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Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration

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Bioactive Materials 2022年第6期7卷 153-168页

作者： Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen ruichao cao Zongchao Liu Yuling Li Jie Hao Department of Orthopedics Orthopedic Laboratory of Chongqing Medical UniversityThe First Affiliated Hospital of Chongqing Medical UniversityNo.1 Youyi RoadChongqing40042PR China School of Biomedical Engineering Shanghai Jiao Tong University1954 Huashan RoadShanghai200030PR China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China Department of Orthopaedics Affiliated Hospital of North Sichuan Medical CollegeNo.63 Wenhua RoadNanchongSichuan637000PR China Department of Orthopaedics Affiliated Hospital of Traditional Chinese MedicineSouthwest Medical UniversityNo.182 Chunhui RoadSichuan646699PR China

Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic ***,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in *** uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation ***,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity *** was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in *** the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in ***,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment.

关键词： Hydrogel microsphere Microfluidic Lactate Tissue regeneration Injection

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黄土高原生境质量时空演变及其驱动因素

水土保持通报 2022年第6期42卷 343-350页

作者：周璐红曹瑞超长安大学土地工程学院陕西西安710054 长安大学地球科学与资源学院陕西西安710054 陕西省土地整治重点实验室陕西西安710054

[目的]分析黄土高原生境质量的时空演变和影响因素,为黄土高原的生态治理和保障区域生态安全提供科学参考。[方法]运用InVEST模型评价了黄土高原生境质量,利用空间自相关分析法分析生境质量时空关联性,采用地理探测器分析了影响生境质... 详细信息

[目的]分析黄土高原生境质量的时空演变和影响因素,为黄土高原的生态治理和保障区域生态安全提供科学参考。[方法]运用InVEST模型评价了黄土高原生境质量,利用空间自相关分析法分析生境质量时空关联性,采用地理探测器分析了影响生境质量的驱动因子并进行单因子探测及交互探测。[结果]①2000—2020年,黄土高原20.5%的区域生境质量上升,7.18%的区域生境质量下降,区域生境质量呈稳定提升的趋势。②2000,2010和2020年黄土高原全局Moran’s I分别为0.714,0.706和0.694,生境质量在空间分布上呈现集聚现象并具有较高的空间正相关性,Moran’s I指数值降低说明空间集聚性小幅度下降,空间分布差异性渐趋均衡。③黄土高原生境质量因子影响程度大小顺序为:NDVI>降水>GDP>坡度>高程>人口>气温,研究期内各驱动因子对生境质量的决定力变化幅度不大且影响顺序未发生明显改变,说明各因子对生境质量的影响较稳定。[结论]应充分考虑黄土高原的实际情况,兼顾生态与经济两方面协同发展的目标,未来黄土高原可根据各生态区块的生境质量状况,制定更加具有针对性的管理措施,增强生态系统服务功能,并以其为基础寻求新型经济增长模式。

关键词：生境质量 InVEST模型空间自相关地理探测器黄土高原

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O2O模式下服装网络定制顾客忠诚度研究

丝绸 2015年第1期52卷 42-46页

作者：李露谢红曹蕊超上海工程技术大学服装学院上海201620

通过对具有一定经济基础的网上购物族和有过定制经历的人群进行调研,研究基于O2O电子商务模式下服装网络定制的顾客忠诚度。根据构建顾客忠诚度的结构方程模型观念架构图对客户潜在定制需求进行挖掘。首先利用SPSS对调研数据进行统计分... 详细信息

通过对具有一定经济基础的网上购物族和有过定制经历的人群进行调研,研究基于O2O电子商务模式下服装网络定制的顾客忠诚度。根据构建顾客忠诚度的结构方程模型观念架构图对客户潜在定制需求进行挖掘。首先利用SPSS对调研数据进行统计分析,然后采用AMOS软件对顾客忠诚度模型进行验证,最后得出结论:1)网上定制服务信息宣传对顾客满意度有较强的正面影响;2)线下所实施的面对面的定制服务,是增强顾客定制满意度的主要因素;3)顾客参与定制过程,更易激发客户定制好奇心,增强定制体验快感,促使客户在网上预约定制消费行为。

