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Zonally Asymmetric Temperature Trends near the Northern Middle and High Latitude Stratopause during Winter

Journal of Meteorological Research 2023年第4期37卷 441-453页

作者： Tao WANG Wenshou TIAN ruhua zhang Jiali LUO Wuhu FENG College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China National Centre for Atmospheric Science(NCAS) School of Earth and EnvironmentUniversity of LeedsLeeds LS29JTUK

The temperature trend near the stratopause is rarely evaluated owing to the limited long-term observations of global temperature. In this study, the spatial patterns of the temperature trends near the northern stratopause are investigated by using satellite and reanalysis datasets. Our analysis reveals a zonally asymmetric temperature trend pattern near the northern mid-to-high latitude stratopause during January, and this pattern underwent an evident transition around the 2000s. From 1980 to 2003, there was a cooling trend in the Western Hemisphere and a warming trend in the Eastern Hemisphere. In contrast, a reversed zonally asymmetric temperature trend pattern existed in the east–west direction from 2003 to 2020. Although the warming trends are statistically insignificant, they contrasted with the overall cooling trend in the upper stratosphere due to ozone depletion and an increase in well-mixed greenhouse gases in recent decades. The zonally asymmetric temperature trends were induced by the transition in the intensity of quasi-stationary planetary wavenumber 1(wave 1) near the stratopause. The increasing(decreasing) trend of the intensity of wave 1 enhanced(weakened) its meridional temperature advection near the stratopause before(after) the 2000s;consequently, a zonally asymmetric temperature trend pattern exists in the east–west direction near the stratopause. The transition in the intensity of the stratospheric wave 1 around the 2000s is most likely caused by the transition in the intensity of wave 1 activity in the troposphere.

关键词： stratospheric temperature trend zonally asymmetric temperature pattern quasi-stationary planetary wavenumber 1

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A Technique for Estimation of Box Dimension about Fractional Integral

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理论数学进展(英文) 2023年第10期13卷 714-724页

作者： ruhua zhang School of Science Xihua University Chengdu China

This paper discusses further the roughness of Riemann-Liouville fractional integral on an arbitrary fractal continuous functions that follows Rfs. [1]. A novel method is used to reach a similar result for an arbitrary fractal function , where is the Riemann-Liouville fractional integral. Furthermore, a general resultis arrived at for 1-dimensional fractal functions such as with unbounded variation and(or) infinite lengths, which can infer all previous studies such as [2] [3]. This paper’s estimation reveals that the fractional integral does not increase the fractal dimension of f(x), i.e. fractional integration does not increase at least the fractal roughness. And the result has partly answered the fractal calculus conjecture and completely answered this conjecture for all 1-dimensional fractal function (Xiao has not answered). It is significant with a comparison to the past researches that the box dimension connection between a fractal function and its Riemann-Liouville integral has been carried out only for Weierstrass type and Besicovitch type functions, and at most Hlder continuous. Here the proof technique for Riemann-Liouville fractional integral is possibly of methodology to other fractional integrals.

关键词： Upper Box Dimension Riemann-Liouville Fractional Integral Fractal Continuous Function Box Dimension

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Low expression of centrosomal protein 78(CEP78)is associated with poor prognosis of colorectal cancer patients

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Chinese Journal of Cancer 2016年第10期35卷 509-517页

作者： Meifang zhang Tingmei Duan Li Wang Jianjun Tang Rongzhen Luo ruhua zhang Tiebang Kang State Key Laboratory of Oncology in South China Collaborative Innova-tion Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Research Department Sun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China.

Background: Centrosomal protein 78(CEP78) has been characterized as a component of the centrosome required for the regulation of centrosome-related events during the cell cycle, but its role in human cancers remains unclear. This study aimed to investigate the role and the clinical value of CEP78 in colorectal cancer(CRC).Methods: Quantitative real-time polymerase chain reaction(q RT-PCR) and immunohistochemistry were performed to examine CEP78 expression in CRC tissues and adjacent noncancerous tissues. The association between CEP78 expression and clinical outcomes of CRC patients was determined. The effect of CEP78 on cell growth was examined in vitro by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay, colony formation, and flow cytometry assays and in vivo using a nude mouse model.Results: The expression level of CEP78 was significantly lower in tumor tissues than in the adjacent normal tissues(P < 0.01). Low CEP78 expression was significantly associated with poor differentiation(P etastasis(P = 0.003), large tumor size(P = 0.017), lymphatic mtient= 0.034), distant metastasis(P s with low CEP78 expression h= 0.029), and advanced stage(P Meier analysis indicated that paad shorter survival than those wit= 0.011). Kaplan–h high CEP78 expression(P < 0.01). Overexpression of CEP78 in CRC cells significantly reduced cell viability and colony formation in vitro and halted tumor growth in vivo. Further study showed that CEP78 reintroduction in CRC cells resulted in G2/M phase arrest rather than cell apoptosis.Conclusions: CEP78 might function as a tumor suppressor and serve as a novel prognostic marker in CRC.

