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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton

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Science China Life Sciences 2025年

作者： Yanlong Li Yinuo Fu Yaoyao Li rui Zhang Jing Yang Huanhuan ma Ling min Xianlong Zhang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,Casein Kinase I (GhCKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhCKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhCKI genes,using CRISPR/Cas9 and CRISPR/Cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhCKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhCKI promoter editing mutants is that the trans-acting factors GhmYB73 and GhmYB4,which positively regulate GhCKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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西南地区河成湖与火山湖土地利用对水质的多时空尺度影响差异

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湖泊科学 2025年第1期37卷 132-148,I0011-I0014页

作者：刘捷刘睿左书林张静重庆师范大学地理与旅游学院重庆401331 重庆师范大学 GIS应用研究重庆市重点实验室重庆401331

为探究不同时空尺度下不同湖泊类型土地利用对水质的影响差异,以四川省自贡市富顺西湖(河成湖)和云南省腾冲市青海湖(火山湖)为研究对象,提取6个空间尺度(50、60、70、80、90、100 m湖岸带缓冲区)的景观格局指数,结合雨季(2022年7月)和... 详细信息

为探究不同时空尺度下不同湖泊类型土地利用对水质的影响差异,以四川省自贡市富顺西湖(河成湖)和云南省腾冲市青海湖(火山湖)为研究对象,提取6个空间尺度(50、60、70、80、90、100 m湖岸带缓冲区)的景观格局指数,结合雨季(2022年7月)和旱季(2023年4月)湖泊水质参数,采用冗余分析法定量探究不同时空尺度下土地利用对两类湖泊水质影响的差异性。结果表明:(1)富顺西湖与腾冲青海湖水质参数季节性差异显著,雨季水质优于旱季,两个湖泊水环境质量存在显著差异,腾冲青海湖水环境质量优于富顺西湖,腾冲青海湖符合地表水环境Ⅱ类、Ⅲ类水质标准,富顺西湖达到Ⅳ类、Ⅴ类水质标准。(2)富顺西湖在旱季和50~60 m湖岸带缓冲区尺度下土地利用参数对水质变量的解释率最大,腾冲青海湖在雨季和60 m湖岸带缓冲区尺度下土地利用参数对水质变量的解释率最大。(3)土地利用指数对两类湖泊水质的影响各不相同。富顺西湖流域内斑块密度、景观形状指数和聚合度指数与多数水质指标呈正相关,“源”景观聚集程度和破碎化程度高会加剧对水质的威胁。腾冲青海湖流域内林地面积占比和聚合度指数对水质具有正效应,能够改善水环境质量;斑块指数和景观形状指数值的增加会加剧斑块破碎化,导致水质恶化。本研究基于不同时空尺度对土地利用与两类湖泊水质关系的差异性进行深入探讨,指导不同类型湖泊的区域规划与管理,为湖泊环境质量评价及保护和制定针对性的湖泊缓冲带设置、生态修复等策略提供科学依据,进而促进湖泊水质安全和水资源可持续利用。

关键词：土地利用水质多尺度效应冗余分析西南地区湖泊

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元·汾渭裂谷文章多——漫步地震五千年(12)

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地震科学进展 2025年第1期55卷 43-62页

作者：冯锐中国地震台网中心北京100045

元朝的山西洪洞于1303年发生8级地震,揭示了汾渭裂谷系在构造和运动上的一系列特殊性。该区地震活动具有准周期性、南移北跳和强震复发的特点。分析了汾渭裂谷的形成、雁行断裂构造、构造应力场和深部高温体的环境背景。为深入认识地球... 详细信息

元朝的山西洪洞于1303年发生8级地震,揭示了汾渭裂谷系在构造和运动上的一系列特殊性。该区地震活动具有准周期性、南移北跳和强震复发的特点。分析了汾渭裂谷的形成、雁行断裂构造、构造应力场和深部高温体的环境背景。为深入认识地球动力学过程,需要扩展眼光,介绍了对地壳块体旋转问题的研究,涉及到鄂尔多斯块体旋转、亚洲中部大区域的地块旋转、汾渭裂谷和贝加尔裂谷的对比、地幔密度分布、喜马拉雅构造结和全球非对称等基本问题。

关键词：汾渭裂谷地壳块体的旋转雁行断裂地幔

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The role of undifferentiated adipose-derived stem cells in peripheral nerve repair

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Neural Regeneration Research 2018年第5期13卷 757-763页

作者： rui Zhang Joseph m.Rosen Dartmouth Geisel School of medicine Dartmouth-Hitchcock Medical Center

