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Nano Research 2024年第6期17卷 5073-5079页

作者： Ge Yu ruilong Li Yida zhang Xingen Lin Gongming Wang Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China

IrRu bimetallic oxides are recognized as the promising acidic oxygen evolution reaction(OER)catalysts,but breaking the trade-off between their activity and stability is an unresolved question.Meanwhile,addressing the issues of mass transport obstruction of IrRu bimetallic oxides under high current remains a challenge for the development of proton exchange membrane water electrolysis(PEM-WE).Herein,we prepared an IrRuO_(x)nanomeshes(IrRuO_(x)NMs)with high coordination number(CN)of Ir-O-Ru bonds in a mixed molten salt with high solubility of the Ir/Ru precursor.X-ray absorption spectroscopy analysis revealed that the IrRuO_(x)NMs possess high coordination number of Ir-O-Ru bonds(CNIr-O-Ru=5.6)with a distance of 3.18Å.Moreover,the nanomesh structures of IrRuO_(x)NMs provided hierarchical channels to accelerate the transport of oxygen and water,thus further improving the electrochemical activity.Consequently,the IrRuO_(x)NMs as OER catalysts can simultaneously achieve high activity and stability with low overpotential of 196 mV to reach 10 mA·cm^(−2)and slightly increase by 70 mV over 650 h test.Differential electrochemical mass spectrometry tests suggest that the preferred OER mechanism for IrRuO_(x)NMs is the adsorbent evolution mechanism,which is beneficial for the robust structural stability.

关键词： oxygen evolution reaction IrRuO_(x) Ir-O-Ru bonds two-dimensional(2D)nanomesh proton exchange membrane device mass transport

miR-125b reverses cisplatin resistance by regulating autophagy via targeting RORA/BNIP3L axis in lung adenocarcinoma

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Oncology Research 2024年第4期32卷 643-658页

作者： LEI LIU NA GUO XIANGLING LI QIAN XU ruilong HE LIMIN CHENG CHUNYAN DANG XINYU BAI YIYING BAI XIN WANG QIANHUI CHEN LI zhang Department of Immunology Chengde Medical UniversityChengde067000China Department of Pathology Chengde Medical UniversityChengde067000China Department of Oncology The Affiliated Hospital of Chengde Medical UniversityChengde067000China Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical UniversityChengde067000China

The platinum-based chemotherapy is one of the most frequently used treatment protocols for lung adenocarcinoma(LUAD),and chemoresistance,however,usually results in treatment failure and limits its application in the clinic.It has been shown that microRNAs(miRNAs)play a significant role in tumor chemoresistance.In this study,miR-125b was identified as a specific cisplatin(DDP)-resistant gene in LUAD,as indicated by the bioinformatics analysis and the real-time quantitative PCR assay.The decreased serum level of miR-125b in LUAD patients was correlated with the poor treatment response rate and short survival time.MiR-125b decreased the A549/DDP proliferation,and the multiple drug resistance-and autophagy-related protein expression levels,which were all reversed by the inhibition of miR-125b.In addition,xenografts of human tumors in nude mice were suppressed by miR-125b,demonstrating that through autophagy regulation,miR-125b could reverse the DDP resistance in LUAD cells,both in vitro and in vivo.Further mechanistic studies indicated that miR-125b directly repressed the expression levels of RORA and its downstream BNIP3L,which in turn inhibited autophagy and reversed chemoresistance.Based on these findings,miR-125b in combination with DDP might be an effective treatment option to overcome DDP resistance in LUAD.

