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Strong,tough,and thermally conductive nacre-inspired boron nitride nanosheet/epoxy layered nanocomposites

Nano Research 2024年第2期17卷 820-828页

作者： Huagao Wang Rongjian Lu Lei Li Cheng liang Jia Yan rui liang Guoxing Sun Lei Jiang Qunfeng Cheng School of Chemistry Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of EducationBeihang UniversityBeijing 100191China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Department of Stomatology Fifth Medical CenterChinese PLA General HospitalBeijing 100039China Department of Engineering Science Faculty of Innovation EngineeringMacao University of Science and TechnologyAvenida Wai LongTaipaMacao 999078 China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao 999078China Institute of Energy Materials Science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Thermally conductive polymer nanocomposites integrated with lightweight,excellent flexural strength,and high fracture toughness(KIc)would be of great use in many fields.However,achieving all of these properties simultaneously remains a great challenge.Inspired by natural nacre,here we demonstrate a lightweight,strong,tough,and thermally conductive boron nitride nanosheet/epoxy layered(BNNEL)nanocomposite.Because of the layered structure and enhancing the interfacial interactions through hydrogen bonding and Si–O–B covalent bonding,the resulting nacre-inspired BNNEL nanocomposites show high fracture toughness of~4.22 MPa·m^(1/2),which is 7 folds as high as pure epoxy.Moreover,the BNNEL nanocomposites demonstrate sufficient flexural strength(~168.90 MPa,comparable to epoxy resin),while also being lightweight(~1.23 g/cm^(3)).Additionally,the BNNEL nanocomposites display a thermal conductivity(κ)of~0.47 W/(m·K)at low boron nitride nanosheet loading of 2.08 vol.%,which is 2.7 times higher than that of pure epoxy resin.The developed nacre-inspired strategy of layered structure design and interfacial enhancement provides an avenue for fabricating high mechanical properties and thermally conductive polymer nanocomposites.

关键词： nacre-inspiration nanocomposites flexural strength fracture toughness(KIc) thermal conductivity

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Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis

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Oncology Research 2024年第3期32卷 563-576页

作者： YANG ZHANG NANNAN QIN XIJUN WANG rui liang QUAN LIU RUOYI GENG TIANXIAO JIANG YUNFEI LIU JINWEI LI Graduate School Kunming Medical UniversityKunming650000China Depatment of Vascular Surgery Fuwai Yunnan Cardiovascular HospitalAfliated Cardiovascular Hospital of Kunming Medical UniversityKunming650000China Department of Neurosurgery West China HospitalSichuan UniversityChengdu610000China Department of Neurosurgery The Fourth Afiliated Hospital of Guangxi Medical UniversityLiuzhou545000China Depatment of Gynecology Oncology The Fourth Afliated Hospital of Guangxi Medical UniversityLiuzhou545000China School of Basic Medical Sciences Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China College of Bioengineering Chongqing UniversityChongqing400030China Department of General Visceraland Transplant SurgeryLudwig Maximilians University MunichMunich81377Germany

Glycogen metabolism plays a key role in the development of hepatoellular carcinoma(HCC),but the function of glycogen metabolism genes in the tumor microenvironment(TME)is still to be elucidated.Single cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells and 65 glycogen metabolism genes were analyzed bya nonnegative matrix factorization(NMF).The prognosis and immune response of new glycogen TME cell dusters were predicted by using HCC and immunotherapy cohorts from public databases.HOC single cell analysis was divided into fibroblasts,NT T cells,macrophages,endothelial clls,and B cells,which were separately divided into new cell clusters by glycogen metabolism gene annotation.Pseudo temporal trajectory analysis demonstrated the temporal differentiation trajectory of different glycogen subtype cell dusters.Cellular communication analysis revealed extensive interactions between endothelial cells with glycogen metabolizing TME cell.related subtypes and diferent glycogen subtype cell clusters.SCENIC analysis of transcription factors upstream of TME cell clusters with different glycogen metabolism.In addition,TME cell dusters of glycogen metabolism were found to be enriched in expression in CAF subtypes,CD8 depleted,M1,and M2 types.Bulk seq analysis showed the prognostic signifcance of glycogen metabolism.mediated TME cell dusters in HCC,while a significant immune response was found in the immunotherapy cohort in patients treated with immune checkpoint blockade(ICB),especially for CAFs,T cells,and macrophages In summary,our study reveals for the first time that glycogen metabolism mediates intercellular communication in the hepatocellular carcinoma microenvironment while elucidating the anti-tumor mechanisms and immune prognostic responses of different subtypes of cell dusters.