关键词： O2O 顾客忠诚度结构方程模型定制需求服装

Zeros of Complete Symmetric Polynomials over Finite Fields

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Journal of Systems Science & Complexity 2024年第4期37卷 1772-1788页

作者： cao Wei School of Mathematics and Statistics Minnan Normal UniversityZhangzhou 363000China

Wan and Zhang(2021) obtained a nontrivial lower bound for the number of zeros of complete symmetric polynomials over finite fields,and proposed a problem whether their bound can be *** this paper,the author improves Wan-Zhang's bound from three *** proposed results are based on the estimates related to the number of certain permutations and the value sets of non-permutation polynomials associated to the complete symmetric *** the author believes that there are still possibilities to improve the bounds and hence Wan-Zhang's bound.

关键词： Complete symmetric polynomial finite field permutation polynomial value set

Quantitative phase imaging based on holography:trends and new perspectives

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Light(Science & Applications) 2024年第7期13卷 1235-1277页

作者： Zhengzhong Huang Liangcai cao Department of Precision Instrument Tsinghua UniversityBeijing 100084China

In 1948,Dennis Gabor proposed the concept of holography,providing a pioneering solution to a quantitative description of the optical *** 75 years of development,holographic imaging has become a powerful tool for optical wavefront measurement and quantitative phase *** emergence of this technology has given fresh energy to physics,biology,and materials *** holography(DH)possesses the quantitative advantages of wide-field,non-contact,precise,and dynamic measurement capability for *** has unique capabilities for the propagation of optical fields by measuring light scattering with phase *** offers quantitative visualization of the refractive index and thickness distribution of weak absorption samples,which plays a vital role in the pathophysiology of various diseases and the characterization of various *** provides a possibility to bridge the gap between the imaging and scattering *** propagation of wavefront is described by the complex *** complex-value in the complex-domain is reconstructed from the intensityvalue measurement by camera in the ***,we regard the process of holographic recording and reconstruction as a transformation between complex-domain and real-domain,and discuss the mathematics and physical principles of *** review the DH in underlying principles,technical approaches,and the breadth of *** conclude with emerging challenges and opportunities based on combining holographic imaging with other methodologies that expand the scope and utility of holographic imaging even *** multidisciplinary nature brings technology and application experts together in label-free cell biology,analytical chemistry,clinical sciences,wavefront sensing,and semiconductor production.

关键词： holographic phase precise

Dynamic Setting Method of Assessment Indicators for Power Curves of Renewable Energy Sources Considering Scarcity of Reserve Resources

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 101-114页

作者： Minghao cao Jilai Yu the Department of Electrical Engineering Harbin Institute of TechnologyHarbinChina

With the increasing proportion of renewable energy sources(RESs)in power grid,the reserve resource(RR)scarcity for correcting power deviation of RESs has become a potential ***,the power curve of RES needs to be more rigorously *** RR scarcity varies during different time periods,so the values of assessment indicators should be dynamically *** assessment indicators in this paper include two aspects,i.e.,deviation exemption ratio and penalty ***,this paper proposes a method for dynamically calculating the supply capacity and RR cost,primarily taking into account the operating status of thermal units,forecast information of RES,and load ***,after clarifying the logical relationship between the degree of RR scarcity and the values of assessment indicators,this paper establishes a mapping function between *** on this mapping function,a dynamic setting method for assessment indicators is *** the future,RES will generally be equipped with battery energy storage systems(BESSs).Reasonably utilizing BESSs to reduce the power deviation of RESs can increase the expected income of ***,this paper proposes a power curve optimization strategy for RESs considering self-owned *** case study demonstrates that the dynamic setting method of assessment indicators can increase the revenue of RESs while ensuring that the penalty fees paid by RESs to the grid are sufficient to cover the RR ***,the power curve optimization strategy can help RESs further increase income and fully utilize BESSs to reduce power deviation.