Peripheral nerve injuries impose significant health and economic consequences, yet no surgical repair can deliver a complete recovery of sensory or motor function. Traditional methods of repair are less than ideal： direct coaptation can only be performed when tension-free repair is possible, and transplantation of nerve autograft can cause donor-site morbidity and neuroma formation. Cell-based therapy delivered via nerve conduits has thus been explored as an alternative method of nerve repair in recent years. Stem cells are promising sources of the regenerative core material in a nerve conduit because stem cells are multipotent in function, abundant in supply, and more accessible than the myelinating Schwann cells. Among different types of stem cells, undifferentiated adipose-derived stem cell（uASC）, which can be processed from adipose tissue in less than two hours, is a promising yet underexplored cell type. Studies of uASC have emerged in the past decade and have shown that autologous uASCs are non-immunogenic, easy to access, abundant in supply, and efficacious at promoting nerve regeneration. Two theories have been proposed as the primary regenerative mechanisms of uASC： in situ trans-differentiation towards Schwann cells, and secretion of trophic and anti-inflammatory factors. Future studies need to fully elucidate the mechanisms, side effects, and efficacy of uASC-based nerve regeneration so that uASCs can be utilized in clinical settings.

关键词： peripheral nerve injury adipose-derived stem cells Schwann cells cell therapy nerve conduits axonal regeneration stem cell differentiation neurotrophic factors anti-apoptosis immunosuppression

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multi-conductor Line models for Harmonic Load-flow Calculations in LV Networks with High Penetration of PV Generation

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Journal of modern Power Systems and Clean Energy 2022年第5期10卷 1288-1301页

作者： Fernando m.Camilo m.E.Almeida rui Castro V.Fernao Pires Institutode Engenhariade Sistemas e Computadores Investigacao eDesenvolvimento(INESC-ID)and TecnicoUniversity of LisbonLisbonPortugal ESTSetubal Polytechnics of SetubalSetuibalPortugal

Low-voltage(LV) distribution networks are unbalanced and present loads with nonlinear behavior, which introduce harmonics in the networks. The predictable increase in photovoltaic microgeneration(PV μG) accentuates this unbalanced characteristic, as well as poses new technical problems,namely voltage rise and reverse power flow. To accurately account for the distributed PV and loads in the LV network, unbalanced three-phase power flow algorithms should be utilized,where different approaches may be used to represent lines with various degrees of accuracy. The more accurate algorithm considers the electromagnetic coupling between the line conductors,whereas the simpler algorithm represents each conductor of the line as a single-phase line with pure resistive behavior. This paper aims to analyze the influence of the line model on the load flow in a highly unbalanced LV network with a high penetration of PV production, and considers the impact of the harmonics produced by nonlinear loads. Based on the results obtained,it is possible to identify the most suitable model to be used, depending on the study to be performed. Different scenarios of PV generation and loads are addressed in this paper.

关键词： Line model nonlinear loads photovoltaic microgeneration unbalanced distribution network

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metallogenic‘factories’and resultant highly anomalous mineral endowment on the craton margins of China

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Geoscience Frontiers 2022年第2期13卷 1-20页

作者： Li-Qiang Yang Jun Deng David I.Groves m.Santosh Wen-Yan He Nan Li Liang Zhang rui-rui Zhang Hong-rui Zhang State Key Laboratory of Geological Processes and mineral Resources China University of GeosciencesBeijing 100083China ministry of Natural Resources Key Laboratory of Gold mineralization Processes and Resources Utilization Shandong Institute of Geological SciencesJinan 250013China Centre for Exploration Targeting University of Western AustraliaCrawleyWA 6009Australia Dept.of Earth Sciences University of AdelaideSA 5005Australia Division of Interdisciplinary Science Faculty of ScienceKochi UniversityKochi 780-8520Japan

The current margins of the North China and Yangtze Cratons provide arguably the best examples globally of anomalously high mineral endowment within a 100 km buffer zone,hosting 66 diverse world-class to giant ore systems that help explain China’s premier position as a producer of multiple metal and mineral *** the cratonization of these crustal blocks during the Neoarchean-Paleoproterozoic,with incorporation of iron ores on assembled micro-block margins,the margins of the cratons experienced multiple convergence and rifting events leading to metasomatism and fertilization of their underlying sub-continental lithospheric *** rifted margins with trans-lithosphere faults provided pathways for Cu-Au(mo-W-Sn)-bearing felsic to Ni-Cu-bearing ultrabasic intrusions and REE-rich carbonatite magmas,and for the development of marginal sedimentary basins with both Cu-Pb-Zn-rich source units and reactive carbonate or carbonaceous host *** was diachronous formation of hydrothermal orogenic gold,antimony,and bismuth systems in the narrow orogenic belts between the *** in the mesozoic Paleo-Pacific subduction systems resulted in asthenosphere upwelling and lithosphere extension and thinning in the North China Craton,leading to anomalous heat flow and formation of orogenic gold deposits,including those of the giant Jiaodong gold province on its north-eastern *** gold deposits,many of which formed from fluids liberated by devolatilization of previously metasomatized sub-continental lithospheric mantle,helped propel China to be the premier gold producer *** thick sub-continental lithospheric mantle of the cold buoyant cratons helped the preservation of some of the world’s oldest porphyry-skarn and epithermal mineral *** craton margins globally control the formation and preservation of a diverse range of mineral deposits,China represents the premier example in terms of metal endowment due to the anomalous length