关键词： Glycogen metabolism Metabolic map Single cell Tumor microenvironment Liver cancer Prognosis Immunotherapy

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Decentralized Bilateral Risk-based Self-healing Strategy for Power Distribution Network with Potentials from Central Energy Stations

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 179-190页

作者： Chaoxian Lv rui liang Yuanyuan Chai School of Electrical Engineering China University of Mining and TechnologyXuzhouChina School of Electrical Engineering Hebei University of TechnologyTianjinChina

Owing to potential regulation capacities from flexible resources in energy coupling,storage,and consumption links,central energy stations(CESs)can provide additional support to power distribution network(PDN)in case of power disruption.However,existing research has not explicitly revealed the emergency response of PDN with leveraging multiple CESs.This paper proposes a decentralized self-healing strategy of PDN to minimize the entire load loss,in which multi-area CESs’potentials including thermal storage and building thermal inertia,as well as the flexible topology of PDN,are reasonably exploited for service recovery.For sake of privacy preservation,the co-optimization of PDN and CESs is realized in a decentralized manner using adaptive alternating direction method of multipliers(ADMM).Furtherly,bilateral risk management with conditional value-at-risk(CVaR)for PDN and risk constraints for CESs is integrated to deal with uncertainties from outage duration.Case studies are conducted on a modified IEEE 33-bus PDN with multiple CESs.Numerical results illustrate that the proposed strategy can fully utilize the potentials of multi-area CESs for coordinated load restoration.The effectiveness of the performance and behaviors’adaptation against random risks is also validated.

关键词： Power distribution network(PDN) central energy station(CES) bilateral risk management self-healing alternating direction method of multipliers(ADMM)

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Current status and perspectives of regulatory T cell-based therapy

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Journal of Genetics and Genomics 2022年第7期49卷 599-611页

作者： Guojun Qu Jieqiong Chen Yangyang Li Yaqin Yuan rui liang Bin Li Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Shanghai Affinity Biopharmaceutical Co. Ltd.781 Cailun RoadShanghai 201203China Unit of Immune and Metabolic Regulation School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China

The CD4FOXP3regulatory T(Treg)cells are essential for maintaining immune homeostasis in healthy individuals.Results from clinical trials of Treg cell-based therapies in patients with graft versus host disease(GVHD),type 1 diabetes(T1D),liver transplantation,and kidney transplantation have demonstrated that adoptive transfer of Treg cells is emerging as a promising strategy to promote immune tolerance.Here we provide an overview of recent progresses and current challenges of Treg cell-based therapies.We summarize the completed and ongoing clinical trials with human Treg cells.Notably,a few of the chimeric antigen receptor(CAR)-Treg cell therapies are currently undergoing clinical trials.Meanwhile,we describe the new strategies for engineering Treg cells used in preclinical studies.Finally,we envision that the use of novel synthetic receptors,metabolic regulators,combined therapies,and in vivo generated antigen-specific or engineered Treg cells through the delivery of modified mRNA and CRISPR-based gene editing will further promote the advances of next-generation Treg cell therapies.