关键词： Renewable energy battery energy storage system(BESS) power curve assessment reserve service parameter setting

Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming

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Journal of Bionic Engineering 2024年第1期21卷 177-191页

作者： Yiwei Hao Yonghui cao Yingzhuo cao Xiong Mo Qiaogao Huang Lei Gong Guang Pan Yong cao School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China Unmanned Vehicle Innovation Center Ningbo Institute of NPUNingbo 315103China Key Laboratory of Unmanned Underwater Vehicle Technology of Ministry of Industry and Information Technology Xi'an 710072China

Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral *** is still difficult for a robotic fish to swim autonomously in a confined area as a real ***,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding *** generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw *** verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave *** experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic ***,the swimming ability of the robotic manta is verified by field tests.

关键词： Biomimetic robotic manta Central Pattern Generator Closed-loop control Backward swimming

Multi-scenario land use prediction and layout optimization in Nanjing Metropolitan Area based on the PLUS model

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Journal of Geographical Sciences 2024年第7期34卷 1415-1436页

作者： cao Ji cao Weidong cao Yuhong WANG Xuewei ZHANG Yizhen MA Jinji School of Geography and Tourism Anhui Normal UniversityWuhuAnhui241002China School of Ecology and Environment Anhui Normal UniversityWuhuAnhui241002China

The metropolitan area is a crucial spatial element in promoting new urbanization in *** possesses theoretical and empirical value in the determination of the evolutionary patterns and development trends necessary for regional integration and high-quality *** study focused on Nanjing Metropolitan Area,the first national metropolitan area in China,and established three development scenarios by combining ecological–economic spatial conflict(EESC)zones and national key ecological functional *** scenarios simulate the spatial distribution of future land use and land cover change(LUCC)using the development zone planning function of the patch generation land use simulation(PLUS)*** results show that:(1)Between 2000 and 2020,the most prominent characteristics of land use change were largely the massive expansion of built-up land and the significant decline of farmland,while changes in the area of ecological land were less evident.(2)EESC areas experienced significant changes over the past 20 years,but the overall level of conflict was *** land was the main land use type in the lowest-conflict area,while built-up land was the main land use type in the highest-conflict area.(3)From 2030 to 2050,further expansion of built-up areas is expected,with continued decrease of *** regulation of these land use changes can be achieved through different development zone *** economic development scenario had the largest built-up land area,while the ecological protection scenario had the largest farmland *** study simulates the spatial pattern changes in the metropolitan area based on spatial conflict patterns and national main functional area planning process,providing a scientific reference for future spatial planning and management.

关键词： land use change spatial conflict patch-generating simulation land use prediction Nanjing Metropolitan Area

Making the Complicated Simple:A Minimizing Carrier Strategy on Innovative Nanopesticides

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Nano-Micro Letters 2024年第10期16卷 31-46页

作者： Wenjie Shangguan Qiliang Huang Huiping Chen Yingying Zheng Pengyue Zhao Chong cao Manli Yu Yongsong cao Lidong cao State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193People's Republic of China College of Plant Protection China Agricultural UniversityBeijing 100193People's Republic of China State Key Laboratory of Element-Organic Chemistry Department of Chemical BiologyCollege of ChemistryNankai UniversityTianjin 300071People's Republic of China

The flourishing progress in nanotechnology offers boundless opportunities for agriculture,particularly in the realm of nanopesticides research and ***,concerns have been raised regarding the human and environmental safety issues stemming from the unrestrained use of non-therapeutic nanomaterials in *** is also important to consider whether the current development strategy of nanopesticides based on nanocarriers can strike a balance between investment and return,and if the complex material composition genuinely improves the efficiency,safety,and circularity of ***,we introduced the concept of nanopesticides with minimizing carriers(NMC)prepared through prodrug design and molecular self-assembly emerging as practical tools to address the current limitations,and compared it with nanopesticides employing non-therapeutic nanomaterials as carriers(NNC).We further summarized the current development strategy of NMC and examined potential challenges in its preparation,performance,and ***,we asserted that the development of NMC systems can serve as the innovative driving force catalyzing a green and efficient revolution in nanopesticides,offering a way out of the current predicament.

关键词： Nanopesticides Green agrochemicals Self-assembly Nanomaterial safety Sustainable development strategies