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城镇中压配电网的规划设计

农村电气化 2003年第7期 16-17页

作者：吴家生孙瑞兵河北省丰润电力局 064000

文章介绍了城镇配电网规划设计中遇到的负荷调查预测、负荷调整、网络主干布局、负荷分配、主干分段、方案优化选择等问题的解决方法 ,供农网规划设计部门参考。

关键词：城镇中压配电网电网规划设计负荷预测负荷调整电力系统

Solvothermal-assisted liquid-phase exfoliation of large size and high quality black phosphorus

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Journal of Materiomics 2018年第2期4卷 129-134页

作者： Zhe Yan Xuexia He Liaona She Jie sun ruibing Jiang Hua Xu Feng Shi Zhibin Lei Zong-Huai Liu Key Laboratory of Applied Surface and Colloid Chemistry(Shaanxi Normal University) Ministry of EducationXi'an 710062China School of Materials Science and Engineering Shaanxi Normal UniversityXi'an 710062China Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119China

Black phosphorus(BP),especially for BP nanosheets,with unique layered structure among two dimensional(2D)materials has attracted much attention due to its outstanding physical properties,such as ultra-high mobility,in-plane anisotropic ***,the small horizontal-size of reported BP limits its applications in the integrated circuit or some functional *** this work,a solvothermalassisted liquid-phase exfoliation technique is firstly employed for preparing large size and high-quality BP *** the high-polar acetonitrile solvent,solvothermal treatment weakens the Van der Waals forces of block *** with the subsequently ultrasonic processing,effective exfoliation of large size and high-quality BP nanosheets are *** TEM,AFM and Raman results indicate that the prepared BP nanosheets are high quality with an average thickness of about 2 nm,and the horizontalsize is up to 10μ*** facile and effective method for exfoliated BP nanosheets provides a promising strategy for the exfoliation of other 2D materials.

关键词： Two dimensional materials black phosphorus Liquid exfoliation Solvothermal method

Supramolecular Manipulation of Intracellular Acidic Vesicles to Improve Cellular Self-Repair and Self-Defense

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CCS Chemistry 2024年第6期6卷 1487-1498页

作者： Ziyi Wang Chen sun Yu Dong Yuan-Fu Ding Chen Zhao Ian Wa Ho Jiahong Lu ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao 999078China

Lysosomes are the“cell stomach”that digests various species including macromolecules and pathogens for self-repair and self-defense upon fusion with endosomes,autophagosomes,and ***,artificially manipulating intracellular vesicles could potentially promote lysosome-mediated intracellular digestion for disease prevention and ***,a supramolecular strategy to efficiently tether and fuse acidic vesicles(i.e.,lysosomes,late endosomes,autolysosomes,and phagosomes)has been developed for the first time to enhance the digestion of cellular wastes and foreign matter,including pathogens.A linear polyethylene glycol(PEG)derivative dually tagged with morpholine(MOR)and adamantane(ADA)on the opposite side,namely,MOR-PEG-ADA,was designed to target intracellular acidic vesicles via MOR and to decorate their surfaces with ***,the addition of cucurbit[7]uril(CB[7])grafted hyaluronic acid(HA)induced supramolecular tethering and fusion of acidic vesicles via strong host-guest interactions between CB[7]of CB[7]-HA and ADA residing on the surface of acidic *** a proof-ofconcept,the overall cellular metabolism,including endogenous autophagy and the exogenous endocytosis and phagocytosis,was effectively upregulated,demonstrating that supramolecular regulation of the dynamics of intracellular acidic vesicles may promote the lysosome’s digestion to significantly improve cellular self-repair and self-defense.

关键词： supramolecular chemistry organelle regulation intracellular acidic vesicles lysosomes selfdefense self-repair

Supramolecular Vesicles Based on Gold Nanorods for Precise Control of Gene Therapy and Deferred Photothermal Therapy

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CCS Chemistry 2022年第5期4卷 1745-1757页

作者： Ludan Yue Kuikun Yang Jianwen Wei Mengze Xu Chen sun Yuanfu Ding Zhen Yuan Shu Wang ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao SAR 999078 Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Cancer Center Faculty of Health Sciences and Center for Cognitive and Brain SciencesUniversity of MacaoTaipaMacao SAR 999078

In spite of being a promising therapeutic modality,gene therapy has limited clinical applications,mostly due to the lack of spatiotemporal resolution and inadequate ***,we present a facile strategy to remotely control intracellular gene expression by using gold nanorod-(Au NR)derived,host-guest interaction-mediated supramolecular vesicles as a gene carrier and photothermal *** pulsed laser irradiation,mild photothermal conditions dissociate supramolecular vesicles to release gene and simultaneously activate heat shock protein-70 promoter(Hsp70)for spatiotemporally initiating gene expression inside cancer ***,upon introducing a polymeric guest species specifically into cancer cells,the dissociated Au NRs functionalized with macrocyclic host molecules could re-aggregate rapidly in cells to retard exocytosis of these NRs,thereby allowing deferred photothermal therapy to enhance the overall therapeutic outcome.

