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A single nucleotide mutation in the dual-oxidase 2(DUOX2) gene causes some of the panda's unique metabolic phenotypes

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National Science Review 2022年第2期9卷 34-42页

作者： Agata M.rudolf Qi Wu Li Li Jun Wang Yi Huang Jacques Togo Christopher Liechti Min Li Chaoqun Niu Yonggang Nie Fuwen Wei John R.Speakman State Key Laboratory of Molecular Development Institute of Genetics and Developmental Biology Chinese Academy of Sciences Institute of Zoology Chinese Academy of Sciences Institute of Microbiology Chinese Academy of Sciences Institute of Biological and Environmental Sciences University of Aberdeen Centre of Excellence for Animal Ecology and Genetics Chinese Academy of Sciences Shenzhen Key Laboratory of Metabolic Health Center for Energy Metabolism and Reproduction Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

The giant panda(Ailuropoda melanoleuca) is an iconic bear native to China,famous for eating almost exclusively *** unusual dietary behavior for a carnivore is enabled by several key adaptations including low physical activity,reduced organ sizes and hypothyroidism leading to lowered energy *** adaptive phenotypes have been hypothesized to arise from a panda-unique single-nucleotide mutation in the dual-oxidase 2(DUOX2) gene,involved in thyroid hormone *** test this hypothesis,we created genome-edited mice carrying the same point mutation as the panda and investigated its effect on metabolic *** mice were 27% smaller than heterozygous and wild-type ones,had 13 % lower body mass-adjusted food intake,5 5 % decreased physical activity,lower mass of kidneys(11%) and brain(5%),lower serum thyroxine(T4:36%),decreased absolute(12%) and mass-adjusted(5%) daily energy expenditure,and altered gut *** with T4 reversed the effects of the *** work uses a state-of-the-art genome editing approach to demonstrate the link between a single-nucleotide mutation in a key endocrine-related gene and profound adaptive changes in the metabolic phenotype,with great importance in ecology and evolution.

关键词： giant panda DUOX2 mutation metabolic rate thyroid hormones DUOX2 mice and microbiota

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Comprehensive Metabolic Profiling of Modified Gegen Qinlian Decoction by Ultra-high-Performance Liquid Chromatography-Diode Array Detection-Q-Exactive-Orbitrap-Electrospray Ionization-Mass Spectrometry/Mass Spectrometry and Application of High-Performance

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 11-32页

作者： Xuehong Nöst Eva-Maria Pferschy-Wenzig Xiao-Tong Yu Min Li Xiao-Lin Tong rudolf Bauer Department of Pharmacognosy Institute of Pharmaceutical SciencesUniversity of GrazGrazAustria Department of Endocrinology Guang’Anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Endocrinology Laboratory of Molecular BiologyGuang’Anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina

Objective:Gegen Qinlian decoction(GQD)is a classical traditional Chinese medicine formulation which has been used for almost 2000 *** Guang'anmen Hospital,Beijing,a modified GQD version(m GQD)with seven instead of four herbal ingredients has been applied to treat Type 2 *** control is a crucial prerequisite for the therapeutic application of herbal *** the identification of products derived from classical GQD,the Chinese Pharmacopeia requires the analysis of only three marker *** m GQD is a more complex mixture containing seven herbs and hundreds of constituents,the pharmacopoeia method for GQD is *** and Methods:A more comprehensive characterization of the formula's constituents has been developed using ultra-high-performance liquid chromatography-diode array detection(UHPLC-DAD)-Q-Exactive-mass spectrometry(MS)in electrospray ionization positive and negative ***,a new method for the fingerprint analysis of m GQD via high-performance thin-layer chromatography(HPTLC)has been ***:Altogether,91 compounds have been assigned to their originating plants and 84 substances were identified either by comparison with authentic references or with data from the *** HPTLC method is based on the application of two different mobile phases and is able to detect both lipophilic and hydrophilic constituents of m ***:The modified GQD was extensively characterized by UHPLC combined with DAD and Q-Exactive Orbitrap high-resolution MS detection,leading to the assignment and identification of compounds present in the *** addition,a new method for the fingerprint analysis of the m GQD using HPTLC was established,which allows fast and simple identification of the herbal ingredients in the mixture.

