检索结果-南通市图书馆

Establishment of injury models in studies of biological effects induced by microwave radiation

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2021年第2期8卷 253-272页

作者： yun-Fei Lai Hao-Yu Wang rui-yun peng Beijing Institute of Radiation Medicine Beijing 100850China

Microwave radiation has been widely used in various fields,such as communication,industry,medical treatment,and military *** radiation may cause injuries to both the structures and functions of various organs,such as the brain,heart,reproductive organs,and endocrine organs,which endanger human ***,it is both theoretically and clinically important to conduct studies on the biological effects induced by microwave *** successful establishment of injury models is of great importance to the reliability and reproducibility of these *** this article,we review the microwave exposure conditions,subjects used to establish injury models,the methods used for the assessment of the injuries,and the indicators implemented to evaluate the success of injury model establishment in studies on biological effects induced by microwave radiation.

关键词： Microwave radiation Injury model Biological effects Methods Biological indicators Review

Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

在线全文

学校读者我要写书评

暂无评论

Journal of Medical Colleges of PLA(China) 2016年第4期31卷 212-218页

作者： Hui Wang rui-yun peng Department of Experimental Pathology Beijing Institute of Radiation Medicine

With key roles in essential brain functions ranging from the long-term potentiation(LTP) to synaptic plasticity,the N-methyl-D-aspartic acid receptor(NMDAR) can be considered as one of the fundamental glutamate receptors in the central nervous *** role of NMDA R was first identified in synaptic plasticity and has been extensively *** molecules,such as Ca^(2+),postsynaptic density 95(PSD-95),calcium/calmodulin-dependent protein kinase II(Ca MK II),protein kinase A(PKA),mitogen-activated protein kinase(MAPK) and cyclic adenosine monophosphate(c AMP) responsive element binding protein(CREB),are of special importance in learning and *** review mainly focused on the new research of key molecules connected with learning and memory,which played important roles in the NMDAR signaling pathway.

关键词： N-methyl-D-aspartic acid receptors Long-term potentiation Synaptic plasticity Learning and memory

Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptorα-chain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第19期12卷 3055-3059页

作者： rui-Juan Wang rui-yun peng Kai-Fei Fu Ya-Bing Gao rui-Gang Han Wen-Hua Hu Qing-Liang Luo Jun-Jie Ma Institute of Radiation Medicine Academy of Military Medical Sciences Beijing 100850 China

AIM： To explore the effect of recombinant human interleukin-11 （rhIL-11） on the expressions of interleukin-11 receptor α-chain （IL-11Rα） and an additional signal transducer glycoprotein 130 （gp130） in intestinal epithelium cell line-6 （IEC-6） after neutron irradiation. METHODS： Cultured IEC-6 cells were exposed to 4.0Gy neutron and treated with 100 ng/mL rhIL-11 12 h prior to or immediately after irradiation. The apoptosis and necrosis rates and expressions of IL-11Rα and gp130 were observed by flow cytometry, immunohistochemistry, Western blot and image analysis. RESULTS： The apoptosis rate of IEC-6 cells was increased by irradiation at 6 h （P 〈 0.01）, IL-11 stimulation resulted in a decreased apoptosis rate in irradiated IEC-6 cells （P 〈 0.05）. In normal control IEC-6 cells, intense immunoreactivity of IL-11Rα was located within the cell membrane and cytoplasm. The level of IL-11Rα expression significantly decreased at 6 h after irradiation （P 〈 0.01） and restored at 24 h after irradiation. In IEC-6 cells treated with both radiation and rhIL-11, the level of IL- 11Rα expression was higher than that of irradiated cells （P 〈 0.05）. When it came to gp130 protein, it was located in the cytoplasm of IEC-6 cells. After irradiation, we found a progressive decrease in the expression of gp130 protein （P 〈 0.05） in 48 hours post-radiation, while in rhIL-11-stimulated cells, it came back to normal level at 24 h after irradiation and decreased at 48 h, but was still higher than that of only irradiated cells （P 〈 0.05）. CONCLUSION： rhIL-11 can protect IEC-6 cells from neutron irradiation. The protective effect of rhIL-11 might be connected with its ability to up-regulate the expressions of specific ligand-binding subunit IL-11Rα and signal-transducing subunit gp130.