关键词： supramolecular vesicles host-guest chemistry self-assembly photothermal therapy inducible gene therapy

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红外加热技术在农业物料加工中的应用

农业机械学报 2007年第7期38卷 177-182页

作者：王相友操瑞兵孙传祝山东理工大学轻工与农业工程学院山东理工大学工程技术学院

介绍了生物材料红外吸收光谱的原理和特点,总结了红外加热技术的优点,列举了几种农业生物材料干燥数学模型以及合理选择干燥模型的标准。通过大量的实例阐述了红外辐射技术在谷物干燥、果蔬脱水以及农产品消毒杀菌方面的应用和研究。在... 详细信息

介绍了生物材料红外吸收光谱的原理和特点,总结了红外加热技术的优点,列举了几种农业生物材料干燥数学模型以及合理选择干燥模型的标准。通过大量的实例阐述了红外辐射技术在谷物干燥、果蔬脱水以及农产品消毒杀菌方面的应用和研究。在此基础上提出了红外干燥技术在生物材料加工中的进一步研究方向。

关键词：生物材料干燥红外辐射

PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance

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Research 2023年第3期2022卷 171-185页

作者： Rongjun Zou Jun Tao Jie He Chaojie Wang Songtao Tan Yu Xia Xing Chang ruibing Li Ge Wang Hao Zhou Xiaoping Fan Department of Cardiovascular Surgery Guangdong Provincial Hospital of Chinese MedicineThe Second Afiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120GuangdongChina The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou 510405GuangdongChina Department of Cardiovascular Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120GuangdongChina Senior Department of Cardiology The Sixth Medical Center of People's Liberation Army General HospitalBeijing 100048China Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China.

Disruption of the mitochondrial quality surveillance(MQS)system contributes to mitochondrial dysfunction in diabetic cardiomyopathy(DCM).In this study,we observed that cardiac expression of phosphoglycerate mutase 5(PGAM5),a mitochondrial Ser/Thr protein phosphatase,is upregulated in mice with streptozotocin-induced ***,DCM-related cardiac structural and functional deficits were negated in cardiomyocyte-specific Pgam5 knockout(Pgam5^(CKO))*** stress impaired adenosine triphosphate production,reduced respiratory activity,and prolonged mitochondrial permeability transition pore opening in acutely isolated neonatal cardiomyocytes from control Pgam5^(f/f) mice,and these effects were markedly prevented in cardiomyocytes from Pgam5^(CKO) ***,three main MQS-governed processes—namely,mitochondrial fission/fusion cycling,mitophagy,and biogenesis—were disrupted by hyperglycemia in Pgam5^(f/f),but not in Pgam5^(CKO),*** the basis of bioinformatics prediction of interaction between PGAM5 and prohibitin 2(PHB2),an inner mitochondrial membrane-associated scaffolding protein,co-immunoprecipitation,and immunoblot assays demonstrated that PGAM5 dephosphorylates PHB2 on *** of cardiomyocytes with phosphodefective or phosphomimetic Ser91 mutants of PHB2 confirmed a critical role for PGAM5-mediated dephosphorylation of PHB2 in mitochondrial dysfunction associated with hyperglycemic ***,knockin mice expressing phosphomimetic PHB2^(S91D) were resistant to diabetes-induced cardiac *** findings highlight the PGAM-PHB2 axis as a novel and critical regulator of mitochondrial dysfunction in DCM.

关键词： PHB2 cycling impaired

Biomimetic Recognition-Based Bioorthogonal Host-Guest Pairs for Cell Targeting and Tissue Imaging in Living Animals

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CCS Chemistry 2022年第6期4卷 1977-1989页

作者： Yan-Long Ma Chen sun Zeshun Li Ziyi Wang Jianwen Wei Qian Cheng Li-Shuo Zheng Xiao-Yong Chang Kai Li ruibing Wang Wei Jiang Shenzhen Grubbs Institute Guangdong Provincial Key Laboratory of Catalysisand Department of ChemistrySouthern University of Science and TechnologyShenzhen 518055 State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical ScienceMoE Frontiers Science Center for Precision OncologyUniversity of MacaoTaipaMacao 999078 Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055