关键词： Fructus jujubae HPTLC Modified gegen qinlian decoction Radix et rhizoma glycyrrhizae praeparata cum melle Radix puerariae lobatae Radix scutellariae Rhizoma coptidis Rhizoma anemarrhenae Rhizoma zingiberis UHPLC-DAD-Q-Exactive-MS

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Reduced upper limb lean mass on dual energy X-ray absorptiometry predicts adverse outcomes in male liver transplant recipients

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World Journal of Transplantation 2022年第6期12卷 120-130页

作者： Penelope Hey rudolf Hoermann Paul Gow Timothy P Hanrahan Adam G Testro Ross Apostolov Marie Sinclair Liver Transplant Unit Austin HealthHeidelberg 3084Australia Department of Medicine University of MelbourneMelbourne 3052Australia

BACKGROUND Pre-transplant muscle wasting measured by computed tomography has been associated with adverse clinical outcomes after liver transplantation including increased rates of sepsis and hospitalisation *** limb lean mass(LM)measured by dual-energy X-ray absorptiometry(DEXA)was recently identified as a novel predictor of sarcopenia-associated mortality in men waitlisted for *** To investigate the use of DEXA LM in predicting gender-stratified early posttransplant *** Liver transplant recipients who underwent pre-transplant DEXA body composition imaging between 2002 and 2017 were *** included posttransplant mortality and graft failure,bacterial infections,acute cellular rejection(ACR)and intensive care and total hospital length of *** Four hundred and sixty-nine patients met inclusion criteria of which 338 were male(72%).Median age was 55.0 years(interquartile range 47.4,59.7)and model for end-stage liver disease(MELD)score *** time from assessment to transplantation was 7 mo(3.5,12).Upper limb LM was inversely associated with bacterial infections at 180 d post-transplant(hazard ratio=0.42;95%confidence interval:0.20-0.89;P=0.024)in males *** was a negative correlation between upper limb LM and intensive care(τb=-0.090,P=0.015)and total hospital length of stay(τb=-0.10,P=0.0078)in *** women,neither MELD nor body composition parameters were associated with post-transplant adverse outcomes or increased length of *** composition parameters,MELD and age were not associated with 90-d mortality or graft failure in either *** were no significant predictors of early *** Sarcopenia is an independent and potentially modifiable predictor of increased post-transplant bacterial infections and hospital length of stay in men with *** upper limb LM provides a novel measure of muscle wasting that has prognostic value in this *** lack of association in women req

关键词： Dual-energy X-ray absorptiometry Sarcopenia Body composition Liver transplantation Survival

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重叠系数对电弧增材制造Al-Mg合金的结构和力学性能的影响

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Journal of Central South University 2023年第4期30卷 1075-1085页

作者： Volosevich DARYA Nasonovskiy KONSTANTIN Voropaev ARTEM Gushchina MARINA Korsmik rudolf Kliimova-Korsmik OLGA World-Class Research Center“Advanced Digital Technologies” State Marine Technical UniversitySaint Petersburg 190121Russia Peter the Great Saint-Petersburg Polytechnic University Saint Petersburg 195251Russia

本文研究了直接电弧生长制备Al-Mg合金厚壁样品的结构特征和力学性能。由于该制备方法具有高生产率和低成本的优点,在近几十年来得到了特别的关注。该工艺的高生产率使电弧增材制造适用于生产大壁厚的材料。通过改变重叠系数,可以实现... 详细信息

本文研究了直接电弧生长制备Al-Mg合金厚壁样品的结构特征和力学性能。由于该制备方法具有高生产率和低成本的优点,在近几十年来得到了特别的关注。该工艺的高生产率使电弧增材制造适用于生产大壁厚的材料。通过改变重叠系数,可以实现厚壁零件的准确成形,并得到指定的尺寸。重叠系数的变化导致材料尺寸、形态以及金属间化合物分布的变化,并影响其力学行为。本文考虑了不同重叠系数下晶粒结构形成的特征,金属间化合物成分及厚壁材料力学性能。发现样品中有两种金属间化合物Mg2Si和Al6(Fe,Mn),它们的大小和形态随重叠系数的变化而改变,从而导致材料力学性能的各向异性。当重叠系数为0.4时,其抗拉强度、屈服强度和伸长率均达到最高值,分别为319 MPa,150 MPa和16.1%。

关键词：铝合金增材制造电弧增材制造厚壁相组成力学性能

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Microstructural evolution and delayed hydride cracking of FSW-AZ31 magnesium alloy during SSRT

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Transactions of Nonferrous Metals Society of China 2014年第10期24卷 3060-3069页

作者：曾荣昌 Wolfgang DIETZEL rudolf ZETTLER 甘为民孙芯芯山东科技大学材料科学与工程学院青岛266590 Institute of Materials Research Helmholtz-Zentrum Geesthacht

Evolution of microstructure including texture and fractography in a friction-stir welded（FSW） AZ31 magnesium alloy was investigated. The texture was measured using a neutron diffractometer. The microstructure and fractography of stress corrosion cracking（SCC） samples were observed by optical and scanning electron microscopy, respectively. An X-ray diffraction study was carried out on the fractured surfaces of the SCC specimens. The results indicated that a strong basal fiber was formed on the base material, whereas the grains in the stir zone were reoriented with their most basal planes tilted 25 o to the welding direction. Feather-like twins and hydride formed under slow strain rate tensile（SSRT） stress in air and aggressive solutions, respectively. Transgranular cracks propagated and finally failed on the retreating side in the solution. The hydride phase confirmed to sit on the fracture surface demonstrated the delayed hydride cracking（DHC） mechanism of the alloy.

