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An intravascular needle coated by ZnO nanoflowers for in vivo elimination of circulating tumor cells

Nano Research 2023年第1期16卷 873-881页

作者： Jinqi Li Xinlei Li Yangfeng Zhang Kun Jin Ye Yuan ruiqi ming Yuhua Yang Tongsheng Chen MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.South China Normal UniversityQingyuan 511500China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

Circulating tumor cells(CTCs)are recognized as the main source of tumor recurrence and *** the CTCs in peripheral blood provides a new strategy to reduce the probability of recurrence or ***,we proposed a concept to eliminate CTCs by inserting a needle in the superficial blood *** the property of ZnO and the structure of nanoflowers,we designed a medical needle coated with ZnO nanoflowers(ZNFs),which killed about 90%of captured CTCs in vitro and prevented the injecting CTCs from spreading to lung tissue in BABL/c mouse *** in vitro and in vivo demonstrated that the CTCs not only were captured and killed,but also detached from the needle surface after dead,enabling the ZNFs needle continually eliminate ***,a theoretical model was presented to explain the penetration mechanism of cells by nanostructures,which indicated that nanoflowers structure can puncture CTCs more easily than vertical nanowire *** concept of inserting an intravascular needle provides a potential strategy to lower the concentration of CTCs in blood and reduce the probability of tumor recurrence or metastasis.

关键词： ZnO nanoflowers circulating tumor cells elimination cancer treatment theoretical model

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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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Neural Regeneration Research 2025年第8期20卷 2408-2419页

作者： ruiqi Qiu mingzhu Yang Xiuxiu Jin Jingyang Liu Weiping Wang Xiaoli Zhang Jinfeng Han Bo Lei Henan Eye Hospital Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Eye Institute Henan Academy of Innovations in Medical ScienceZhengzhouHenan ProvinceChina Branch of National Clinical Research Center for Ocular Disease Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenan ProvinceChina

Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell ***,there is no effective treatment for retinitis pigmentosa caused by PDE6B ***-associated virus(AAV)-mediated gene therapy is a promising strategy for treating retinitis *** aim of this study was to explore the molecular mechanisms by which AAV2-PDE6B rescues retinal *** do this,we injected retinal degeneration 10(rd10)mice subretinally with AAV2-PDE6B and assessed the therapeutic effects on retinal function and structure using dark-and light-adapted electroretinogram,optical coherence tomography,and ***-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment,and the results from this analysis were verified by real-time polymerase chain reaction and western ***2-PDE6B injection significantly upregulated PDE6βexpression,preserved electroretinogram responses,and preserved outer nuclear layer thickness in rd10 *** expressed proteins between wild-type and rd10 mice were closely related to visual perception,and treating rd10 mice with AAV2-PDE6B restored differentially expressed protein expression to levels similar to those seen in wild-type *** Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-PDE6B injection were enriched in phototransduction ***,the phototransductionrelated proteins Pde6α,Rom1,Rho,Aldh1a1,and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-PDE6B ***,Bax/Bcl-2,p-ERK/ERK,and p-c-Fos/c-Fos expression levels decreased in rd10 mice following AAV2-PDE6B *** data suggest that AAV2-PDE6B-mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upr

关键词： apoptosis AAV2-PDE6B ERK1/2 gene therapy phototransduction proteomics rd10 retinitis pigmentosa

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen Qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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3D-Ni_(3)S_(2)微球电催化尿素氧化辅助制氢研究

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湖北大学学报（自然科学版） 2024年第6期46卷 784-791页

作者：付鑫蒋瑞懿蒲博明瑞奇吕骞田丽红湖北大学化学化工学院湖北武汉430062

电催化尿素氧化(UOR)替代动力学缓慢的析氧反应(OER)为高效制氢提供了新的思路。本研究通过简单的二次水热法制备了三维Ni_(3)S_(2)/NF微球催化剂(3D-Ni_(3)S_(2)/NF),由于独特的3D结构为UOR提供了高度开放的活性区域,并加快了电荷转移... 详细信息

