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Precise prediction model and simplified scoring system for sustained combined response to interferon-α

World Journal of Gastroenterology 2010年第27期16卷 3465-3471页

作者： Qian-Guo Mao ru-mian zhang Jin-Shui Pan Kuang-Nan Fang Jian-Ping Zhu Qing-Yang Hong Hepatology Unit and Department of Infectious Diseases Xiamen Hospital of Traditional Chinese Medicine Xiamen 361000 Fujian Province China Division of Gastroenterology Zhongshan Hospital Xiamen University Gastroenterology Institute of Xiamen University Gastroenterology Center of Xiamen Xiamen 361004 China Department of Planning and Statistics Xiamen University Xiamen 361005 China College of Information Science and Technology Xiamen UniversityXiamen 361005Fujian ProvinceChina

AIM:To establish a predictive algorithm which may serve for selecting optimal candidates for interferon-α(IFN-α) ***:A total of 474 IFN-α treated hepatitis B virus e antigen(HBeAg)-positive patients were enrolled in the present *** patients' baseline characteristics,such as age,gender,blood tests,activity grading(G) of intrahepatic inflammation,score(S) of liver fibrosis,hepatitis B virus(HBV) DNA and genotype were evaluated;therapy duration and response of each patient at the 24th wk after cessation of IFN-α treatment were also recorded.A predictive algorithm and scoring system for a sustained combined response(CR) to IFN-α therapy were *** 10% of the patients were randomly drawn as the test *** to IFN-α therapy were divided into CR,partial response(PR) and non-response(NR).The mixed set of PR and NR was recorded as PR+***:Stratified by therapy duration,the most significant baseline predictive factors were alanine aminotransferase(ALT),HBV DNA level,aspartate aminotransferase(AST),HBV genotype,S,G,age and *** to the established model,the accuracies for sustained CR and PR+NR,respectively,were 86.4% and 93.0% for the training set,81.5% and 91.0% for the test *** the scoring system,the sensitivity and specificity were 78.8% and 80.6%,*** were positive correlations between ALT and AST,and G and S,***:With these models,practitioners may be able to propose individualized decisions that have an integrated foundation on both evidence-based medicine and personal characteristics.

关键词： Chronic hepatitis B Interferon-α Patient selection Predictive model Scoring system Treatment outcome

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新质生产力的运行机理、生成逻辑与模式建构——基于生产力与生产关系辩证统一的视角

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 89-97页

作者：李勇坚张海汝中国社会科学院财经战略研究院北京100005 浙江财经大学浙江杭州310018 江苏省社会科学院经济研究所江苏南京210004

新质生产力是创新发挥主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。纵观三次科技革命变革生产力的历程,新质生产力的产生和发展是生产力与生产关系相互作用的结果... 详细信息

新质生产力是创新发挥主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。纵观三次科技革命变革生产力的历程,新质生产力的产生和发展是生产力与生产关系相互作用的结果,具有生产力与生产关系的双重内涵和发展要求。新质生产力以新型劳动者、新型劳动资料、新型劳动对象及其组合模式和新型生产关系为架构要素与发展基础,其生成逻辑与运行机理是由技术革命性突破引发,在催生新型生产力要素、新型要素组合模式的基础上促使与新质生产力相适应的新型生产关系变革形成,新型生产关系的反作用促进新质生产力进一步生成的过程。发展新质生产力要以实施创新驱动战略、加快产业深度转型、构建要素生态系统和全面深化改革为基本模式和关键路径。亟须加快实现高水平科技自立自强,加快技术革命性创新;促进产业深度转型,构建现代化产业体系;促进生产要素创新配置,构建新质生产要素系统;全面深化改革,加快建立健全与新质生产力相适应的新型生产关系,促进新质生产力加快形成发展。

关键词：新质生产力新型生产关系技术革命性突破全面深化改革

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基于RHT本构模型的连续装药预裂爆破孔距优化研究

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高压物理学报 2025年第1期39卷 109-118页

作者：张伟王建国王勉陶家龙昆明理工大学国土资源工程学院云南昆明650093 云南省教育厅爆破新技术工程研究中心云南昆明650093

为解决北衙金矿在使用预裂爆破技术时整体爆破效果不佳的问题,基于RHT损伤本构模型,利用ANSYS/LS-DYNA数值模拟软件,开展了不同孔距下预裂爆破的数值模拟研究。结果表明:当预裂孔炮孔间距为120 cm时,孔间裂纹存在较为明显的分叉,且裂纹... 详细信息

