检索结果-南通市图书馆

Existence of Positive Solutions of Second-order Periodic Boundary Value Problems with Sign-Changing Green＇s Function

在线全文

学校读者我要写书评

暂无评论

Acta mathematicae Applicatae Sinica 2017年第2期33卷 263-268页

作者： Cheng-hua GAO Fei ZHANG ru-yun ma Department of mathematics Northwest Normal University Lanzhou 730070 China

In this paper, we consider the existence of positive solutions of second-order periodic boundary value problem where 0 〈 ε 〈 1/2, g ： [0, 2π] →R is continuous, f ： [0, ∞） →R is continuous and λ 〉 0 is a pa... 详细信息

关键词： periodic boundary value problem existence positive solutions sign-changing Green's functions

Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of “same treatment for different diseases” in traditional Chinese medicine

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2021年第2期13卷 189-201页

作者： ru-pu He Zheng Jin ru-yun ma Fang-di Hu Jian-ye Dai School of Pharmacy Lanzhou UniversityLanzhou 730000China

Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) *** Radix(Codonopsis pilosula,Dangshen in Chinese)with spleen-fortifying effect was employed to understand the strategy of "Same treatment for different diseases",based on its common mechanism in the treatment of gastric diseases including gastric ulcer,gastritis and gastric cancer via network pharmacology ***:Network pharmacology research methods were used to analyze the interaction network and potential mechanisms of Dangshen in treating gastric ulcer,gastritis and gastric *** active components and their target proteins of Dangshen were integrated from TCMSP,BATmaN-TCM *** targets of gastric ulcer,gastritis and gastric cancer were collected through GeneCards,PubMed,TDD and DisGeNET *** screening,the key components and the key targets of Dangshen in treating gastric ulcer,gastritis and gastric cancer were *** KEGG pathway analysis and GO analysis,the important pathways and biological processes were ***:Through data and literature mining,the common and specific pharmaceutical effects and mechanism of Dangshen were summarized in these three gastric *** was shown that Dangshen mainly acted on gastric ulcer,gastritis and gastric cancer through the overall regulation of the PI3K-AkT signaling *** the development of the disease,it will gradually increase the control of inflammation through TNF,NF-κB and other inflammation-related signaling pathways to reduce inflammatory *** tumorigenesis,it pays more attention to inhibiting the ErbB signaling pathways to reduce the proliferation and migration of tumor *** addition,Dangshen's regulation of HIF-1 signaling pathway may also be beneficial for the treatment of gastric ulcer,gastritis and gastric ***:Dangshen achieves spleen-fortifying effect on gastric diseases includi

关键词： Codonopsis Radix gastric cancer gastric ulcer gastritis network pharmacology same treatment for different diseases spleen-fortifying effect

A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： Sai-Nan Liu Jia-Hui Meng Li-yun Cui Hua Chen Lin-Qi Shi ru-Jiang ma Key Laboratory of Functional Polymer materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein *** combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer ***,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different ***,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)*** PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release *** the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their *** cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two *** cytoplasm,the high level of GSH removed the modification of 2-APBA on *** restored RNase A and DOX show a synergistic and enhanced antic-cancer *** system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond

Common mechanism of Citrus Grandis Exocarpium in treatment of chronic obstructive pulmonary disease and lung cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2021年第4期13卷 525-533页

作者： Wei Zhou Min Dong Hao Wu Hui-lin Li Jia-le Xie ru-yun ma Wei-wei Su Jian-ye Dai School of Pharmacy Lanzhou UniversityLanzhou 730000China Department of Pulmonology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM Guangdong Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

Objective:"Same treatment for different diseases"is a unique treatment strategy in traditional Chinese *** kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary disease(COPD)and lung *** Grandis Exocarpium(Huajuhong in Chinese,HJH),a famous herbal,is always applied by Chinese medicine practitioners to dispersion the lung to resolve phlegm based on"syndrome differentiation and treatment"***,the common mechanism for HJH’s treatment of COPD and lung cancer is not ***:In this study,based on network pharmacology and molecular docking technology,the common mechanism of HJH in the treatment of COPD and lung cancer was *** active ingredients and related targets of HJH were integrated from TCMSP,BATmaN-TAM,STP,and Pubchem *** standard names of these targets were united by Uni Prot *** of COPD and lung cancer were enriched through Gene Cards,NCBI(Gene),Therapeutic Target Database,and Dis Ge NET(v7.0)*** the intersection targets of HJH and diseases were *** STRING network and the Cytoscape 3.7.2 were used to construct PPI network,the DAVID database was used to perform GO and KEGG *** Cytoscape 3.6.1 was used to build"ingredient-target-signal pathway"***,Auto Dock 1.5.6 software was used to perform molecular docking of key proteins and ***:Eleven active ingredients in HJH were obtained by searching the database,corresponding to 184 HJH-COPD-lung cancer targets *** results of biological network analysis showed that naringenin,the active component in HJH,could mainly act on target proteins such as AKT1,*** through positive regulation of vasoconstriction and other biological processes,naringenin could regulate estrogen signaling pathway,VEGF signaling pathway,HIF-1 signaling pathway,Erb B signaling pathway,PI3K-Akt signaling pathway to play an important role in the treatment of both COPD and lung can

