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Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China

World Journal of Gastroenterology 2010年第47期16卷 6020-6025页

作者： Guo-Hong Zhang Bo Huang rui-qin mai Department of Pathology Medical College of Shantou University Shantou 515031 Guangdong Province China Department of Laboratory Medicine the FirstAfliated HospitalMedical CollegeShantou UniversityShantou 515041Guangdong ProvinceChina

AIM: To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS: Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 controls were included for meta-analysis. Stratified analyses were carried out to determine the genealcohol and gene-gene interaction with ESCC risk. Potential sources of heterogeneity between studies were explored, and publication bias was also evaluated. RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence in- terval (CI): 2.76-5.67]. Signif icant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00,95% CI: 1.54-2.61]. Compared with the non-alcoholics, Arg/Arg (OR = 25.20, 95% CI: 10.87-53.44) and Glu/ Lys + Lys/Lys (OR = 21.47, 95% CI: 6.44-71.59) were found to interact with alcohol drinking to increase the ESCC risk. ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33). CONCLUSION: The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption. The individuals carrying both risky genotypes have a higher baseline risk of ESCC.

关键词： Esophageal cancer Alcohol metabolizing enzyme genes Polymorphism Susceptibility

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Effect of 1,25-dihydroxyvitamin D3 on mast cells tryptase in asthmatic guinea pigs

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Asian Pacific Journal of Tropical Medicine 2015年第6期8卷 493-496页

作者： Xiao-He Zheng Gui-Dong Zhang Guo-Hong zhang rui-qin mai Ling Shen Department of Respiratory Medicine 1st Affiliated Hospital of Medical College of Shantou University

Objective:To explore the effect of 1,25-dihydroxyvitamin D3 on the mast cell tryptase(MCT) in asthmatic guinea ***:A total of 60 male or female healthy guinea pigs were randomly divided into control group(group A),asthmatic group(group B).and 1,25-dihydroxyvitamin D3 group(group C),with 20 cases in each *** establish asthmatic guinea pig models,1ml peanut oil was tilled into stomach in the morning in group A and group *** 1 ml peanut oil with 1,25-dihydroxyvitamin D3 was filled into stomach in group *** resistance(Re) of asthmatic guinea pigs was detected,and the bronchoalveolar lavage fluid(BALF) cells were *** tissue with HE and MCT immunohistochemical staining were used to observe the pathological changes in lung tissue and the distribution of ***:After injection of different concentration of acetylcholine chloride,the Re in group B and group C were increased significantly compared with group A(P<0.05):compared with group *** Re in group C were decreased significantly(t=-5.385.-5.761.-6.184.-13.574.P<0.05):the total number of BALF cells and eosinophils were increased significantly in group B and C(t=19.618.9.598.10.854.5.388.P<0.05);compared with group *** total number of BALF cells and eosinophils in group C was decreased significantly(t=-5.555.-5.392.P<0.05):the number of tryptase positive cells in group B was increased significantly than that in group A(t=21.312,P<0.05),and in addition to the alveolar septum and submucosa,the cells were also distributed around blood vessels and outside the cells:the number of tryptase positive cells in group C was decreased significantly compared with group *** the difference was statistically significant(t=5.043.P<0.05).Conclusions:After the asthmatic guinea pigs arc treated with 1,25-dihydroxyvitamin D3,their *** degree of inflammatory cells in the trachea and lung tissue and airway inflammatory reaction are reduced significantly.1,25-dihydroxyvitamin D3 has a cert

关键词： 1,25-dihydroxyvitamin D3 Asthmatic guinea pigs Expiratory airway resistance Mast cell tryptase

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Diameter and Temperature Dependence of Thermal Conductivity of Single-Walled Carbon Nanotubes

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Chinese Physics Letters 2011年第6期28卷 210-213页

作者： PAN rui-qin Faculty of Science Shanghai Institute of TechnologyShanghai 201418

Temperature and diameter dependence of the thermal conductivity of several armchair single-walled carbon nanotubes(SWNTs)are studied by nonequilibrium molecular dynamics method with Brenner II *** thermal conductivities are calculated at temperatures from 100 K to 600 *** is found that the thermal conductivity decreases as the temperature increases and increases as the diameter of SWNT *** results demonstrate that these two phenomena are due to the onset of the Umklapp process.