电催化尿素氧化(UOR)替代动力学缓慢的析氧反应(OER)为高效制氢提供了新的思路。本研究通过简单的二次水热法制备了三维Ni_(3)S_(2)/NF微球催化剂(3D-Ni_(3)S_(2)/NF),由于独特的3D结构为UOR提供了高度开放的活性区域,并加快了电荷转移速率,3D-Ni_(3)S_(2)/NF表现出明显优于1D,2D-Ni_(3)S_(2)/NF电催化氧化尿素的活性。在1 mol L^(-1)KOH+0.33 mol L^(-1)尿素电解质溶液,3D-Ni_(3)S_(2)/NF电催化尿素氧化达到100 mA cm^(-2)的电流密度的电位仅需1.38 V ***,比OER电位减少了250 mV,同时在24 h稳定性测试中表现出良好的耐久性。此外,全尿素辅助制氢只需1.66 V即可达到50 mA cm^(-2),表现出比传统电解水(1.86 V)更低的电位。

关键词：镍基催化剂尿素氧化反应电解水制氢金属硫化物

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碳负载Cu-Bi双金属高效电催化CO_(2)还原制备乙醇

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湖北大学学报（自然科学版） 2024年第4期46卷 461-468页

作者：蒋瑞懿付鑫蒲博明瑞奇吕骞田丽红湖北大学化学化工学院湖北武汉430062

采用清洁电能驱动CO_(2)转化为碳氢燃料及高价值的化学品是实现“碳中和”最有应用前景的方式之一。在电催化还原CO_(2)的产物中,乙醇是极具吸引力的产物。Cu基催化剂具有良好电催化还原CO_(2)至C_(2+)产物的活性,但单一的Cu基催化剂不... 详细信息

采用清洁电能驱动CO_(2)转化为碳氢燃料及高价值的化学品是实现“碳中和”最有应用前景的方式之一。在电催化还原CO_(2)的产物中,乙醇是极具吸引力的产物。Cu基催化剂具有良好电催化还原CO_(2)至C_(2+)产物的活性,但单一的Cu基催化剂不稳定,极易容易被氧化,因而可能严重降低电化学还原的电流密度及催化剂活性。本研究采用“一锅法”合成碳负载Cu-Bi双金属催化剂(Cu_(x)Bi_(y)@C)。在0.1 mol/L KCHO_(3)溶液中,CuxBiy@C表现出良好的电催化还原CO_(2)的活性,乙醇产物的选择性接近~100%。在-0.37 V(vs. RHE)过电位下CO_(2)还原为乙醇的法拉第效率可达到76.7%,其生成速率为450.6μmol g^(-1) h^(-1),催化剂在持续10 h的电催化还原过程中保持了良好的稳定性。动力学结果表明Cu、Bi双位点协同有利于质子/电子耦合转移,因而促进C-C偶联生成乙醇。

关键词： Cu-Bi催化剂 CO_(2)还原电催化乙醇

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深圳市2016-2030年55岁及以上中老年人群的疾病负担现况和预测

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中华流行病学杂志 2024年第11期45卷 1550-1558页

作者：席俊彦明睿琦王奕婧付英斌张振张佳白建军向钇凝林晓顾菁郝元涛刘刚中山大学公共卫生学院医学统计学系广州510080 中山大学全球卫生研究中心广州510080 中山大学卫生信息研究中心广州510080 广东医科大学公共卫生学院东莞523808 深圳市疾病预防控制中心业务管理科(基层公共卫生促进部) 深圳518055 深圳市疾病预防控制中心传染病预防控制所深圳518055 北京大学公众健康与重大疫情防控战略研究中心北京100191 北京大学公共卫生学院流行病与卫生统计学系北京100191 重大疾病流行病学教育部重点实验室(北京大学) 北京100191

目的分析2016-2030年深圳市≥55岁中老年人群的疾病负担,为制定健康老龄化策略提供循证依据。方法测算2016-2022年早死损失寿命年(YLL)、伤残损失寿命年(YLD)和伤残调整寿命年(DALY),采用Joinpoint对数线性回归模型检验时间趋势。综合... 详细信息

