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Resolvin D1 Induces mTOR-independent and ATG5-dependent Autophagy in BV-2 Microglial Cells

Current Medical Science 2023年第6期43卷 1096-1106页

作者： Shang-wen PAN li-sha HU Han WANG rui-ting li Ya-jun HE You SHANG Zhong-liang DAI li-xin CHEN Wei XIONG Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Anesthesiology Qingdao Women and Children’s HospitalQingdao UniversityQingdao266034China Department of Anesthesiology The Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhen518020China Department of Pharmacology Medical CollegeJinan UniversityGuangzhou510632China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou510632China

Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral *** is a catabolic process responsible for maintaining cellular *** recent years,autophagy has been demonstrated to play an important role in *** D1(RvD1)is a promising therapeutic mediator that has been shown to exert substantial anti-inflammatory and proresolving ***,whether RvD1-mediated resolution of inflammation in microglia is related to autophagy regulation needs further *** present study aimed to explore the effect of RvD1 on microglial autophagy and its corresponding *** Mouse microglial cells(BV-2)were cultured,treated with RvD1,and examined by Western blotting,confocal immunofluorescence microscopy,transmission electron microscopy,and flow *** RvD1 promoted autophagy in both BV-2 cells and mouse primary microglia by favoring the maturation of autophagosomes and their fusion with ***,RvD1 had no significant effect on the activation of mammalian target of rapamycin(mTOR)***,RvD1-induced mTOR-independent autophagy was confirmed by observing reduced cytoplasmic calcium levels and suppressed calcium/calmodulin-dependent protein kinase II(CaMK II)***,by downregulating ATG5,the increased phagocytic activity induced by RvD1 was demonstrated to be tightly controlled by ATG5-dependent *** The present work identified a previously unreported mechanism responsible for the role of RvD1 in microglial autophagy,highlighting its therapeutic potential against neuroinflammation.

关键词： resolvin D1 microglia mTOR-independent autophagy ATG5-dependent autophagy phagocytosis

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Overview of point-of-care ultrasound in diagnosing intestinal obstruction

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World Journal of Emergency Medicine 2022年第2期13卷 135-140页

作者： rui-ting li Yue Zhao Xiao-jing Zou Hua-qing Shu ting Zhou Shang-wen Pan Xue-hui Gao Hai-yan Huang Hong liu You Shang Department of Critical Care Medicine Institute of Anesthesia and Critical Care MedicineUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Critical Care Medicine Jin Yin-tan HospitalWuhan 430048China

Intestinal obstruction(IO),which refers to a partial or complete blockage of the intestine,is an emergency gastrointestinal disorder commonly seen in the intensive care unit(ICU)and emergency department and associated with high morbidity and mortality.[1,2]Common etiologies of IO include adhesions,hernias,intussusception,foreign bodies,ischemia,tumors,*** in the diagnosis and management of IO is associated with higher mortality due to complications such as bowel necrosis,perforation,sepsis,and septic shock.[3]IO can be divided into small bowel obstruction(SBO)and colonic obstruction(CO).In SBO,74%of cases are caused by adhesions,which may respond to conservative *** is critical to identify which of those cases may progress and require emergent surgical intervention with the help of the diagnostic and assessment *** contrast to SBO,most cases of CO demand *** this instance,appropriate assessment tools are required to define the location of the obstruction,which will assist in the proper surgical procedure.[4]

关键词： intestine diagnosis ischemia

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PA-E18G substitution in influenza A virus confers resistance to ZX-7101,a cap-dependent endonuclease inhibitor

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Virologica Sinica 2023年第4期38卷 559-567页

作者： Dan Luo Qing Ye rui-ting li Hang-Yu Zhou Jing-Jing Guo Suo-Qun Zhao Sen Zhang Tao Jiang Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing 100071China State Key Laboratory of Medical Molecular Biology Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhou 215123China