关键词：中心体蛋白结直肠癌预后患者细胞周期聚合酶链反应 RT-PCR 实验检测

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Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library

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Cancer Biology & Medicine 2020年第3期17卷 782-794页

作者： Yuanzhong Wu Liwen Zhou Zifeng Wang Xin Wang ruhua zhang Lisi Zheng Tiebang Kang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China

Objective:Osteosarcoma is the most common primary malignant bone tumor.However,the survival of patients with osteosarcoma has remained unchanged during the past 30 years,owing to a lack of efficient therapeutic targets.Methods:We constructed a kinome-targeting CRISPR-Cas9 library containing 507 kinases and 100 nontargeting controls and screened the potential kinase targets in osteosarcoma.The CRISPR screening sequencing data were analyzed with the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout(MAGeCK)Python package.The functional data were applied in the 143B cell line through lenti-CRISPR-mediated gene knockout.The clinical significance of kinases in the survival of patients with osteosarcoma was analyzed in the R2:Genomics Analysis and Visualization Platform.Results:We identified 53 potential kinase targets in osteosarcoma.Among these targets,we analyzed 3 kinases,TRRAP,PKMYT1,and TP53RK,to validate their oncogenic functions in osteosarcoma.PKMYT1 and TP53RK showed higher expression in osteosarcoma than in normal bone tissue,whereas TRRAP showed no significant difference.High expression of all 3 kinases was associated with relatively poor prognosis in patients with osteosarcoma.Conclusions:Our results not only offer potential therapeutic kinase targets in osteosarcoma but also provide a paradigm for functional genetic screening by using a CRISPR-Cas9 library,including target design,library construction,screening workflow,data analysis,and functional validation.This method may also be useful in potentially accelerating drug discovery for other cancer types.

关键词： Osteosarcoma kinase CRISPR-Cas9 library TRRAP PKMYT1 TP53RK

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基于公交优先的直线式公交站台共享超车道时空资源优化分析

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重庆交通大学学报（自然科学版） 2024年第5期43卷 38-45页

作者：张汝华马明迪陈雷钰赵冰狄金灿山东大学齐鲁交通学院山东济南250012

受城市道路红线条件限制,许多公交车站只能设置直线式公交站台;这种形式的站台很容易产生拥堵排队和机动车冲突的交通现象。基于此,提出了一种共享超车道感应信号控制的优化方案,使用VISSIM软件对共享超车道前后车辆的延误水平进行了仿... 详细信息

受城市道路红线条件限制,许多公交车站只能设置直线式公交站台;这种形式的站台很容易产生拥堵排队和机动车冲突的交通现象。基于此,提出了一种共享超车道感应信号控制的优化方案,使用VISSIM软件对共享超车道前后车辆的延误水平进行了仿真分析。研究结果表明:通过设置共享超车道能有效地缓解公交车辆在公交站点拥堵排队和机动车冲突的交通现象;在交通量较大和公交发车频率较高情况下,通过设置带有共享超车道的直线式公交站台能有效地提升公交服务水平,保障近道路交叉口上游路段的公交优先通行和社会车辆有序通行,提升了交通的流畅性与安全性。

关键词：交通工程直线式公交站台公交优先共享超车道公交专用道 VISSIM交通仿真

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SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1516-1527页

作者： Liwen Zhou Lisi Zheng Kaishun Hu Xin Wang ruhua zhang Yezi Zou Li Zhong Shang Wang Yuanzhong Wu Tiebang Kang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-sen Memorial HospitalSun Yat‐sen UniversityGuangzhouChina

Human single-stranded DNA-binding protein 1(hSSB1)is required for the efficient recruitment of the MRN complex to DNA doublestrand breaks and is essential for the maintenance of genome integrity.However,the mechanism by which hSSB1 recruits NBS1 remains elusive.Here,we determined that hSSB1 undergoes SUMOylation at both K79 and K94 under normal conditions and that this modification is dramatically enhanced in response to DNA damage.SUMOylation of hSSB1,which is specifically fine-tuned by PIAS2α,and SENP2,not only stabilizes the protein but also enhances the recruitment of NBS1 to DNA damage sites.Cells with defective hSSB1 SUMOylation are sensitive to ionizing radiation,and global inhibition of SUMOylation by either knocking out UBC9 or adding SUMOylation inhibitors significantly enhances the sensitivity of cancer cells to etoposide.Our findings reveal that SUMOylation,as a novel posttranslational modification of hSSB1,is critical for the functions of this protein,indicating that the use of SUMOylation inhibitors(e.g.,2-D08 and ML-792)may be a new strategy that would benefit cancer patients being treated with chemo-or radiotherapy.