为解决北衙金矿在使用预裂爆破技术时整体爆破效果不佳的问题,基于RHT损伤本构模型,利用ANSYS/LS-DYNA数值模拟软件,开展了不同孔距下预裂爆破的数值模拟研究。结果表明:当预裂孔炮孔间距为120 cm时,孔间裂纹存在较为明显的分叉,且裂纹扩展范围较大;当炮孔间距为130 cm时,裂纹向四周扩展的范围减小,且炮孔周围岩石的损伤程度明显降低;当炮孔间距增加至140 cm时,相邻预裂孔连线上的裂纹仅在局部连通,无法实现孔间贯穿。上述结果说明,130 cm的炮孔间距在降低预裂爆破自身对岩体的扰动与实现有效爆破成缝之间达到了平衡。基于数值模拟试验结果开展了现场试验,爆破效果良好。研究结果可为矿山的预裂爆破设计和施工提供参考。

关键词：预裂爆破连续装药孔距优化 RHT本构模型

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Invariant properties of representations under cleft extensions

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Science China Mathematics 2007年第1期50卷 121-131页

作者： Fang LI mian-mian zhang Department of Mathematics Zhejiang UniversityHangzhou310027China

The main aim of this paper is to give the invariant properties of representations of algebras under cleft extensions over a semisimple Hopf algebra. Firstly, we explain the concept of the cleft extension and give a relation between the cleft extension and the crossed product which is the approach we depend upon. Then, by making use of them, we prove that over an algebraically closed field k, for a finite dimensional Hopf algebra H which is semisimple as well as its dual H*, the representation type of an algebra is an invariant property under a finite dimensional H-cleft extension . In the other part, we still show that over an arbitrary field k, the Nakayama property of a k-algebra is also an invariant property under an H -cleft extension when the radical of the algebra is H-stable.

关键词： cleft extensions crossed product Nakayama algebra representation type 16G60 16W30 16S40

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Microbial self-healing of cracks in cement-based materials and its influencing factors

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Frontiers of Structural and Civil Engineering 2023年第11期17卷 1630-1642页

作者： Xiaoniu YU Qiyong zhang Xuan zhang mian LUO Jiangsu Key Laboratory of Construction Materials Southeast UniversityNanjing 211189China College of Engineering and Technology Southwest UniversityChongqing 400715China School of Civil Engineering and Architecture Jiangsu University of Science and TechnologyZhenjiang 212114China College of Civil Science and Engineering Yangzhou UniversityYangzhou 225127China

Cement-based materials are brittle and crack easily under natural *** can reduce service life because the transport of harmful substances can cause corrosion damage to the *** review discusses the feasibility of using microbial self-healing agents for crack *** and spherical carriers can be used to load microbial self-healing agents and protect microbes,which prolongs the self-healing *** area self-healing ratio,permeability,mechanical strength,precipitation depth method,numerical modeling,and ultrasonic method can be employed to identify the self-healing effect of ***,the self-healing mechanism is systematically *** results showed that microbial self-healing agents can repair cracks in cement-based materials in underground projects and dam *** difficulties and future development of self-healing cracks were analyzed.A microbial selfhealing agent was embedded in the cement-based material,which automatically repaired the developing *** the development of intelligent building materials,self-healing cracks have become the focus of attention.

关键词： cement-based materials cracks microbial self-healing agent mechanism intelligent building materials

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A Spectral Element Method to Compute Earth’s Free Core Nutation

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Research in Astronomy and Astrophysics 2023年第9期23卷 171-179页

作者： mian zhang Cheng-Li Huang CAS Key Laboratory of Planetary Sciences Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The Free Core Nutation(FCN)is a rotational mode caused by non-alignment of the rotation axis of the core and of the *** period observed by VLBI and superconducting gravimetry is around 430 sidereal days(Sd)with precision of better than 1 Sd,while its“theoretical”period calculated by traditional approaches and a given Earth model ranges from 450 to 470 *** gap of about 30 Sd is significant compared with its observation *** propose a spectral element method to compute the period of FCN and obtain a period of 434 Sd which is very close to the observed value.

关键词： Earth-planets and satellites interiors-methods numerical

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A Linear Operator Method to Compute the Normal Modes with Rotation of any Asymmetric 3D Planet with Pure Vector Spherical Harmonics

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Research in Astronomy and Astrophysics 2023年第10期23卷 224-254页

In order to compute the free core nutation of the terrestrial planets, such as Earth and Mars, the Moon and lower degree normal modes of the Jovian planets, we propose a linear operator method(LOM). Generalized surface spherical harmonics(GSSHs) are usually applied to the elliptical models with a stress tensor, which cannot be expressed in vector spherical harmonics explicitly. However, GSSHs involve complicated math. LOM is an alternative to GSSHs,whereas it only deals with the coupling fields of the same azimuthal order m, as is the case when a planet model is axially symmetric and rotates about that symmetry axis. We extend LOM to any asymmetric 3D model. The lower degree spheroidal modes of the Earth are computed to validate our method, and the results agree very well with what is observed. We also compute the normal modes of a two-layer Saturn model as a simple application.