Cap-dependent endonuclease(CEN)in the polymerase acidic protein(PA)of influenza A virus(IAV)represents a promising drug target due to its critical role in viral gene *** CEN inhibitor,baloxavir marboxil(BXM),was approved in Japan and the US in 2018 and several other countries *** with the clinical use of BXM,the emergence and spread of IAV variants with reduced susceptibility to BXM have aroused serious ***,we comprehensively characterized the in vitro and in vivo antiviral activities of ZX-7101A,an analogue of *** active form of prodrug ZX-7101 showed broad-spectrum antiviral potency against various IAV subtypes,including pH1N1,H3N2,H7N9 and H9N2,in MDCK cells,and the 50%effective concentration(EC_(50))was calculated to nanomole level and comparable to that of baloxavir acid(BXA),the active form of ***,in vivo assays showed that administration of ZX-7101A conferred significant protection against lethal pH1N1 challenge in mice,with reduced viral RNA loads and alleviated pulmonary ***,serial passaging of H1N1 virus in MDCK cells under selection pressure of ZX-7101 led to a resistant variant at the 15th *** genetic and sequencing analysis demonstrated that a single E18G substitution in the PA subunit contributed to the reduced susceptibility to both ZX-7101 and *** together,our results not only characterized a new CEN inhibitor of IAV but also identified a novel amino acid substitution responsible for CEN inhibitor resistance,which provides critical clues for future drug development and drug resistance surveillance.

关键词： Influenza virus Cap-dependent endonuclease(CEN) Baloxavir marboxil(BXM) Drug resistance

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Transient acquisition of cross-species infectivity during the evolution of SARS-CoV-2

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National Science Review 2021年第11期8卷 85-87页

作者： Qi Chen Xing-Yao Huang Meng-Xu Sun rui-ting li Hongjing Gu Ying Tian Rong-Rong Zhang Dan Luo Chao Zhou Yifei Zhang Tianshu Cao Na-Na Zhang Yong-Qiang Deng Xiao-Feng li Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences

Since the coronavirus disease 2019(COVID-19) pandemic began,its causative agent,severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),has spread *** the global transmission of SARS-CoV-2,mutations in the viral ...

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Preparation and performance of highly-conductive dual-doped li_(7)La_(3)Zr_(2)O_(12)solid electrolytes for thermal batteries

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Green Energy & Environment 2025年第2期10卷 399-409页

作者： Wei li Shu Zhang Xinya Bu Jing Luo Yi Zhang Mengyu Yan ting Quan Yanli Zhu State Key Laboratory of Explosion Science and Safety Protection Beijing Institute of TechnologyBeijing100081China Xi'an North Qinghua Electromechanical Co. Ltd.Xi'an710025China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120China

Garnet li_(7)La_(3)Zr_(2)O_(12)(LLZO)electrolytes have been recognized as a promising candidate to replace liquid/molten-state electrolytes in battery applications due to their exceptional performance,particularly Ga-doped LLZO(LLZGO),which exhibits high ionic ***,the limited size of the liþtransport bottleneck restricts its high-current discharging *** present study focuses on the synthesis of Ga^(3+)þand Ba^(2+)þco-doped LLZO(LLZGBO)and investigates the influence of doping contents on the morphology,crystal structure,liþtransport bottleneck size,and ionic *** particular,Ga_(0.32)Ba_(0.15)exhibits the highest ionic conductivity(6.11E-2 S cm^(-1) at 550 C)in comparison with other compositions,which can be attributed to its higher-energy morphology,larger bottleneck and unique liþtransport *** addition to Ba^(2+),Sr^(2+)þand Ca^(2+)have been co-doped with Ga3þinto LLZO,respectively,to study the effect of doping ion radius on crystal structures and the properties of *** characterization results demonstrate that the easier liþtransport and higher ionic conductivity can be obtained when the electrolyte is doped with larger-radius *** a result,the assembled thermal battery with Ga_(0.32)Ba_(0.15)-LLZO electrolyte exhibits a remarkable voltage platform of 1.81 V and a high specific capacity of 455.65 mA h g^(-1) at an elevated temperature of 525℃.The discharge specific capacity of the thermal cell at 500 mA amounts to 63%of that at 100 mA,showcasing exceptional high-current discharging *** assembled as prototypes with fourteen single cells connected in series,the thermal batteries deliver an activation time of 38 ms and a discharge time of 32 s with the current density of 100 mA cm^(-2).These findings suggest that Ga,Ba co-doped LLZO solid-state electrolytes with high ionic conductivities holds great potential for high-capacity,quick-initiating and high-current discharging thermal batteries.