目的分析2016-2030年深圳市≥55岁中老年人群的疾病负担,为制定健康老龄化策略提供循证依据。方法测算2016-2022年早死损失寿命年(YLL)、伤残损失寿命年(YLD)和伤残调整寿命年(DALY),采用Joinpoint对数线性回归模型检验时间趋势。综合使用贝叶斯年龄-时期-队列模型和灰色系统模型预测2030年的YLL、YLD和DALY。结果2016-2022年,DALY粗率在55~74岁呈短期波动,在≥85岁显著升高;各年龄段的非传染性疾病YLL和YLD比例远大于传染性疾病/营养疾病以及伤害。2022年,各年龄段的YLL顺位第1位分别为肿瘤(55~74岁)和心血管疾病(≥75岁),YLD顺位第1位均为肌肉骨骼疾病。至2030年,各年龄组的YLL和YLD顺位第1位不变,部分疾病或伤害的负担顺位上升。结论深圳市≥55岁各年龄段的疾病负担现况和预测具有不同的特点,应根据相应的疾病负担模式合理分配社会及医疗资源。

关键词：健康老龄化疾病负担时间趋势贝叶斯灰色系统预测模型

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Synthesis of yolk-shell Bi_(2)O_(3)@TiO_(2) submicrospheres with enhanced potassium storage

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Science China Chemistry 2022年第9期65卷 1807-1816页

作者： Yifan Xu Hehe Zhang Tangjing Ding ruiqi Tian Dongmei Sun ming-Sheng Wang Xiaosi Zhou Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005China

Due to their enormous potential for large-scale energy storage,rechargeable potassium-ion batteries have been widely researched and ***,the drastic volume change of electrode materials induced by the huge size of potassium ions during cycling remains a challenge for the construction of stable ***,we propose a novel weak acid etching strategy to design and fabricate robust yolk-shell spheres with enough internal void space,in which the Bi_(2)O_(3) nanospheres are well confined in the compartments of TiO_(2) submicrospheres(y-Bi_(2)O_(3)@TiO_(2)).In situ transmission electron microscopy(TEM)and ex situ Xray diffraction(XRD)are conducted to elucidate the structural evolution of y-Bi_(2)O_(3)@TiO_(2) and the interaction between K^(+)and Bi_(2)O_(3) during *** to the yolk-shell nanoarchitecture and the superior buffering property of outer TiO_(2) covering,the as-obtained composite shows a high specific capacity of 383.5 mAh g^(−1) at 100 mA g^(−1),a considerable rate capacity of 134.1 mAh g^(−1) at 2 A g^(−1) and a stable cycling performance of 216.8 mAh g^(−1) at 500 mA g^(−1) over 500 cycles when used for potassium ***,the potassium-ion full battery,constructed by pairing y-Bi_(2)O_(3)@TiO_(2) anode with the thermally annealed 3,4,9,10-perylenetetracarboxylic dianhydride(PTCDA)cathode,exhibits an outstanding cycling ***,this carefully-designed strategy can inspire the further development of superior energy storage materials in the near future.

关键词： Bi_(2)O_(3) amorphous TiO_(2) yolk-shell structure anode potassium-ion batteries

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Coupling Sb_(2)WO_(6)microflowers and conductive polypyrrole for efficient potassium storage by enhanced conductivity and K^(+) diffusivity

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Journal of Energy Chemistry 2024年第2期89卷 250-258,I0007页

作者： ruiqi Tian Hehe Zhang Zeyu Yuan Yuehua Man Jianlu Sun Jianchun Bao ming-Sheng Wang Xiaosi Zhou School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023JiangsuChina State Key Lab of Physical Chemistry of Solid Surfaces College of MaterialsXiamen UniversityXiamen 361005FujianChina

