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算法管理与员工创造力:借算法之势而创还是困数字牢笼而息

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系统管理学报 2024年第3期33卷 782-800页

作者：赵爽马君上海大学管理学院上海200444

算法管理替代传统经验管理已成为不可逆转的趋势。集成“最佳实践”智慧的算法管理是帮助员工站在“巨人肩上”从而拥有更多的时间和空间产生创造力,还是导致员工产生认知依赖或束缚于“数字牢笼”而使得创造力乏善可陈尚未得知。基于... 详细信息

算法管理替代传统经验管理已成为不可逆转的趋势。集成“最佳实践”智慧的算法管理是帮助员工站在“巨人肩上”从而拥有更多的时间和空间产生创造力,还是导致员工产生认知依赖或束缚于“数字牢笼”而使得创造力乏善可陈尚未得知。基于自我决定理论,构建了算法管理影响员工创造力的非线性框架。研究1(预研究)通过Python对社交媒体数据进行文本分析,获取社会大众对算法管理的情感倾向,并在此基础上提炼出增益效应和损耗效应两条不同的情感倾向,为探索算法管理对创造力的非线性效应奠定基础。研究2进一步探索了非线性成因以及员工“自下而上”的工作重塑在这一过程中所发挥的作用。结果发现:算法管理对创造力存在倒U型影响,内在动机起部分中介作用,工作重塑则可以缓解两者的倒U型关系。研究阐明了算法管理的“过犹不及”效应以及工作重塑促使算法管理“扬长补短”的内在机制,对企业优化算法管理从而推动创新发展具有重要意义。

关键词：算法管理员工创造力工作重塑自我决定理论文本分析倒U效应

Design of a novel hybrid quantum deep neural network in INEQR images classification

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Chinese Physics B 2024年第6期33卷 230-238页

作者：王爽王柯涵程涛赵润盛马鸿洋郭帅 School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China School of Sciences Qingdao University of TechnologyQingdao 266033China

We redesign the parameterized quantum circuit in the quantum deep neural network, construct a three-layer structure as the hidden layer, and then use classical optimization algorithms to train the parameterized quantum circuit, thereby propose a novel hybrid quantum deep neural network(HQDNN) used for image classification. After bilinear interpolation reduces the original image to a suitable size, an improved novel enhanced quantum representation(INEQR) is used to encode it into quantum states as the input of the HQDNN. Multi-layer parameterized quantum circuits are used as the main structure to implement feature extraction and classification. The output results of parameterized quantum circuits are converted into classical data through quantum measurements and then optimized on a classical computer. To verify the performance of the HQDNN, we conduct binary classification and three classification experiments on the MNIST(Modified National Institute of Standards and Technology) data set. In the first binary classification, the accuracy of 0 and 4 exceeds98%. Then we compare the performance of three classification with other algorithms, the results on two datasets show that the classification accuracy is higher than that of quantum deep neural network and general quantum convolutional neural network.

关键词： quantum computing image classification quantum–classical hybrid neural network quantum image representation interpolation

Results of 23 yr of Pulsar Timing of PSR J1453-6413

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Research in Astronomy and Astrophysics 2023年第10期23卷 357-366页

作者： Wei Li Shi-Jun Dang Jian-Ping Yuan Lin Li Wei-Hua Wang Lun-Hua Shang Na Wang Qing-Ying Li Ji-Guang Lu Fei-Fei Kou shuang-Qiang Wang Shuo Xiao Qi-Jun Zhi Yu-Lan Liu ru-shuang zhao Ai-Jun Dong Bin Zhang Zi-Yi You Yan-Qing Cai Ya-Qin Yang Ying-Ying Ren Yu-Jia Liu Heng Xu School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China Guizhou Radio Astronomy Observatory Guizhou UniversityGuiyang 550025China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China College of Mathematics and Physics Wenzhou UniversityWenzhou 325035China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

In this paper,we presented the 23.3 yr of pulsar timing results of PSR J1456-6413 based on the observations of Parkes 64 m radio *** detected two new glitches at MJD 57093(3)and 59060(12)and confirmed its first glitch at MJD 54554(10).The relative sizes(Δν/ν)of these two new glitches are 0.9×10^(-9)and 1.16×10^(-9),*** the“Cholesky”timing analysis method,we have determined its position,proper motion,and two-dimensional transverse velocities from the data segments before and after the second glitch,***,we detected exponential recovery behavior after the first glitch,with a recovery timescale of approximately 200 days and a corresponding exponential recovery factor Q of approximately 0.15(2),while no exponential recovery was detected for the other two *** interestingly,we found that the leading component of the integral pulse profile after the second glitch became stronger,while the main component became *** results will expand the sample of pulsars with magnetosphere fluctuation triggered by the glitch event.

