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Nuclear Science and Techniques 2021年第3期32卷 107-119页

作者： An-Kang Hu rui Qiu Huan Liu Zhen Wu Chun-Yan Li Hui Zhang Jun-Li Li rui-jie yang Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging Tsinghua UniversityMinistry of EducationBeijing 100084China Nuctech Company Limited Beijing 100084China Department of Radiation Oncology Peking University Third HospitalBeijing 100191China

The Monte Carlo(MC)simulation is regarded as the gold standard for dose calculation in brachytherapy,but it consumes a large amount of computing *** development of heterogeneous computing makes it possible to substantially accelerate calculations with hardware ***,this study develops a fast MC tool,called THUBrachy,which can be accelerated by several types of hardware *** can simulate photons with energy less than 3 MeV and considers all photon interactions in the energy *** was benchmarked against the American Association of Physicists in Medicine Task Group No.43 Report using a water phantom and validated with Geant4 using a clinical case.A performance test was conducted using the clinical case,showing that a multicore central processing unit,Intel Xeon Phi,and graphics processing unit(GPU)can efficiently accelerate the ***-accelerated THUBrachy is the fastest version,which is 200 times faster than the serial version and approximately 500 times faster than *** proposed tool shows great potential for fast and accurate dose calculations in clinical applications.

关键词： High-dose-rate brachytherapy Monte Carlo Heterogeneous computing Hardware accelerators

Two new species of Polyalthiopsis(Annonaceae) based on morphological characters and phylogenetic evidence,with a supplementary description of *** from China

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Plant Diversity 2023年第2期45卷 185-198页

作者： Bin yang Jin-Yue Li rui-jie yang Hong-Bo Ding Min Deng Chun-Fen Xiao Yun-Juan Zuo Yun-Hong Tan Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences&Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303YunnanChina The Key Laboratory of Rare and Endangered Forest Plants of National Forestry and Grassland Administration&The Key Laboratory for Silviculture and Forest Resources Development of Yunnan Province Yunnan Academy of Forestry and GrasslandKunming 650201YunnanChina College of Life Science University of Chinese Academy of SciencesHuairou DistrictBeijing 101408China School of Ecology and Environmental Science Yunnan UniversityKunming 650091YunnanChina Center for Gardening and Horticulture Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303YunnanChina

Two new species of Polyalthiopsis(Annonaceae),*** *** & Bin yang from Guangxi and Yunnan Provinces and *** *** & Bin yang from Yunnan Province,are described and *** is morphologically similar to *** in having narrowly elliptic-oblong,lemon to yellowish green petals,but differs by having obovoid monocarps,a higher number of leaf secondary veins,leaf blades usually widest above the middle,and a lower ratio of leaf blade length to *** is morphologically similar to *** in having axillary inflorescences,1-3(-4) flowers,elliptic leaves,and ellipticovate petals,but differs in the numbers of carpels per flower and ovules per *** molecular phylogenetic analysis using five plastid markers confirm that the two new species belong to the genus Polyalthiopsis and show clear interspecific divergences between *** and *** and between them and other species in the *** descriptions,colored photographs,and habitat and distribution data for the two new species are *** addition,the fruit morphology of *** is described for the first time,based on living *** distributions and a diagnostic key for all Polyalthiopsis species are also presented.

关键词： Annonaceae Morphology Polyalthia Polyalthiopsis Southeast Yunnan

In vitro Dosimetric Study of Biliary Stent Loaded with Radioactive ^125I Seeds

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Chinese Medical Journal 2017年第9期130卷 1093-1099页

作者： Li-Hong Yao Jun-jie Wang Charles Shang Ping Jiang Lei Lin Hai-Tao Sun Lu Liu Hao Liu Di He rui-jie yang Department of Radiation Oncology Peking University Third Hospital Beijing 100191 China Department of Physics Florida Atlantic University Boca Raton FL 33431 USA Department of Radiation Oncology Lynn Cancer Institute Boca Raton FL 33486 USA Department of Computer Science and Engineering University of Washington Seattle WA 98195 USA LMAM School of Mathematical Sciences Peking University geijing 100871 China