Although metal oxide compounds are considered as desirable anode materials for potassium-ion batteries(PIBs)due to their high theoretical capacity,the large volume variation remains a key issue in realizing metal oxide anodes with long cycle life and excellent rate *** this study,polypyrroleencapsulated Sb_(2)WO_(6)(denoted Sb_(2)WO_(6)@PPy)microflowers are synthesized by a one-step hydrothermal method followed by in-situ polymerization and coating by *** the nanosheet-stacked Sb_(2)WO_(6)microflower structure,the improved electronic conductivity,and the architectural protection offered by the PPy coating,Sb_(2)WO_(6)@PPy exhibits boosted potassium storage properties,thereby demonstrating an outstanding rate property of 110.3 m A h g^(-1)at 5 A g^(-1)and delivering a long-period cycling stability with a reversible capacity of 197.2 m A h g^(-1)after 500 cycles at 1 A g^(-1).In addition,the conversion and alloying processes of Sb_(2)WO_(6)@PPy in PIBs with the generation of intermediates,K_(2)WO_(4)and K_(3)Sb,is determined by X-ray photoelectron spectroscopy,transmission electron microscopy,and exsitu X-ray diffraction during potassiation/*** functional theory calculations demonstrate that the robust coupling between PPy and Sb_(2)WO_(6)endues it with a much stronger total density of states and a built-in electric field,thereby increasing the electronic conductivity,and thus effectively reduces the K^(+)diffusion barrier.

关键词： Sb_(2)WO_(6) Polypyrrole coating Anode Potassium-ion battery In-situ TEM observation

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Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials

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Journal of Traditional Chinese Medicine 2020年第3期40卷 343-354页

作者： Liu Liuqing Liu Yanfeng Yang ming Xu Guiqin Li ruiqi Xu Xiuli Pan Xue Liang Jialing Department of Gynecology the 1st Clinical Medical College of Beijing University of Chinese MedicineBeijing 100700China Department of Gynecology Dongzhimen Hospital of Beijing University of Chinese MedicineBeijing 100700China Center for Evidence Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Scientific Research Management the 1st Affiliated Hospital of Anhui University of Chinese MedicineHefei 230001China Department of Gynecology Shunyi HospitalBeijing Hospital of Traditional Chinese MedicineBeijing 101300China

OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for *** were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment.

关键词： Ovarian reserve Tonifying kidney and regulating liver Randomized controlled trial Systematic review Meta-analysis

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[Cs_(6)Cl][Ga_(5)GeQ_(12)](Q=S,Se):two novel porous layered chalcohalides exhibiting two-band emission and ion exchange properties

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Science China Chemistry 2022年第10期65卷 1903-1910页

作者： ruiqi Wang Xian Zhang Fuqiang Huang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

The salt-inclusion materials have drawn significant attention for their manifold structural chemistry and novel physical/chemical ***,two new salt-inclusion chalcohalides,[Cs_(6)Cl][Ga_(5)GeQ_(12)](Q=S,Se),have been discovered via hightemperature flux *** two isostructural compounds are constructed by porous[Ga_(5)GeQ_(12)]^(5−)layers with[ClCs_(6)]^(5+)octahedra filled in the ***[Ga_(5)GeQ_(12)]^(5−)layer is composed of the honeycomb-like(Ga/Ge)_(18)Q_(42)rings containing(Ga/Ge)_(3)Q_(9)trimer as basic *** band gaps of the two compounds are 3.90 and 2.89 eV,respectively.[Cs_(6)Cl][Ga_(5)GeS_(12)]exhibits interesting two-band emission properties which are related to the intermediate-band electronic structure revealed by density functional theory(DFT)*** to the porous layered structure,[Cs_(6)Cl][Ga_(5)GeS_(12)]exhibits topological ion exchange ability towards Cd^(2+)ions with the maximum sorption capacity of 250 mg/g and high distribution coefficient(Kd)near 106 mL/*** work further enriches the structural diversity of salt-inclusion materials and extends their potential application range to ion exchange adsorption.

关键词： heteroanionic compound layered structure two-band emission ion exchange properties

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