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玻璃体切割联合视网膜前膜剥离术后的视功能和生活质量

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 16-17页

作者： ghazi-Nouri s.M.s. Tranos P.g. rubin g.s. 王海燕 Vitreoretinal Research Unit Moorfields Eye HospitalCity RoadLondon EC1V 2PDUnited Kingdom

Aim:To investigate the effect of epiretinal membrane(ERM)-peel on patients’health related quality of life(HR-QOL)and to explore the association between self reported HR-QOL and conventional measures of visual ***:The National Eye Institute 25 Item Visual Function Questionnaire(VFQ-25)and the 36 Item short-Form Health survey(sF-36)were self administered by 20 patients before and 4 months following *** and post-operative data collected included logMAR near and distant visual acuity(VA),contrast sensitivity,and *** scores were compared preoperatively and postoperatively and their correlation with traditional methods of visual function evaluation ***:Postoperatively there was no significant improvement in mean logMAR ***,eight(40%)subjects improved by two or more ETDRs lines and nine eyes(45%)reached a final VA of 6/18 or *** decreased significantly(p=0.019)and there was significant improvement in VFQ-25 mean scores for the general vision(p = 0.03),distance activities(p=0.05),and composite score(p = 0.03).Baseline binocular VA was significantly correlated with baseline VFQ-25 composite score(r=0.631,p=0.004).Conclusions:ERM surgery appears to improve patients’subjective perception of visual function as indicated by higher composite scores in VFQ-25 and improved metamorphopsia in the absence of significant improvement in mean logMAR VA.

关键词：玻璃体切割视网膜前膜视功能生活质量剥离术近视力远视力视物变形对比敏感度健康调查表

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黄斑裂孔术后视功能及主观视力知觉研究

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 24-24页

作者： Tranos P.g. ghazi-Nouri s.M.s. rubin g.s. 王海燕

To evaluate the functional and anatomical results of macular hole surgery and to explore its effect on patients’Health-Related Quality Of Life (HR-QOL) and to investigate the associations between self-reported HR-QOL and conventional measures of visual function. Case series. The National Eye Institute 25-Item V isual Function Questionnaire (VFQ-25) and the 36-Item short-Form Health surve y (sF-36) were self-administered by 30 patients before and 4 months after macu lar hole surgery. Preoperative, intraoperative, and postoperative clinical data were collected including visual acuity, contrast sensitivity, and metamorphopsia . Multi-item scales rating different aspects of HR-QOL were compared before an d after surgery, and their correlation with traditional methods of outcome evalu ation was analyzed. Macular hole closure was achieved in 26 patients (87%). Mea n LogMAR visual acuity improved by 6±10 letters for distance and 7 ±12 letters for near. Metamorphopsia was reduced by a mean of 35±70 squares on Amsler char t, and Pelli-Robson contrast sensitivity decreased by a mean of -0.09 ±0.3 lo g units postoperatively. The VFQ-25 composite score as well as scale scores ass ociated with general vision, near vision, vision-related mental health, and rol e difficulties were significantly improved (P successful closure o f macular hole. Conversely out of the eight sF-36 health concepts, limitation i n usual role activities because of emotional problems was the only one that sign ificantly improved postoperatively. Both baseline and postoperative best-correc ted visual acuity significantly correlated with most of the VFQ subscale scores before and after surgery, respectively. In this case-se-ries, macular hole sur gery appears to have a beneficial effect on patients’subjective perception of v isual function. The use of vision-targeted health status questionnaires in conj unction with detailed clinical examination provides a more comprehensive overvie w of indivi

关键词：黄斑裂孔视功能视物变形手术干预对比敏感度简明健康调查表功能恢复情况临床数据眼科研究所系列分析

Unveiling the early universe:Axion-like particles and their role in primordial structure formation

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science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 178-179页

作者： sergey g.rubin National Research Nuclear University MEPhI(Moscow Engineering Physics Institute) Moscow 115409Russia

The groundbreaking discovery of gravitational waves(g.s.by the LIgO-VIRgO-KAgRO collaboration has revolutionized our understanding of the universe and opened up a new way of observing cosmic events. Unlike light waves... 详细信息

关键词： universe gravitational cosmic

Arm motion control model based on central pattern generator

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Applied Mathematics and Mechanics(English Edition) 2017年第9期38卷 1247-1256页

作者： Zhigang ZHENg rubin WANg Institute for Cognitive Neurodynamics East China University of Science and TechnologyShanghai 200237China

According to the theory of Matsuoka neural oscillators and with the con- sideration of the fact that the human upper arm mainly consists of six muscles, a new kind of central pattern generator （CPg） neural network consisting of six neurons is pro- posed to regulate the contraction of the upper arm muscles. To verify effectiveness of the proposed CPg network, an arm motion control model based on the CPg is established. By adjusting the CPg parameters, we obtain the neural responses of the network, the angles of joint and hand of the model with MATLAB. The simulation results agree with the results of crank rotation experiments designed by Ohta et al., showing that the arm motion control model based on a CPg network is reasonable and effective.

