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99Tc~m-高锝酸盐/MIBI减数显像时加服高氯酸盐是快速有效的甲状旁腺显像方法

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国际放射医学核医学杂志 2001年第1期25卷 21-22页

作者： rubello d 沈钰如马寄晓

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Role of ^(18)F-FdG PET/CT in detection of hematogenous metastases of advanced differentiated thyroid carcinoma: a systematic review and meta-analysis

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 213-225页

作者： Natale Quartuccio domenico rubello Nuclear Medicine Unit A.R.N.A.S.CivicoDi Cristina and Benfratelli HospitalsPalermo 90144Italy Nuclear Medicine Unit Santa Maria della Misericordia HospitalRovigo 45100Italy.

The aim of this study was to collect the evidence on the performance of 2-deoxy-2-[^(18)F]fluoro-d-glucose(^(18)F-FdG)Positron Emission Tomography/Computed Tomography(PET/CT)in terms of detection rate(dR)and diagnostic accuracy in identifying hematogenous metastases in patients with differentiated thyroid cancer and compare its performance with that of other imaging techniques.A comprehensive PubMed/MEdLINE database research was carried out to retrieve studies documenting the performance of^(18)F-FdG PET/CT in depicting hematogenous metastases in patients with differentiated thyroid *** analysis was performed on a per-patient and per-lesion *** literature search yielded 15 articles to be included in the systematic review.^(18)F-FdG PET/CT showed a pooled dR of 85.08%on a per-patient analysis and 89.70%on a per-lesion *** bone lesions,a high dR(81.78%)was found for^(18)F-FdG PET/*** the sub-group analysis of lung lesions,pooled dR was 92.77%for^(18)F-FdG PET/CT,95.02%for CT,and 64.93%for magnetic resonance imaging(MRI).On a per-patient analysis,^(18)F-FdG PET/CT demonstrated a pooled sensitivity(SS)of 87.3%[95%confidence interval(CI):77.3%-94%]and a pooled specificity(SP)of 95.6%(95%CI:87.6-99.1).On a per-lesion analysis(328 metastases),PET/CT showed a pooled SS and SP of 86.3%(95%CI:73.5%-93.5%)and 93.4%(95%CI:71.7%-98.8%)in the detection of hematogenous *** presented systematic review and meta-analysis favor the use of^(18)F-FdG PET/CT in the detection of hematogenous metastases in patients with differentiated thyroid *** limited literature warrants further studies to confirm our findings.

关键词： PET/CT hematogenous metastases lung bone thyroid cancer FdG meta-analysis

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Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography

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World Journal of Radiology 2016年第6期8卷 635-655页

作者： Ka-Kit Wong Arpit Gandhi Benjamin L Viglianti Lorraine M Fig domenico rubello Milton d Gross division of Nuclear Medicine Department of RadiologyUniversity of Michigan Nuclear Medicine Service VA Ann Arbor Healthcare System Radiology Service VA Ann Arbor Healthcare System department of Nuclear Medicine RadiologyNeuro RadiologyMedical PhysicsSanta Maria della Misericordia Hospital

AIM: To review the benefits of single photon emission computed tomography(SPECT)/computed tomography(CT) hybrid imaging for diagnosis of various endocrine ***: We performed MEdLINE and Pub Med searches using the terms: "SPECT/CT"; "functional anatomic mapping"; "transmission emission tomography"; "parathyroid adenoma"; "thyroid cancer"; "neuroendocrine tumor"; "adrenal"; "pheochromocytoma"; "paraganglioma"; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts(case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this ***: The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the biodistribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for ^(99m)Tc-sestamibi parathyroid scintigraphy and ^(99m)Tc-pertechnetate thyroid scintigraphy, ^(123)I- or ^(131)I-radioiodine for staging of differentiated thyroid carcinoma, ^(111)In- and ^(99m)Tclabeled somatostatin receptor analogues for detection of neuroendocrine tumors, ^(131)I-norcholesterol(NP-59) scans for assessment of adrenal cortical hyperfunction, and ^(123)I- or ^(131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and ***: SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating

关键词： Parathyroid adenoma Neuroendocrine tumor Single photon emission computed tomography/ computed tomography Single photon emission computed tomography-computed tomography Thyroid cancer Pheochromocytoma Paraganglioma

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甲状旁腺核素显像在原发性甲状旁腺功能亢进症外科手术治疗中的作用

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中华核医学与分子影像杂志 2018年第7期38卷 508-514页

作者：季艳会(译) 孟召伟(审校) 天津医科大学总医院核医学科 300052

原发性甲状旁腺功能亢进症（PHPT）是一种常见的、具有潜在破坏性的内分泌系统疾病，手术是其唯一治愈方法。过去近20年来甲状旁腺手术方式发生了改变，常规双侧颈部探测不再是唯一的手术方式。鉴于甲状旁腺核素显像能特异性定位甲状旁... 详细信息

原发性甲状旁腺功能亢进症（PHPT）是一种常见的、具有潜在破坏性的内分泌系统疾病，手术是其唯一治愈方法。过去近20年来甲状旁腺手术方式发生了改变，常规双侧颈部探测不再是唯一的手术方式。鉴于甲状旁腺核素显像能特异性定位甲状旁腺手术位置、寻找异位甲状旁腺及多腺体疾病，其在手术方式选择上发挥了重要作用。该文是核医学医师、内分泌及内分泌外科医师互相协作的成果，文章强调了在任何PHPT手术前行甲状旁腺显像的重要性，即使是常规双侧颈部探查也应这样执行；讨论了甲状旁腺切除术的优缺点、甲状旁腺核素显像指导手术利弊；讨论了持续或复发的甲状旁腺功能亢进症再次手术界定腺体范围的最优策略：陈述了新型PET示踪剂的潜在应用价值，特别是^18F-氟代胆碱。

关键词：甲状旁腺功能亢进症 MIBI 双示踪剂甲状旁腺减影显像 SPECT/CT PET/CT ^18F- 氟代胆碱:^11C-蛋氨酸

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