检索结果-南通市图书馆

Asian Journal of Andrology 2018年第6期20卷 621-625页

作者： rui zhi xue Zheng-Yan Tang zhi Chen Liang Huang Department of Urology Xiangya Hospital of Central South University Changsha 410000 China Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease Changsha 410000 China

Symptomatic seminal vesicle cysts （SVCs）, especially those of a large size, can be removed by surgical treatments. Currently, open surgeries for SVC are rarely performed due to their extensive surgical trauma, and minimally invasive surgical therapies for treating seminal vesicle cysts are still in the early stages. In addition, relevant studies are mostly confined to case reports. In this study, we retrospectively reviewed 53 patients who had received transperitoneal laparoscopic unroofing or fenestration under seminal vesiculoscopy for SVC in our institution. Both surgeries decreased the cyst volume to a significant extent; however, according to the remnant lesion size after rechecking images, seminal vesiculoscopic fenestration tended to have a higher recurrence than laparoscopic unroofing. Regarding complications, two individuals in the laparoscopic unroofing group experienced ureteral injury and rectal injury, while patients in the fenestration group only had temporary hemospermia, which indicates that fenestration surgery tends to have less severe complications than laparoscopic unroofing. There was no solid evidence confirming semen improvement after these surgical therapies in our study. Future studies with a prospective design, larger sample size, and longer follow-up period are required to verify and further explore our findings.

关键词： cyst fenestration laparoscopy seminal vesicle unroofing vesiculoscopy

Vasectomy reversal in China during the recent decade:insights from a multicenter retrospective investigation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第3期25卷 416-420页

作者： Li-Juan Ren rui-zhi xue Zi-Qiang Wu Er-Lei zhi Wei Li Liang Huang Xu-Yu Xiang Dao-Yuan Li xue-Ming Lin Department of Urology First Hospital of Shanxi Medical UniversityTaiyuan 030000China Department of Urology Xiangya Hospital of Central South UniversityChangsha 410000China Department of Urology Shanghai General HospitalShanghai 200000China Department of Urology Second Hospital of Tianjin Medical UniversityTianjin 300000China Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou 510000China Department of Urology First Affiliated Hospital of Nanchang UniversityNanchang 330000China Department of Urology Hainan General HospitalHaikou 570100China

To date,there is little information about the demography of vasectomy reversal(VR)patients or the factors currently influencing VR effectiveness in China,especially after the universal two-child policy was released in *** this research,demographic data and perioperative medical records of VR patients were extracted from seven major hospitals in different provinces or municipalities of ***,a telephone survey of the patients was conducted to collect follow-up ***,448 VR cases from the past 13 years were *** results were analyzed by stratified comparison to investigate factors that can influence postoperative vas deferens patency and pregnancy *** statistical methods were used,and all of the protocols were approved by the Ethics Committees of the institutes in this *** results showed that the annual operation volume of VR quadrupled after the two-child policy was *** and a long duration of vasectomy were significantly associated with a lower patency rate.A follow-up survey showed that the general postoperative pregnancy rate was 27.2%.For female partners over the age of 35 years,the postoperative pregnancy rate showed a more severe decline,but only 35.5%of them had been given a fertility examination before their husbands’VR *** work revealed that more patients in China have been demanding VR in recent ***-quality microsurgery and a short duration of vasectomy are crucial for restoring patency by *** andrologists should perform a preoperative fertility evaluation of the patients’female partners.

关键词： demography microsurgery multicenter vasectomy reversal

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye xue-zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian Tang Yuan-Ming Pan Wei Li rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

全谷物及杂豆添加量在小鼠与人体间剂量换算分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

食品科学 2025年第2期46卷 118-125页

作者：支莉朱益清赵亮星陈睿赵卿宇王超薛勇沈群国家粮食产业(青稞深加工)技术创新中心国家粮油标准测试研究中心中国农业大学食品科学与营养工程学院北京100083

适量摄入全谷物及杂豆可以改善糖代谢和脂代谢,但摄入量过高可能产生不利影响。由于缺乏相应的换算关系,小鼠饲料中的摄入量无法直接作为人群摄入量的参考。本文介绍小鼠饲料中常见的全谷物及杂豆的添加量,并通过等效系数法、比表面积... 详细信息