关键词： Craton margin Ore deposits Geodynamic setting Fertile mantle lithosphere mineral exploration

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Food,polyphenols and neuroprotection

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Neural Regeneration Research 2017年第4期12卷 582-583页

作者： rui F.m.Silva Lea Pogacnik Research Institute for medicines(imed.ULisboa)and Department of Biochemistry and Human Biology(DBBH) Faculty of PharmacyUniversidade de LisboaLisboaPortugal Department of Food Science and Technology Biotechnical FacultyUniversity of LjubljanaLjubljana Slovenia

Neuron loss and neurodegeneration are the common denom- inators of what are known as neurodegenerative diseases. Although the clinical manifestations of some neurodegenerative diseases are mainly associated with ageing, it is believed that onset of disease and neuronal death occurs progressively through life, well betore the first symptoms appear. So, one of the main dilemmas regarding neurodegenerative disease ther-apies is that treatment often starts long after the neurodegeneration has occurred, when a great number of neurons have already been lost. Furthermore,

关键词： Food EGCG

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Constraining the non-Einsteinian polarizations of gravitational waves by pulsar timing array

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Science China(Physics,mechanics & Astronomy) 2019年第7期62卷 63-75页

作者： rui Niu Wen Zhao CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of China School of Astronomy and Space Science University of Science and Technology of China

Pulsar timing array(PTA) provides an excellent opportunity to detect the gravitational waves(GWs) in nanoHertz frequency *** particular, due to the larger number of "arms" in PTA, it can be used to test gravity by probing the non-Einsteinian polarization modes of GWs, including two spin-1 shear modes labeled by "sn" and "se", the spin-0 transverse mode labeled by "b" and the longitudinal mode labeled by "l". In this paper, we investigate the capabilities of the current and potential future PTAs, which are quantified by the constraints on the amplitudes parameters(c_b, c_(sn), c_(se), c_l), by observing an individual supermassive black hole binary in Virgo cluster. We find that for binary with total mass m_c= 8.77 × 10~8 m_⊙ and GW frequency f = 10^(-9) Hz, the PTA at current level can detect these GW modes if c_b> 0.00106, c_l> 0.00217, c_(se)> 0.00271, c_(sn)> 0.00141, which will be improved by about two orders if considering the potential PTA in SKA era. Interesting enough, due to effects of the geometrical factors, we find that in SKA era, the constraints on the l, sn, se modes of GWs are purely dominated by several pulsars, instead of the full pulsars in PTA.

关键词： gravitational waves pulsar timing array

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Thermodynamic Behavior Research Analysis of Twin-roll Casting Lead Alloy Strip Process

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Chinese Journal of mechanical Engineering 2017年第2期30卷 352-362页

作者： Chengcan JIANG Yannian rui School of mechanical and Electric Engineering SoochowUniversityJiangsu 215021China

The thermodynamic behavior of twin-roll casting （TRC） lead alloy strip process directly affects the forming of the lead strip, the quality of the lead strip and the production efficiency. However, there is little research on the thermodynamics of lead alloy strip at home and abroad. The TRC lead process is studied in four parameters： the pouring temperature of molten lead, the depth of molten pool, the roll casting speed, and the rolling thickness of continuous casting. Firstly, the thermodynamic model for TRC lead process is built. Secondly, the thermodynamic behavior of the TRC process is simulated with the use of Fluent. Through the thermodynamics research and analysis, the process parameters of cast rolling lead strip can be obtained： the pouring temperature of molten lead： 360-400 ℃, the depth of molten pool： 250-300 mm, the roll casting speed： 2.5-3 m/min, the rolling thickness： 8-9 mm. Based on the above process parameters, the optimal parameters（the pouring temperature of molten lead： 375-390 ℃, the depth of molten pool： 285-300 mm, the roll casting speed： 2.75-3 m/min, the rolling thickness： 8.5-9 mm） can be gained with the use of the orthogonal experiment. Finally, the engineering test of TRC lead alloy strip is carried out and the test proves the thermodynamic model is scientific, necessary and correct. In this paper, a detailed study on the thermodynamic behavior of lead alloy strip is carried out and the process parameters of lead strip forming are obtained through the research, which provide an effective theoretical guide for TRC lead alloy strip process.

关键词： TRC lead alloy strip Thermodynamic model Thermodynamic behavior Theoretical guide

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