关键词： Lung adenocarcinoma miRNAs Cisplatin Resistance Autophagy

Single-wavelength-excited fluorogenic nanoprobe for accurate realtime ratiometric analysis of broad pH fluctuations in mitophagy

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Nano Research 2022年第7期15卷 6515-6521页

作者： Xin zhang Juan Chen Jiwen Hu Anna du Rietz Xiongyu Wu ruilong zhang Zhongping zhang Kajsa Uvdal zhangjun Hu Department of Physics Chemistryand Biology(IFM)Linköping UniversityLinköping SE 58183Sweden School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China

Mitophagy has a critical role in maintaining cellular homeostasis through acidic lysosomes engulfing excess or impaired mitochondria,thereby pH fluctuation is one of the most significant indicators for tracking mitophagy.Then such precise pH tracking demands the fluorogenic probe that has tailored contemporaneous features,including mitochondrial-specificity,excellent biocompatibility,wide pH-sensitive range of 8.0–4.0,and especially quantitative ability.However,available molecular probes cannot simultaneously meet all the requirements since it is extremely difficult to integrate multiple functionalities into a single molecule.To fully address this issue,we herein integrate two fluorogenic pH sensitive units,a mitochondria-specific block,cellpenetrating facilitator,and biocompatible segments into an elegant silica nano scaffold,which greatly ensures the applicability for real-time tracking of pH fluctuations in mitophagy.Most significantly,at a single wavelength excitation,the integrated pHsensitive units have spectra-distinguishable fluorescence towards alkaline and acidic pH in a broad range that covers mitochondrial and lysosomal pH,thus enabling a ratiometric analysis of pH variations during the whole mitophagy.This work also provides constructive insights into the fabrication of advanced fluorescent nanoprobes for diverse biomedical applications.

关键词： mitochondrial pH mitophagy ratiometric fluorescence nanoprobe cell imaging

Real-time quantification of nuclear RNA export using an intracellular relocation probe

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Chinese Chemical Letters 2022年第8期33卷 3865-3868页

作者： Jie Shen Juan Chen Dong Wang Zhengjie Liu Guangmei Han Bianhua Liu Mingyong Han ruilong zhang Guodong Liu Zhongping zhang School of Chemistry and Chemical Engineering Information Materials and Intelligent Sensing Laboratory of Anhui Provinceand Institute of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Key Laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University) Ministry of EducationHefei 230601China Key Lab of Photovoltaic and Energy Conservation Materials Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China School of Life and Health Sciences Anhui Science and Technology UniversityChuzhou 233100China

Nuclear RNA export into the cytoplasm is one of the key steps in protein expression to realize biological functions.Despite the broad availability of nucleic acid dyes,tracking and quantifying the highly dynamic process of RNA export in live cells is challenging.When dye-labeled RNA enters the cytoplasm,the dye molecules are released upon degradation of the RNA,allowing them to re-enter the cell nucleus.As a result,the ratio between the dye exported with RNA into the cytoplasm and the portion staying inside the nucleus cannot be determined.To address this common limitation,we report the design of a smart probe that can only check into the nucleus once.When adding to cells,this probe rapidly binds with nuclear RNAs in live cells and reacts with intrinsic H_(2)S.This reaction not only activates the fluorescence for RNA tracking but also changes the structure of probe and consequently its intracellular localization.After disassociating from exported RNAs in cytoplasm,the probe preferentially enters lysosomes rather than cell nucleus,enabling real-time quantitative measurement of nuclear RNA exports.Using this probe,we successfully evaluated the effects of hormones and cancer drugs on nuclear RNA export in live cells.Interestingly,we found that hormones inhibiting RNA exports can partially offset the effect of chemotherapy.

关键词： RNA export Quantification Relocation probe Fluorescence imaging Hormone

雍正改制与清代科举的新传统——以登极恩科和恩诏科举广额为例

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史林 2024年第1期 151-167,220页

作者：张瑞龙中国人民大学历史学院 100872

雍正登极恩诏中并无特开恩科之款,特开登极恩科是在此后另行专诏颁布。雍正开创登极恩科,提高、扩大恩诏科举广额的名数和范围,和他继位之初与宗室诸王的党争及其在八旗中的势力不占优势有关。此举旨在借助民人尤其是汉人的力量来稳固... 详细信息