Bioconjugation methods offer very important tools in studying biological *** host-guest pairs provide an alternative and complementary conjugation method to bioorthogonal reactions and biological association ***,macrocyclic hosts that can be used for in situ capture are limited and often rely on extremely high binding ***,we report an alternative bioorthogonal host-guest pair that relies on highly selective molecular recognition in *** host,namely amide naphthotube,possesses a biomimetic cavity with inward-directing hydrogen bonding sites and shows selective and strong binding to the guest(2-phenyl pyrimidine)even in biological *** anchoring the tetraphenyl ethylene-modi fied hosts to cell surfaces,the bioorthogonal host-guest pair can be applied in cell surface recognition,cell-cell interactions,and tissue imaging in *** bioorthogonality is originated from the high binding selectivity of the biomimetic macrocyclic host,which is different from other known host-guest pairs that have been applied in biological *** research provides a new noncovalent bioconjugation tool and a new concept for designing bioorthogonal host-guest pairs for biological applications.

关键词： cell targeting tissue imaging bioconjugation bioorthogonal host-guest pair naphthotube

Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma

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Bioactive Materials 2021年第12期6卷 4707-4716页

作者： Yuxun Ding Xiaohui Xiao Lingli Zeng Qiuping Shang Wei Jiang Sha Xiong Xiaohui Duan Jun Shen ruibing Wang Jinshan Guo Yue Pan Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineDepartment of RadiologyMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou510120China Longgang E.N.T.Hospital&Shenzhen Key Laboratory of E.N.T. Institute of E.N.T.ShenzhenGuangdong518116China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Department of Histology and Embryology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Despite extensive use of radiotherapy in nasopharyngeal carcinoma(NPC)treatment because of its high radiosensitivity,there have been huge challenges in further improving therapeutic effect,meanwhile obviously reducing radiation *** this end,synergistic chemoradiotherapy has emerged as a potential strategy for highly effective NPC ***,we developed RGD-targeted platinum-based nanoparticles(RGD-PtNPs,denoted as RPNs)to achieve targeted chemoradiotherapy for *** nanoparticles consist of an RGD-conjugated shell and a cis-platinum(CDDP)crosslinking *** advantage of RGD,the RPNs may effectively accumulate in tumor,penetrate into tumor tissues and be taken by cancer cells,giving rise to a high delivery efficiency of *** they are fully enriched in tumor sites,the CDDP loaded RPNs can act as radiotherapy sensitizer and chemotherapy *** means of X-ray-promoted tumor cell uptake of nanoparticle and CDDP-induced cell cycle arrest in radiation-sensitive G2/M phases,RPNs may offer remarkable therapeutic outcome in the synergistic chemoradiotherapy for NPC.

关键词： Nasopharyngeal carcinoma(NPC) Chemoradiotherapy Polymeric nanoparticles Precise treatment

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确定P-V曲线中质壁分离点的方法比较

南京林业大学学报（自然科学版） 2016年第4期40卷 89-94页

作者：段瑞兵孙慧珍东北林业大学生态研究中心黑龙江哈尔滨150040

质壁分离渗透势（Ψtlp ）与质壁分离相对含水量（ CRW，tlp ）作为重要的水分生理参数，被认为是衡量树木耐旱性强弱的重要指标。为了验证不同方法确定质壁分离点的差异，笔者对比了Ⅰ型与Ⅱ型标绘P-V曲线类型，采用Ⅱ型标绘方式，利... 详细信息

质壁分离渗透势（Ψtlp ）与质壁分离相对含水量（ CRW，tlp ）作为重要的水分生理参数，被认为是衡量树木耐旱性强弱的重要指标。为了验证不同方法确定质壁分离点的差异，笔者对比了Ⅰ型与Ⅱ型标绘P-V曲线类型，采用Ⅱ型标绘方式，利用常见的数学法、图形法和程序法分析了东北东部山区主要树种的Ψtlp和CRW，tlp。结果表明：Ⅰ型8个树种Ψtlp和CRW，tlp平均值分别较Ⅱ型高出0．20 MPa和3．17％。其中两种标绘类型对针叶树兴安落叶松和红松参数求解影响大于阔叶树。不同标绘类型改变了树种间参数的对比关系。Ⅱ型中除了程序法求解春榆Ψtlp显著高于数学法外（P＜0．05），其他树种3种方法求解Ψtlp及CRW，tlp均无显著性差异（P＞0．05）。3种方法求解的同一参数间的线性方程决定系数在0．63～0．90之间（ P＜0．01）。其中，数学法与图形法线性关系最好，数学法与程序法、图形法与程序法线性关系次之。Ⅱ型标绘P-V曲线图形变化平缓，曲线部分与直线部分分界明显，可较好地估计水分参数。图形法在适用性上具有优势。

关键词： P-V曲线质壁分离渗透势质壁分离相对含水量质壁分离点确定方法