关键词： process conductivity thermal

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乳酸干预破骨细胞条件培养基促进内皮细胞血管的生成

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中国组织工程研究 2025年第11期29卷 2210-2217页

作者：黄宏莉聂闻麦昱颖覃媛廖红兵广西医科大学口腔医学院/附属口腔医院口腔修复科广西壮族自治区南宁市530021 广西口腔颌面修复与重建研究重点实验室广西壮族自治区南宁市530021

背景:聚乳酸作为可降解的骨组织工程支架材料被广泛用于组织再生与修复研究,在促进组织愈合与新骨形成、血管生成中具有重要作用。目的:观察聚乳酸降解终产物乳酸对破骨细胞的作用,以及乳酸干预后破骨细胞条件培养基对血管内皮细胞增殖... 详细信息

背景:聚乳酸作为可降解的骨组织工程支架材料被广泛用于组织再生与修复研究,在促进组织愈合与新骨形成、血管生成中具有重要作用。目的:观察聚乳酸降解终产物乳酸对破骨细胞的作用,以及乳酸干预后破骨细胞条件培养基对血管内皮细胞增殖、迁移和小管形成功能的影响。方法:(1)取对数生长期的小鼠单核巨噬细胞系RAW264.7,贴壁后分别加入含0,5,10,20 mmol/L乳酸的破骨诱导培养基(含核因子κB受体活化因子配体、体积分数10%胎牛血清的DMEM培养基),培养5 d后分别进行抗酒石酸酸性磷酸酶与细胞骨架纤维状肌动蛋白染色,培养24h后采用RT-PCR检测抗酒石酸酸性磷酸酶5 m RNA表达。(2)取对数生长期的RAW264.7细胞,贴壁后分2组培养:对照组加入破骨诱导培养基,实验组加入含10 mmol/L乳酸的破骨诱导培养基,培养5 d后更换为无血清DMEM培养基继续培养24 h,离心取上清液,分别与等体积含体积分数10%胎牛血清DMEM培养基混合后作用条件培养基备用。取对数生长期的人脐静脉内皮细胞,分别与对照组、实验组条件培养基共培养,通过CCK-8、Transwell、划痕、成管实验观察细胞的增殖、迁移和成管能力,通过RT-PCR和Western Blot检测血管生成相关基因和蛋白的表达。结果与结论:(1)抗酒石酸酸性磷酸酶与肌动蛋白染色结果显示,5,10 mmol/L乳酸可促进RAW264.7细胞破骨向分化,其中以10 mmol/L乳酸的促进作用更显著;RT-PCR检测结果显示,5,10,20 mmol/L乳酸均可提高酒石酸酸性磷酸酶5 m RNA的表达,其中以10 mmol/L乳酸的提高作用最显著;(2)与对照组条件培养基相比,实验组条件培养基可促进人脐静脉内皮细胞的增殖、迁移与成管能力(P<0.05),提高血管内皮生长因子、血管生成素1的m RNA和蛋白表达(P<0.05);(3)结果表明,乳酸诱导分化的破骨细胞条件培养基可促进内皮细胞的血管生成,机制可能与提高血管内皮生长因子、血管生成素1表达相关。

关键词：破骨细胞条件培养基乳酸人脐静脉内皮细胞血管生成内皮细胞

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Comparative study on the organoleptic quality of wild and farmed large yellow croaker Larimichthys crocea

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Journal of Oceanology and Limnology 2020年第1期38卷 260-274页

作者： MA rui MENG Yuqiong ZHANG Wenbing mai Kangsen Key Laboratory of Aquaculture Nutrition and Feed(Ministry of Agriculture)&Key Laboratory of Mariculture(Ministry of Education) Ocean University of ChinaQingdao 266003China State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

