗。将抗体用于滴定AdC68、重组AdC68及AdC68重组疫苗,并开展方法学验证。结果表达制备的AdC68-hex蛋白能有效诱导小鼠的病毒产生抗AdC68-hex抗体。抗AdC68-hex重组单抗用于重组AdC68滴定具备良好的专属性、耐用性,在4.56~9.57 lg感染单位/ml范围内具备良好的线性、准确度和精密度。结论制备的重组抗AdC68-hex单抗适用于AdC68及AdC68重组疫苗载体相关的基因治疗药物及疫苗等的检测。

关键词：黑猩猩腺病毒68型六邻体抗体/单克隆病毒滴定

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Hyperbolic tangent Function-Based Protocols for Global/Semi-Global Finite-Time Consensus of Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1381-1397页

作者： Zongyu Zuo Jingchuan tang ruiqi Ke Qing-Long Han Seventh Research Division Beihang University(BUAA)Beijing 100191China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia IEEE

This paper investigates the problem of global/semi-global finite-time consensus for integrator-type multi-agent *** hyperbolic tangent function-based protocols are pro-posed to achieve global and semi-global finite-time consensus for both single-integrator and double-integrator multi-agent systems with leaderless undirected and leader-following directed commu-nication *** new protocols not only provide an explicit upper-bound estimate for the settling time,but also have a user-prescribed bounded control *** addition,compared to some existing results based on the saturation function,the pro-posed approach considerably simplifies the protocol design and the stability *** examples and an application demonstrate the effectiveness of the proposed protocols.

关键词： Consensus protocol finite-time consensus hyper-bolic tangent function multi-agent systems.

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不同散热翅片结构下的芯片散热性能分析

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湘潭大学学报（自然科学版） 2024年第5期46卷 48-58页

作者：李方刘平唐瑞琪赵明超周友行湘潭大学机械工程与力学学院湖南湘潭411105 易普力向红(湖南)机械化工有限责任公司湖南岳阳414100

为了缓解芯片热点散热问题,基于一种结合微通道和针翅形散热片的混合散热器,提出了3种具有不同截面形状翅片的微通道散热器,运用计算流体力学方法展开相关研究,分析了3种微通道散热器的背景区域和热点区域的温度场以及流场分布特性,选... 详细信息

为了缓解芯片热点散热问题,基于一种结合微通道和针翅形散热片的混合散热器,提出了3种具有不同截面形状翅片的微通道散热器,运用计算流体力学方法展开相关研究,分析了3种微通道散热器的背景区域和热点区域的温度场以及流场分布特性,选取散热器峰值温度、温差、压降和等效热阻作为性能参数,评估3种散热器的散热性能.结果表明,在4种冷却液入口流速(0.2 m·s^(-1)、0.4 m·s^(-1)、0.6 m·s^(-1)、0.8 m·s^(-1))下,圆柱形翅片的微通道散热器均呈现出最低的峰值温度、最小的温差和最低的等效热阻,以入口冷却液流速为0.2 m·s^(-1)为例,圆柱形、四棱柱形、三棱柱形翅片的微通道散热器热源面的最高温度分别为358 K、360 K、364 K,温差分别为21.3 K、22.1 K、23.7 K,说明圆柱形翅片具有最佳综合传热性能.

关键词：微通道散热器翅片结构微电子芯片计算流体力学

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Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice

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Frontiers of Medicine 2019年第4期13卷 471-481页

作者： Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu ruiqi tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li National Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Division of Hepatobiliary and Pancreatic Surgery Department of Surgery the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Division of Throat Surgery the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Center of Safety Evaluation Zhejiang Academy of Medical Sciences Hangzhou 310053 China

Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients.

关键词： antibiotics tacrolimus glucose disorders microbiome

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Boron nitride microribbons strengthened and toughened alumina composite ceramics with excellent mechanical,dielectric,and thermal conductivity properties

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Journal of Advanced Ceramics 2024年第4期13卷 496-506页

作者： Jilin Wang Dongping Lu Weiping Xuan Yuchun Ji ruiqi Chen Shaofei Li Wenbiao Li Wenzhuo Chen Shilin tang Guoyuan Zheng Fei Long Guangxi Key Laboratory of Optical and Electronic Materials and Devices Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of ResourcesSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004China Key Laboratory of New Processing Technology for Nonferrous Metals and Materials of Ministry of Education Guilin University of TechnologyGuilin 541004China School of Materials Science and Engineering Peking UniversityBeijing 100871China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina

Aluminum oxide(Al_(2)O_(3))ceramics have been widely utilized as circuit substrates owing to their exceptional *** this study,boron nitride microribbon(BNMR)/Al_(2)O_(3)composite ceramics are prepared using spark plasma sintering(SPS).This study examines the effect of varying the amount of toughened phase BNMR on the density,mechanical properties,dielectric constant,and thermal conductivity of BNMR/Al_(2)O_(3)composite ceramics while also exploring the mechanisms behind the toughening and increased thermal conductivity of the fabricated *** results showed that for a BNMR content of 5 wt%,BNMR/Al_(2)O_(3)composite ceramics displayed more enhanced characteristics than pure Al_(2)O_(3)*** particular,the relative density,hardness,fracture toughness,and bending strength were 99.95%±0.025%,34.11±1.5 GPa,5.42±0.21 MPa·m^(1/2),and 375±2.5 MPa,*** values represent increases of 0.76%,70%,35%,and 25%,respectively,compared with the corresponding values for pure Al_(2)O_(3)***,during the SPS process,BNMRs are subjected to high temperatures and pressures,resulting in the bending and deformation of the Al_(2)O_(3)matrix;this leads to the formation of special thermal pathways within *** dielectric constant of the composite ceramics decreased by 25.6%,whereas the thermal conductivity increased by 45.6%compared with that of the pure Al_(2)O_(3)*** results of this study provide valuable insights into ways of enhancing the performance of Al_(2)O_(3)-based ceramic substrates by incorporating novel BNMRs as a second *** improvements are significant for potential applications in circuit substrates and related fields that require high-performance materials with improved mechanical properties and thermal conductivities.

关键词： boron nitride microribbons/aluminum oxide(BNMRs/Al_(2)O_(3))composite ceramics boron nitride microribbon(BNMR) spark plasma sintering(SPS) strengthening and toughening thermal conductivity

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Mechanism Study of A Neuritogenic Compound On PC 12 Cells

Mechanism Study of A Neuritogenic Compound On PC 12 Cells

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2012长三角药物化学研讨会

作者： Lijuan Gao ruiqi tang Yan Luo Lan Xiang Jianhua Qi Laboratory of Bioactive Natural Products Chemistry College of Pharmaceutical SciencesZhejiang University

Studying the structure-activity relationships(SARs) of neuritogenic benzoates,isolated from Gentiana rigescens Franch("Longdan"),about 100 benzoates derivatives were synthesized and tested neuritogenic *** a result,tetradecyl 2,3-dihydroxybenzoate showed the best neuritogenic activity and was determined as a lead compound,named as ***-001 induced significant neurite outgrowth at 1 M on PC 12 cells compared with nerve growth factor(NGF) as a positive control(40 ng/mL).Subsequently,the mechanism study of ABG-001-induced neurite outgrowth was *** inhibitors related to neurite

关键词： neuritogenic tetradecyl 2,3-dihydroxybenzoate extracellular signal-regulated kinase 1/2,phosphoinositide 3-kinase protein kinase C.

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基于自相关侧峰消除的北斗B1C快速高精度捕获算法

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中国惯性技术学报 2021年第1期29卷 62-68页

作者：许睿唐瑞琪罗凯曾庆化刘建业南京航空航天大学自动化学院南京211106

北斗三号播发的B1C信号采用二进制偏移载波(BOC)调制方式和10 ms周期的伪随机码,可以与现存L1频段上的导航信号共有载波频率,同时提高导航信号的跟踪精度和伪距测量精度。然而,BOC调制会带来相关函数多峰性问题,10 ms周期的伪随机码会... 详细信息

北斗三号播发的B1C信号采用二进制偏移载波(BOC)调制方式和10 ms周期的伪随机码,可以与现存L1频段上的导航信号共有载波频率,同时提高导航信号的跟踪精度和伪距测量精度。然而,BOC调制会带来相关函数多峰性问题,10 ms周期的伪随机码会极大增加信号捕获的计算量,影响捕获速度,同时长码的跟踪需要更小带宽的跟踪环路,这对捕获精度提出更高要求。为此,根据北斗B1C信号的特点,在利用ASPeCT技术消除BOC信号相关副峰的基础上,兼顾捕获的快速性与精度,提出一种北斗BIC信号快速高精度捕获算法。所提算法先利用多级搜索和降采样策略快速实现信号的粗捕获,将捕获频率范围缩小,再利用多项式曲线拟合的方法进行多普勒频率精捕获,提高捕获精度。在多级搜索过程中,相关计算融合ASPeCT技术,通过本地码与副载波调制码构造无副峰相关函数,确保搜索过程无模糊度。所提捕获算法经接收前端采集的北斗B1C信号测试,实验表明,该捕获方法对相关副峰的消除程度可达到86.70%,多普勒频率误差缩小到1 Hz以内,捕获耗时相对缩短了近2/3,实现了快速高精度捕获,保障了后续跟踪算法的成功率。

关键词：北斗卫星导航系统 BOC调制 ASPeCT算法快速捕获精捕获

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