关键词： Regulatory T cell FOXP3 Chimeric antigen receptor Cell therapy CRISPR-Based gene editing mRNA-based therapy

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超高性能混凝土与钢筋劈裂黏结强度试验研究

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建筑结构学报 2024年第6期45卷 254-261页

作者：梁芮黄远新疆大学建筑工程学院新疆乌鲁木齐830047 湖南大学工程结构损伤诊断湖南省重点实验室湖南长沙410082

超高性能混凝土(UHPC)作为一种新型复合材料,可增强与钢筋界面的黏结性能,减少黏结长度。目前,针对UHPC黏结性能的研究,大多采用拔出试验或搭接拉伸试验,难以模拟结构中梁和柱等弯曲受力构件的实际黏结情况,需要对弯曲应力状态下UHPC与... 详细信息

超高性能混凝土(UHPC)作为一种新型复合材料,可增强与钢筋界面的黏结性能,减少黏结长度。目前,针对UHPC黏结性能的研究,大多采用拔出试验或搭接拉伸试验,难以模拟结构中梁和柱等弯曲受力构件的实际黏结情况,需要对弯曲应力状态下UHPC与中长锚钢筋的黏结行为展开研究。为此,对17根搭接梁式试件进行四点弯曲加载试验,研究UHPC强度、纤维体积率、保护层厚度、搭接长度及搭接段箍筋配置对UHPC与钢筋黏结强度的影响。结果表明:UHPC梁式试件主要发生劈裂黏结破坏;增加UHPC强度和保护层厚度有助于提高黏结强度;黏结强度随搭接长度增加而减小;在搭接段配置箍筋可有效提高试件黏结强度,但箍筋对黏结强度的提高作用存在一个阈值,当达到阈值时,增加箍筋数量对黏结强度的提高将不再明显。此外,对现有黏结强度计算模型进行了评估,发现现有计算模型对UHPC劈裂黏结强度预测结果较为保守,离散程度偏大。在此基础上,提出了改进的UHPC劈裂黏结强度计算表达式,可准确反映各种设计参数对劈裂黏结强度的影响,计算结果与本文及相关文献试验结果之比的平均值为1.076,变异系数为0.149。

关键词：超高性能混凝土中长锚钢筋搭接梁式试验黏结性能劈裂黏结强度

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State-of-the-art applications of machine learning in the life cycle of solid waste management

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Frontiers of Environmental Science & Engineering 2023年第4期17卷 53-69页

作者： rui liang Chao Chen Akash Kumar Junyu Tao Yan Kang Dong Han Xianjia Jiang Pei Tang Beibei Yan Guanyi Chen School of Environmental Science and Engineering Tianjin UniversityTianjin 300350China School of Mechanical Engineering Tianjin University of CommerceTianjin 300134China Tianjin Key Laboratory of Biomass Wastes Utilization/Tianjin Engineering Research Center of Bio Gas/Oil Technology Tianjin 300072China School of Science Tibet UniversityLhasa 850012China

Due to the superiority of machine learning(ML)data processing,it is widely used in research of solid waste(SW).This study analyzed the research and developmental progress of the applications of ML in the life cycle of SW.Statistical analyses were undertaken on the literature published between 1985 and 2021 in the Science Citation Index Expanded and Social Sciences Citation Index to provide an overview of the progress.Based on the articles considered,a rapid upward trend from 1985 to 2021 was found and international cooperatives were found to have strengthened.The three topics of ML,namely,SW categories,ML algorithms,and specific applications,as applied to the life cycle of SW were discussed.ML has been applied during the entire SW process,thereby affecting its life cycle.ML was used to predict the generation and characteristics of SW,optimize its collection and transportation,and model the processing of its energy utilization.Finally,the current challenges of applying ML to SW and future perspectives were discussed.The goal is to achieve high economic and environmental benefits and carbon reduction during the life cycle of SW.ML plays an important role in the modernization and intellectualization of SW management.It is hoped that this work would be helpful to provide a constructive overview towards the state-of-the-art development of SW disposal.