关键词： Neutron IEC-6 Interleukin-11 IL-11Rα Gp130

Detection of hepatitis C virus NS5 protein and genome in Chinese carcinoma of the extrahepatic bile duct and its significance

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第6期6卷 800-804页

作者： Ming Yi Chen Zhi Qiang Huang Le Zhen Chen Ya Bing Gao rui yun peng De Wen Wang Research Institute of General Surgery Department of Hepatobiliary SurgeryGeneral Hospital of the Chinese Peoples Liberation Army(PLA)Beijing 100853China Department of Pathology General Hospital of PLABeijing 100855China Experimental Pathologic Laboratory Institute of Medical RadiologyAcademy of Military Medical SciencesBeijing 100850China

AIM To investigate the hepatitis C virus(HCV)infection in the tissues of carcinoma ofextrahepatic bile duct and study *** HCV NS5 protein and HCV RNA weredetected by labeled streptavidin biotin(LSAB)method and in situ reverse transcriptionpolymerase chain reaction(IS-RT-PCR)insections of 51 cases of carcinoma ofextrahepatic bile duct and 34 cases of controlgroup(without malignant biliary disease).RESULTS In 51 cases of carcinoma ofextrahepatic bile duct,HCV NS5 protein wasdetected in 14(27.5%),which was clearlystained in the cytoplasm of cancer cell but not inthe nucleus or cell *** RNA wasdetected in 18(35.4%),which was located inthe nucleus of cancer cell in 12 cases and in thecytoplasm in 6 *** NS5 protein and RNAcoexistence was found in 2 *** 34 cases ofcontrol group,HCV RNA was detected in 2(5.9%).HCV NS5 protein and RNA positive cellswere found either scattered or in *** The prevalence of hepatitis C viral infection in the tissues of carcinoma ofextrahepatic bile duct was significantly higherthan in control group(X^2=9.808,P=0.002).The findings suggest a correlation between HCVinfection and carcinoma of extrahepatic bileduct,which is different from the *** infection might be involved inthe development of carcinoma of extrahepaticbile duct.

关键词： hepatitis C virus bile duct neoplasm polymerase chain reaction immunohistochemistry risk factors genes, suppressor, tumor transfection genome

Biological effects and mechanisms of shortwave radiation： a review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2018年第1期5卷 79-84页

作者： Chao Yu rui-yun peng Beijing Institute of Radiation Medicine Beijing 100850 China

With the increasing knowledge of shortwave radiation,it is widely used in wireless communications,radar observations,industrial manufacturing,and medical *** of the benefits from shortwave,these wide applications expose humans to the risk of shortwave electromagnetic radiation,which is alleged to cause potential damage to biological *** review focused on the exposure to shortwave electromagnetic radiation,considering in vitro,in vivo and epidemiological results that have provided insight into the biological effects and mechanisms of ***,some protective measures and suggestions are discussed here in the hope of obtaining more benefits from shortwave with fewer health risks.

关键词： Shortwave Electromagnetic radiation Biological effects

Apoptosis of Lewis Lung Carcinoma Cells Induced by Microwave via p53 and Proapoptotic Proteins In vivo

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第1期130卷 15-22页

作者： Kou-Dong Zhang Lin-Rong Tong Shui-Ming Wang rui-yun peng Hai-Dong Huang Yu-Chao Dong Xing-Xing Zhang Qiang Li Chong Bai Department of Respiratory and Critical Care Medicine Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Respiratory Medicine Yancheng First People's Hospital Yancheng Jiangsu 224000 China Department of Respiratory Medicine Chenggong Hospital Xiamen University Xiamen Fujian 361000 China Institute of Radiation Medicine The Academy of Military Medical Sciences Beijing 100850 China

Background： Microwave therapy is a minimal invasive procedure and has been employed in clinical practice for the treatment of various types of cancers. However, its therapeutic application in non-small-cell lung cancer and the underlying mechanism remains to be investigated. This study aimed to investigate its effect on Lewis lung carcinoma （LLC） tumor in vivo. Methods： Fifty LLC tumor-bearing C57BL/6 mice were adopted to assess the effect of microwave radiation on the growth and apoptosis of LLC tumor in vivo. These mice were randomly assigned to 10 groups with 5 mice in each group. Five groups were treated by single pulse microwave at different doses for different time, and the other five groups were radiated by multiple-pulse treatment of a single dose. Apoptosis of cancer cells was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. Western blotting was applied to detect the expression of proteins. Results： Single pulse of microwave radiation for 5 min had little effect on the mice. Only 15-min microwave radiation at 30 mW/cm2 significantly increased the mice body temperature （2.20 ± 0.82）℃ as compared with the other groups （0.78 ± 0.29 ℃, 1.24 ± 0.52 ℃, 0.78 ± 0.42 ℃, respectively）, but it did not affect the apoptosis of LLC tumor cells significantly. Continous microwave radiation exposure, single dose microwave radiation once per day for up to seven days, inhibited cell division and induced apoptosis of LLC tumor cells in a dose- and duration-dependent manner. It upregulated the protein levels of p53, Caspase 3, Bax and downregulated Bcl-2 protein. Conclusions： Multiple exposures of LLC-bearing mice to microwave radiation effectively induced tumor cell apoptosis at least partly by upregulating proapoptotic proteins and downregulating antiapoptotic proteins. Continuous radiation at low microwave intensity Ibr a short time per day is promising in treating non-small-cell lung cancer.