关键词： chronic obstructive pulmonary disease Citrus Grandis Exocarpium lung cancer mechanism molecular docking network pharmacology same treatment for different diseases

Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1514-1531页

作者： Yong Pan Yi-ru Zhang Ling-yun Wang Li-Na Wu Ying-Qiu ma Zhou Fang Shi-Bo Li Department of Infectious Disease Zhoushan HospitalWenzhou Medical UniversityZhoushan 316021Zhejiang ProvinceChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in ***,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain *** To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for *** The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal *** expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC *** targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan *** univariate and multivariate analysis were utilized to identify independent prognostic *** CDKN2A was frequently mutated and deleted in *** single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle *** CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully ***5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC *** association between GAS5 expression and methylation,immune infilt-ration was ***,traditional Chinese medicine effective components targeting GAS5 were *** This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and ***,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

关键词： Hepatocellular carcinoma Competitive endogenous RNA Molecular mechanism Prognosis Biomarker

magnetocaloric effect and phase transition critical behavior of La0.75Sr0.25Mn0.9Co0.1O3 compound synthesized under the high pressure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2024年第3期6卷 621-632页

作者： Jing Zhao Lei Gao Jian-Jun Zhao Wei Wei Hui-Qin yun ru Xing Huai-Jin ma Xiang Jin Luo-Meng Chao School of Physical Science and Technology Key Laboratory of Magnetism and Magnetic Materials for Higher Education in Inner Mongolia Autonomous Region Baotou Teachers' College National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Physics and Electronic Information Inner Mongolia Normal University College of Science Inner Mongolia University of Science and Technology

In this study,a novel method is proposed for producing perovskite rare-earth manganese oxide magnetic refrigeration materials that exhibit superior properties compared to similar *** maximum magnetic entropy change values for this sample are 1.44 and 3.75 J·kg-1·K-1for magnetic fields of 2 and 7 T,***,its relative cooling power has been calculated to be 101.96 and 404.78 J·kg-1,indicating good *** results were obtained using the sample synthesized under a pressure of 4 GPa,and the sample has undergone a second phase *** critical behavior of the sample fits well with the mean field *** different magnetic fields,there is a significant overlap between the values of the maximum magnetic entropy change and the temperature-averaged entropy change,indicating that the refrigeration performance of the sample after high pressure can approach its maximum capability.

关键词： High-pressure synthesis magnetocaloric effect Relative cooling power magnetic phase transition

带跳跃非线性项的p-Laplacian问题的结点解

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

数学学报（中文版） 2014年第1期57卷 189-194页

作者：代国伟马如云西北师范大学数学与统计学院兰州730070

研究了带跳跃非线性项的p-Laplacian方程结点解的存在性.如果该问题的非线性项跨越其对应齐次问题的Fucik谱,我们证明了该问题至少存在一个结点解.

关键词： Fucik谱结点解跳跃非线性项

在线全文

学校读者我要写书评

暂无评论

非齐次算子方程的势分歧定理及其应用

数学学报（中文版） 2022年第2期65卷 263-274页

作者：代国伟马如云大连理工大学数学科学学院大连116024 西安电子科技大学数学与统计学院西安710071

本文研究了算子方程λ(f’_(1)(x)+f’_(2)(x))=g’_(1)(x)+g’_(2)(x)的分歧现象.假设f’_(2)≡0,f_(1)和g_(1)是a-齐次的,及其他合适条件,Fucík等人证明λf’_(1)(x)=g’_(1)(x)的每一个LS-特征值都是上述算子方程的分歧点.这里我们研究非齐次情形f_(1)+f_(2).当f_(1),f_(2),g_(1)和g_(2)满足合适条件时,我们获得了和Fucík等人相同的结论.作为预备,我们获得了一个新的Lyusternik-Shnirel’man定理.作为抽象定理的应用,我们研究了一个非局部椭圆问题从任意LS-特征值产生的分歧现象.

关键词： Lyusternik-Shnirel’man定理势分歧非局部方程

SDCC: software-defined collective communication for distributed training

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第9期67卷 105-125页

作者： Xin JIN Zhen ZHANG yunshan JIA yun ma Xuanzhe LIU School of Computer Science Peking University Department of Computer Science and Technology Johns Hopkins University

Communication is crucial to the performance of distributed training. Today's solutions tightly couple the control and data planes and lack flexibility, generality, and performance. In this study, we present SDCC, a software-defined collective communication framework for distributed training. SDCC is based on the principle of modern systems design to effectively decouple the control plane from the data *** abstracts the operations for collective communication in distributed training with dataflow operations and unifies computing and communication with a single dataflow graph. The abstraction, together with the unification, is powerful: it enables users to easily express new and existing collective communication algorithms and optimizations, simplifies the integration with different computing engines(e.g., Py Torch and Tensor Flow) and network transports(e.g., Linux TCP and kernel bypass), and allows the system to improve performance by exploiting parallelism exposed by the dataflow graph. We further demonstrate the benefits of SDCC in four use cases.

关键词： machine learning systems distributed training deep learning collective communication software-defined networking