关键词： Machine learning(ML) Solid waste(SW) Bibliometrics SW management Energy utilization Life cycle

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OPO老年教育教学改革的探索与实践——以广东老年大学为例

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成人教育 2024年第3期44卷 43-49页

作者：梁瑞明广东开放大学继续教育学院广州510091

为响应我国积极应对人口老龄化的国家战略,老年教育致力于帮助老年人解决养老、健康、社会参与等方面的问题。通过探索构建OPO(Offline Plus Online)教育教学改革模式,力图解决学位难求、学习路径单一、学习资源缺乏、智能技术应用障碍... 详细信息

为响应我国积极应对人口老龄化的国家战略,老年教育致力于帮助老年人解决养老、健康、社会参与等方面的问题。通过探索构建OPO(Offline Plus Online)教育教学改革模式,力图解决学位难求、学习路径单一、学习资源缺乏、智能技术应用障碍等一系列难题,以期为推动我国老年教育事业的健康发展提供智力支持。

关键词：老年教育教学改革实践路径

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Microwave assisted synthesis of PQ-GDY@NH_(2)-UIO-66(Zr) for improved photocatalytic removal of NOx under visible light

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Journal of Environmental Sciences 2023年第12期134卷 126-137页

作者： Qingyu Yang Shuangjun Li rui liang Lei Gao Shao Zhang Junfen Jia Yiran Liu Rundong Lyv Guisheng Li Shengxiong Xiao Dieqing Zhang The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry of Ministry of EducationShanghai Key Laboratory of Rare Earth Functional Materialsand Shanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234China

Pyrazinoquinoxaline-based graphdiyne (PQ-GDY) contains a fixed number of sp-sp2hybridized carbon atoms and pyrazine-like sp2hybridized N atoms.In this paper,NH_(2)-UIO-66(Zr) on PQ-GDY substrate was successfully constructed with the help of microwaveassisted heating.PQ-GDY surface acts as a microwave antenna under microwave irradiation to rapidly absorb microwave energy and form hot spots (hot spot effect),which facilitates the formation of well-dispersed NH2-UIO-66(Zr) with good crystallinity.Transient absorption spectra show that high hole transport property of PQ-GDY can accelerate the migration of photogenerated holes from NH2-UIO-66(Zr) to PQ-GDY and greatly reduce the recombination rate of photogenerated electrons and holes due to the strong interaction between PQ-GDY and NH2-UIO-66(Zr).Under visible light (λ≥420 nm),PQ-GDY@NH_(2)-UIO-66(Zr) shows high photocatalytic stability and high NO_(x)removal rate up to 74%,which is 44% higher than that of primitive NH_(2)-UIO-66(Zr).At the same time,it inhibits the formation of toxic byproducts (NO2) and limits its concentration to a low level.

关键词： Nitrogen oxides Photocatalysis Graphite acetylene Metal-organic backbone

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Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy

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World Journal of Gastrointestinal Oncology 2022年第12期14卷 2340-2352页