雍正登极恩诏中并无特开恩科之款,特开登极恩科是在此后另行专诏颁布。雍正开创登极恩科,提高、扩大恩诏科举广额的名数和范围,和他继位之初与宗室诸王的党争及其在八旗中的势力不占优势有关。此举旨在借助民人尤其是汉人的力量来稳固统治。雍正七年以孔庙庆云恩诏科举广额,实则与曾静案密切相关,其目的亦在于此。凡此皆与雍正朝用人行政和权力结构中的“重用汉人”相似。由于登极大典的至高礼仪规格和覃恩条款的极强延续性,雍正开创的登极恩科且恩诏科举广额,作为皇权的礼仪性缘饰,被后世继统之君援用,成为清代科举的新传统。恩诏科举广额的其他恩例,在雍正以降或遭取消废止、或被降低规格,清代恩诏科举广额的恩例由此形成鲜明的等级体系。在清代的制度和政治变革中,“雍正改制”或可作为一个独立的制度史时段。

关键词：清代科举恩诏科举广额登极恩科新传统雍正改制

One-step Condensation/copolymerization of VTES and DVB for Self-assembly Bionic Superhydrophobic Surface Coating and Study on Oil-water Separation

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Journal of Bionic Engineering 2021年第3期18卷 559-573页

作者： ruilong zhang Zhiping Zhou Yi Wang Xiaohui Dai Li Chen Jiangdong Dai Research School of Polymeric Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 2120133China State Key Laboratory of NBC Protection for Civilian Beijing 102205China Institute of Green Chemistry and Chemical Technology Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu ProvinceSchool of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Mimicry of nature drives the development of bionic materials.Bionic superhydrophobic materials are a kind of high-efficiency materials to handle oil spills and water pollution.However,the stability of surface coatings of the superhydrophobic materials remains a challenge.Herein,a new category of self-assembly bionic superhydrophobic surface coating was prepared via one-step condensation/copolymerization of vinyltriethoxysilane(VTES)and divinylbenzene(DVB),which realized the close combination of covalent bonds between organic(e.g.DVB)and inorganic matter(e.g.VTES),and avoided the swelling of polydivinylbenzene(PDVB)in the process of collection of oil from water.This organic-inorganic hybrid polymer could self-assembly deposit on the surface of sponge even other substrates.For example,P(VTES-DVB)-Si0_(2)/MS obtained by assembling P(VTES-DVB)-Si0_(2)on the surface of Melamine Sponge(MS)exhibited superhydrophobicity with a Water Contact Angle(WCA)of 157.3,the optimal adsorption capacity of 77 g g 136 g g-1 for diverse oils,and an excellent separation efficiency of 99.3%.Besides,the excellent acid and alkali resistance of P(VTES-DVB)-Si0_(2)/MS suggested the potential value in practical oil-water separation.P(VTES-DVB)-Si0_(2)showed the outstanding hydrophobic performance by using as coating on different substrates.This work provided a new idea about the stable combination of organic and inorganic matter in the surface modification.

关键词： superhydrophobic surface coating oil-water separation condensation copolymerization self-assembly organic-inorganic hybridism

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新能源汽车故障与维修关键技术探究

时代汽车 2024年第5期 180-182页

作者：张蕤珑上海师范大学上海市201400

社会经济的发展极大提升了人们的生活水平,新能源汽车的利用率也在逐年提升,在践行环保、可持续发展理念方面起着积极作用。但新能源汽车进入市场的时间较短,受到技术、售后服务体系、管理制度等因素的影响,存在着故障与维修问题,并且... 详细信息

社会经济的发展极大提升了人们的生活水平,新能源汽车的利用率也在逐年提升,在践行环保、可持续发展理念方面起着积极作用。但新能源汽车进入市场的时间较短,受到技术、售后服务体系、管理制度等因素的影响,存在着故障与维修问题,并且主要集中在电池系统、控制系统、充电系统等方面。本文就深入探讨新能源汽车的常见故障问题,分析新能源汽车故障与维修现状,并提出新能源汽车故障与维修关键技术与应用策略,以期为相关企业开展工作提供参考。