关键词： Element doping Thermal battery Solid electrolyte LLZO Ionic conductivity

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Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry

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Signal Transduction and Targeted Therapy 2022年第1期7卷 34-37页

作者： Shulong Zu Dan Luo lili li Qing Ye rui-Tinq li Yanan Wang Meilinq Gao Heng Yang Yong-Qiang Deng Genhong Cheng Center for Systems Medicine Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Institute of Systems Medicine Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Suzhou Institute of Systems Medicine SuzhouJiangsuChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijingChina Suzhou Func Biotech Inc SuzhouJiangsuChina Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCAUSA

Dear Editor,COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still a threat to millions of lives *** SARS-CoV-2 vaccines have been approved to reduce the severity and death associated with COVID-19,the number of SARS-CoV-2-infected cases still remains high,especially with the appearance of various mutant strains such as P.1.351 and P.1.617(also known as South Africa strain and India strain,respectively),which may reduce the efficacy of vaccine *** is an urgent need to develop effective antiviral agents to treat C0VID-19 patients,especially with those infected with SARS-CoV-2 variants of concern.

关键词： acute vaccine respiratory

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Sulfur doping and oxygen vacancy in In2O3 nanotube co-regulate intermediates of CO2 electroreduction for efficient HCOOH production and rechargeable Zn-CO2 battery

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Journal of Energy Chemistry 2025年第2期101卷 474-484页

作者： Yu li Zhengrong Xu Quanxin Guo Qin li rui liu Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education School of Materials Science and Engineering Tongji University

By manipulating the distribution of surface electrons,defect engineering enables effective control over the adsorption energy between adsorbates and active sites in the CO2reduction reaction（CO2RR）.Herein,we report a hollow indium oxide nanotube containing both oxygen vacancy and sulfur doping（V_o-Sx-In2O3） for improved CO2-to-HCOOH electroreduction and *** componential synergy significantly reduces the*OCHO formation barrier to expedite protonation process and creates a favorable electronic micro-environment for*HCOOH *** a result,the CO2RR performance of Vo-Sx-In2O3outperforms Pure-In2O3and V_o-In2O3,where V_o-S53-In2O3exhibits a maximal HCOOH Faradaic efficiency of 92.4% at-1,2 V *** hydrogen electrode（RHE） in H-cell and above 92%over a wide window potential with high current density(119.1 mA cm-2at-1.1 V ***) in flow ***,the rechargeable Zn-CO2battery utilizing V_o-S53-In2O3as cathode shows a high power density of 2.29 mW cm-2and a long-term stability during charge-discharge *** work provides a valuable perspective to elucidate co-defective catalysts in regulating the intermediates for efficient CO2RR.

关键词： CO2 electroreduction In2O3 Intermediate Oxygen vacancy Sulfur doping Zn-CO2 battery

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Electrospraying Si/SiO_(x)/C and Sn/C nanosphere arrays on carbon cloth for high-performance flexible lithium-ion batteries

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Journal of Semiconductors 2025年第1期46卷 234-243页

作者： Di Chen rui li Chunxue liu Kai Jiang School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China College of Physics and Mathematics University of Science and TechnologyBeijing 100083China Falculty of Hepato-Pancreato-Biliary Surgery Chinese PLA General HospitalInstitute of Hepatobiliary Surgery of Chinese PLA& Key Laboratory of Digital Hepetobiliary SurgeryChinese PLABeijing 100853China

Exploring electrode materials with larger capacity,higher power density and longer cycle life was critical for developing advanced flexible lithium-ion batteries(liBs).Herein,we used a controlled two-step method including electrospraying followed with calcination treatment by CVD furnace to design novel electrodes of Si/Si_(x)/C and Sn/C microrods array consisting of nanospheres on flexible carbon cloth substrate(denoted as Si/Si_(x)/C@CC,Sn/C@CC).Microrods composed of cumulated nanospheres(the diameter was approximately 120 nm)had a mean diameter of approximately 1.5μm and a length of around 4.0μm,distributing uniformly along the entire woven carbon *** of Si/Si/Si_(x)/C@CC and Sn/C@CC products were synthesized as binder-free anodes for li-ion battery with the features of high reversible capacity and excellent *** Si/Six/C electrode exhibited high specific capacity of about 1750 mA∙h∙g^(−1)at 0.5 A∙g^(−1)and excellent cycling ability even after 1050 cycles with a capacity of 1388 mA∙h∙g^(−1).Highly flexible Si/Si_(x)/C@CC//liCoO_(2)batteries based on liquid and solid electrolytes were also fabricated,exhibiting high flexibility,excellent electrical stability and potential applications in flexible wearable electronics.