关键词： Stars (stars:)pulsars:individual(PSR J1453-6413) stars:neutron

Efficacy and safety of low-dose tetracycline,amoxicillin quadruple therapy in Helicobacter pylori infection:A retrospective single center study

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World Journal of Gastroenterology 2024年第39期30卷 4295-4304页

作者： Yi-ru zhao Xin-Jie Wang Meng-Jia Zhu Ang-Li Chen Dian Zhang Qin Du John J Kim Wei-Ling Hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated HospitalMedical SchoolZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Keck School of Medicine University of Southern CaliforniaLos AngelesCA 90089-9021United States Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)eradication rates have declined with the rise of antibiotic-resistant strains in recent *** highly effective with a low prevalence of resistance,standard dose tetracycline is associated with frequent adverse *** efficacy and safety of low-dose tetracycline as part of tetra-cycline and amoxicillin-containing bismuth quadruple therapy are not well *** To compare the efficacy and safety of low-dose compared to standard dose tetracycline with combined amoxicillin-containing bismuth quadruple therapy in patients with *** *** Consecutive patients with *** infection receiving tetracycline,amoxicillin,proton pump inhibitor,and bismuth for 14 days at Sir run run Shaw Hospital(1/2022-6/2023)were *** low-dose tetracycline group received tetracycline 500 mg twice daily(bid)while the standard dose group received 750 mg bid or 500 mg three times daily(tid).Primary endpoints were *** eradication rate and treatment-related adverse events.

关键词： Helicobacter pylori Tetracycline Amoxicillin Eradication Adverse events Bismuth quadruple therapy

GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases

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The Innovation 2024年第2期5卷 27-41页

作者： Zheyan Fang Gang zhao shuang zhao Xueting Yu runyang Feng You-en Zhang Haomin Li Lei Huang Zhenyang Guo Zhentao Zhang Mukaddas Abdurahman Hangnan Hong Peng Li Bing Wu Jinhang Zhu Xin Zhong Dong Huang Hao Lu Xin zhao zhaoyang Chen Wenbin Zhang Junjie Guo Hongchao Zheng Yue He Shengying Qin Haojie Lu Yun zhao Xiangdong Wang Junbo Ge Hua Li Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Medical Examination Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology and Institute of Clinical Medicine Renmin HospitalHubei University of MedicineShiyan 442000China Clinical Data Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Molecular Celland Cancer BiologyUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Bio-X Institute Key Laboratory for The Genetics of Developmental and Neuropsychiatric DisordersShanghai Jiao Tong UniversityShanghai 200030China Department of Cardiology Heart Center of Fujian ProvinceFujian Medical University Union HospitalFuzhou 350001China Department of Cardiology Sir Run Run Shaw Hospitalaffiliated with Zhejiang University School of MedicineHangzhou 310020China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Cardiology Shanghai Xuhui District Central HospitalShanghai 200031China Department of Cardiology Shanghai Eighth People’s HospitalShanghai 200235China Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology Shanghai Tech University100 Haike RoadShanghai 201210China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Pulmonary and Critical Care Medicine Zhongshan Hospital

Partial endothelial-to-mesenchymal transition(EndMT)is an intermediate phenotype observed in endothelial cells(ECs)undergoing a transition toward a mesenchymal state to support neovascularization during(patho)physiological ***,we investigated the occurrence of partial EndMT in ECs under hypoxic/ischemic conditions and identified general transcription factor IIH subunit 4(GTF2H4)as a positive regulator of this *** addition,we discovered that GTF2H4 collaborates with its target protein excision repair cross-complementation group 3(ERCC3)to co-regulate partial ***,by using phosphorylation proteomics and site-directed mutagenesis,we demonstrated that GTF2H4 was involved in the phosphorylation of receptor coactivator 3(NCOA3)at serine 1330,which promoted the interaction between NCOA3 and p65,resulting in the transcriptional activation of NF-κB and the NF-kB/Snail signaling axis during partial *** vivo experiments confirmed that GTF2H4 significantly promoted partial EndMT and angiogenesis after ischemic ***,our findings reveal that targeting GTF2H4 is promising for tissue repair and offers potential opportunities for treating hypoxic/ischemic diseases.

关键词： ischemic activation GTF

Cuproptosis:A potential therapeutic target in clear cell renal cell carcinoma

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Chinese Medical Journal 2024年第11期137卷 1378-1380页

作者： Yuetong zhao Jie Li Xiaojie Lu shuang Wu Yunze Xing Yaxuan Fang Bo Yang Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Nephrology National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological *** ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in *** studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in *** most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ***,cuproptosis induction may offer a new approach for ccRCC treatment.