关键词： Apoptosis Lewis Lung Carcinoma Cells Microwave Radiation Non-small-cell Lung Cancer

Gria:an efficient deterministic concurrency control protocol

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第4期18卷 25-37页

作者： Xinyuan WANG yun peng Hejiao HUANG School of Computer Science and Technology Harbin Institute of TechnologyShenzhen 518055China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China

Deterministic databases are able to reduce coordination costs in a *** property has fostered a significant interest in the design of efficient deterministic concurrency control ***,the state-of-the-art deterministic concurrency control protocol Aria has three ***,it is impractical to configure a suitable batch size when the read-write set is ***,Aria running in low-concurrency scenarios,e.g.,a single-thread scenario,suffers from the same conflicts as running in high-concurrency ***,the single-version schema brings write-after-write *** address these issues,we propose Gria,an efficient deterministic concurrency control *** has the following ***,the batch size of Gria is ***,Gria’s conflict probability in low-concurrency scenarios is lower than that in high-concurrency ***,Gria has no write-after-write conflicts by adopting a multi-version *** further reduce conflicts,we propose two optimizations:a reordering mechanism as well as a rechecking *** evaluation result on two popular benchmarks shows that Gria outperforms Aria by 13x.

关键词： deterministic concurrency control transaction processing

Impact of Annealing on the Melt Recrystallization of a-PDLA/α-PLLA Double-layered Films

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第2期42卷 230-238,I0009页

作者： yun-peng Li Hao-Ran Shen Shao-Juan Wang Hao Zhang Jian Hu rui Xin Xiao-Li Sun Shou-Ke Yan Key Laboratory of Rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plasticsQingdao University of Science&TechnologyQingdao266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Poly(lactic acid)(PLA) as a bio-based polymer with biodegradability and biocompatibility has attracted much attention. To manipulate its properties for different applications, regulation of crystal structure and crystalline morphology becomes an attractive research topic. In this work, the structure evolution of layered samples containing an amorphous poly(D-lactide)(PDLA) layer and a crystalline poly(L-lactide)(PLLA)layer with highly oriented edge-on α lamellar crystals after annealing at 150 ℃ or/and after melt-recrystallization has been studied by AFM, FTIR,and TEM combined with electron diffraction. The results demonstrate that melt recrystallization of the as-prepared sample leads to the formation of abundant randomly oriented PLA stereo-complex(PLA SC) crystals. Annealing at 150 ℃ results in the formation of a small amount of oriented PLA SC crystals at the interface. These PLA SC crystals show great impact on the recrystallization behavior of sample after melting at 190 ℃ and then crystallizing at 90 ℃. First, they impede the mutual diffusion of the overlying PDLA and underlying PLLA, and thus reduce their stereocomplexation ability as manifested by the decreased amount of PLA SC crystals. Second, they act as substrate to initiate the epitaxial crystallization of the overlying PDLA and underlying PLLA, which ensures the production of a highly oriented structure of PDLA and PLLA after melt recrystallization again.

关键词： Poly(L-lactide) Poly(D-lactide) Double layer Stereocomplex

Effects and mechanisms of a microcurrent dressing on skin wound healing: a review

在线全文

学校读者我要写书评

暂无评论

Journal of Medical Colleges of PLA(China) 2014年第3期29卷 177-185页

作者： Chao Yu Zong-Qian Hu rui-yun peng Beijing Institute of Radiation Medicine

The variety of wound types has resulted in a wide range of wound dressings, with new products frequently being introduced to target different aspects of the wound healing process. The ideal wound dressing should achieve rapid healing at a reasonable cost, with minimal inconvenience to the patient. Microcurrent dressing, a novel wound dressing with inherent electric activity, can generate low-level microcurrents at the device-wound contact surface in the presence of moisture and can provide an advanced wound healing solution for managing wounds. This article offers a review of the effects and mechanisms of the microcurrent dressing on the healing of skin wounds.

关键词： Microcurrent dressing Electric stimulation Skin wound healing