关键词： magnesium alloys stress corrosion cracking friction stir welding texture microstructure

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Thickness determination of MoS2,MoSe2,WS2 and WSe2 on transparent stamps used for deterministic transfer of 2D materials

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Nano Research 2019年第7期12卷 1691-1695页

作者： Najme S. Taghavi Patricia Gant Peng Huang Iris Niehues Robert Schmidt Steffen Michaelis de Vasconcellos rudolf Bratschitsch Mar Garcia-Hernandez Riccardo Frisenda Andres Castellanos-Gomez Materials Science Factory Instituto de Ciencia de Materiales de Madrid (ICMM)Consejo Superior de Investigaciones Cientificas (CSIC)Sor Juana Ines de la Cruz 328049 MadridSpain Faculty of Physics Khaje Nasir Toosi University of Technology (KNTU)Tehran 19697 64499Iran State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Institute of Physics and Center for Nanotechnology University of Munster48149 MunsterGermany

Here,we propose a method to determine the thickness of the most common transition metal dichalcogenides (TMDCs) placed on the surface of transparent stamps,used for the deterministic placement of two-dimensional materials,by analyzing the red,green and blue channels of transmission-mode optical microscopy images of the *** particular,the blue channel transmittance shows a large and monotonic thickness dependence,making it a very convenient probe of the flake *** method proves to be robust given the small flake-to-flake variation and the insensitivity to doping changes of *** also tested the method for MoSe2,WS2 and *** results provide a reference guide to identify the number of layers of this family of materials on transparent substrates only using optical microscopy.

关键词： transition metal dichalcogenides optical identification transparent substrate trasmittance

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Manual Endourology 2005

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2005年

作者： rudolf Hohenfellner Jens-Uwe Stolzenburg

来源：畅想之星图书光盘版（南... 评论

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多色点集直线划分的复杂性及其近似算法

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计算机工程 2015年第2期41卷 298-302页

作者：陈崇琛 rudolf Fleischer 复旦大学计算机科学技术学院上海201203

多色点集划分研究如何将含有不同颜色点的平面划分为各个区域,每个区域中只包含一种颜色的点。这是计算几何中的一种组合优化问题。但是现有的多边形划分方式性能较差。为此,提出用直线来划分平面。针对平面上多色点集的直线划分,将其... 详细信息

多色点集划分研究如何将含有不同颜色点的平面划分为各个区域,每个区域中只包含一种颜色的点。这是计算几何中的一种组合优化问题。但是现有的多边形划分方式性能较差。为此,提出用直线来划分平面。针对平面上多色点集的直线划分,将其离散化,证明其可以被非确定性图灵机在多项式时间内判定。并将Max2SAT问题在多项式时间内归约到组合优化问题,证明多色点集直线划分为NP难,从而证明其是NP完全的。利用最优化版本的特有性质,运用贪心方法构造出多项式时间的近似算法,并L归约到Setcover问题,以此证明算法的近似比为O(lgn)。

关键词：计算几何计算复杂性近似算法划分算法组合优化 NP完全

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媒介进化是什么——新媒介历史的理论化阐释

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国际新闻界 2007年第10期 53-58页

作者： rudolf Stber 尹良润德国Ander Universat大学天津师范大学新闻与传播学院

此文对新媒介的出现提出了一种解释。媒介不只是技术发明的后果,它衍生于发明和"社会制度化"这样一个两阶段过程。技术发明只是改进了旧媒介。在创新阶段,新媒介开始被制度化。社会制度化的过程从根本上改变了媒介。本文探讨出版业、电... 详细信息

此文对新媒介的出现提出了一种解释。媒介不只是技术发明的后果,它衍生于发明和"社会制度化"这样一个两阶段过程。技术发明只是改进了旧媒介。在创新阶段,新媒介开始被制度化。社会制度化的过程从根本上改变了媒介。本文探讨出版业、电报、电影、电台、电视和多媒体之间竞争性的媒介历史。同时审视了新媒介的出现与社会、政治、文化、经济和技术基础的关系。

关键词：进化理论创新发明媒介史新媒介

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Abriss der Logistik,Mit besonderer Beriicksichtigung der Relationstheorie und ihrer Anwendungen

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清华大学学报(自然科学版) 1932年第2期 287-292页

作者： Von Dr.rudolf Carnap ,张申府

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