关键词： planets and satellites:interiors Earth planets and satellites:gaseous planets

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Effects of Combined Treatment with Sansanmycin and Macrolides on Pseudomonas aeruginosa and Formation of Biofilm

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Biomedical and Environmental Sciences 2009年第2期22卷 170-177页

作者： YUE LI YUN-YING XIE ru-XIAN CHEN HONG-zhang XU GUO-JI zhang JIN-ZHE LI AND XIAO-mian LI Department of Microbiology Tianjin Medical University Tianjin 300070 China Department of Microbiology and Biochemical Pharmacy Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences Beijing 100050 China

Objective To observe the effects of combined treatment with sansanmycin and macrolides on Pseudomonas aeruginosa and formation of biofilm. Methods Micro-dilution method was used to determine the minimal inhibitory concentrations （MICs） of sansanmycin, gentamycin, carbenicillin, polymyxin B, roxithromycin, piperacillin, and tazobactam. PAl and PA27853 biofilms were observed under optical microscope after staining and under SEM after treatment with sansanmycin at different dosages and combined treatment with sansanmycin and roxithromycin. Viable bacteria in PAl and PA27853 biofilms were counted after treatment with sansanmycin at different dosages or combined treatment with sansanmycin and roxithromycin. Results The MIC of sansanmycin was lower than that of gentamycin and polymyxin B, but was higher than that of carbenicillin. Roxithromycin enhanced the penetration of sansanmycin to PAl and PA27853 strains through biofilms. PAl and PA27853 biofilms were gradually cleared with the increased dosages of sansanmycin or with the combined sansanmycin and roxithromycin. Conclusion Sub-MIC levels of roxithromycin and sansanmycin substantially inhibit the generation of biofilms and proliferation of bacteria. Therefore, combined antibiotics can be used in treatment of intractable bacterial infection.

关键词： Sansanmycin Macrolides Pseudomonas aeruginosa Biofilm

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Mechanokinetics of receptor-ligand interactions in cell adhesion

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Acta Mechanica Sinica 2015年第2期31卷 248-258页

作者： Ning Li Shouqin Lü Yan zhang mian Long Key Laboratory of Microgravity(National Microgravity Laboratory) Center of Biomechanics and Bioengineeringand Beijing Key Laboratory of Engineered Construction and MechanobiologyInstitute of MechanicsChinese Academy of Sciences

Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade,platelet thrombosis,as well as tumor *** mediate cell adhesion,the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum,i.e.,two-dimensional（2D）binding,which is different from the binding of a soluble ligand in fluid phase to a receptor,i.e.,three-dimensional（3D） *** numerous works have been focused on3 D kinetics of receptor-ligand interactions in the immune system,2D kinetics and its regulations have been less understood,since no theoretical framework or experimental assays were established until *** only does the molecular structure dominate 2D binding kinetics,but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ***,we provide an overview of current progress in 2D binding and regulations,mainly from our *** issues of theoretical frameworks,experimental measurements,kinetic rates and binding affinities,and force regulations are discussed.

关键词： Receptor-ligand interactions Selectins β_2 integrins 2D binding kinetics

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Tribocorrosion behavior of antibacterial Ti-Cu sintered alloys in simulated biological environments

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Rare Metals 2022年第6期41卷 1921-1932页

作者： Jia-Qi zhang Shuang Cao Ying Liu mian-mian Bao Jing Ren Sheng-Yi Li Er-Lin zhang Jian-Jie Wang Departments of Immunology College of Basic MedicineJiamusi UniversityJiamusi 154007China Key Laboratory for Anisotropy and Texture of Materials School of Materials Science and EngineeringEducation Ministry of ChinaNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Ti-Cu alloys have strong antibacterial proper-ties,high strength and excellent corrosion resistance,which might be used in orthopedic and dental *** this paper,the tribocorrosion behaviors of Ti-Cu alloy with different Cu contents were investigated in four simulated biological environments compared with *** results showed that Ti-Cu sintered alloy exhibited higher corro-sion resistance,lower coefficient friction and wear loss than cp-Ti in all tested solutions due to the formation of fine and homogeneously distributed Ti_(2)Cu phase,espe-cially in solution with lower F ion and *** Cu content and extrusion process improved the corrosion resistance and the wear resistance because of high Ti_(2)Cu phase fraction and fine grain ***,aggressive solution,such as the solution with lower F ion and pH,accelerated wear in comparison with other solutions for cp-Ti and Ti-Cu sintered *** electron microscope(SEM)surface morphology demonstrated that the wear mecha-nism of cp-Ti during tribocorrosion process was mainly abrasive wear and adhesive wear while that of Ti-Cu alloy was abrasive *** summary,Ti-Cu sintered alloys showed much better tribocorrosion property than cp-Ti,which shows great potential application in condition for wear and corrosion resistance.

关键词： Ti-Cu alloys Tribocorrosion Corrosion Wear In vitro Antibacterial metal alloy

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