关键词： metabolism chemotherapy potential

Expert consensus on endodontic therapy for patients withsystemic conditions

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International Journal of Oral Science 2024年第3期16卷 390-397页

作者： Xin Xu Xin Zheng Fei Lin Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Jiyao Li Lili Chen Zuomin Wang Hongkun Wu Zhiyue Lu Jizhi zhao Yuhong Liang Jin zhao Yihuai Pan shuang Pan Xiaoyan Wang Deqin Yang Yanfang Ren Lin Yue Xuedong Zhou State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital StomatologyPeking UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of Oral DiseasesDepartment of Operative Dentistry&EndodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Center for Microscope Enhanced Dentistry Beijing Stomatological HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina Department of Endodontics School of StomatologyChina Medical UniversityShenyangChina College&Hospital of Stomatology Guangxi Medical UniversityNanningChina Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Stomatology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Geriatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina Beijing Hospital National Center of GerontologyBeijingChina Department of Stomatology Peking Union Medical College Hospit

The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. Asystemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining thenecessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is acollaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence,aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontictherapy in patients with compromised overall health.

关键词： patients diagnosis prognosis

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岩棉复合保温外模板承载力及温度效应分析

哈尔滨工业大学学报 2024年第1期56卷 130-138页

作者：赵建军付佳欣李爽结构工程灾变与控制教育部重点实验室(哈尔滨工业大学) 哈尔滨150090 土木工程智能防灾减灾工业和信息化部重点实验室(哈尔滨工业大学) 哈尔滨150090

为了提高建筑外围护结构施工效率及解决传统外保温系统长期存在的易脱落和易着火问题,提出了一种集保温和建筑模板于一体的岩棉复合保温外模板(RW-CIEF)体系。RW-CIEF由内到外依次为内侧加强层、岩棉保温芯材、黏结层、保温过渡层以及... 详细信息

为了提高建筑外围护结构施工效率及解决传统外保温系统长期存在的易脱落和易着火问题,提出了一种集保温和建筑模板于一体的岩棉复合保温外模板(RW-CIEF)体系。RW-CIEF由内到外依次为内侧加强层、岩棉保温芯材、黏结层、保温过渡层以及外侧加强层。以哈尔滨市为例,基于全寿命周期成本(life cycle cost,C lc)确定了岩棉保温芯材的最佳厚度。采用有限元分析与理论计算相结合的方法探求了RW-CIEF在工程中的可行性,分析了RW-CIEF的抗弯性能、施工承载力及温度效应下的应力和变形,讨论了开槽形式、开槽宽度、开槽深度以及开槽间距对RW-CIEF抗弯性能的影响。结果表明:RW-CIEF的抗弯性能理论计算结果与有限元分析结果有较高的一致性;开槽处理可有效提高RW-CIEF的抗弯性能,综合抗弯性能、热工特性及加工角度,建议开槽形式选用对应开井字槽或对应开纵槽,开槽深度和宽度均为10 mm,开槽间距为150 mm;设计的RW-CIEF满足施工承载力,可保证外围护结构保温工程施工质量;由温度效应产生的最大拉应力和压应力均未超过RW-CIEF的外侧加强层承载力,反映出RW-CIEF出现夏季空鼓或冬季开裂现象的可能性极小。提出的RW-CIEF体系可为外围护结构保温工程及建筑模板工程未来研究方向提供一种新的思路和方法。

关键词：岩棉复合保温外模板抗弯性能开槽处理施工承载力温度效应

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SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM

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Science China Life Sciences 2024年

作者： Hong-Guo Duan shuang Wang Wen-Jie Shu Yong-Jia Tong Hai-Zhen Long Guo-Hong Li Hai-Ning Du Meng-Jie zhao Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismEmergency CenterZhongnan Hospital of Wuhan UniversityRNA InstituteWuhan University The Institute for Advanced Studies Wuhan University Shenzhen Bay Laboratory Hubei Key Laboratory of Cell Homeostasis College of Life Sciences TaiKang Center for Life and Medical Sciences Frontier Science Center for Immunology and Metabolism Wuhan University

The minichromosome maintenance complex(MCM) DNA helicase is an important replicative factor during DNA replication. The proper chromatin loading of MCM is a key step to ensure replication initiation during S phase. Because replication initiation is regulated by multiple biological cues, additional changes to MCM may provide better understanding towards this event. Here, we report that histidine methyltransferase SETD3 promotes DNA replication in a manner dependent on enzymatic activity. Nascent-strand sequencing(NS-seq)shows that SETD3 regulates replication initiation, as depletion of SETD3 attenuates early replication origins firing. Biochemical studies reveal that SETD3 binds MCM mainly during S phase, which is required for the CDT1-mediated chromatin loading of MCM. This MCM loading relies on histidine-459 methylation(H459me) on MCM7 which is catalyzed by SETD3. Impairment of H459 methylation attenuates DNA synthesis and chromatin loading of MCM. Furthermore, we show that CDK2 phosphorylates SETD3 at Serine-21 during the G1/S phase,which is required for DNA replication and cell cycle progression. These findings demonstrate a novel mechanism by which SETD3 methylates MCM to regulate replication initiation.

关键词： histidine methylation SETD3 DNA replication MCM replication origin firing