Tamoxifen and clomiphene inhibit SARS-CoV-2 infection by suppressing viral entry
作者机构：Center for Systems MedicineInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Institute of Systems MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Suzhou Institute of Systems MedicineSuzhouJiangsuChina State Key Laboratory of Pathogen and BiosecurityBeijing Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijingChina Suzhou Func Biotech IncSuzhouJiangsuChina Department of MicrobiologyImmunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCAUSA
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第1期
页 面：34-37页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
基 金：This project is supported by the Chinese Academy of Medical Sciences Initiative for Innovative Medicine(2021-I2M-1-047,2019-I2M-5-049 and 2016-I2M-1-005) Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-PT310-006,2019XK310002,2018TX31001,and 3332018131) the National Natural Science Foundation of China(91542201,81925025,82102371,82174055,82073181,81802870,and 2017YFA0506200) the National Key Research and Development Project(2020YFC0841700) NIH R01AI069120,AI158154,and AI140718 grants,the UCLA AIDS Institute UCLA David Geffen School of Medicine-Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Award Program.H.Y.is supported by science funds from Jiangsu Province(BK20211554,BK20170407) the Innovative and Entrepreneurial Team grant(2018-2021)from Jiangsu Province.L.L.is supported by Innovative Entrepreneurial Doctor grant(2020-2022)from Jiangsu Province.R.L.is supported by the Chinese Postdoctoral Science Foundation(2020T130135ZX)
主 题：acute vaccine respiratory
摘 要：Dear Editor,COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still a threat to millions of lives *** SARS-CoV-2 vaccines have been approved to reduce the severity and death associated with COVID-19,the number of SARS-CoV-2-infected cases still remains high,especially with the appearance of various mutant strains such as P.1.351 and P.1.617(also known as South Africa strain and India strain,respectively),which may reduce the efficacy of vaccine *** is an urgent need to develop effective antiviral agents to treat C0VID-19 patients,especially with those infected with SARS-CoV-2 variants of concern.
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