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An intravascular needle coated by ZnO nanoflowers for in vivo elimination of circulating tumor cells

Nano Research 2023年第1期16卷 873-881页

作者： Jinqi Li Xinlei Li Yangfeng Zhang Kun Jin Ye Yuan Ruiqi Ming Yuhua Yang Tongsheng Chen MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.South China Normal UniversityQingyuan 511500China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

Circulating tumor cells(CTCs)are recognized as the main source of tumor recurrence and metastasis.Eliminating the CTCs in peripheral blood provides a new strategy to reduce the probability of recurrence or metastasis.Here,we proposed a concept to eliminate CTCs by inserting a needle in the superficial blood vessel.Using the property of ZnO and the structure of nanoflowers,we designed a medical needle coated with ZnO nanoflowers(ZNFs),which killed about 90%of captured CTCs in vitro and prevented the injecting CTCs from spreading to lung tissue in BABL/c mouse model.Results in vitro and in vivo demonstrated that the CTCs not only were captured and killed,but also detached from the needle surface after dead,enabling the ZNFs needle continually eliminate CTCs.Furthermore,a theoretical model was presented to explain the penetration mechanism of cells by nanostructures,which indicated that nanoflowers structure can puncture CTCs more easily than vertical nanowire structure.The concept of inserting an intravascular needle provides a potential strategy to lower the concentration of CTCs in blood and reduce the probability of tumor recurrence or metastasis.

关键词： ZnO nanoflowers circulating tumor cells elimination cancer treatment theoretical model

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Synthesis of yolk-shell Bi_(2)O_(3)@TiO_(2) submicrospheres with enhanced potassium storage

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Science China Chemistry 2022年第9期65卷 1807-1816页

作者： Yifan Xu Hehe Zhang Tangjing Ding ruiqi Tian Dongmei Sun ming-Sheng Wang Xiaosi Zhou Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China

Due to their enormous potential for large-scale energy storage,rechargeable potassium-ion batteries have been widely researched and developed.However,the drastic volume change of electrode materials induced by the huge size of potassium ions during cycling remains a challenge for the construction of stable anodes.Herein,we propose a novel weak acid etching strategy to design and fabricate robust yolk-shell spheres with enough internal void space,in which the Bi_(2)O_(3) nanospheres are well confined in the compartments of TiO_(2) submicrospheres(y-Bi_(2)O_(3)@TiO_(2)).In situ transmission electron microscopy(TEM)and ex situ Xray diffraction(XRD)are conducted to elucidate the structural evolution of y-Bi_(2)O_(3)@TiO_(2) and the interaction between K^(+)and Bi_(2)O_(3) during cycling.Thanks to the yolk-shell nanoarchitecture and the superior buffering property of outer TiO_(2) covering,the as-obtained composite shows a high specific capacity of 383.5 mAh g^(−1) at 100 mA g^(−1),a considerable rate capacity of 134.1 mAh g^(−1) at 2 A g^(−1) and a stable cycling performance of 216.8 mAh g^(−1) at 500 mA g^(−1) over 500 cycles when used for potassium storage.Subsequently,the potassium-ion full battery,constructed by pairing y-Bi_(2)O_(3)@TiO_(2) anode with the thermally annealed 3,4,9,10-perylenetetracarboxylic dianhydride(PTCDA)cathode,exhibits an outstanding cycling stability.Hopefully,this carefully-designed strategy can inspire the further development of superior energy storage materials in the near future.

关键词： Bi_(2)O_(3) amorphous TiO_(2) yolk-shell structure anode potassium-ion batteries

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Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2020年第3期40卷 343-354页

作者： Liu Liuqing Liu Yanfeng Yang ming Xu Guiqin Li ruiqi Xu Xiuli Pan Xue Liang Jialing Department of Gynecology the 1st Clinical Medical College of Beijing University of Chinese MedicineBeijing 100700China Department of Gynecology Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China Center for Evidence Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Scientific Research Management the 1st Affiliated Hospital of Anhui University of Chinese MedicineHefei 230001China Department of Gynecology Shunyi HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101300China

OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for Meta-analysis.There were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment.

