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Excitation spectral microscopy for highly multiplexed fluoresce nee imagi ng and quantitative biose rising

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Light(Science & Applications) 2021年第6期10卷 1041-1052页

作者： Kun Chen rui yan Limin Xiang Ke Xu College of Chemistry University of CaliforniaBerkeleyCAUSA. Division of Molecular Biophysics and Integrated Bioimaging Lawrence Berkeley National LaboratoryBerkeleyCAUSA. Chan Zuckerberg Biohub San FranciscoCAUSA

The multiplexing capability of fluorescence microscopy is severely limited by the broad fluorescence spectral *** imaging offers potential solutions,yet typical approaches to disperse the local emission spectra notably impede the attain able *** we show that using a sin gle,fixed fluoresc ence emission detection band,through frame-synchronized fast seanning of the excitation wavelength from a white lamp via an acousto-optic tun able filter,up to six subcellular targets,labeled by common fluorophores of substantial spectral overlap,can be simultaneously imaged in live cells with low(〜1%)crosstalks and high temporal resolutions(down to~10 ms).The dem on strated capability to quantify the abundances of different fluorophores in the same sample through unmixing the excitation spectra next enables us to devise novel,quantitative imaging schemes for both bi-state and Forster resonance energy transfer fluorescent biosensors in live *** thus achieve high sensitivities and spatiotemporal resolutions in quantifying the mitochondrial matrix pH and intracellular macromolecular crowding,and further demonstrate,for the first time,the multiplexing of absolute pH imaging with three additional target organelles/proteins to elucidate the complex,Parkin-mediated mitophagy ***,excitation spectral microscopy provides exceptional opportunities for highly multiplexed fluorescence *** prospect of acquiring fast spectral images without the need for fluorescence dispersion or care for the spectral response of the detector offers tremendous potential.

关键词： spectral excitation exceptional

Cobalt-Catalyzed C-H Allylation of Arenes with Allylic Amines

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Chinese Journal of Chemistry 2021年第5期39卷 1205-1210页

作者： rui yan Hang Yu Zhong-Xia Wang CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry University of Science and Technology of ChinaHefeiAnhui 230026China Colloborotive Innovation Center of Chemical Science and Engineering Tianjin 300072China

[Cp^(*)Co(CO)l_(2)]effectively catalyzes pyridyl-directed C-H allylation of arenes with allylic amines in the presence of AgOAc and CF_(3)*** reaction features ortho-position monoallylation of 2-pyridylarenes,giving the allylated arenes in moderate to high yields.A range of functional groups including OMe,Me,Ph,F,Cl,Br,CF_(3),C(0)Me,COOEt,and COOH groups are ***-idyl-directed C-H allylation of arenes were also performed under the same *** of 2-phenylpyrimidine,2-(4-methoxyphenyl)pyrimidine/and 2-(3-fluorophenyl)pyrimidine leads to a mixture of ortho-position mono-and bisallylation *** of other 2-(substituted aryl)pyrimidines resulted in ortho-position monoallylation products.

关键词： C-H activation C-N activation Homogeneous catalysis Cobalt catalysis Allylation

Study of the electrochemical oxidation mechanism of formaldehyde on gold electrode in alkaline solution

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Chinese Chemical Letters 2013年第2期24卷 159-162页

作者： rui-Wen yan Bao-Kang Jin Department of Chemistry Anhui University

Received 7 November 2012 Received in revised form 10 December 2012 Accepted 31 December 2012 Available online 4 February 2013

关键词： Rapid-scan time-resolved FTIRFormaldehydeElectrochemical oxidation

Estimating soil erosion response to land use/cover change in a catchment of the Loess Plateau, China

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International Soil and Water Conservation Research 2018年第1期6卷 13-22页

作者： rui yan Xiaoping Zhang Shengjun yan Hao Chen State Key Laboratory of Soil Erosion and Dry land Farming on the Loess Plateau Northwest A&F University Institute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water ResourcesYanglingShaanxi 712100China