适量摄入全谷物及杂豆可以改善糖代谢和脂代谢,但摄入量过高可能产生不利影响。由于缺乏相应的换算关系,小鼠饲料中的摄入量无法直接作为人群摄入量的参考。本文介绍小鼠饲料中常见的全谷物及杂豆的添加量,并通过等效系数法、比表面积法、体型系数法、食物比重法、体表面积指数法、能量换算法和营养素换算法探讨了小鼠饲料中全谷物及杂豆添加量与人群膳食推荐量之间的剂量效应关系。研究表明,当人群全谷物及杂豆推荐摄入量为50~150 g时,相当于在每日进食量为3 g的小鼠饲料中添加5%~50%的全谷物及杂豆。对于小鼠而言,饲料中全谷物及杂豆的添加量超过50%可能存在过量摄入的风险。本研究为未来建立全谷物及杂豆在小鼠饲料添加量与人群推荐摄入量之间的换算关系提供了重要参考。

关键词：剂量换算全谷物杂豆体表面积

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： zhi-Wei Fu Yue-Jing Li Ran Yu rui-Qing Guo Li-Xia Gao Sheng-Xia Zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

七氟烷复合丙泊酚麻醉对老年胃癌根治术患者术后疼痛程度、细胞免疫及早期认知功能的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

实用老年医学 2016年第10期30卷 818-821页

作者：王臻毛智军王晖薛彤杨瑞陕西省人民医院麻醉科陕西省西安市710068 陕西省人民医院普外二科陕西省西安市710068

目的观察七氟烷复合丙泊酚麻醉对老年胃癌根治术患者术后疼痛程度、细胞免疫及早期认知功能的影响。方法选取104例行胃癌根治术的老年患者,随机分为观察组(53例)和对照组(51例)。2组给予相同的麻醉诱导方法,在麻醉维持期观察组给予七氟... 详细信息

目的观察七氟烷复合丙泊酚麻醉对老年胃癌根治术患者术后疼痛程度、细胞免疫及早期认知功能的影响。方法选取104例行胃癌根治术的老年患者,随机分为观察组(53例)和对照组(51例)。2组给予相同的麻醉诱导方法,在麻醉维持期观察组给予七氟烷吸入复合丙泊酚静脉麻醉,而对照组给予丙泊酚全凭静脉麻醉。观察2组术后疼痛、细胞免疫及认知功能的变化。结果 (1)2组视觉模拟评分(VAS)比较差异有统计学意义(P=0.046),随着时间的延长均表现出先升高后降低的趋势(F时间=10.117,P<0.001),观察组VAS评分升高的幅度小于对照组(F交互=5.584,P=0.019);(2)2组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比较差异有统计学意义(F_(分组)=8.223、5.092、5.115、5.658,P<0.05),随着时间的延长均表现出先降低后升高的趋势(F_(时间)=10.028、8.825、6.658、9.138,P<0.05),观察组降低的幅度小于对照组(F_(交互)=7.837、5.673、6.002、7.158,P<0.05);(3)2组简明精神状态检查量表(MMSE)评分比较差异有统计学意义(F_(分组)=7.798,P<0.001),随着时间的延长均表现出先降低后升高的趋势(F时间=12.209,P<0.001),观察组降低的幅度大于对照组(F交互=7.081,P=0.002)。结论与丙泊酚全凭麻醉比较,七氟烷复合丙泊酚麻醉用于老年胃癌根治术患者可减轻患者术后疼痛且对细胞免疫的抑制较小,但短期内对认知功能的影响较大。

关键词：老年人胃癌根治术七氟烷丙泊酚术后疼痛细胞免疫认知功能

维普期刊数据库

不同加载速度下巴厘菠萝果皮穿刺力学特性研究

在线全文

学校读者我要写书评

暂无评论

农机化研究 2025年第3期47卷 169-175页

作者：薛忠潘睿张秀梅中国热带农业科学院南亚热带作物研究所广东湛江524091 中国热带农业科学院农业机械研究所广东湛江524091 农业农村部热带果树生物学重点实验室广东湛江524091

对菠萝果皮穿刺力学特性进行研究,旨在为果实品质评价提供参考,为菠萝采收、加工设备优化改进提供参考,为减轻菠萝果损伤提供理论依据。以巴厘菠萝果皮为研究对象,根据菠萝生长规律将果皮划分为上、中、下3个部位,基于WSW-50E微机控制... 详细信息