Background： A novel radioactive ^125I seed-loaded biliary stent has been used for patients with malignant biliary obstruction. However, the dosimetric characteristics of the stents remain unclear. Therefore, we aimed to describe the dosimetry of the stents of different lengths -- with different number as well as activities of ^125I seeds. Methods： The radiation dosimetry of three representative radioactive stent models was evaluated using a treatment planning system （TPS）, thermoluminescent dosimeter （TLD） measurements, and Monte Carlo （MC） simulations. In the process of TPS calculation and TLD measurement, two different water-equivalent phantoms were designed to obtain cumulative radial dose distribution. Calibration procedures using TLD in the designed phantom were also conducted. MC simulations were performed using the Monte Carlo N-Particle extended version 2.5 general purpose code to calculate the radioactive stent＇s three-dimensional dose rate distribution in liquid water. Analysis of covariance was used to examine the factors influencing radial dose distribution of the radioactive stent. Results： The maximum reduction in cumulative radial dose was 26% when the seed activity changed from 0.5 mCi to 0,4 mCi for the same length of radioactive stents. The TLD＇s dose response in the range of 0-10 mGy irradiation by ^137Cs y-ray was linear： y = 182225x - 6651.9 （R2 = 0.99152; y is the irradiation dose in mGy, x is the TLDs＇ reading in nC）. When TLDs were irradiated by different energy radiation sources to a dose of 1 mGy, reading of TLDs was different. Doses at a distance of 0.1 cm from the three stents＇ surface simulated by MC were 79, 93, and 97 Gy. Conclusions： TPS calculation, TLD measurement, and MC simulation were performed and were found to be in good agreement. Although the whole experiment was conducted in water-equivalent phantom, data in our evaluation may provide a theoretical basis for dosimetry for the clinical application.

关键词： Brachytherapy Computer Simulation Phantom Radiometry Thermoluminescent Dosimetry

子宫内膜癌螺旋断层放疗与静态调强放疗的剂量学比较

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癌症 2009年第11期28卷 1121-1126页

作者：杨瑞杰徐寿平姜伟娟王俊杰解传滨北京大学第三医院肿瘤中心放疗科北京100191 中国人民解放军总医院放疗科北京100853

背景与目的:螺旋断层放疗(helical tomotherapy,HT)在很多肿瘤治疗中体现了剂量学优势,但目前尚没有子宫内膜癌术后全盆腔HT的报道。本研究通过比较子宫内膜癌术后全盆腔HT与固定机架角静态调强放疗(step-and-shoot intensity-modulated... 详细信息

背景与目的:螺旋断层放疗(helical tomotherapy,HT)在很多肿瘤治疗中体现了剂量学优势,但目前尚没有子宫内膜癌术后全盆腔HT的报道。本研究通过比较子宫内膜癌术后全盆腔HT与固定机架角静态调强放疗(step-and-shoot intensity-modulated radiation therapy,SaS-IMRT)剂量学的差异,探讨子宫内膜癌术后全盆腔HT是否具有剂量学优势。方法:选择10例接受子宫内膜癌术后全盆腔放疗患者,对每例患者分别设计全盆腔SaS-IMRT和HT计划。比较两组计划的靶区、危及器官和正常组织剂量分布。结果:SaS-IMRT和HT计划的平均PTV100是95.6%和95.8%(P=0.72)。两组计划平均适形指数都是0.87,平均均匀性指数是1.10和1.07(P=0.00)。与SaS-IMRT计划相比,HT计划直肠和膀胱平均剂量分别下降了1.3Gy和3.0Gy,小肠加结肠、盆腔骨接受中低剂量照射的体积增加,盆腔骨平均剂量增加1.1Gy。HT计划正常组织V5、V10、V20分别增加13.0%、18.0%和5.0%(P=0.00),平均剂量增加2.5Gy(P=0.00)。结论:与SaS-IMRT比较,HT靶区剂量更均匀,能够更好地保护膀胱和直肠。小肠和结肠、盆腔骨及正常组织接受中低剂量照射的体积增加,其临床意义尚需进一步研究。

关键词：子宫内膜癌/放射治疗调强放疗螺旋断层放疗全盆腔放疗剂量学

Parallel Synthesis and Antimicrobial Activities of Gramicidine S and its Analogues

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Parallel Synthesis and Antimicrobial Activities of Gramicidi...

Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

2006中国微生物学会第九次全国会员代表大会暨学术年会

作者： Yan Ding, Chuan-Guang Qin , rui-jie Zhang, yang Li Faculty of Life Science, Northwestern Polytechnical University, Xi’an 710072, Shaanxi, China

Gramicidin S is a cyclic decapeptide antibiotic which is produced by Bacillus brevis. In this paper, a novel method is described for the facile parallel synthesis of gramicidin S and its analogues, using standard solid-phase synthetic technology and a direct cyclization-cleavage step. Compared with previous approaches, the presented

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, jie Jia, Jian Hui Wang, Yu yang, Chun Cheng Jiang, Qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li yang Wei Kang Zhou Xin Huang Xing Zhou jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu yang Lei Xiao Zhiyong Kan Jing Guo Qiang Li Wanqi jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li jie Miao Zhina Zhang Mingxuan yang Zhuoran Wang Bo yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-jie Shi Yu-Xin yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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