The vegetation restoration project, named the Grain to Green Program, has been operating for more than ten years in the upper reaches of the Beiluo River basin, located in the Loess Plateau of China. It is significant to be able to estimate the success of preventing soil erosion. In this study, the Revised Universal Soil Loss Equation (RUSLE) and the Sediment Distributed Delivery (SEDD) model were used to assess the annual soil loss derived from water erosion. The results showed that the study area suffered from primary land use changes, with increasing grassland and forest and decreasing farmland from 1990 to 2010. Based on that, the average soil erosion modulus decreased from 18,189.72 t/(km2 a) in 1990– 7408.93 t/(km2 a) in 2000 and 2857.76 t/(km2 a) in 2010. Compared with 1990, the average soil erosion modulus decreased by 59.0% and 84.3% for 2000 and 2010, respectively. Benefiting from the increased vegetation coverage and improved ecological environment, the soil erosion in this study area clearly declined. This research also found that the distribution of the three years of soil erosion was similarly based on topographic factors. The soil erosion modulus varied with different land use types and decreased in the order of residential area>farmland>grassland>forest. The average soil erosion modulus gradually increased with the increase of the slope gradient, and 76.08% of the total soil erosion was concentrated in the region with a gradient more than 15 degrees. The soil erosion modulus also varied with slope aspects in the order of sunny slope>half-sunny slope>half-shady slope>shady slope. This research provides useful reference for soil and water conservation and utilization in this area and offers a technical basis for using the RUSLE to estimate soil erosion in the Loess Plateau of China.

关键词： Loess Plateau Land use changes RUSLE SEDD Soil erosion

Analysis of burnup performance and temperature coefficient for a small modular molten‑salt reactor started with plutonium

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Nuclear Science and Techniques 2023年第1期34卷 178-189页

作者： Xue‑Chao Zhao yang Zou rui yan Xiang‑Zhou Cai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China

In a thorium-based molten salt reactor(TMSR),it is difficult to achieve the pure 232Th–^(233)U fuel cycle without sufficient^(233)U fuel ***,the original molten salt reactor was designed to use enriched uranium or plutonium as the starting *** exploiting plutonium as the starting fuel and thorium as the fertile fuel,the high-purity^(233)U produced can be separated from the spent fuel by fluorination ***,the molten salt reactor started with plutonium can be designed as a^(233)U breeder with the burning plutonium extracted from a pressurized water reactor(PWR).Combining these advantages,the study of the physical properties of plutonium-activated salt reactors is *** study mainly focused on the burnup performance and temperature reactivity coefficient of a small modular molten-salt reactor started with plutonium(SM-MSR-Pu).The neutron spectra,^(233)U production,plutonium incineration,minor actinide(MA)residues,and temperature reactivity coefficients for different fuel salt volume fractions(VF)and hexagon pitch(P)sizes were calculated to analyze the burnup behavior in the *** on the comparative analysis results of the burn-up calculation,a lower VF and larger P size are more beneficial for improving the burnup ***,from a passive safety perspective,a higher fuel volume fraction and smaller hexagon pitch size are necessary to achieve a deep negative feedback ***,an excellent burnup performance and a deep negative temperature feedback coefficient are incompatible,and the optimal design range is relatively narrow in the optimized design of an *** a comprehensive consideration,P=20 cm and VF=20%are considered to be relatively balanced design *** on the fuel off-line batching scheme,a 250 MWth SM-MSR-Pu can produce approximately 29.83 kg of ^(233)U,incinerate 98.29 kg of plutonium,and accumulate 14.70 kg of MAs per year,and the temperature reactivity coefficie

关键词： Molten salt fuel Incinerate plutonium 233U production Temperature reactivity coefficient

Near-surface model reconstruction using pseudo well-surface simultaneous travel time tomographic inversion

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Mining Science and Technology 2010年第5期20卷 747-751页

作者： LI Yu yan Pei PAN yanhui yan rui State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology Beijing 100083 China Xiamen Research Center of Seismologic Surveying Fujian 361021 China Department of Computer Engineering Ordnance Engineering College Shijiazhuang 050003 China

The static correction of a near-surface model may be improved by using travel time tomographic *** discuss unfavorable factors in the inversion of surface seismic waves that have been analyzed by the first *** factors show that sources and geophones arranged on the surface,or close to the surface,give a first break that only includes the direct wave and the up going wave from the down going to up going *** up going waves have weak directivity when they arrive at a geophone and so the rays passing through the grids have small directional differences and a narrow *** lessons from the advantages of Vertical Seismic Profiling(VSP) acquisition mode we describe a pseudo well-surface simultaneous travel time tomographic inversion of a near-surface *** well depth should be increased in the surface seismic study to produce a pure up going wave,to enhance the verticality of the rays and to increase the azimuth and shorten path length of the *** of the effect of well depth on a pseudo well-surface simultaneous travel time tomographic inversion model are *** results show that the static corrections are improved significantly when the well depth extends below the weathered or sub-weathered *** root mean square error of the statics is 1.14 or 0.93 ms for these two situations,respectively.