关键词： Ovarian reserve Tonifying kidney and regulating liver Randomized controlled trial Systematic review Meta-analysis

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Coupling Sb_(2)WO_(6)microflowers and conductive polypyrrole for efficient potassium storage by enhanced conductivity and K^(+) diffusivity

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Journal of Energy Chemistry 2024年第2期89卷 250-258,I0007页

作者： ruiqi Tian Hehe Zhang Zeyu Yuan Yuehua Man Jianlu Sun Jianchun Bao ming-Sheng Wang Xiaosi Zhou School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023JiangsuChina State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005FujianChina

Although metal oxide compounds are considered as desirable anode materials for potassium-ion batteries(PIBs)due to their high theoretical capacity,the large volume variation remains a key issue in realizing metal oxide anodes with long cycle life and excellent rate property.In this study,polypyrroleencapsulated Sb_(2)WO_(6)(denoted Sb_(2)WO_(6)@PPy)microflowers are synthesized by a one-step hydrothermal method followed by in-situ polymerization and coating by pyrrole.Leveraging the nanosheet-stacked Sb_(2)WO_(6)microflower structure,the improved electronic conductivity,and the architectural protection offered by the PPy coating,Sb_(2)WO_(6)@PPy exhibits boosted potassium storage properties,thereby demonstrating an outstanding rate property of 110.3 m A h g^(-1)at 5 A g^(-1)and delivering a long-period cycling stability with a reversible capacity of 197.2 m A h g^(-1)after 500 cycles at 1 A g^(-1).In addition,the conversion and alloying processes of Sb_(2)WO_(6)@PPy in PIBs with the generation of intermediates,K_(2)WO_(4)and K_(3)Sb,is determined by X-ray photoelectron spectroscopy,transmission electron microscopy,and exsitu X-ray diffraction during potassiation/depotassiation.Density functional theory calculations demonstrate that the robust coupling between PPy and Sb_(2)WO_(6)endues it with a much stronger total density of states and a built-in electric field,thereby increasing the electronic conductivity,and thus effectively reduces the K^(+)diffusion barrier.

关键词： Sb_(2)WO_(6) Polypyrrole coating Anode Potassium-ion battery In-situ TEM observation

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推动高标准农田良性发展:关键问题与对策建议

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山西农业大学学报(社会科学版) 2023年第6期22卷 31-42页

作者：王瑞琪高鸣西北农林科技大学经济管理学院陕西杨凌712100 农业农村部农村经济研究中心北京100810

建设高标准农田是推进农业现代化、保障国家粮食安全的关键举措。结合政策实施的阶段性特征,可将高标准农田建设历程划分为初级探索、逐步规范、强力推进与提质增效四个阶段。尽管我国高标准农田建设的成效显著,但对标新时代农业现代化... 详细信息

建设高标准农田是推进农业现代化、保障国家粮食安全的关键举措。结合政策实施的阶段性特征,可将高标准农田建设历程划分为初级探索、逐步规范、强力推进与提质增效四个阶段。尽管我国高标准农田建设的成效显著,但对标新时代农业现代化高质量发展要求,仍然面临公众参与不足、生态效益不佳、保障力度不强、“重建设、轻管护”等实践困境,亟需深入分析其内在阻力与外在压力,从人才吸纳与应用、农田优化与管护、资金投入与使用等方面推进高标准农田建设“提质增效”,确保粮食“稳产增产高产”。

关键词：高标准农田农业现代化粮食安全良性发展

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太阳能热利用系统能势匹配程度的对比分析

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太阳能学报 2022年第9期43卷 119-124页

作者：张沛晔穆瑞琪刘明严俊杰西安交通大学动力工程多相流国家重点实验室西安710049

基于太阳能热利用系统,建立能势分析模型,对太阳能聚光过程、光热发电、光热化学等主要环节进行能量分析和能势分析,并对光热发电、光热化学2种技术路线进行对比。结果表明太阳能与吸热工质能势不匹配是太阳能热利用系统效率的关键限制... 详细信息

基于太阳能热利用系统,建立能势分析模型,对太阳能聚光过程、光热发电、光热化学等主要环节进行能量分析和能势分析,并对光热发电、光热化学2种技术路线进行对比。结果表明太阳能与吸热工质能势不匹配是太阳能热利用系统效率的关键限制因素,热功转化、热化学过程的不可逆性相对较小。现有太阳能光热、光热化学热利用系统的效率均较低,有较大的提升潜力。

关键词：能质系数太阳能热利用太阳能热发电热化学反应

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Intracellular RNA Labeling Technologies for the Analysis of RNA Biology

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CHINESE JOURNAL OF CHEMISTRY 2024年第7期42卷 790-801页

作者： Zhao, ruiqi Fang, Xin Weng, Xiaocheng Wuhan Univ Ctr Gene Diag Dept Clin Lab Dept NeurosurgZhongnan Hosp Wuhan 430071 Hubei Peoples R China Wuhan Univ Coll Chem & Mol Sci Key Lab Biomed Polymers Minist Educ Wuhan 430072 Hubei Peoples R China

As a cornerstone of the central dogma of molecular biology, RNA plays vital roles in living organisms. Over the past few decades, many RNA labeling technologies have been developed to elucidate the biological function of RNA. These technologies have significantly advanced our understanding of RNA secondary structure, localization, and turnover. Additionally, taking advantage of these innovative RNA labeling approaches, plenty of tool kits have been devised for the regulation of RNA-related biological process, such as gene expression and gene editing. In this review, we primarily focus on an array of intracellular RNA labeling methods, encompassing chemical probes-based labeling, metabolic labeling, and proximity-dependent labeling. We also provide a brief overview of their applications in the research of RNA biology. Finally, the perspectives of RNA labeling are also discussed.