关键词： electrospraying Si/SiO_(x)/C Sn/C lithium-ion batteries

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Experiments and modeling of microstructural and mechanical behaviors of laser-welded Ni-based superalloy at high temperatures

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Chinese Journal of Aeronautics 2025年第1期38卷 99-114页

作者： ting HOU Yong li Degang WANG Yuelin WANG Marko VILOTIC School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Department of Structure Shenyang Aircraft Designand Research InstituteShenyang 110000China Engineering Center Shenyang Aircraft CorporationShenyang 110000China Faculty of Technical Science University of Novi SadNovi Sad 21102Serbia

The performance of welded Ni-based superalloys at high temperatures is essential to be evaluated due to their particular service environment for aero-engines and high-speed *** tensile properties and related microstructural evolutions such as the carbide precipitate and grain of a laser-welded Ni-based alloy were experimentally and numerically investigated at different temperatures(20,300,500,800℃).The results show that at room temperature,the strength of the Base Material(BM)was slightly smaller,with a difference of less than 1%,than the Welded Material(WM),which can be attributed to the more uniformly distributed needle-shaped carbide precipitates in the WM than those nonuniformly coarser spherical ones in the *** at 300℃ and 500℃,the strength of WM decreased more obviously compared with that of BM due to the more apparent growth of grain:13.52%loss in yield strength in WM alloys as compared with BM alloys at 300℃,and 16.57% at 500℃.At 800℃,the strength of BM and WM both decreased to a similar level due to Dynamic Recrystallization(DRX).However,a much higher elongation was observed for the BM than WM(less than 50%of BM),which can be attributed to the enhanced dislocation accumulation capability of the large spherical carbides along grain boundaries on the fracture surface in ***,a unified model considering the welding effects on both microstructures(dislocation,carbides,and grain)and mechanical properties evolutions at different temperatures was developed and *** on this model,the key temperature ranges(20–600℃)where apparent weakening of strength and uniform plasticity occurs for welded structures were identified,providing a direct guidance for potential structure and process design.

关键词： Ni-based superalloy Microstructure Mechanical properties Constitutive model High temperature

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A comprehensive review of deactivation and modification of selective catalytic reaction catalysts installed in cement kilns

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Journal of Environmental Sciences 2025年第2期148卷 451-467页

作者： Yang Zheng Yi Xing Guoliang li Jiajia Gao rui li Qi liu Tao Yue School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

After the ultralow emission transformation of coal-fired power plants,cement production became China’s leading industrial emission source of nitrogen *** gas dust contents at the outlet of cement kiln preheaters were as high as 80-100 g/m^(3),and the calcium oxide content in the dust exceeded 60%.Commercial V_(2)O_(5)(-WO3)/TiO_(2) catalysts suitable for coal-fired flue gas suffer from alkaline earth metal Ca poisoning of cement kiln flue *** studies have also identified the poisoning of cement kiln selective catalytic reaction(SCR)catalysts by the heavy metals lead and *** of the poisoning process is the primary basis for analyzing the catalytic *** review summarizes and analyzes the SCR catalytic mechanism and chronicles the research progress concerning this poisoning *** on the catalytic and toxification mechanisms,it can be inferred that improving the anti-poisoning performance of a catalyst enhances its acidity,surface redox performance-active catalytic sites,and shell layer *** data provide support in guiding engineering practice and reducing operating costs of SCR ***,future research directions for SCR denitrification catalysts in the cement industry are *** study provides critical support for the development and optimization of poisoning-resistant SCR denitrification catalysts.

关键词： Cement Flue Gas NH_(3)-SCR CaO Poisoning Mechanism Anti-poisoning Modification

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