作者： Wen-Qian Yang rui liang Man-Qi Gao Yu-Zhen Liu Bo Qi Bao-Sheng Zhao Department of Thoracic Surgery The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina Esophageal Cancer Institute Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina Life Science Research Center The First Affiliated Hospital of Xinxiang Medical UniversityWeihui 453100Henan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC),the predominant type of esophageal cancer,has a 5-year survival rate less than 20%.Although the cause of poor prognosis is the high incidence and mortality of ESCC,the high rate of metastasis after esophageal cancer surgery is the main cause of death after the surgery.Bromodomain-containing protein 4(BRD4),an epigenetic reader of chromatinacetylated histones in tumorigenesis and development,plays an essential role in regulating oncogene expression.BRD4 inhibition and BRD4 inhibition-based treatment can potentially suppress ESCC growth.However,the effects and mechanisms of action of BRD4 on ESCC cell migration remain unclear.AIM To explore the effect of BRD4 on cell migration of ESCC in vitro and its possible molecular mechanism.METHODS Human ESCC cell lines KYSE-450 and KYSE-150 were used.The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay was performed to examine cell proliferation,and the transwell migration assay was conducted to test ESCC cell migration.JQ1,a BRD4 inhibitor,was applied to cells,and BRD4 siRNA was transfected into ESCC cells to knockdown endogenous BRD4.GFP-RFP-LC3 adenovirus was infected into ESCC cells to evaluate the effect of JQ1 on autophagy.Western blotting was performed to determine the protein levels of BRD4,E-cadherin,vimentin,AMP-activated protein kinase(AMPK),and p-AMPK.RESULTS BRD4 was either downregulated by small interfering RNA or pretreated with JQ1 in ESCC cells,leading to increased tumor migration in ESCC cells in a dose-and time-dependent manner.Inhibition of BRD4 not only significantly suppressed cell proliferation but also strongly increased cell migration by inducing epithelial-mesenchymal transition(EMT).The protein expression of vimentin was increased and E-cadherin decreased in a dose-dependent manner,subsequently promoting autophagy in KYSE-450 and KYSE-150 cells.Pretreatment with JQ1,a BRD4 inhibitor,inhibited BRD4-induced LC3-II activation and upregulated AMPK phosphorylation in a dosedepend

关键词： JQ1 Bromodomain-containing protein 4 Cell migration Cell autophagy Epithelialmesenchymal transition Esophageal squamous cell carcinoma

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Resistance genes mediate differential resistance to pine defensive substances α-Pinene and H_(2)O_(2) in Bursaphelenchus xylophilus with different levels of virulence

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Journal of Forestry Research 2021年第4期32卷 1753-1762页

作者： Lin rui Hongbin Liu rui liang Xiaoqin Wu Co-Innovation Center for Sustainable Forestry in Southern China College of ForestryNanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China Jiangsu Key Laboratory for Prevention and Management of Invasive Species Nanjing Forestry UniversityNanjing 210037JiangsuPeople’s Republic of China

The pine wood nematode(PWN),Bursaphelenchus xylophilus(Steiner & Buhrer) Nickle,is the pathogen of pine wilt disease(PWD) which can devastate forests.PWN can be of hi gh or low severity and the mechanisms underlying the differences in virulence are unclear.Therefore,it is necessary to study the relationship between differentiation of PWN severity and its resistance to the main defensive substances of pine species(i.e.,α-pinene and H_(2)O_(2)).The feeding rate and fecundity of PWN was examined at different levels of virulence under conditions of a-pinene and H_(2)O_(2) stress.Moreover,the expression patterns of the main resistance genes of PWN with different virulence were determined under conditions of α-pinene and H_(2)O_(2) stress.The feeding rate and fecundity of the high virulence strain AMA3 were higher than those of the low virulence strain YW4.The expression levels of the autophagy gene BxATG5,cytochrome P450 gene BxCYP33 D3,and glutathione S-transferase genes BxGST1 and BxGST3 in AMA3 increased significantly upon exposure to α-pinene for 2 h,while these genes showed smaller degrees of upregulation in YW4.Under conditions of H_(2)O_(2) stress,the expression levels of BxATG5,catalase genes Bxy-ctl-1 and Bxy-ctl-2,and the 2-cysteine peroxiredoxin gene BxPrx in AMA3 were higher than those in YW4.These findings suggest that high virulence PWN has greater resistance to pine defensive substances α-pinene and H_(2)O_(2) than low virulence PWN,and resistance genes mediate the differential resistance of PWN strains.This study will contribute to the clarification of the mechanism underlying virulence differentiation of PWN and will advance understanding of the pathogenic mechanism of PWD.

关键词： Pine wood nematode Virulence Defensive substances Autophagy gene Detoxification gene Antioxidant gene

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