关键词： RNA Chemical probes Metabolic labeling Proximity-dependent labeling RNA structures Gene sequencing RNA recognition MAMMALIAN MESSENGER-RNA NEWLY SYNTHESIZED RNA IN-VIVO GENE-EXPRESSION MICROARRAY ANALYSIS RIBOSOMAL-RNA LIVING CELLS REVEALS CLICK DNA

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热采井井筒热应力耦合分析

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地下空间与工程学报 2011年第1期7卷 83-86页

作者：吕瑞琪许明河南油田设计院河南唐河473400 重庆大学土木工程学院重庆400045

本文利用AD INA软件建立了热采井井筒热应力耦合的瞬态分析模型。计算结果表明,最大热应力发生在套管内壁,且超过了N80套管的热弹性屈服极限;由于套管材料的膨胀系数大于水泥环的膨胀系数,在注汽过程中水泥环限制了套管的热膨胀,从而在... 详细信息

本文利用AD INA软件建立了热采井井筒热应力耦合的瞬态分析模型。计算结果表明,最大热应力发生在套管内壁,且超过了N80套管的热弹性屈服极限;由于套管材料的膨胀系数大于水泥环的膨胀系数,在注汽过程中水泥环限制了套管的热膨胀,从而在套管外壁也产的较大的热应力。焖井结束后,套管上会积累较高的残余应力。该分析为提出合理的热采井套管损坏预防措施提供了可靠的依据。

关键词：热采井热应力耦合套管损坏有限元分析

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[Cs_(6)Cl][Ga_(5)GeQ_(12)](Q=S,Se):two novel porous layered chalcohalides exhibiting two-band emission and ion exchange properties

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Science China Chemistry 2022年第10期65卷 1903-1910页

作者： ruiqi Wang Xian Zhang Fuqiang Huang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

The salt-inclusion materials have drawn significant attention for their manifold structural chemistry and novel physical/chemical properties.Herein,two new salt-inclusion chalcohalides,[Cs_(6)Cl][Ga_(5)GeQ_(12)](Q=S,Se),have been discovered via hightemperature flux methods.The two isostructural compounds are constructed by porous[Ga_(5)GeQ_(12)]^(5−)layers with[ClCs_(6)]^(5+)octahedra filled in the holes.The[Ga_(5)GeQ_(12)]^(5−)layer is composed of the honeycomb-like(Ga/Ge)_(18)Q_(42)rings containing(Ga/Ge)_(3)Q_(9)trimer as basic unit.The band gaps of the two compounds are 3.90 and 2.89 eV,respectively.[Cs_(6)Cl][Ga_(5)GeS_(12)]exhibits interesting two-band emission properties which are related to the intermediate-band electronic structure revealed by density functional theory(DFT)calculations.Owing to the porous layered structure,[Cs_(6)Cl][Ga_(5)GeS_(12)]exhibits topological ion exchange ability towards Cd^(2+)ions with the maximum sorption capacity of 250 mg/g and high distribution coefficient(Kd)near 106 mL/g.This work further enriches the structural diversity of salt-inclusion materials and extends their potential application range to ion exchange adsorption.

关键词： heteroanionic compound layered structure two-band emission ion exchange properties

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A Note on Maximizing Regularized Submodular Functions Under Streaming

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Tsinghua Science and Technology 2023年第6期28卷 1023-1029页

作者： Qinqin Gong Kaiqiao Meng ruiqi Yang Zhenning Zhang Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China

Recent progress in maximizing submodular functions with a cardinality constraint through centralized and streaming modes has demonstrated a wide range of applications and also developed comprehensive theoretical guarantees.The submodularity was investigated to capture the diversity and representativeness of the utilities,and the monotonicity has the advantage of improving the coverage.Regularized submodular optimization models were developed in the latest studies(such as a house on fire),which aimed to sieve subsets with constraints to optimize regularized utilities.This study is motivated by the setting in which the input stream is partitioned into several disjoint parts,and each part has a limited size constraint.A first threshold-based bicriteria(1/3,2/3/)-approximation for the problem is provided.

关键词： submodular optimization regular model streaming algorithms threshold technique

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