Precise prediction model and simplified scoring system for sustained combined response to interferon-α

作     者：Qian-Guo Mao Ru-Mian Zhang Jin-Shui Pan Kuang-Nan Fang Jian-Ping Zhu Qing-Yang Hong 

作者机构：Hepatology Unit and Department of Infectious Diseases Xiamen Hospital of Traditional Chinese Medicine Xiamen 361000 Fujian Province China Division of Gastroenterology Zhongshan Hospital Xiamen University Gastroenterology Institute of Xiamen University Gastroenterology Center of Xiamen Xiamen 361004 China Department of Planning and Statistics Xiamen University Xiamen 361005 China College of Information Science and TechnologyXiamen UniversityXiamen 361005Fujian ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第27期

页      面：3465-3471页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：Chronic hepatitis B Interferon-α Patient selection Predictive model Scoring system Treatment outcome 

摘      要：AIM:To establish a predictive algorithm which may serve for selecting optimal candidates for interferon-α(IFN-α) ***:A total of 474 IFN-α treated hepatitis B virus e antigen(HBeAg)-positive patients were enrolled in the present *** patients baseline characteristics,such as age,gender,blood tests,activity grading(G) of intrahepatic inflammation,score(S) of liver fibrosis,hepatitis B virus(HBV) DNA and genotype were evaluated;therapy duration and response of each patient at the 24th wk after cessation of IFN-α treatment were also recorded.A predictive algorithm and scoring system for a sustained combined response(CR) to IFN-α therapy were *** 10% of the patients were randomly drawn as the test *** to IFN-α therapy were divided into CR,partial response(PR) and non-response(NR).The mixed set of PR and NR was recorded as PR+***:Stratified by therapy duration,the most significant baseline predictive factors were alanine aminotransferase(ALT),HBV DNA level,aspartate aminotransferase(AST),HBV genotype,S,G,age and *** to the established model,the accuracies for sustained CR and PR+NR,respectively,were 86.4% and 93.0% for the training set,81.5% and 91.0% for the test *** the scoring system,the sensitivity and specificity were 78.8% and 80.6%,*** were positive correlations between ALT and AST,and G and S,***:With these models,practitioners may be able to propose individualized decisions that have an integrated foundation on both evidence-based medicine and personal characteristics.