关键词：新能源汽车故障与维修关键技术

Robust,fluorine-free and superhydrophobic composite melamine sponge modified with dual silanized SiO_(2) microspheres for oil-water separation

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Chinese Journal of Chemical Engineering 2021年第5期34卷 50-60页

作者： ruilong zhang Zhiping Zhou Wenna Ge Yi Lu Tianshu Liu Wenming Yang Jiangdong Dai School of Material Science and Engineering Jiangsu UniversityZhenjiang 212013China Institute of Green Chemistry and Chemical Technology School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China School of Mechanical Engineering Dalian University of TechnologyDalian 116023China Entry-Exit Inspection Quarantine Bureau Zhenjiang 212008China

Massive oily wastewater discharged from industrial production and human daily life have been an urgent environmental and ecological challenge.Superhydrophobic materials have attracted tremendous attention due to their unique properties and potential applications in the treatment of wastewater.In this study,a novel superhydrophobic/superoleophilic composite melamine sponge modified with dual silanized SiO_(2) microspheres was fabricated simply by a two-step sol-gel method using vinyltriethoxysilane and hexadecyltrimethoxysilane as functional agent,which exhibited a water contact angle of 153.2°and a water sliding contact angle of 4.8°.Furthermore,the composite sponge showed the excellent oil adsorption performance and the compressive elasticity reaching up to 130 g·g^(-1) of dichloromethane and 33.1 kPa of compressive stress.It was worth noting that the composite sponge presented the excellent separation efficiency(up to 99.5%)in the processes of continuous oil/water separation.The robust superhydrophobic composite melamine sponge provided the possibility with the practical application for oil-water separation.

关键词： Superhydrophobic sponge Two-step sol-gel method Oil-water separation Dual silanized SiO_(2) microspheres

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X波段接收机强电磁脉冲的毁伤效应

火力与指挥控制 2024年第4期49卷 164-169页

作者：雷文博张国伟何瑞龙高燕婷中北大学机电工程学院太原030051

为解决低轨道侦察卫星的侦察行动使战场丧失隐蔽性的问题,采用电磁脉冲攻击卫星接收机的毁伤方法,利用电磁仿真软件CST、电路仿真软件ADS对电子目标进行建模,进行电磁脉冲辐照模拟试验。结果表明,高功率微波发射源以30 GW的发射功率、70... 详细信息

为解决低轨道侦察卫星的侦察行动使战场丧失隐蔽性的问题,采用电磁脉冲攻击卫星接收机的毁伤方法,利用电磁仿真软件CST、电路仿真软件ADS对电子目标进行建模,进行电磁脉冲辐照模拟试验。结果表明,高功率微波发射源以30 GW的发射功率、70 dB的发射增益,在距离目标400 km处,可造成接收机设备部分器件损毁;若以30 GW的发射功率、90 dB的发射增益、在距离目标400 km处,可造成接收机设备完全损毁。结果验证了电磁脉冲武器攻击低轨道微小卫星接收机方案的可行性。

关键词：侦察卫星接收天线高功率微波前门耦合毁伤效应数值仿真

Impact Analysis of MTD on the Frequency Stability in Smart Grid

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 275-277页

作者： Zhenyong zhang ruilong Deng the State Key Laboratory of Public Big Data and the College of Computer Science and Technology Guizhou UniversityGuiyang 550025China IEEE the State Key Laboratory of Industrial Control Technology Zhejiang UniversityHangzhou 310027China

Dear Editor, In order to accommodate the effects of false data injection attacks(FDIAs), the moving target defense(MTD) strategy is recently proposed to enhance the security of the smart grid by perturbing branch susceptances. However, most pioneer work only focus on the defending performance of MTD in terms of detecting FDIAs and the impact of MTD on the static factors such as the power and economic losses.

关键词： Smart MTD Impact