关键词： surface seismic travel time tomography well-surface simultaneous near-surface model static correction

Cardiometabolic and panvascular multimorbidity associated with motoric cognitive risk syndrome in older adults

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Journal of Geriatric Cardiology 2024年第10期21卷 944-953页

作者： rui SHE Zhong-rui yan Peng WANG Ya-Jun LIANG Cheng-Xuan QIU Department of Rehabilitation Sciences the Hong Kong Polytechnic UniversityHong KongChina Department of Ne-urology Jining No.1 People’s HospitalJiningChina Department of Global Public Health Karolinska InstitutetStock-holmSweden Aging Research Center and Center for Alzheimer Research Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet-Stockholm UniversityStockholmSweden Department of Neurology Shandong Pr-ovincial Hospital Affiliated to Shandong First Medical UniversityJinanChina

Background Motoric cognitive risk(MCR)syndrome as a pre-dementia syndrome often co-occurring with chronic health *** study aims to investigate the prevalence of MCR and its association with cardiometabolic and panvascular multimorb-idity among older people living in rural *** This population-based study included 1450 participants who were aged≥60 years(66.2%women)and who underto-ok the second wave examination of the Confucius Hometown Aging Project in Shandong,China when information to define MCR was *** were collected through in-person interviews,clinical examinations,and laboratory *** and pa-nvascular multimorbidity were defined following the international *** was defined as subjective cognitive complaints and slow gait speed in individuals free of dementia and functional *** logistic regression models were used to exa-mine the associations of MCR with *** MCR was present in 6.3%of all participants,and the prevalence increased with advancing *** disea-se,ischemic heart disease,heart failure,and increased serum cystatin C were associated with increased likelihoods of MCR(mult-ivariable-adjusted odds ratio range:1.90-3.02,P<0.05 for all).Furthermore,there was a dose-response relationship between the nu-mber of cardiometabolic diseases and panvascular diseases and the likelihood of *** multivariable-adjusted odds ratio(95%CI)of MCR associated with cardiometabolic and panvascular multimorbidity were 2.47(1.43-4.26)and 3.85(2.29-6.47),*** Older adults with cardiometabolic and panvascular multimorbidity are at a higher likelihood of *** fin-dings may have implications for identifying older adults at pre-dementia state as targets for early preventive interventions to delay dementia onset.

关键词： morbidity likelihood older

Distributed sensor fault diagnosis for a formation system with unknown constant time delays

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Science China(Information Sciences) 2018年第11期61卷 128-143页

作者： Donghua ZHOU Liguo QIN Xiao HE rui yan ruiliang DENG College of Electrical Engineering and Automation Shandong University of Science and Technology Department of Automation TNList Tsinghua University

In this paper, a distributed velocity sensor fault diagnosis scheme is presented for a formation of a second-order multi-agent system with unknown constant communication time delays. An existing distributed proportion-derivation(DPD) formation control law is adopted and a delay-independent condition is proposed to guarantee the asymptotical formation stability of the formation system based on the Nyquist stability criterion. Then a distributed fault diagnosis scheme is developed. In each agent, a distributed fault detection residual generator(DFDRG) and a bank of distributed fault isolation residual generators(DFIRGs) are designed based on the closed-loop model of the whole system. Each DFIRG is built up on the basis of a reduced-order unknown input observer(UIO) which is robust to the fault of one neighboring agent. According to the robust relationship between DFIRGs and faults, distributed fault isolation can be achieved. Conditions are presented to guarantee that each agent is able to diagnose faults of itself and its neighbors despite the disturbance of time delays. Finally, outdoor experimental results illustrate the effectiveness of the proposed schemes.

关键词： formation systems distributed fault diagnosis sensor faults time delays quadrotor unmanned helicopters

Study on inherent neutron sources in MSR

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Nuclear Science and Techniques 2018年第4期29卷 146-154页

作者： rui-Min Ji Cheng-Gang Yu Ming-Hai Li rui yan yang Zou Gui-Min Liu Shanghai Institute of Applied Physics Chinese Academy of Sciences Jiading Campus Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China

The molten salt reactor(MSR) has received much recent attention. The presence of beryllium and the mixing of actinides with light nuclei in the fuel salt result in a relatively strong neutron source that can affect the surveillance at subcritical and transient characteristics during operation. In this study, we predict the inherent neutron sources based on a MSR model. The calculation shows that in the fresh core, the inherent neutron sources are mainly from alpha-induced neutrons. After power operation, the inherent neutron sources become remarkably stronger due to photoneutrons. Although being an insignificant part in the total neutron population during operation, the inherent neutron sources can be used as the installed neutron source after shutdown. If the MSR has continuously operated at full power(2 MWt) for 10 days,then there would be no need for the installed source within80 days after shutdown. After operating constantly for500 days, the installed neutron source can be eliminated within 2 years after shutdown.

关键词： MSR Fuel salt Inherent neutron source Photoneutron Alpha-induced neutron