关键词： SSB1 damage NBS1

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RMI2 plays crucial roles in growth and metastasis of lung cancer

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Signal Transduction and Targeted Therapy 2020年第1期5卷 907-909页

作者： Weixiang Zhan Yina Liu Ying Gao Run Gong Wen Wang ruhua zhang Yuanzhong Wu Tiebang Kang Denghui Wei State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouChina The Sixth Affiliated Hospital Sun Yat-sen University510000 GuangzhouChina Department of Abdominal Oncology The Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University519000 ZhuhaiGuangdongChina

Dear Editor,Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death in the world,but its therapeutic targets are still being explored.Genome instability as a key hallmark of cancer not only contributes to cancer initiation and progression,1 but also creates vulnerabilities that are relatively specific to cancer cells,which may be potential therapeutic targets for cancer patients.During DNA Double-Strand Breaks(DSBs)repair,BTR(BLM-Topo IIIα-RMI1/RMI2)complex promotes the dissolution of double Holliday junctions to form non-crossover products and is often considered as a tumor suppressor.2 However,the function of each individual component of this BTR complex in cancer remains largely unknown.

关键词： cancer metastasis Lung

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Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes

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Signal Transduction and Targeted Therapy 2021年第3期6卷 909-924页

作者： Li Zhong Dan Liao Jingjing Li Wenqiang Liu Jingxuan Wang Cuiling Zeng Xin Wang Zhiliang Cao ruhua zhang Miao Li Kuntai Jiang Yi-Xin Zeng Jianhua Sui Tiebang Kang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Department of Oncology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhaiGuangdongChina National Institute of Biological Sciences BeijingChina Sun Yat-sen University School of Medicine ShenzhenChina Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouChina

It remains unknown for decades how some of the therapeutic fusion proteins positive in a small percentage of cancer cells account for patient outcome.Here,we report that osteosarcoma Rab22a-NeoF1 fusion protein,together with its binding partner PYK2,is sorted into exosomes by HSP90 via its KFERQ-like motif(RVLFLN^(142)).The exosomal Rab22a-NeoF1 fusion protein facilitates the pulmonary pre-metastatic niche formation by recruiting bone marrow-derived macrophages.The exosomal PYK2 activates RhoA in its negative recipient osteosarcoma cells and induces signal transducer and activator of transcription 3 activation in its recipient macrophages to increase M2 phenotype.Consequently,lung metastases of its recipient osteosarcoma cells are promoted by this exosomal Rab22a-NeoF1 fusion protein,and this event can be targeted by disrupting its interaction with PYK2 using a designed internalizing RGD peptide.

关键词： osteosarcoma lung metastasis

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一种新型大直径锻造钢球B3的组织性能探究

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热加工工艺 2024年第9期53卷 104-107页

作者：任成艳张如华徐强曾效舒黄明富龚雪剑南昌大学机电工程学院江西南昌330031 共青科技职业学院江西九江332020 江西铜业集团渊余干冤锻铸有限公司江西上饶335100

以性能较好的Ф125 mm锻球为参照,对新用于锻造钢球的B3钢力学性能及微观组织进行研究。结果表明:Ф140 mm B3钢球的整体硬度在56.0~59.5 HRC,冲击韧性在23.00~29.90 J/cm^(2);B3钢球表层组织主要为针状马氏体,心部除马氏体外还有较多... 详细信息

以性能较好的Ф125 mm锻球为参照,对新用于锻造钢球的B3钢力学性能及微观组织进行研究。结果表明:Ф140 mm B3钢球的整体硬度在56.0~59.5 HRC,冲击韧性在23.00~29.90 J/cm^(2);B3钢球表层组织主要为针状马氏体,心部除马氏体外还有较多的托氏体与贝氏体。导致该现象的原因是锻球心部Mn、Cr含量分布不均匀,以及淬火温度偏低,锻球心部冷速不够,过冷奥氏体易转变成细片团状托氏体,同时较高的含碳量降低了马氏体转变温度,加剧了锻球心部向贝氏体和托氏体转变的倾向。

关键词：锻造磨球微观组织扫描电镜能谱仪

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ECCENTRICITY CHANGE IN TUBE SINKING

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Acta Metallurgica Sinica(English Letters) 1991年第9期4卷 184-190页

作者： YAO Ruohao ZHONG Jianhua HUANG Jianfang zhang ruhua South Institute of Metallurgy,Ganzhou,Jiangxi,China South Inst of Metallurgy Jiangxi China

The rectification of eccentricity was revealed to be more effective in tube sinking than drawing with a mandrel.The ratio of thickness to diameter of tube blank on both sides of thick and thin wall seems to be the principal influential factor in rectifying eccentricity.The greater the ini- tial outside diameter and the initial wall thickness difference are and the less the initial wall thickness of the tube blank is,the better the rectification is.

关键词： sinking tube eccentricity rectifying

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