To fill the blank in systematic study on the organoleptic quality of large yellow croaker Larimichthys crocea,we analyzed the organoleptic quality of the fish meat of wild,trash-fish-fed,and compound-feed-fed large yellow *** fish(weight:500 g)per group were sampled in the same period,and 89 indices of fish organoleptic quality were measured and *** reveal significant differences in the body condition factor,skin/muscle color,flesh texture,odor,and taste aspects between wild and farmed *** with the wild fish,farmed fish showed fatter body shape,whiter skin or muscle color,tender muscle,higher level of fishy odor or volatile intensity,but lower delicious *** addition,compared with trash-fish feeding,compound-feed feeding could improve the body shape,skin color,flesh texture,and fish taste of large yellow croaker,but it also increased the fishy *** principle component analysis and cluster analysis,the present study preliminarily established the systematic evaluation with multiple indices to the quality of large yellow *** shall be helpful for the evaluation or improvement of the quality of farmed large yellow croaker.

关键词： large yellow croaker appearance texture odor taste

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Si掺杂对Ga_(2)O_(3)/BP异质结光电性能调控的第一性原理研究

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原子与分子物理学报 2025年第4期42卷 131-137页

作者：李佳宏郝增瑞薛瑞鑫阚红梅关玉琴内蒙古工业大学理学院呼和浩特010010

近年来,氧化镓(Ga_(2)O_(3))是新一代超宽禁带(4.9 eV)半导体,基于优越的热稳定和化学稳定性、高击穿场强和可见光透过率等优点,在日盲紫外探测器和透明光电器件领域中引起了广泛的关注.但是,Ga_(2)O_(3)基光电器件存在迁移率较低而限... 详细信息

近年来,氧化镓(Ga_(2)O_(3))是新一代超宽禁带(4.9 eV)半导体,基于优越的热稳定和化学稳定性、高击穿场强和可见光透过率等优点,在日盲紫外探测器和透明光电器件领域中引起了广泛的关注.但是,Ga_(2)O_(3)基光电器件存在迁移率较低而限制其应用的现象,而构建合适的Ga_(2)O_(3)异质结是改善光电探测器的光电性能的有效手段之一.基于第一性原理构建β-Ga_(2)O_(3)/BP异质结模型,研究了氧空位(Vo)和Si掺杂对β-Ga_(2)O_(3)/BP异质结光电性质的调控以及相关机理.结果显示:β-Ga_(2)O_(3)/BP异质结结构有效降低β-Ga_(2)O_(3)功函数,提高灵敏度,Si掺杂降低结合能,增强稳定性;β-Ga_(2)O_(3)/BP异质结有效减小带隙,Si掺杂以及氧空位的存在,进一步减小带隙,增强光导电性,并且Si掺杂引起了光电导各向异性.此结果对改善Ga_(2)O_(3)基异质结光电性能提供理论参考.

关键词： β-Ga_(2)O_(3)/BP异质结缺陷光电性质第一性原理

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Analysis and Improvement on a Hash-Based Authentication Scheme for Multi-Server Architecture

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Wuhan University Journal of Natural Sciences 2021年第5期26卷 394-404页

作者： LI rui KANG Baoyuan mai Kaiqiang School of Computer Science and Technology Tiangong UniversityTianjin 300387China

In order to meet people’s demand for various types of network services,researchers have conducted extensive research on authentication schemes for multi-server *** various schemes have been proposed,most of them still have safety defects and fail to meet safety ***,Haq et al presented an efficient Hash-based authenticated key agreement scheme for multi-server scheme and claimed that their scheme can withstand all well-known ***,we find that their scheme is vulnerable to replay attack,tracking attack and malicious server impersonation user *** we propose an improved *** also analyze the security of the improved scheme and compare with Haq et al’s scheme in security and computational ***,we use the AVISPA(Automated Validation of Internet Security Protocols and Applications)tool to verify the security of the improved scheme.