关键词： central pattern generator (CPg) arm motion joint angle hand angle,crank rotation experiment

Control strategy of central pattern generator gait movement under condition of attention selection

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Applied Mathematics and Mechanics(English Edition) 2016年第7期37卷 957-966页

作者： Wei WANg rubin WANg Institute for Cognitive Neurodynamics East China University of Science and Technology

As a typical rhythmic movement, human being.s.rhythmic gait movement can be generated by a central pattern generator （CPg） located in a spinal cord by self- oscillation. some kinds of gait movements are caused by gait frequency and amplitude variances. As an important property of human being.s.motion vision, the attention selection mechanism plays a vital part in the regulation of gait movement. In this paper, the CPg model is amended under the condition of attention selection on the theoretical basis of Matsuoka neural oscillators. Regulation of attention selection signal for the CPg model parameters and structure is studied, which consequentially causes the frequency and amplitude chang.s.of gait movement output. Further, the control strategy of the CPg model gait movement under the condition of attention selection is discussed, showing that the attention selection model can regulate the output model of CPg gait movement in three different ways. The realization of regulation on the gait movement frequency and amplitude shows a variety of regulation on the CPg gait movement made by attention selection and enriches the controllability of CPg gait movement, which demonstrates potential influence in engineering applications.

关键词： gait movement attention selection central pattern generator (CPg),movement control strategy

Immune checkpoint inhibitor-mediated colitis in g.s.rointestinal malignancies and inflammatory bowel disease

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World Journal of g.s.rointestinal Oncology 2021年第8期13卷 772-798页

作者： Alexa R Weingarden samuel J s rubin John gubatan Division of g.s.roenterology and Hepatology Department of MedicineStanford UniversityRedwood CityCA 94063United States stanford University school of Medicine Stanford UniversityRedwood CityCA 94063United States

Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer *** re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many g.s.rointestinal(gI)***,these therapies can also induce autoimmune-like side effects in healthy tissue across the *** of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with gI *** also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology.

关键词： Immune checkpoint inhibitors Cytotoxic T-lymphocyte antigen 4 Programmed cell death protein-1 Inflammatory bowel disease g.s.rointestinal cancer

Challeng.s.Associated with Creeping Disasters in Disaster Risk science and Practice:Considering Disaster Onset Dynamics

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International Journal of Disaster Risk science 2022年第1期13卷 1-11页

作者： Reidar staupe-Delgado Olivier rubin Department of social sciences and Business.Roskilde University 4000 RoskildeDenmark Department of Technology and safety UiT The Arctic University of Norway9037 TromsONorway

In this article,we set out to reconcile a general conceptualization of disaster temporalities by drawing on the epitome example of a creeping disaster,namely *** argument is driven by the recognition that slowly manifesting disaster impacts pose distinct challeng.s.for decision makers and researchers while there is a tendency for the disaster literature to overlook the role of disaster onset *** specifically and as a starting point,we identify four key themes that merit particular attention when dealing with creeping disasters:(1)our understanding of disaster as a phenomenon;(2)measurement and operationalization;(3)early warning and response;and(4)disaster management and *** integrating conceptual discussions of disaster with famine scholarship—a phenomenon often excluded from mainstream disaster research—this article provides fresh perspectives on disaster science as well as a number of implications for how we think about disaster risk reduction.

关键词： Disaster response Early warning Famine disasters slow-onset disasters

Disease exacerbation is common in inflammatory bowel disease patients treated with immune checkpoint inhibitors for malignancy

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World Journal of Clinical Cases 2022年第6期10卷 1787-1794页

作者： samuel J s rubin Tatiana Balabanis John gubatan Aida Habtezion Division of g.s.roenterology and Hepatology Department of MedicineStanford University School of MedicineStanfordCA 94305United States

BACKgROUND Colitis is a known potential toxicity of immune checkpoint inhibitors(ICIs).studies evaluating the risk of disease exacerbation following ICI treatment in patients with pre-existing inflammatory bowel disease(IBD)are *** To assess the clinical characteristics of IBD patients treated with ICIs and determine prevalence of subsequent IBD *** We conducted a retrospective cohort study of all patients in the stanford Research Repository database with pre-existing IBD who were exposed to *** The prevalence of IBD exacerbation following ICI was 36.8% amongst 19 patients meeting inclusion *** with exacerbations had more g.s.rointestinalrelated hospitalizations(4 of 7)than patients without exacerbations(0 of 12;P=0.0090).CONCLUsION The prevalence of IBD exacerbations following ICI was higher than reported rates of ICI-induced colitis and diarrhea in the general population and was associated with hospitalization.

关键词： Inflammatory bowel disease Immune checkpoint inhibitors Immunotherapy Malignancy

Dynamic multivariate multiscale entropy based analysis on brain death diagnosis

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science China(Technological sciences) 2015年第3期58卷 425-433页

作者： NI Li CAO JianTing WANg rubin Institute for Cognitive Neurodynamics East China University of Science and Technology Department Electronic Engineering Saitama Institute of Technology Brain science Institute RIKEN 2-1 HirosawaSaitama 351-0198 Japan

The recently introduced multivariate multiscale sample entropy(MMsE)well evaluates the long correlations in multiple channels,so that it can reveal the complexity of multivariate biological *** existing MMsE algorithm deals with short time series statically whereas long time series are common for real-time computation in practical *** a solution,we novelly proposed our dynamic MMsE(DMMsE)as an extension of *** helps us gain greater insight into the complexity of each section of time series,producing multifaceted and more robust estimates than the standard *** simulation results illustrated the feasibility and well performance in the brain death diagnosis.

关键词： EEg.s.gnals approximate entropy sample entropy brain death diagnosis