对菠萝果皮穿刺力学特性进行研究,旨在为果实品质评价提供参考,为菠萝采收、加工设备优化改进提供参考,为减轻菠萝果损伤提供理论依据。以巴厘菠萝果皮为研究对象,根据菠萝生长规律将果皮划分为上、中、下3个部位,基于WSW-50E微机控制电子万能试验机,选取2、5、10、20、50 mm/min等5个加载速度对菠萝不同部位进行穿刺力学特性试验,分析不同加载速度、不同穿刺部位和不同穿刺压头截面对果皮穿刺强度的影响。试验结果表明:果皮中部穿刺强度最低,下部穿刺强度最高;压头截面与不同穿刺部位对果皮穿刺强度均呈现负相关极显著(p<0.01),不同穿刺部位对果皮穿刺强度均呈现正相关极显著(p<0.01),压头截面与穿刺部位对穿刺强度影响极显著(p<0.01)。由此得出结论:果皮穿刺强度与压头截面、穿刺部位呈极显著相关关系,加载速度与穿刺强度呈不相关关系。

关键词：菠萝果皮加载速度压头截面穿刺强度

维普期刊数据库博看期刊

Dynamic characteristics of the planetary gear train excited by time-varying meshing stiffness in the wind turbine

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2018年第9期25卷 1104-1112页

作者： rui-ming Wang zhi-ying Gao Wen-rui Wang Yang xue De-yi Fu State Key Laboratory of Operation and Control of Renewable Energy & Storage Systems China Electric Power Research Institute School of Mechanical Engineering University of Science and Technology Beijing

Wind power has attracted increasing attention as a renewable and clean energy. Gear fault frequently occurs under extreme environment and complex loads. The time-varying meshing stiffness is one of the main excitations. This study proposes a 5 degree-of-freedom torsional vibration model for the planetary gear system. The influence of some parameters(e.g., contact ratio and phase difference) is discussed under different conditions of a single teeth pair and double pairs of teeth. The impact load caused by the teeth face fault, ramped load induced by the complex wind conditions, and the harmonic excitation are investigated. The analysis of the time-varying meshing stiffness and the dynamic meshing force shows that the dynamic design under different loads can be made to avoid resonance, can provide the basis for the gear fault location of a wind turbine, and distinguish the fault characteristics from the vibration signals.

关键词： wind turbine planetary gear time-varying meshing stiffness dynamic characteristics

维普期刊数据库

BnWRI1 coordinates fatty acid biosynthesis and photosynthesis pathways during oil accumulation in rapeseed

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2014年第6期56卷 582-593页

作者： xue-Long Wu zhi-Hong Liu Zhang-Hua Hu rui-zhi Huang Institute of Virology and Biotechnology Zhejiang Academy of Agricultural Sciences Key Laboratory of Plant Metabolic Engineering of Zhejiang Province

Photosynthesis in“green”seeds, such as rapeseed, soybean, and Arabidopsis, plays a substantial role in the improved efficiency of oil accumulation. However, the molecular mecha-nism underpinning the coordinated expression of fatty acid （FA） biosynthesis-and photosynthesis-related genes in such develop-ing seeds remains to be elucidated. Here, we found that seed-specific overexpression of BnWRI1, a WRI1 homolog from rapeseed （Brassica napus cv. ZGY2）, results in enhanced chlorophyl content in developing seeds and increased oil content and seed mass in matured seeds. BnWRI1 was co-expressed with BnBCCP and BnCAB, two marker genes of FA biosynthesis and photosynthesis during seed development, respectively. Over-expression of BnWRI1 increased expression of both marker genes. Further, the nuclear-localized BnWRI1 protein was found to act as a transcription activator. It could bind to the GT1-element and/or GCC-box, which are widespread in the upstream regions of genes involved in FA biosynthesis and photosynthesis pathways. Accordingly, BnWRI1 could interact with promoters of BCCP2 and LHB1B2 in vivo. These results suggested that BnWRI1 may coordinate FA biosynthesis and photosynthesis pathways in developing seeds via directly stimulating expression of GT1-element and/or GCC-box containing genes.

关键词： BnWRI1 Brassica napus oil accumulation photosynthesis transcription factor

维普期刊数据库