关键词： multi-server architecture authentication security one-way hash function AVISPA

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An improved de-interleaving algorithm of radar pulses based on SOFM with self-adaptive network topology

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Journal of Systems Engineering and Electronics 2020年第4期31卷 712-721页

作者： JIANG Wen FU Xiongjun CHANG Jiayun qin rui School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China

As a core part of the electronic warfare(EW) system,de-interleaving is used to separate interleaved radar signals. As interleaved radar pulses become more complex and denser, intelligent classification of radar signals has become very important. The self-organizing feature map(SOFM) is an excellent artificial neural network, which has huge advantages in intelligent classification of complex data. However, the de-interleaving process based on SOFM is faced with the problems that the initialization of the map size relies on prior information and the network topology cannot be adaptively adjusted. In this paper, an SOFM with self-adaptive network topology(SANT-SOFM) algorithm is proposed to solve the above problems. The SANT-SOFM algorithm first proposes an adaptive proliferation algorithm to adjust the map size, so that the initialization of the map size is no longer dependent on prior information but is gradually adjusted with the input data. Then,structural optimization algorithms are proposed to gradually optimize the topology of the SOFM network in the iterative process,constructing an optimal SANT. Finally, the optimized SOFM network is used for de-interleaving radar signals. Simulation results show that SANT-SOFM could get excellent performance in complex EW environments and the probability of getting the optimal map size is over 95% in the absence of priori information.

关键词： de-interleaving self-organizing feature map(SOFM) self-adaptive network topology(SANT)

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Pronounced temporal changes in soil microbial community and nitrogen transformation caused by benzalkonium chloride

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Journal of Environmental Sciences 2023年第4期126卷 827-835页

作者： rui Yang Shaohong Zhou Lilan Zhang Cunli qin State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China Key Laboratory of Three Gorges Reservoir Region’s Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China

As one typical cationic disinfectant, quaternary ammonium compounds(QACs) were approved for surface disinfection in the coronavirus disease 2019 pandemic and then unintentionally or intentionally released into the surrounding environment. Concerningly, it is still unclear how the soil microbial community succession happens and the nitrogen(N)cycling processes alter when exposed to QACs. In this study, one common QAC(benzalkonium chloride(BAC) was selected as the target contaminant, and its effects on the temporal changes in soil microbial community structure and nitrogen transformation processes were determined by q PCR and 16S r RNA sequencing-based methods. The results showed that the aerobic microbial degradation of BAC in the two different soils followed first-order kinetics with a half-life(4.92 vs. 17.33 days) highly dependent on the properties of the soil. BAC activated the abundance of N fixation gene(nif H) and nitrification genes(AOA and AOB) in the soil and inhibited that of denitrification gene(nar G). BAC exposure resulted in the decrease of the alpha diversity of soil microbial community and the enrichment of Crenarchaeota and Proteobacteria. This study demonstrates that BAC degradation is accompanied by changes in soil microbial community structure and N transformation capacity.

关键词： Benzalkonium chloride Soil Degradation kinetics Microbial community structure Nitrogen cycling

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Reimaging biological barriers affecting distribution and extravasation of PEG/peptidemodified liposomes in xenograft SMMC7721 tumor

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Acta Pharmaceutica Sinica B 2020年第3期10卷 546-556页

作者： Hailing Tang Mengjie rui Junhua mai Wei Guo Yuhong Xu Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Jiangsu UniversityZhenjiang 212001China Department of Nanomedicine the Methodist Hospital Research InstituteHoustonTX 77030USA Institute of Cancer Stem Cell Dalian Medical UniversityDalian 116044China

Liposomes,as one of the most successful nanotherapeutics,have a major impact on many biomedical *** this study,we performed laser scanning confocal microscope(LSCM)and immunohistochemistry(IHC)assays to investigate the intra-tumor transport and antitumor mechanism of GE11 peptideconjugated active targeting liposomes(GE11-TLs)in SMMC7721 xenograft *** to classification of individual cell types in high resolution images,biodistribution of macrophages,tumor cells,cells with high epidermal growth factor receptor(EGFR)expres sion and interstitial matrix in tumor microenvironment,in addition,their impacts on intra-tumor penetration of GE11-TLs were *** I collagen fibers and macrophage flooded in the whole SMMC7721 tumor *** angiogenesis was of great heterogeneity from the periphery to the center ***,the receptor-binding site barriers were supposed to be the leading cause of poor penetration of *** anticipate these images can give a deep reconsideration for rational design of target nanoparticles for overcoming biological barriers to drag delivery.

关键词： GE11 Liposome Target delivery Biology barrier EGFR SMMC7721

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